Brain activity reconstruction from non-stationary M/EEG data using spatiotemporal constraints

Magneto/Electroencephalography (M/EEG)-based neuroimaging is a widely used noninvasive technique for functional analysis of neuronal activity. One of the most prominent advantages of using M/EEG measures is the very low implementation cost and its height temporal resolution. However, the number of l...

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Autores:: Grisales Franco, Fily Mateos

Tipo de recurso:

Fecha de publicación:: 2016

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

Description
Summary:	Magneto/Electroencephalography (M/EEG)-based neuroimaging is a widely used noninvasive technique for functional analysis of neuronal activity. One of the most prominent advantages of using M/EEG measures is the very low implementation cost and its height temporal resolution. However, the number of locations measuring magnetic/electrical is relatively small (a couple of hundreds at best) while the discretized brain activity generators (sources) are several thousand. This fact corresponds an ill-posed mathematical problem commonly known as the M/EEG inverse problem. To solve such problems, additional information must be apriori assumed to obtain a unique and optimal solution. In the present work, a methodology to improve the accuracy and interpretability of the inverse problem solution is proposed, using physiologically motivated assumptions. Firstly, a method constraining the solution to a sparse representation in the space-time domain is introduce given a set of methodologies to syntonize the present parameters. Secondly, we propose a new source connectivity approach explicitly including spatiotemporal information of the neural activity extracted from M/EEG recordings. The proposed methods are compared with the state-of-art techniques in a simulated environment, and afterward, are validated using real-world data. In general, the contributed approaches are efficient and competitive compared to state-of-art brain mapping methods

Brain activity reconstruction from non-stationary M/EEG data using spatiotemporal constraints

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