Modelo y simulación de dinámica de crecimiento de mieloma

ilustraciones, diagramas

Autores:: Sánchez Gutiérrez, Juan Felipe

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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oai_identifier_str	oai:repositorio.unal.edu.co:unal/85721
network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Modelo y simulación de dinámica de crecimiento de mieloma
dc.title.translated.eng.fl_str_mv	Model and Simulation of dynamics of myeloma growth
title	Modelo y simulación de dinámica de crecimiento de mieloma
spellingShingle	Modelo y simulación de dinámica de crecimiento de mieloma 000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores 610 - Medicina y salud::616 - Enfermedades mieloma múltiple modelos teóricos simulación por ordenador Multiple Myeloma Computer Simulation Remodelación ósea Crecimiento tumoral Tumor Modelo de Komarova Osteoclastos Osteoblastos Coplamiento tumor hueso Bone remodeling Tumor Growth Tumor Coupling tumor–bone Komarova’s model Osteoclasts Osteoblasts
title_short	Modelo y simulación de dinámica de crecimiento de mieloma
title_full	Modelo y simulación de dinámica de crecimiento de mieloma
title_fullStr	Modelo y simulación de dinámica de crecimiento de mieloma
title_full_unstemmed	Modelo y simulación de dinámica de crecimiento de mieloma
title_sort	Modelo y simulación de dinámica de crecimiento de mieloma
dc.creator.fl_str_mv	Sánchez Gutiérrez, Juan Felipe
dc.contributor.advisor.spa.fl_str_mv	Garzón Alvarado, Diego Alexander
dc.contributor.author.spa.fl_str_mv	Sánchez Gutiérrez, Juan Felipe
dc.contributor.researchgroup.spa.fl_str_mv	Gnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.contributor.orcid.spa.fl_str_mv	JUAN FELIPE SANCHEZ GUTIERREZ, [0000-0002-7821-5234]
dc.subject.ddc.spa.fl_str_mv	000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores 610 - Medicina y salud::616 - Enfermedades
topic	000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores 610 - Medicina y salud::616 - Enfermedades mieloma múltiple modelos teóricos simulación por ordenador Multiple Myeloma Computer Simulation Remodelación ósea Crecimiento tumoral Tumor Modelo de Komarova Osteoclastos Osteoblastos Coplamiento tumor hueso Bone remodeling Tumor Growth Tumor Coupling tumor–bone Komarova’s model Osteoclasts Osteoblasts
dc.subject.decs.spa.fl_str_mv	mieloma múltiple modelos teóricos simulación por ordenador
dc.subject.decs.eng.fl_str_mv	Multiple Myeloma Computer Simulation
dc.subject.proposal.spa.fl_str_mv	Remodelación ósea Crecimiento tumoral Tumor Modelo de Komarova Osteoclastos Osteoblastos Coplamiento tumor hueso
dc.subject.proposal.eng.fl_str_mv	Bone remodeling Tumor Growth Tumor Coupling tumor–bone Komarova’s model Osteoclasts Osteoblasts
description	ilustraciones, diagramas
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-02-26T19:10:45Z
dc.date.available.none.fl_str_mv	2024-02-26T19:10:45Z
dc.date.issued.none.fl_str_mv	2024-02
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/85721
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/85721 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.indexed.spa.fl_str_mv	Bireme
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.format.extent.spa.fl_str_mv	xvi, 103 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Mecánica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ingeniería
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garzón Alvarado, Diego Alexander3bd3300e515de537404ed24aaad21afe600Sánchez Gutiérrez, Juan Felipebe7ffe13c3d83734e2f2dfa0cc76a465600Gnum Grupo de Modelado y Métodos Numericos en IngenieríaJUAN FELIPE SANCHEZ GUTIERREZ, [0000-0002-7821-5234]2024-02-26T19:10:45Z2024-02-26T19:10:45Z2024-02https://repositorio.unal.edu.co/handle/unal/85721Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEn este trabajo se presentan tres capítulos con modelos in-silico desarrollados a través de ecuaciones diferenciales y solucionados computacionalmente, que proporcionan una perspectiva del acoplamiento entre el ciclo de remodelación ósea y las poblaciones tumorales. Comprender las dinámicas entre el tejido sano, las células que realizan el proceso de remodelación y las diferentes patologías, como el osteosarcoma o los tumores metastásicos, es fundamental para crear estrategias m´as personalizadas y especializadas para mitigar los efectos de estas enfermedades o curarlas por completo. Los modelos presentados proveen información mas detallada de la dinámica real de la remodelación ósea en pacientes por masas tumorales. Ofrecen un marco innovador y una base solida para el desarrollo de nuevos modelos, herramientas y técnicas que permitan el desarrollo de la medicina personalizada, con una perspectiva mas completa y controlada de los procesos fisiológicos y patológicos. Se espera que en el futuro, estos modelos sean aun mas robustos y versátiles, brindando un mayor apoyo para la toma de decisiones mas acertadas en cada caso clínico particular. (Texto tomado de la fuente).This work presents three chapters with in-silico models developed through differential equations and computationally solved, providing a perspective of the coupling between the bone remodeling cycle and tumor populations. Understanding the dynamics between healthy tissue, cells involved in the remodeling process, and different pathologies, such as osteosarcoma or metastatic tumors, is fundamental for creating more personalized and specialized strategies to mitigate the effects of these diseases or cure them completely. The models presented provide more detailed information about the real dynamics of bone remodeling in patients with tumor masses. They offer an innovative framework and a solid foundation for the development of new models, tools, and techniques that enable personalized medicine, with a more comprehensive and controlled perspective of physiological and pathological processes. It is expected that in the future, these models will become even more robust and versatile, providing greater support for making more accurate decisions in each specific clinical case.MaestríaMagíster en Ingeniería MecánicaIngeniería de diseño y biomecánicaxvi, 103 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería MecánicaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores610 - Medicina y salud::616 - Enfermedadesmieloma múltiplemodelos teóricossimulación por ordenadorMultiple MyelomaComputer SimulationRemodelación óseaCrecimiento tumoralTumorModelo de KomarovaOsteoclastosOsteoblastosCoplamiento tumor huesoBone remodelingTumor GrowthTumorCoupling tumor–boneKomarova’s modelOsteoclastsOsteoblastsModelo y simulación de dinámica de crecimiento de mielomaModel and Simulation of dynamics of myeloma growthTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBireme[Ait Oumghar et al., 2020] Ait Oumghar, I., Barkaoui, A., and Chabrand, P. 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