Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica
ilustraciones, diagramas, fotografías
- Autores:
-
Rodríguez Vera, Edward Andrés
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/85403
- Palabra clave:
- 000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
530 - Física::532 - Mecánica de fluidos
610 - Medicina y salud::615 - Farmacología y terapéutica
sistemas de liberación de medicamentos
diseño de fármacos
mecánica de fluidos
Drug Delivery Systems
Drug Design
Flow Mechanics
MIcrofluidos
Película polimérica
Dinámica de fluidos computacional
Sistemas de liberación modificada
Diseño integrado de producto y proceso
MIcrofluidics
Polymeric film
Computational fluid dynamics
Modified release system
Integrated product and process development
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| dc.title.translated.eng.fl_str_mv |
Study of mass transport phenomena at a microscopic scale, for its application in the design of modified release systems of the polymeric film type |
| title |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| spellingShingle |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica 000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación 530 - Física::532 - Mecánica de fluidos 610 - Medicina y salud::615 - Farmacología y terapéutica sistemas de liberación de medicamentos diseño de fármacos mecánica de fluidos Drug Delivery Systems Drug Design Flow Mechanics MIcrofluidos Película polimérica Dinámica de fluidos computacional Sistemas de liberación modificada Diseño integrado de producto y proceso MIcrofluidics Polymeric film Computational fluid dynamics Modified release system Integrated product and process development |
| title_short |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| title_full |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| title_fullStr |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| title_full_unstemmed |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| title_sort |
Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica |
| dc.creator.fl_str_mv |
Rodríguez Vera, Edward Andrés |
| dc.contributor.advisor.spa.fl_str_mv |
Vallejo Díaz, Bibiana Margarita |
| dc.contributor.author.spa.fl_str_mv |
Rodríguez Vera, Edward Andrés |
| dc.contributor.researchgroup.spa.fl_str_mv |
Investigación en Procesos de Transformación de Materiales Para la Industria Farmacéutica |
| dc.subject.ddc.spa.fl_str_mv |
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación 530 - Física::532 - Mecánica de fluidos 610 - Medicina y salud::615 - Farmacología y terapéutica |
| topic |
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación 530 - Física::532 - Mecánica de fluidos 610 - Medicina y salud::615 - Farmacología y terapéutica sistemas de liberación de medicamentos diseño de fármacos mecánica de fluidos Drug Delivery Systems Drug Design Flow Mechanics MIcrofluidos Película polimérica Dinámica de fluidos computacional Sistemas de liberación modificada Diseño integrado de producto y proceso MIcrofluidics Polymeric film Computational fluid dynamics Modified release system Integrated product and process development |
| dc.subject.decs.spa.fl_str_mv |
sistemas de liberación de medicamentos diseño de fármacos mecánica de fluidos |
| dc.subject.decs.eng.fl_str_mv |
Drug Delivery Systems Drug Design Flow Mechanics |
| dc.subject.proposal.spa.fl_str_mv |
MIcrofluidos Película polimérica Dinámica de fluidos computacional Sistemas de liberación modificada Diseño integrado de producto y proceso |
| dc.subject.proposal.eng.fl_str_mv |
MIcrofluidics Polymeric film Computational fluid dynamics Modified release system Integrated product and process development |
| description |
ilustraciones, diagramas, fotografías |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023-08-02 |
| dc.date.accessioned.none.fl_str_mv |
2024-01-22T20:02:36Z |
| dc.date.available.none.fl_str_mv |
2024-01-22T20:02:36Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/85403 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/85403 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
| language |
spa |
| dc.relation.indexed.spa.fl_str_mv |
Bireme |
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Plasticization of aqueous poly(vinyl alcohol) and hydroxypropyl methylcellulose with polyethylene glycols and glycerol. European Polymer Journal, 29(7), 937-943. https://doi.org/10.1016/0014-3057(93)90289-R Seiffert, S., & Thiele, J. (2020). Microfluidics: Theory and practice for beginners. De Gruyter. Setapa, A., Ahmad, N., Mohd Mahali, S., & Mohd Amin, M. C. I. (2020). Mathematical Model for Estimating Parameters of Swelling Drug Delivery Devices in a Two-Phase Release. Polymers, 12(12), Article 12. https://doi.org/10.3390/polym12122921 Shamsi, M., Mohammadi, A., Manshadi, M. K. D., & Sanati-Nezhad, A. (2019). Mathematical and computational modeling of nano-engineered drug delivery systems. Journal of Controlled Release, 307, 150-165. https://doi.org/10.1016/j.jconrel.2019.06.014 Siepmann, J., Kranz, H., Bodmeier, R., & Peppas, N. A. (1999). HPMC-Matrices for Controlled Drug Delivery: A New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics. Pharmaceutical Research, 16(11), 1748-1756. https://doi.org/10.1023/A:1018914301328 Siepmann, J., & Siepmann, F. (2012). Modeling of diffusion controlled drug delivery. Journal of Controlled Release, 161(2), 351-362. https://doi.org/10.1016/j.jconrel.2011.10.006 Skolotneva, E., Cretin, M., & Mareev, S. (2021). A Simple 1D Convection-Diffusion Model of Oxalic Acid Oxidation Using Reactive Electrochemical Membrane. Membranes, 11(6), 431. https://doi.org/10.3390/membranes11060431 Skoog, D. A., Holler, F. J., & Crouch, S. R. (2018). Principles of instrumental analysis (Seventh edition). Cengage Learning. Soylak, M., Unsal, Y. E., Yilmaz, E., & Tuzen, M. (2011). Determination of rhodamine B in soft drink, waste water and lipstick samples after solid phase extraction. 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Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Vallejo Díaz, Bibiana Margaritaae0fdc78b870634d89f3dda3a3e15fb9Rodríguez Vera, Edward Andrés88d99f3f8e74038c35498d423573e7abInvestigación en Procesos de Transformación de Materiales Para la Industria Farmacéutica2024-01-22T20:02:36Z2024-01-22T20:02:36Z2023-08-02https://repositorio.unal.edu.co/handle/unal/85403Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasEn esta investigación se estudiaron los fenómenos de transporte de masa y momento en un dispositivo de dimensiones milimétricas, fabricado con el propósito de recrear un modelo simplificado de cavidad nasal; este dispositivo permite la inserción de una película polimérica y el flujo de un fluido simulado de sangre. La descripción de estos fenómenos se realizó a través del planteamiento de un modelo matemático que fue discretizado con un esquema combinado de diferencias finitas centradas y diferencias finitas hacia atrás, incorporando un método de avance temporal semi-implícito. Para validar el modelo matemático se realizó un experimento que consiste en insertar una película polimérica cargada de rodamina dentro del dispositivo de estudio y se capturan imágenes en un microscopio de fluorescencia a diferentes tiempos; por otro lado, a la salida del dispositivo se recolectan muestras que se cuantifican posteriormente por medio de un espectrofotómetro UV-vis. También, se desarrollaron una serie de experimentos complementarios que retroalimentan la simulación. El resultado de las operaciones computacionales sumado a la estandarización del método de elaboración de películas seleccionado (vertimiento en placa) permitió aplicar bases científicas y matemáticas al diseño de películas poliméricas siguiendo algunos conceptos de la metodología del Diseño Integrado de Producto y Proceso. Gracias a los experimentos y las herramientas computacionales, se plantearon una serie de casos para el análisis de la influencia de parámetros en el desempeño de la liberación de películas poliméricas. (Texto tomado de la fuente).In the current research, the mass and momentum transport phenomena were studied in a device of millimeter dimensions, manufactured with the purpose of recreating a simplified model of the nasal cavity; this device allows the insertion of a polymeric film and the flow of a simulated blood fluid. Phenomena description was carried out through the approach of a mathematical model that was discretized with a combined centered finite differences and backwards finite differences schemes, incorporating a semi-implicit time advance method. To validate the mathematical model, it was developed an experiment that consists of inserting a rhodamine-loaded polymeric film inside the study device and capturing images in a fluorescence microscope at different times; on the other hand, at the exit of the device, samples are collected and quantified by means of a UV-vis spectrophotometer. Also, a series of complementary experiments were elaborated to feed back the simulation. The results of the computational operations added to the standardization method to produce films (casting) allowed to apply scientific and mathematical bases to polymeric films design following some concepts of the Integrated Product and Process Development methodology. As a result of the experiments and the computational tools, a series of cases were raised for the analysis of the influence of parameters on the release performance of polymeric films.MaestríaMagíster en Ciencias FarmacéuticasFarmacotecnia e ingeniería farmacéuticaxviii, 148 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias FarmacéuticasFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación530 - Física::532 - Mecánica de fluidos610 - Medicina y salud::615 - Farmacología y terapéuticasistemas de liberación de medicamentosdiseño de fármacosmecánica de fluidosDrug Delivery SystemsDrug DesignFlow MechanicsMIcrofluidosPelícula poliméricaDinámica de fluidos computacionalSistemas de liberación modificadaDiseño integrado de producto y procesoMIcrofluidicsPolymeric filmComputational fluid dynamicsModified release systemIntegrated product and process developmentEstudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película poliméricaStudy of mass transport phenomena at a microscopic scale, for its application in the design of modified release systems of the polymeric film typeTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeAchberger, K., Probst, C., Haderspeck, J., Bolz, S., Rogal, J., Chuchuy, J., Nikolova, M., Cora, V., Antkowiak, L., Haq, W., Shen, N., Schenke-Layland, K., Ueffing, M., Liebau, S., & Loskill, P. 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Analytical Chemistry, 90(11), 6357-6361. https://doi.org/10.1021/acs.analchem.8b01146Facultad de Ciencias - Universidad Nacional de ColombiaBibliotecariosEstudiantesInvestigadoresMaestrosMedios de comunicaciónPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85403/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1010237370.2023.pdf1010237370.2023.pdfTesis de Maestría en Ciencias Farmacéuticasapplication/pdf2884076https://repositorio.unal.edu.co/bitstream/unal/85403/2/1010237370.2023.pdf329142437a801a338d35149a952e39c5MD52THUMBNAIL1010237370.2023.pdf.jpg1010237370.2023.pdf.jpgGenerated Thumbnailimage/jpeg4888https://repositorio.unal.edu.co/bitstream/unal/85403/3/1010237370.2023.pdf.jpge0b72014b36c78c67f6782eefc7d8877MD53unal/85403oai:repositorio.unal.edu.co:unal/854032024-08-21 23:13:35.755Repositorio Institucional Universidad Nacional de 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