Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas

ilustraciones, gráficas, tablas

Autores:
Bolivar Baquero, Oscar Andres
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
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oai:repositorio.unal.edu.co:unal/80253
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/80253
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología::571 - Fisiología y temas relacionados
Anatomía y histología
Cells - Morphology
Morfología de las células
Nervio facial
Hipocampo
Espinas dendríticas
Células piramidales
Árbol dendrítico
Golgi-cox
Facial nerve
Hippocampus
Dendritic spines
Pyramidal cells
Dendritic arborization
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_88613a542f1fe257aec1057f14c61f3b
oai_identifier_str oai:repositorio.unal.edu.co:unal/80253
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
dc.title.translated.none.fl_str_mv Evaluation of morphological changes in hippocampal neurons produced by facial nerve injury in rats
title Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
spellingShingle Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
570 - Biología::571 - Fisiología y temas relacionados
Anatomía y histología
Cells - Morphology
Morfología de las células
Nervio facial
Hipocampo
Espinas dendríticas
Células piramidales
Árbol dendrítico
Golgi-cox
Facial nerve
Hippocampus
Dendritic spines
Pyramidal cells
Dendritic arborization
title_short Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
title_full Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
title_fullStr Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
title_full_unstemmed Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
title_sort Evaluación de los cambios morfológicos en neuronas hipocampales producidos por lesión del nervio facial en ratas
dc.creator.fl_str_mv Bolivar Baquero, Oscar Andres
dc.contributor.advisor.none.fl_str_mv Troncoso, Julieta
dc.contributor.author.none.fl_str_mv Bolivar Baquero, Oscar Andres
dc.contributor.researchgroup.spa.fl_str_mv Neurofisiología Comportamental
dc.subject.ddc.spa.fl_str_mv 570 - Biología::571 - Fisiología y temas relacionados
topic 570 - Biología::571 - Fisiología y temas relacionados
Anatomía y histología
Cells - Morphology
Morfología de las células
Nervio facial
Hipocampo
Espinas dendríticas
Células piramidales
Árbol dendrítico
Golgi-cox
Facial nerve
Hippocampus
Dendritic spines
Pyramidal cells
Dendritic arborization
dc.subject.decs.esp.fl_str_mv Anatomía y histología
dc.subject.lemb.eng.fl_str_mv Cells - Morphology
dc.subject.lemb.spa.fl_str_mv Morfología de las células
dc.subject.proposal.spa.fl_str_mv Nervio facial
Hipocampo
Espinas dendríticas
Células piramidales
Árbol dendrítico
dc.subject.proposal.eng.fl_str_mv Golgi-cox
Facial nerve
Hippocampus
Dendritic spines
Pyramidal cells
Dendritic arborization
description ilustraciones, gráficas, tablas
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-09-22T00:58:57Z
dc.date.available.none.fl_str_mv 2021-09-22T00:58:57Z
dc.date.issued.none.fl_str_mv 2021-09-03
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/80253
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/80253
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Troncoso, Julieta26e90f617bba712b6a0dcbbfeb1b7dbfBolivar Baquero, Oscar Andres2766bc8427c96731d00a614de1840c24Neurofisiología Comportamental2021-09-22T00:58:57Z2021-09-22T00:58:57Z2021-09-03https://repositorio.unal.edu.co/handle/unal/80253Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasDistintos modelos de lesión de nervios periféricos en ratas se han utilizado ampliamente para estudiar los cambios estructurales que ocurren, no solamente en las neuronas directamente afectadas, sino también en otras estructuras del sistema nervioso central relacionadas con el procesamiento sensoriomotor. El Grupo de Neurofisiología Comportamental, de la Universidad Nacional de Colombia, además de describir cambios a nivel morfológico, molecular y electrofisiológico generados en la corteza motora primaria de vibrisas por la lesión del nervio facial en ratas, ha descrito una disminución de la plasticidad a largo plazo en la sinapsis comisural CA3CA1 del hipocampo, asociada a este tipo de lesión. Sumado a ello, se ha encontrado un aumento en los niveles plasmáticos de corticosterona, una disminución en la consolidación de la memoria espacial y un aumento de la activación microglial en el hipocampo de animales con axotomía del nervio facial. En este trabajo se analizó la morfología neuronal de las células piramidales de las regiones CA3 y CA1 del hipocampo en ratas con lesión reversible o irreversible del nervio facial. Para este fin, se realizó una tinción del tejido cerebral con el método Golgi-cox en animales lesionados y sacrificados a distintos tiempos post-lesión, que se compararon con cerebros de animales control. Se evaluó la complejidad dendrítica mediante el análisis de Sholl y se calculó la densidad de espinas dendríticas de las regiones basal y apical. Se encontró que ambos tipos de lesión son capaces de producir disminuciones significativas en: 1) la complejidad del árbol dendrítico; 2) la longitud total de dendritas y 3) el número de espinas dendríticas. No obstante, se evidencia una tendencia a la recuperación de estas modificaciones en animales con lesión reversible del nervio facial (es decir, que son capaces de recuperar la función motora tras la lesión). Esta tendencia de reversión de las modificaciones está correlacionada con la recuperación funcional que los sujetos demuestran entre los días postoperatorios 14 y 35. Se concluye que la lesión del nervio facial, con la posibilidad de recuperación funcional o no, es capaz de producir cambios anatómicos en las neuronas piramidales de las regiones CA1 y CA3 del hipocampo. Dichos cambios denotan una reducción general de la complejidad del árbol dendrítico y de la densidad de espinas, que tiende a revertirse si hay recuperación de la función motora. (Texto tomado de la fuente)Several models of peripheral nerve injury in rats have been widely used to study the structural changes that occur in the injured neurons and other central nervous system structures related to sensorimotor processing. The Behavioral Neurophysiology Group (Universidad Nacional de Colombia), has described morphological, molecular and electrophysiological changes in the vibrissae primary motor cortex associated with facial nerve injury in rats. Moreover, recently it has been reported a decrease in long-term potentiation of hippocampal CA3-to-CA1 commissural synapse, related with this type of peripheral injury. In addition, it has been found increased corticosterone plasmatic levels, impediment in spatial memory consolidation, and hippocampal microglial activation in animals with facial nerve axotomy. In this work we analyzed the neuronal morphology of hippocampal CA3 and CA1 pyramidal cells in animals with reversible or irreversible facial nerve injury. For this purpose, brain tissue of injured animals sacrificed at different post-lesion times, were staining with Golgi-cox method and compared with control brains. It was found that both irreversible and reversible facial nerve injury produced significant decreases in 1) complexity of the dendritic tree; 2) dendrites total length; and 3) dendritic spine’s density. However, a trend toward recovery of these modifications is evident in animals with reversible facial nerve injury (i.e., that are able to recover motor function after injury). This trend is correlated with the recovery of motor function between 14- and 35-days post-injury. It is concluded that facial nerve injury produced significant changes in hippocampal CA1 and CA3 pyramidal neurons morphology. Such changes demonstrate a general reduction in the complexity of the dendritic tree and spine density, which tends to reverse if recovery of motor function is allowed.Fundación para la Promoción de la Investigación y la Tecnología. 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

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