Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l.
The butanolic fraction obtained from the extract of Cecropia peltata L (NV: "Yarumo"), medicinal plant used by popular tradition in Colombia as tranquilizer, displays in ICR albino mice an anticonvulsant, anxiolytic and sedative profile, according to electroshock, pentylenetetrazole, marbl...
- Autores:
-
Ospina Chávez, Jimena
Rincón Velanda, Javier
Guerrero Pabón, Mario
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/49329
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/49329
http://bdigital.unal.edu.co/42786/
http://bdigital.unal.edu.co/42786/2/
- Palabra clave:
- Cecropia peltata
flavonoide
ansiolítico
anticonvulsivante
sedante
Cecropia peltata flavonoids
anxiolytic
anticonvulsant
sedative
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| title |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| spellingShingle |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. Cecropia peltata flavonoide ansiolítico anticonvulsivante sedante Cecropia peltata flavonoids anxiolytic anticonvulsant sedative |
| title_short |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| title_full |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| title_fullStr |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| title_full_unstemmed |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| title_sort |
Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. |
| dc.creator.fl_str_mv |
Ospina Chávez, Jimena Rincón Velanda, Javier Guerrero Pabón, Mario |
| dc.contributor.author.spa.fl_str_mv |
Ospina Chávez, Jimena Rincón Velanda, Javier Guerrero Pabón, Mario |
| dc.subject.proposal.spa.fl_str_mv |
Cecropia peltata flavonoide ansiolítico anticonvulsivante sedante Cecropia peltata flavonoids anxiolytic anticonvulsant sedative |
| topic |
Cecropia peltata flavonoide ansiolítico anticonvulsivante sedante Cecropia peltata flavonoids anxiolytic anticonvulsant sedative |
| description |
The butanolic fraction obtained from the extract of Cecropia peltata L (NV: "Yarumo"), medicinal plant used by popular tradition in Colombia as tranquilizer, displays in ICR albino mice an anticonvulsant, anxiolytic and sedative profile, according to electroshock, pentylenetetrazole, marble burying and barbiturate sleeping tests (80 mg/kg, p. o., p = 0.05 vs. control). At the same time Cecropia peltata does not to seem to alter the locomotor function nor to have antidepressant effect, according to their effect in wiring and forced swimming tests. The effect of this fraction was greater than ethanolic, aqueous and hexanic fractions. Additionally, a sub-fraction from butanolic part, rich in flavonoids, elicits a "dose-response" effect in maximum electroshock-induced seizures (80 - 240 mg/kg). These findings suggest that flavonoid metabolites play a key role in the pharmacological activity of Cecropia peltata and support the traditional use of this species. |
| publishDate |
2013 |
| dc.date.issued.spa.fl_str_mv |
2013 |
| dc.date.accessioned.spa.fl_str_mv |
2019-06-29T08:35:47Z |
| dc.date.available.spa.fl_str_mv |
2019-06-29T08:35:47Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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publishedVersion |
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https://repositorio.unal.edu.co/handle/unal/49329 |
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http://bdigital.unal.edu.co/42786/ http://bdigital.unal.edu.co/42786/2/ |
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https://repositorio.unal.edu.co/handle/unal/49329 http://bdigital.unal.edu.co/42786/ http://bdigital.unal.edu.co/42786/2/ |
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spa |
| language |
spa |
| dc.relation.spa.fl_str_mv |
http://revistas.unal.edu.co/index.php/rccquifa/article/view/45119 |
| dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
| dc.relation.ispartofseries.none.fl_str_mv |
Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 2 (2013); 244-259 0034-7418 1909-6356 |
| dc.relation.references.spa.fl_str_mv |
Ospina Chávez, Jimena and Rincón Velanda, Javier and Guerrero Pabón, Mario (2013) Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 2 (2013); 244-259 0034-7418 1909-6356 . |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Revista Colombiana de Ciencias Químico Farmacéuticas |
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Universidad Nacional de Colombia |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ospina Chávez, Jimenaa7620725-2150-4b13-b4ac-038d168919f4300Rincón Velanda, Javier7786fb11-0d37-4cf1-bc95-3dcfef3a3266300Guerrero Pabón, Mario5d1bfab0-0680-4711-88fd-bbcab366c0c73002019-06-29T08:35:47Z2019-06-29T08:35:47Z2013https://repositorio.unal.edu.co/handle/unal/49329http://bdigital.unal.edu.co/42786/http://bdigital.unal.edu.co/42786/2/The butanolic fraction obtained from the extract of Cecropia peltata L (NV: "Yarumo"), medicinal plant used by popular tradition in Colombia as tranquilizer, displays in ICR albino mice an anticonvulsant, anxiolytic and sedative profile, according to electroshock, pentylenetetrazole, marble burying and barbiturate sleeping tests (80 mg/kg, p. o., p = 0.05 vs. control). At the same time Cecropia peltata does not to seem to alter the locomotor function nor to have antidepressant effect, according to their effect in wiring and forced swimming tests. The effect of this fraction was greater than ethanolic, aqueous and hexanic fractions. Additionally, a sub-fraction from butanolic part, rich in flavonoids, elicits a "dose-response" effect in maximum electroshock-induced seizures (80 - 240 mg/kg). These findings suggest that flavonoid metabolites play a key role in the pharmacological activity of Cecropia peltata and support the traditional use of this species.La fracción butanólica del extracto de Cecropia peltata L, (N. V.: "Yarumo"), especie medicinal utilizada por la tradición popular en Colombia con fines tranquilizantes, presenta en ratones albinos ICR un perfil de tipo anticonvulsivante, ansiolítico y sedante, según las pruebas de electroshock, pentilentetrazol, ocultamiento de esferas y potenciación de sueño barbitúrico (80 mg/kg, v. o., p = 0,05 vs. control). Paralelamente, carece de efectos de tipo locomotor y antidepresivo, según las pruebas del alambre y nado forzado. El efecto de esta fracción fue superior al presentado por el extracto etanólico y las fracciones acuosa y hexánica. Además, la subfracción butanólica rica en flavonoides, presenta un efecto "dosis-respuesta" en la prueba de convulsión máxima inducida por electroshock (80 mg/kg - 240 mg/kg). Estos hallazgos sugieren que los metabolitos de tipo flavonoide podrían ser responsables de la actividad farmacológica de Cecropia peltata y dan soporte al uso tradicional de esta especie.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/45119Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 2 (2013); 244-259 0034-7418 1909-6356Ospina Chávez, Jimena and Rincón Velanda, Javier and Guerrero Pabón, Mario (2013) Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 2 (2013); 244-259 0034-7418 1909-6356 .Neuropharmacological profile of the butanolic fraction obtained from leaves of cecropia peltata l.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTCecropia peltataflavonoideansiolíticoanticonvulsivantesedanteCecropia peltata flavonoidsanxiolyticanticonvulsantsedativeORIGINAL45119-216488-1-SM.pdfapplication/pdf572655https://repositorio.unal.edu.co/bitstream/unal/49329/1/45119-216488-1-SM.pdf736ee68b55b4d0b7f3358819ef102026MD51THUMBNAIL45119-216488-1-SM.pdf.jpg45119-216488-1-SM.pdf.jpgGenerated Thumbnailimage/jpeg5890https://repositorio.unal.edu.co/bitstream/unal/49329/2/45119-216488-1-SM.pdf.jpg0837d7596e5f8fd9eb9fba72524e766cMD52unal/49329oai:repositorio.unal.edu.co:unal/493292022-12-14 23:03:56.999Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |