Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures
Nimodipine (NMD) is a drug used as cerebral vasodilator whose physicochemical properties in solution have not been studied completely. In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the equilibrium solubility of NMD in some polyethylene glycol 400 + ethanol m...
- Autores:
-
Gómez, Jorge L.
Rodríguez, Gerson A.
Cristancho, Diana M.
Delgado, Daniel R.
Mora, Carolina P.
Yurquina, Alicia
Martínez, Fleming
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/49322
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/49322
http://bdigital.unal.edu.co/42779/
http://bdigital.unal.edu.co/42779/2/
- Palabra clave:
- nimodipina
PEG 400 + etanol
Método Extendido de Solubilidad de Hildebrand
mezclas binarias
parámetro de solubilidad
Nimodipine
PEG 400 + ethanol
Extended Hildebrand Solubility Approach
binary mixtures
solubility parameter
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| title |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| spellingShingle |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures nimodipina PEG 400 + etanol Método Extendido de Solubilidad de Hildebrand mezclas binarias parámetro de solubilidad Nimodipine PEG 400 + ethanol Extended Hildebrand Solubility Approach binary mixtures solubility parameter |
| title_short |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| title_full |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| title_fullStr |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| title_full_unstemmed |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| title_sort |
Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures |
| dc.creator.fl_str_mv |
Gómez, Jorge L. Rodríguez, Gerson A. Cristancho, Diana M. Delgado, Daniel R. Mora, Carolina P. Yurquina, Alicia Martínez, Fleming |
| dc.contributor.author.spa.fl_str_mv |
Gómez, Jorge L. Rodríguez, Gerson A. Cristancho, Diana M. Delgado, Daniel R. Mora, Carolina P. Yurquina, Alicia Martínez, Fleming |
| dc.subject.proposal.spa.fl_str_mv |
nimodipina PEG 400 + etanol Método Extendido de Solubilidad de Hildebrand mezclas binarias parámetro de solubilidad Nimodipine PEG 400 + ethanol Extended Hildebrand Solubility Approach binary mixtures solubility parameter |
| topic |
nimodipina PEG 400 + etanol Método Extendido de Solubilidad de Hildebrand mezclas binarias parámetro de solubilidad Nimodipine PEG 400 + ethanol Extended Hildebrand Solubility Approach binary mixtures solubility parameter |
| description |
Nimodipine (NMD) is a drug used as cerebral vasodilator whose physicochemical properties in solution have not been studied completely. In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the equilibrium solubility of NMD in some polyethylene glycol 400 + ethanol mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order three (overall deviation lower than 1.3%), when the W interaction parameter is related to the solubility parameter of the mixtures. Moreover, the mean deviation obtained in the estimated solubility with respect to experimental solubility was lower than the one obtained directly by means of an empiric regression in order three of the logarithm experimental solubility as a function of the mixtures' solubility parameters (1.7%). |
| publishDate |
2013 |
| dc.date.issued.spa.fl_str_mv |
2013 |
| dc.date.accessioned.spa.fl_str_mv |
2019-06-29T08:35:22Z |
| dc.date.available.spa.fl_str_mv |
2019-06-29T08:35:22Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
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https://repositorio.unal.edu.co/handle/unal/49322 |
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http://bdigital.unal.edu.co/42779/ http://bdigital.unal.edu.co/42779/2/ |
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https://repositorio.unal.edu.co/handle/unal/49322 http://bdigital.unal.edu.co/42779/ http://bdigital.unal.edu.co/42779/2/ |
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spa |
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spa |
| dc.relation.spa.fl_str_mv |
http://revistas.unal.edu.co/index.php/rccquifa/article/view/45105 |
| dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
| dc.relation.ispartofseries.none.fl_str_mv |
Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 1 (2013); 103-121 0034-7418 1909-6356 |
| dc.relation.references.spa.fl_str_mv |
Gómez, Jorge L. and Rodríguez, Gerson A. and Cristancho, Diana M. and Delgado, Daniel R. and Mora, Carolina P. and Yurquina, Alicia and Martínez, Fleming (2013) Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 1 (2013); 103-121 0034-7418 1909-6356 . |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
| dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Revista Colombiana de Ciencias Químico Farmacéuticas |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gómez, Jorge L.a575369e-9c28-4c71-ac95-2e0709cb2d6f300Rodríguez, Gerson A.75f1febb-f282-4d27-97fa-3735792b7d0a300Cristancho, Diana M.a1159ef3-2439-4737-a346-79197fdf29bd300Delgado, Daniel R.213a35e0-f933-43bc-a609-4a4f50f4c757300Mora, Carolina P.61eb1c59-9c45-49f5-a29b-903973dd2848300Yurquina, Aliciab54e17b4-0800-42b0-b653-ea3d6badcd8a300Martínez, Flemingbe007cbd-0d6f-4f71-bc0c-9a77ef95fca23002019-06-29T08:35:22Z2019-06-29T08:35:22Z2013https://repositorio.unal.edu.co/handle/unal/49322http://bdigital.unal.edu.co/42779/http://bdigital.unal.edu.co/42779/2/Nimodipine (NMD) is a drug used as cerebral vasodilator whose physicochemical properties in solution have not been studied completely. In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the equilibrium solubility of NMD in some polyethylene glycol 400 + ethanol mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order three (overall deviation lower than 1.3%), when the W interaction parameter is related to the solubility parameter of the mixtures. Moreover, the mean deviation obtained in the estimated solubility with respect to experimental solubility was lower than the one obtained directly by means of an empiric regression in order three of the logarithm experimental solubility as a function of the mixtures' solubility parameters (1.7%).La nimodipina (NMD) es un agente usado como vasodilatador cerebral y cuyas propiedades fisicoquímicas en solución aún no han sido totalmente estudiadas. En la presente investigación se aplicó el Método Extendido de Solubilidad de Hildebrand (MESH) al estudio de la solubilidad de NMD en algunas mezclas binarias PEG 400 + etanol a 298,15 K. Se obtuvo una capacidad predictiva aceptable del MESH (desviación general inferior al 1,3%) al utilizar un modelo polinómico regular de tercer orden, relacionando el parámetro de interacción W con el parámetro de solubilidad de las mezclas solventes. De esta forma, las desviaciones obtenidas en la solubilidad estimada fueron de magnitud inferior a las obtenidas al calcular esta propiedad directamente, utilizando una regresión empírica regular del mismo orden, de la solubilidad experimental del fármaco en función del parámetro de solubilidad de las mezclas disolventes, en la cual se obtuvo una desviación promedio del 1,7%.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/45105Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 1 (2013); 103-121 0034-7418 1909-6356Gómez, Jorge L. and Rodríguez, Gerson A. and Cristancho, Diana M. and Delgado, Daniel R. and Mora, Carolina P. and Yurquina, Alicia and Martínez, Fleming (2013) Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixtures. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 42, núm. 1 (2013); 103-121 0034-7418 1909-6356 .Extended hildebrand solubility approach applied to nimodipine in peg 400 + ethanol mixturesArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTnimodipinaPEG 400 + etanolMétodo Extendido de Solubilidad de Hildebrandmezclas binariasparámetro de solubilidadNimodipinePEG 400 + ethanolExtended Hildebrand Solubility Approachbinary mixturessolubility parameterORIGINAL45105-216319-1-SM.pdfapplication/pdf462892https://repositorio.unal.edu.co/bitstream/unal/49322/1/45105-216319-1-SM.pdfe02bbef61ebca2ee4e7a5f4709320999MD51THUMBNAIL45105-216319-1-SM.pdf.jpg45105-216319-1-SM.pdf.jpgGenerated Thumbnailimage/jpeg5999https://repositorio.unal.edu.co/bitstream/unal/49322/2/45105-216319-1-SM.pdf.jpgd2bfa317550ca846ecef65ee06d9b003MD52unal/49322oai:repositorio.unal.edu.co:unal/493222022-12-14 23:03:55.434Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |