Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton

Ilustraciones, fotografías a color,

Autores:
Beltran Ricaurte, Karl Michael
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/83183
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/83183
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología
Inflamación
Técnicas inmunológicas
Inflammation
Immunological techniques
Células estromales mesenquimales
Cuerpos apoptóticos
Inmunomodulación
Macrófagos
Linfocitos
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_7e90792c819ac702f2bd19dca4a53b56
oai_identifier_str oai:repositorio.unal.edu.co:unal/83183
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
dc.title.translated.eng.fl_str_mv Evaluation of the immunomodulatory effect of apoptotic bodies of Wharton's jelly mesenchymal stromal stromal cells
title Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
spellingShingle Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
570 - Biología
Inflamación
Técnicas inmunológicas
Inflammation
Immunological techniques
Células estromales mesenquimales
Cuerpos apoptóticos
Inmunomodulación
Macrófagos
Linfocitos
title_short Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
title_full Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
title_fullStr Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
title_full_unstemmed Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
title_sort Evaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de Wharton
dc.creator.fl_str_mv Beltran Ricaurte, Karl Michael
dc.contributor.advisor.none.fl_str_mv Salguero, Gustavo
dc.contributor.author.none.fl_str_mv Beltran Ricaurte, Karl Michael
dc.contributor.researchgroup.spa.fl_str_mv Unidad de Terapias Avanzadas IDCBIS
dc.subject.ddc.spa.fl_str_mv 570 - Biología
topic 570 - Biología
Inflamación
Técnicas inmunológicas
Inflammation
Immunological techniques
Células estromales mesenquimales
Cuerpos apoptóticos
Inmunomodulación
Macrófagos
Linfocitos
dc.subject.lemb.spa.fl_str_mv Inflamación
Técnicas inmunológicas
dc.subject.lemb.eng.fl_str_mv Inflammation
Immunological techniques
dc.subject.proposal.spa.fl_str_mv Células estromales mesenquimales
Cuerpos apoptóticos
Inmunomodulación
Macrófagos
Linfocitos
description Ilustraciones, fotografías a color,
publishDate 2022
dc.date.issued.none.fl_str_mv 2022-11-18
dc.date.accessioned.none.fl_str_mv 2023-01-30T16:54:07Z
dc.date.available.none.fl_str_mv 2023-01-30T16:54:07Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/83183
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/83183
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Salguero, Gustavoc8dcddfb8ffa0fed1b1ffe427c79ad46Beltran Ricaurte, Karl Michaeld7a3e350f3514805cf50e2f55a6c5ed7Unidad de Terapias Avanzadas IDCBIS2023-01-30T16:54:07Z2023-01-30T16:54:07Z2022-11-18https://repositorio.unal.edu.co/handle/unal/83183Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Ilustraciones, fotografías a color,Las inmunoterapias basadas en células estromales mesenquimales (CEM) representan herramientas para el tratamiento de enfermedades inflamatorias. Sin embargo, su aplicación clínica actualmente es un reto. La biodistribución de las CEM parece ser deficiente, lo que promueve la activación de la apoptosis y la liberación de cuerpos apoptóticos (AB). Dado que recientemente se ha propuesto una interacción entre los AB derivados de las CEM (CEM-AB) y componentes del sistema inmunitario, en este proyecto se demostró que los CEM-AB ejercen efectos inmunomoduladores sinérgicos en modelos de inflamación in-vitro. Para lo anterior, se obtuvieron CEM de la gelatina de Wharton (WJ) mediante un proceso de disgregación. La exposición a la irradiación gama (25Gy) indujo eficazmente la apoptosis; tal y como demostraron la fragmentación del ADN, la translocación de fosfatidilserina, la expresión de caspasas 3/7 y la pérdida de permeabilidad de la membrana. Los CEM-AB se aislaron, caracterizaron y utilizaron para los ensayos inmunológicos. Tras la activación de linfocitos humanos con perlas anti- CD3/anti-CD28, los CEM-AB no indujeron una inmunosupresión directa, en comparación con controles de células viables. Sin embargo, el pre-condicionamiento de monocitos/macrófagos humanos CD14+ con CEM-AB indujo un fenotipo M2 y desencadenó un potente efecto inhibidor de la proliferación de linfocitos (>90%). El tratamiento con cuerpos apoptóticos también indujo la sobreexpresión de moléculas de punto de control inmunológico y la secreción diferencial de factores de crecimiento. En conjunto, estos hallazgos sugieren que los CEM-AB mejoran la acción inmunosupresora preexistente de las CEM, confiriendo a los macrófagos un fenotipo M2 durante la inflamación. (Texto tomado de la fuente)Immunotherapies based on mesenchymal stromal cells (MSC) represent tools for the treatment of inflammatory diseases. However, their clinical application is currently challenging. The biodistribution of MSC appears to be poor, which promotes the activation of apoptosis and the release of apoptotic bodies (AB). Since an interaction between MSCderived AB (MSC-AB) and components of the immune system has recently been proposed, in this project we demonstrated that MSC-AB exert synergistic immunomodulatory effects in in-vitro models of inflammation. For this purpose, MSC were obtained from Wharton's gelatin (WJ) by a disaggregation process. Exposure to gamma irradiation (25Gy) effectively induced apoptosis; as demonstrated by DNA fragmentation, phosphatidylserine translocation, caspases 3/7 expression and loss of membrane permeability. MSC-AB were isolated, characterized and used for immunological assays. Upon activation of human lymphocytes with anti-CD3/anti-CD28 beads, MSC-AB did not induce direct immunosuppression compared to viable cell controls. However, preconditioning of CD14+ human monocytes/macrophages with MSC-AB induced an M2 phenotype and triggered a potent inhibitory effect on lymphocyte proliferation (>90%). Treatment with apoptotic bodies also induced overexpression of immune checkpoint molecules and differential secretion of growth factors. Taken together, these findings suggest that MSC-AB enhance the preexisting immunosuppressive action of MSC by conferring an M2 phenotype to macrophages during inflammation.MaestríaTerapias avanzadasix, 77 páginasapplication/pdfspa570 - BiologíaInflamaciónTécnicas inmunológicasInflammationImmunological techniquesCélulas estromales mesenquimalesCuerpos apoptóticosInmunomodulaciónMacrófagosLinfocitosEvaluación del efecto inmunomodulador de los cuerpos apoptóticos de células estromales mesenquimales de Gelatina de WhartonEvaluation of the immunomodulatory effect of apoptotic bodies of Wharton's jelly mesenchymal stromal stromal cellsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - Medicina - Maestría en InmunologíaFacultad de MedicinaBogotá - ColombiaUniversidad Nacional de Colombia - Sede BogotáAlmeida-Porada, G., Atala, A. J., & Porada, C. D. (2020). 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Rheumatology, 47(1), 22–30. https://doi.org/10.1093/rheumatology/kem284Instituto Distrital de Ciencia, Biotecnologia e Innovación en SaludEstudiantesLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83183/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1032484125.2022.pdf1032484125.2022.pdfTesis de Maestria en Inmunologíaapplication/pdf2918685https://repositorio.unal.edu.co/bitstream/unal/83183/2/1032484125.2022.pdf241826b252f8edd149e7d0563ed3db9eMD52THUMBNAIL1032484125.2022.pdf.jpg1032484125.2022.pdf.jpgGenerated Thumbnailimage/jpeg4445https://repositorio.unal.edu.co/bitstream/unal/83183/3/1032484125.2022.pdf.jpgc1d9eaf0833c8b888bde8b3339a38831MD53unal/83183oai:repositorio.unal.edu.co:unal/831832024-08-17 00:00:22.032Repositorio Institucional Universidad Nacional de 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