Estudio de decorina durante la gestación en el humano y en la rata

ilustraciones, diagramas

Autores:: Cano Bermúdez, María Alejandra

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Estudio de decorina durante la gestación en el humano y en la rata
dc.title.translated.eng.fl_str_mv	Study of decorina during pregnancy in the human and in the rat
title	Estudio de decorina durante la gestación en el humano y en la rata
spellingShingle	Estudio de decorina durante la gestación en el humano y en la rata 570 - Biología::571 - Fisiología y temas relacionados Pregnancy Embarazo Enfermedades urogenitales femeninas y complicaciones del embarazo Female urogenital diseases and pregnancy complications Pregnancy DCN Placenta Preeclampsia Decorin Pregnancy
title_short	Estudio de decorina durante la gestación en el humano y en la rata
title_full	Estudio de decorina durante la gestación en el humano y en la rata
title_fullStr	Estudio de decorina durante la gestación en el humano y en la rata
title_full_unstemmed	Estudio de decorina durante la gestación en el humano y en la rata
title_sort	Estudio de decorina durante la gestación en el humano y en la rata
dc.creator.fl_str_mv	Cano Bermúdez, María Alejandra
dc.contributor.advisor.none.fl_str_mv	Caminos Pinzón., Jorge Eduardo Garcés Gutiérrez, María Fernanda
dc.contributor.author.none.fl_str_mv	Cano Bermúdez, María Alejandra
dc.contributor.researchgroup.spa.fl_str_mv	Endocrinología y Nutrición Básica
dc.subject.ddc.spa.fl_str_mv	570 - Biología::571 - Fisiología y temas relacionados
topic	570 - Biología::571 - Fisiología y temas relacionados Pregnancy Embarazo Enfermedades urogenitales femeninas y complicaciones del embarazo Female urogenital diseases and pregnancy complications Pregnancy DCN Placenta Preeclampsia Decorin Pregnancy
dc.subject.armarc.eng.fl_str_mv	Pregnancy
dc.subject.decs.spa.fl_str_mv	Embarazo Enfermedades urogenitales femeninas y complicaciones del embarazo
dc.subject.decs.eng.fl_str_mv	Female urogenital diseases and pregnancy complications
dc.subject.lemb.spa.fl_str_mv	Pregnancy
dc.subject.proposal.spa.fl_str_mv	DCN Placenta Preeclampsia
dc.subject.proposal.eng.fl_str_mv	Decorin Pregnancy
description	ilustraciones, diagramas
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-07-07
dc.date.accessioned.none.fl_str_mv	2023-08-30T13:37:07Z
dc.date.available.none.fl_str_mv	2023-08-30T13:37:07Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84614
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84614 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.spa.fl_str_mv	xi, 116 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Maestría en Ciencias - Bioquímica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Caminos Pinzón., Jorge Eduardo4193569c0d48ef2207154a2b7ba51b8cGarcés Gutiérrez, María Fernanda240daa0b42995fa90b0370015502f803Cano Bermúdez, María Alejandra55cb09bb5c2e320fae64bca90123626fEndocrinología y Nutrición Básica2023-08-30T13:37:07Z2023-08-30T13:37:07Z2022-07-07https://repositorio.unal.edu.co/handle/unal/84614Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasDecorina (DCN) es un proteoglicano con funciones sobre la regulación de factores de crecimiento. El objetivo fue determinar los niveles séricos de DCN en gestantes sanas (GN) y con preeclampsia (GP), y los niveles séricos y la expresión de DCN en rata. En humano se incluyeron; GN (n= 50) y GP (n= 20), mujeres tres meses posparto (PP) (n=22) y mujeres no gestantes (NG) (n= 20). En Rata (Rattus norvegicus) se realizó un estudio experimental, se conformaron grupos de 12, 16 y 21 días de gestación y un grupo virgen control. Se usó ELISA para cuantificar DCN en humano y rata, qPCR e inmunohistoquímica. Los resultados mostraron que los niveles séricos de DCN disminuyeron significativamente en GN y GP en comparación con NG (p < 0.001) y PP (p < 0.001). Durante el tercer trimestre, DCN fue significativamente más alto en GP que GN (p < 0.01). En rata DCN no presentó cambios significativos entre la gestación y el grupo virgen control (p > 0.05). La expresión de mRNA de Dcn en placenta fue superior en 12d que en 16d y 21d (p >0.001), y en placenta de 12d DCN se distribuyó en el estroma de las vellosidades coriónicas. En conclusión, los niveles séricos de DCN disminuyeron durante la gestación en mujer y en rata. DCN no represento utilidad diagnóstica en GP. DCN inhiben diferentes factores de crecimiento como factor de crecimiento transformante-beta (TGF-β), y su disminución durante la gestación puede estar relacionada con favorecer la angiogénesis. (Texto tomado de la fuente)Decorin (DCN) is a proteoglycan with functions on the regulation of growth factors. The objective was to determine the serum levels of DCN in healthy pregnant women (GN) and those with preeclampsia (GP), and the serum levels and expression of DCN in rats. In humans they included; GN (n= 50) and GP (n= 20), women three months postpartum (PP) (n=22) and non-pregnant women (NG) (n= 20). In Rat (Rattus norvegicus) an experimental study was carried out, groups of 12, 16 and 21 days of gestation and a virgin control group were formed. ELISA was used to quantify human and rat DCN, qPCR and immunohistochemistry. The results showed that serum levels of DCN were significantly decreased in GN and GP compared to NG (p < 0.001) and PP (p < 0.001). During the third trimester, DCN was significantly higher in GP than GN (p < 0.01). In the DCN rat, there were no significant changes between gestation and the virgin control group (p > 0.05). DCN mRNA expression in placenta was higher at 12d than at 16d and 21d (p >0.001), and in 12d placenta DCN was distributed in the chorionic villus stroma. In conclusion, serum levels of DCN decreased during pregnancy in women and in rats. DCN does not represent diagnostic utility in GP. DCN inhibit different growth factors such as transforming growth factor-beta (TGF-β), and its decrease during pregnancy may be related to favoring angiogenesis.“Valor de biomarcadores séricos en la predicción del desenlace materno-perinatal de la gestante y su evolución a 6 meses”, financiado por Colciencias código 110154531660 y aprobado por el Comité de Ética de la Facultad de Medicina de la Universidad Nacional de Colombia, en el acta número 17 del 13 de octubre 2011.MaestríaEl presente trabajo está clasificado como un estudio retrospectivo, anidado, de casos y controles – observacional y fue llevado a cabo en una cohorte longitudinal de mujeres gestantes seguidas durante la gestación y el posparto, y en mujeres sanas no gestantes.fisiología de la gestaciónxi, 116 páginasapplication/pdfUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BioquímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::571 - Fisiología y temas relacionadosPregnancyEmbarazoEnfermedades urogenitales femeninas y complicaciones del embarazoFemale urogenital diseases and pregnancy complicationsPregnancyDCNPlacentaPreeclampsiaDecorinPregnancyEstudio de decorina durante la gestación en el humano y en la rataStudy of decorina during pregnancy in the human and in the ratTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMH. 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Res., vol. 35, no. 1, pp. 92–100, 2017.colcienciasEstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84614/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53THUMBNAIL1026289197.2023.pdf.jpg1026289197.2023.pdf.jpgGenerated Thumbnailimage/jpeg4291https://repositorio.unal.edu.co/bitstream/unal/84614/5/1026289197.2023.pdf.jpgc5fae02471f3d89395b7349b8ab78b6eMD55ORIGINAL1026289197.2023.pdf1026289197.2023.pdfTesis de Maestría en Ciencias - Bioquímicaapplication/pdf3606259https://repositorio.unal.edu.co/bitstream/unal/84614/4/1026289197.2023.pdf8722f8f3d40aeb834aeb684723f071c3MD54unal/84614oai:repositorio.unal.edu.co:unal/846142023-08-30 23:03:43.615Repositorio Institucional Universidad Nacional de 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

Estudio de decorina durante la gestación en el humano y en la rata

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