Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso
Se describe un adenoma de la pars intermedia de la hipófisis en un equino en Colombia. Se realizó la necropsia a un equino macho castrado de la raza Silla Argentina, de 32 años. Macroscópicamente, el equino estaba en mala condición corporal y con pelaje hirsuto. La hipófisis protruía de la silla tur...
- Autores:
-
Gordillo González, Daniel Felipe
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86397
- Palabra clave:
- 590 - Animales::599 - Mamíferos
630 - Agricultura y tecnologías relacionadas::636 - Producción animal
ADENOMA
NEOPLASMA
ENDOCRINOLOGÍA VETERINARIA
Neoplasms
Veterinary endocrinology
ACTH
Colombia
Equino
Pituitaria
Tumor
ACTH
Equine
Pituitary
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| dc.title.translated.eng.fl_str_mv |
Adenoma of the pars intermedia of the pituitary in a horse in Colombia, morphological and immunohistochemical study. Case report |
| title |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| spellingShingle |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso 590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal ADENOMA NEOPLASMA ENDOCRINOLOGÍA VETERINARIA Neoplasms Veterinary endocrinology ACTH Colombia Equino Pituitaria Tumor ACTH Equine Pituitary |
| title_short |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| title_full |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| title_fullStr |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| title_full_unstemmed |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| title_sort |
Adenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de caso |
| dc.creator.fl_str_mv |
Gordillo González, Daniel Felipe |
| dc.contributor.advisor.none.fl_str_mv |
Doncel Díaz, Benjamín Esquinas Castillo, Paula Cristina |
| dc.contributor.author.none.fl_str_mv |
Gordillo González, Daniel Felipe |
| dc.subject.ddc.spa.fl_str_mv |
590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal |
| topic |
590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal ADENOMA NEOPLASMA ENDOCRINOLOGÍA VETERINARIA Neoplasms Veterinary endocrinology ACTH Colombia Equino Pituitaria Tumor ACTH Equine Pituitary |
| dc.subject.lemb.spa.fl_str_mv |
ADENOMA NEOPLASMA ENDOCRINOLOGÍA VETERINARIA |
| dc.subject.lemb.eng.fl_str_mv |
Neoplasms Veterinary endocrinology |
| dc.subject.proposal.spa.fl_str_mv |
ACTH Colombia Equino Pituitaria Tumor |
| dc.subject.proposal.eng.fl_str_mv |
ACTH Equine Pituitary |
| description |
Se describe un adenoma de la pars intermedia de la hipófisis en un equino en Colombia. Se realizó la necropsia a un equino macho castrado de la raza Silla Argentina, de 32 años. Macroscópicamente, el equino estaba en mala condición corporal y con pelaje hirsuto. La hipófisis protruía de la silla turca, con medidas de 2,3 cm de grosor y 2,8 cm de altura, en la región media se presentaba un nódulo de 1,3 cm de diámetro. Histológicamente, se observaron células neoplásicas sostenidas por tejido conectivo fino y capilares con patrón de crecimiento expansivo, que desplazaba y comprimía la pars distalis y la neurohipófisis. Las células neoplásicas se organizaban en cordones, nidos, pseudorosetas o estructuras similares a folículos con material coloide eosinofílico central. Células poliédricas a ovaladas, algunas con bordes ahusados, citoplasma granular eosinófilo grande, pleomorfismo celular y nuclear leve, megalocariosis leve y pocos núcleos aberrantes. La inmunohistoquímica reveló inmunorreactividad intracitoplasmática fuerte a la hormona adrenocorticótropa y negativa para prolactina, proteína ácida fibrilar glial y enolasa específica neuronal. El análisis ultraestructural de las células neoplásicas mostró gránulos intracitoplasmáticos moderadamente electrodensos entre 160 y 250 nm, abundantes mitocondrias, retículo endoplasmático rugoso bien desarrollado, atipia celular y nuclear leve. En conclusión, este es el primer reporte de un adenoma hipofisiario en caballos de raza Silla Argentina y primer diagnóstico integral de la neoplasia en Colombia y Suramérica (Texto tomado de la fuente). |
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2024 |
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2024-07-04T20:09:04Z |
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2024 |
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Trabajo de grado - Especialización |
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info:eu-repo/semantics/bachelorThesis |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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Boujon CE, Bestetti GE, Meier HP, Straub R, Junkerf U, Rossi GL. 1993. Equine pituitary adenoma: a functional and morphological study. Journal Comparative Pathology. 109(2): 163-78 https:// doi.org/ 10.1016/s0021-9975(08)80260-5 Fortin JS, Hetak AA, Duggan KE, Burglass CM, Penticoff HB, Schott HC. 2021. Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy. Scientific Reports. 11(1). https://doi.org/10.1038/s41598-021-95396-7 Glover CM, Miller LM, Dybdal NO, Lopez A, Duckett WM, McFarlane D. 2009. Extrapituitary and pituitary pathological findings in horses with pituitary pars intermedia dysfunction: a retrospective study. Journal of Equine Veterinary Science. 29(3): 146–153. https://doi.org/10.1016/j.jevs.2009.01.004 Gris AH, Bianchi RM, Schwertz CI, Piva MM, Richter G, Sonne L, Driemeier D, Pavarini SP. 2023. Pituitary pars intermedia dysfunction in horses associated to pituitary adenoma. Pesquisa Veterinaria Brasileira. 43. https://doi.org/10.1590/1678-5150-PVB-7117 Horvath E, Kovacs K. 1976. Ultrastructural classification of pituitary adenomas. Canadian Journal of Neurological Sciences. Journal Canadien Des Sciences Neurologiques. 3(1): 9–21. https://doi.org/10.1017/S0317167100025944 Kirkwood NC, Hughes KJ, Stewart AJ. 2022. Pituitary pars intermedia dysfunction (PPID) in horses. Veterinary Sciences. 9(10): 556. https://doi.org/10.3390/vetsci9100556 McFarlane D. 2007. Advantages and limitations of the equine disease, pituitary pars intermedia dysfunction as a model of spontaneous dopaminergic neurodegenerative disease. Ageing Research Reviews. 6(1): 54–63. https://doi.org/10.1016/j.arr.2007.02.001 McFarlane D. 2011. Equine pituitary pars intermedia dysfunction. Veterinary Clinics of North America - Equine Practice. 27(1): 93–113. https://doi.org/10.1016/j.cveq.2010.12.007 McFarlane D, Hill K, Anton J. 2015. Neutrophil function in healthy aged horses and horses with pituitary dysfunction. Veterinary Immunology and Immunopathology. 165(3–4): 99–106. https://doi.org/10.1016/j.vetimm.2015.04.006 Mete O, Gomez-Hernandez K, Kucharczyk W, Ridout R, Zadeh,G, Gentili F, Ezzat S, Asa SL. 2016. Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas. Modern Pathology. 29(2): 131–142. https://doi.org/10.1038/modpathol.2015.151 Miller MA, Pardo ID, Jackson LP, Moore GE, Sojka JE. 2008. Diagnostic pathology correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction. Veterinary Pathology. 45(1):26-38. https://doi.org/10.1354/vp.45-1-26 Miller MA, Moore GE, Bertin FR, Kritchevsky JE. 2016. What’s new in old horses? postmortem diagnoses in mature and aged equids. Veterinary Pathology. 53(2): 390–398. https://doi.org/10.1177/0300985815608674 Morgan RA, Keen JA, Homer N, Nixon M, McKinnon-Garvin AM, Moses-Williams JA, Davis SR, Hadoke PWF, Walker BR. 2018. Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction. Endocrinology.159(11): 3791–3800. https://doi.org/10.1210/en.2018-00726 Osamura RY, Kajiya H, Takei M, Egashira N, Tobita M, Takekoshi S, Teramoto A. 2008. Pathology of the human pituitary adenomas. Histochemistry and Cell Biology. 130 (3): 495–507. https://doi.org/10.1007/s00418-008-0472-1 Rosol TJ, Meuten DJ. 2017. Tumors of the Endocrine Glands. In Meuten DJ, Editor. Meuten DJ. Tumors in Domestic Animals. 5th Ed. Ames, Iowa: John Wiley & Sons Inc. Blackwell. Spelta C. 2015. Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management. Veterinary Medicine: Research and Reports. 293. https://doi.org/10.2147/vmrr.s74191 Yoshikawa H, Oishi H, Sumi A, Ueki H, Oyamada T, Yoshikawa T. 2001. Spontaneous pituitary adenomas of the pars intermedia in 5 aged horses: histopathological, immunohistochemical and ultrastructural studies. Journal Equine Science.12(4): 119-126. https://doi.org/10.1294/jes.12.119 |
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Universidad Nacional de Colombia |
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Bogotá - Medicina Veterinaria y de Zootecnia - Especialidad en Anatomopatología Veterinaria |
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Facultad de Medicina Veterinaria y de Zootecnia |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Doncel Díaz, Benjamín878f048e72d8d955a3d5b6aefbd22f80Esquinas Castillo, Paula Cristinac9b2a6d51c08201da5e6cb07aef54e05Gordillo González, Daniel Felipe9b5d43bc14783993d6ec6949230f3e472024-07-04T20:09:04Z2024-07-04T20:09:04Z2024https://repositorio.unal.edu.co/handle/unal/86397Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Se describe un adenoma de la pars intermedia de la hipófisis en un equino en Colombia. Se realizó la necropsia a un equino macho castrado de la raza Silla Argentina, de 32 años. Macroscópicamente, el equino estaba en mala condición corporal y con pelaje hirsuto. La hipófisis protruía de la silla turca, con medidas de 2,3 cm de grosor y 2,8 cm de altura, en la región media se presentaba un nódulo de 1,3 cm de diámetro. Histológicamente, se observaron células neoplásicas sostenidas por tejido conectivo fino y capilares con patrón de crecimiento expansivo, que desplazaba y comprimía la pars distalis y la neurohipófisis. Las células neoplásicas se organizaban en cordones, nidos, pseudorosetas o estructuras similares a folículos con material coloide eosinofílico central. Células poliédricas a ovaladas, algunas con bordes ahusados, citoplasma granular eosinófilo grande, pleomorfismo celular y nuclear leve, megalocariosis leve y pocos núcleos aberrantes. La inmunohistoquímica reveló inmunorreactividad intracitoplasmática fuerte a la hormona adrenocorticótropa y negativa para prolactina, proteína ácida fibrilar glial y enolasa específica neuronal. El análisis ultraestructural de las células neoplásicas mostró gránulos intracitoplasmáticos moderadamente electrodensos entre 160 y 250 nm, abundantes mitocondrias, retículo endoplasmático rugoso bien desarrollado, atipia celular y nuclear leve. En conclusión, este es el primer reporte de un adenoma hipofisiario en caballos de raza Silla Argentina y primer diagnóstico integral de la neoplasia en Colombia y Suramérica (Texto tomado de la fuente).An adenoma of the pars intermedia of the pituitary gland is described in a horse in Colombia. The necropsy was performed on a 32-year-old castrated male horse of the Silla Argentina breed. The pituitary gland protruded into the sella turcica and it measured 2.3 cm thick and 2.8 cm height. A 1.3 cm diameter nodule was observed in the pars intermedia. Histologically, neoplastic cells supported by fine connective tissue and capillaries were observed with an expansive growth pattern that displaces and compresses the pars distalis and the neurohypophysis. The neoplastic cells form cords, nests, pseudorosettes were organized in follicle-like structures with central eosinophilic colloid material, divided by fine connective tissue and capillaries. The neoplastic cells were organized into cords, nests, pseudorosettes, or follicle-like structures with central eosinophilic colloid material. Cells were polyhedral to oval, some with tapering edges, large eosinophilic granular cytoplasm, mild cellular and nuclear pleomorphism, mild megalokaryosis, few aberrant nuclei. Immunohistochemistry revealed strong intracytoplasmic immunoreactivity for adrenocorticotropic hormone and negative for prolactin, glial fibrillary acidic protein, and neuronal-specific enolase. Ultrastructural analysis of the neoplastic cells showed electron-dense granules between 160 and 250 nm, abundant mitochondria, well-developed rough endoplasmic reticulum with multiple ribosomes, mild cellular and nuclear atypia. In conclusion, this is the first report of a pituitary adenoma in Silla Argentina horses and the first comprehensive diagnosis of the neoplasia in Colombia and South America.EspecializaciónEspecialista en Anatomopatología Veterinaria28 Páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Especialidad en Anatomopatología VeterinariaFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá590 - Animales::599 - Mamíferos630 - Agricultura y tecnologías relacionadas::636 - Producción animalADENOMANEOPLASMAENDOCRINOLOGÍA VETERINARIANeoplasmsVeterinary endocrinologyACTHColombiaEquinoPituitariaTumorACTHEquinePituitaryAdenoma de la pars intermedia de la hipófisis en un equino en Colombia estudio morfológico e inmunohistoquímico. Reporte de casoAdenoma of the pars intermedia of the pituitary in a horse in Colombia, morphological and immunohistochemical study. Case reportTrabajo de grado - Especializacióninfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPColombiaBoujon CE, Bestetti GE, Meier HP, Straub R, Junkerf U, Rossi GL. 1993. Equine pituitary adenoma: a functional and morphological study. Journal Comparative Pathology. 109(2): 163-78 https:// doi.org/ 10.1016/s0021-9975(08)80260-5Fortin JS, Hetak AA, Duggan KE, Burglass CM, Penticoff HB, Schott HC. 2021. Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy. Scientific Reports. 11(1). https://doi.org/10.1038/s41598-021-95396-7Glover CM, Miller LM, Dybdal NO, Lopez A, Duckett WM, McFarlane D. 2009. Extrapituitary and pituitary pathological findings in horses with pituitary pars intermedia dysfunction: a retrospective study. Journal of Equine Veterinary Science. 29(3): 146–153. https://doi.org/10.1016/j.jevs.2009.01.004Gris AH, Bianchi RM, Schwertz CI, Piva MM, Richter G, Sonne L, Driemeier D, Pavarini SP. 2023. Pituitary pars intermedia dysfunction in horses associated to pituitary adenoma. Pesquisa Veterinaria Brasileira. 43. https://doi.org/10.1590/1678-5150-PVB-7117Horvath E, Kovacs K. 1976. Ultrastructural classification of pituitary adenomas. Canadian Journal of Neurological Sciences. Journal Canadien Des Sciences Neurologiques. 3(1): 9–21. https://doi.org/10.1017/S0317167100025944Kirkwood NC, Hughes KJ, Stewart AJ. 2022. Pituitary pars intermedia dysfunction (PPID) in horses. Veterinary Sciences. 9(10): 556. https://doi.org/10.3390/vetsci9100556McFarlane D. 2007. Advantages and limitations of the equine disease, pituitary pars intermedia dysfunction as a model of spontaneous dopaminergic neurodegenerative disease. Ageing Research Reviews. 6(1): 54–63. https://doi.org/10.1016/j.arr.2007.02.001McFarlane D. 2011. Equine pituitary pars intermedia dysfunction. Veterinary Clinics of North America - Equine Practice. 27(1): 93–113. https://doi.org/10.1016/j.cveq.2010.12.007McFarlane D, Hill K, Anton J. 2015. Neutrophil function in healthy aged horses and horses with pituitary dysfunction. Veterinary Immunology and Immunopathology. 165(3–4): 99–106. https://doi.org/10.1016/j.vetimm.2015.04.006Mete O, Gomez-Hernandez K, Kucharczyk W, Ridout R, Zadeh,G, Gentili F, Ezzat S, Asa SL. 2016. Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas. Modern Pathology. 29(2): 131–142. https://doi.org/10.1038/modpathol.2015.151Miller MA, Pardo ID, Jackson LP, Moore GE, Sojka JE. 2008. Diagnostic pathology correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction. Veterinary Pathology. 45(1):26-38. https://doi.org/10.1354/vp.45-1-26Miller MA, Moore GE, Bertin FR, Kritchevsky JE. 2016. What’s new in old horses? postmortem diagnoses in mature and aged equids. Veterinary Pathology. 53(2): 390–398. https://doi.org/10.1177/0300985815608674Morgan RA, Keen JA, Homer N, Nixon M, McKinnon-Garvin AM, Moses-Williams JA, Davis SR, Hadoke PWF, Walker BR. 2018. Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction. Endocrinology.159(11): 3791–3800. https://doi.org/10.1210/en.2018-00726Osamura RY, Kajiya H, Takei M, Egashira N, Tobita M, Takekoshi S, Teramoto A. 2008. Pathology of the human pituitary adenomas. Histochemistry and Cell Biology. 130 (3): 495–507. https://doi.org/10.1007/s00418-008-0472-1Rosol TJ, Meuten DJ. 2017. Tumors of the Endocrine Glands. In Meuten DJ, Editor. Meuten DJ. Tumors in Domestic Animals. 5th Ed. Ames, Iowa: John Wiley & Sons Inc. Blackwell. Spelta C. 2015. Equine pituitary pars intermedia dysfunction: current perspectives on diagnosis and management. Veterinary Medicine: Research and Reports. 293. https://doi.org/10.2147/vmrr.s74191Yoshikawa H, Oishi H, Sumi A, Ueki H, Oyamada T, Yoshikawa T. 2001. Spontaneous pituitary adenomas of the pars intermedia in 5 aged horses: histopathological, immunohistochemical and ultrastructural studies. 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