Characterization of the adsorption process analogouspeptides on alumina gel
Peptide antigen adsorption on aluminumhydroxide gel must be characterizedwhen formulating vaccines. In this worka peptide belonging to the amino-terminalregion of Plasmodium falciparum MerozoiteSurface Protein and its analogueshave been characterized. The adsorptionof 17 analogues on aluminum hydrox...
- Autores:
-
Trujillo, Mary
Salazar, Luz Mary
Valencia, Jesus
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2011
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/40490
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/40490
http://bdigital.unal.edu.co/30587/
http://bdigital.unal.edu.co/30587/2/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Trujillo, Marycd7b4462-fd78-40fc-9652-da5b9b56eb88300Salazar, Luz Mary2d634872-d948-4a2e-9879-0049bda825fb300Valencia, Jesuscd2baa35-da86-46bb-8481-fb0f9109ec623002019-06-28T09:34:31Z2019-06-28T09:34:31Z2011https://repositorio.unal.edu.co/handle/unal/40490http://bdigital.unal.edu.co/30587/http://bdigital.unal.edu.co/30587/2/Peptide antigen adsorption on aluminumhydroxide gel must be characterizedwhen formulating vaccines. In this worka peptide belonging to the amino-terminalregion of Plasmodium falciparum MerozoiteSurface Protein and its analogueshave been characterized. The adsorptionof 17 analogues on aluminum hydroxidewhich had greater than 10 mmol/L solubilitywas quantified at 298 K. Adsorptioncapacity and affinity constant parameterswere calculated by applying theLangmuir's adsorption model.The results have been presented inthree groups according to adsorption isothermtrajectory. The first group consistsof analogues where the first organizationof peptide molecules was presented atlow concentrations, followed by a rapidincrease in adsorption to high concentrations.The second group consists ofanalogues having an adsorption patternshowing the formation of a first layer atlow peptide concentrations and a secondlayer at greater concentrations. The thirdgroup contains analogues whose adsorptioninvolved the formation of two simplelayers, this being differentiated fromthe second group in that after the secondlayer had been completed, the amountadsorbed grew notably with increasedconcentration.The results revealed a more complexpattern that monolayer or bilayer formation.This work constitutes the firstapproach towards establishing an adsorbedlayer structure model using a peptidesystem.application/pdfspaUniversidad Nacional de Colombiahttp://revistas.unal.edu.co/index.php/rcolquim/article/view/29437Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de QuímicaRevista Colombiana de QuímicaRevista Colombiana de Química; Vol. 40, núm. 3 (2011); 391-399 0120-2804Trujillo, Mary and Salazar, Luz Mary and Valencia, Jesus (2011) Characterization of the adsorption process analogouspeptides on alumina gel. Revista Colombiana de Química; Vol. 40, núm. 3 (2011); 391-399 0120-2804 .Characterization of the adsorption process analogouspeptides on alumina gelArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL29437-105657-1-PB.pdfapplication/pdf1947429https://repositorio.unal.edu.co/bitstream/unal/40490/1/29437-105657-1-PB.pdfa73dd87c1dbca99de30d724e90a09a2cMD51THUMBNAIL29437-105657-1-PB.pdf.jpg29437-105657-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg6953https://repositorio.unal.edu.co/bitstream/unal/40490/2/29437-105657-1-PB.pdf.jpgc8b7b28a33fc4a21bd6586237f2850cfMD52unal/40490oai:repositorio.unal.edu.co:unal/404902023-01-29 23:04:59.001Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |
dc.title.spa.fl_str_mv |
Characterization of the adsorption process analogouspeptides on alumina gel |
title |
Characterization of the adsorption process analogouspeptides on alumina gel |
spellingShingle |
Characterization of the adsorption process analogouspeptides on alumina gel |
title_short |
Characterization of the adsorption process analogouspeptides on alumina gel |
title_full |
Characterization of the adsorption process analogouspeptides on alumina gel |
title_fullStr |
Characterization of the adsorption process analogouspeptides on alumina gel |
title_full_unstemmed |
Characterization of the adsorption process analogouspeptides on alumina gel |
title_sort |
Characterization of the adsorption process analogouspeptides on alumina gel |
dc.creator.fl_str_mv |
Trujillo, Mary Salazar, Luz Mary Valencia, Jesus |
dc.contributor.author.spa.fl_str_mv |
Trujillo, Mary Salazar, Luz Mary Valencia, Jesus |
description |
Peptide antigen adsorption on aluminumhydroxide gel must be characterizedwhen formulating vaccines. In this worka peptide belonging to the amino-terminalregion of Plasmodium falciparum MerozoiteSurface Protein and its analogueshave been characterized. The adsorptionof 17 analogues on aluminum hydroxidewhich had greater than 10 mmol/L solubilitywas quantified at 298 K. Adsorptioncapacity and affinity constant parameterswere calculated by applying theLangmuir's adsorption model.The results have been presented inthree groups according to adsorption isothermtrajectory. The first group consistsof analogues where the first organizationof peptide molecules was presented atlow concentrations, followed by a rapidincrease in adsorption to high concentrations.The second group consists ofanalogues having an adsorption patternshowing the formation of a first layer atlow peptide concentrations and a secondlayer at greater concentrations. The thirdgroup contains analogues whose adsorptioninvolved the formation of two simplelayers, this being differentiated fromthe second group in that after the secondlayer had been completed, the amountadsorbed grew notably with increasedconcentration.The results revealed a more complexpattern that monolayer or bilayer formation.This work constitutes the firstapproach towards establishing an adsorbedlayer structure model using a peptidesystem. |
publishDate |
2011 |
dc.date.issued.spa.fl_str_mv |
2011 |
dc.date.accessioned.spa.fl_str_mv |
2019-06-28T09:34:31Z |
dc.date.available.spa.fl_str_mv |
2019-06-28T09:34:31Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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https://repositorio.unal.edu.co/handle/unal/40490 |
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http://bdigital.unal.edu.co/30587/ http://bdigital.unal.edu.co/30587/2/ |
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https://repositorio.unal.edu.co/handle/unal/40490 http://bdigital.unal.edu.co/30587/ http://bdigital.unal.edu.co/30587/2/ |
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spa |
language |
spa |
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http://revistas.unal.edu.co/index.php/rcolquim/article/view/29437 |
dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Química Revista Colombiana de Química |
dc.relation.ispartofseries.none.fl_str_mv |
Revista Colombiana de Química; Vol. 40, núm. 3 (2011); 391-399 0120-2804 |
dc.relation.references.spa.fl_str_mv |
Trujillo, Mary and Salazar, Luz Mary and Valencia, Jesus (2011) Characterization of the adsorption process analogouspeptides on alumina gel. Revista Colombiana de Química; Vol. 40, núm. 3 (2011); 391-399 0120-2804 . |
dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Universidad Nacional de Colombia |
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