Biomechanical computational model of the elbow development

ilustraciones, tablas

Autores:: Millán Claro, Luis Felipe

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: eng

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv	Biomechanical computational model of the elbow development
dc.title.translated.spa.fl_str_mv	Modelo computacional biomecánico de la formación del codo
title	Biomechanical computational model of the elbow development
spellingShingle	Biomechanical computational model of the elbow development 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería Articulación del Codo Elbow Joint Morfogénesis Morphogenesis Modelado biológico Biological models Elbow Finite element method Limb development Joint morphogenesis Reaction-diffusion Codo Desarrollo de extremidades Método de los elementos finitos Morfogénesis articular Reacción-difusión
title_short	Biomechanical computational model of the elbow development
title_full	Biomechanical computational model of the elbow development
title_fullStr	Biomechanical computational model of the elbow development
title_full_unstemmed	Biomechanical computational model of the elbow development
title_sort	Biomechanical computational model of the elbow development
dc.creator.fl_str_mv	Millán Claro, Luis Felipe
dc.contributor.advisor.none.fl_str_mv	Garzón Alvarado, Diego Alexander Márquez Flórez, Kalenia María
dc.contributor.author.none.fl_str_mv	Millán Claro, Luis Felipe
dc.contributor.researchgroup.spa.fl_str_mv	GNUM - Grupo de Modelado y Métodos Numericos en Ingeniería
dc.subject.ddc.spa.fl_str_mv	620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
topic	620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería Articulación del Codo Elbow Joint Morfogénesis Morphogenesis Modelado biológico Biological models Elbow Finite element method Limb development Joint morphogenesis Reaction-diffusion Codo Desarrollo de extremidades Método de los elementos finitos Morfogénesis articular Reacción-difusión
dc.subject.decs.none.fl_str_mv	Articulación del Codo Elbow Joint Morfogénesis Morphogenesis
dc.subject.lemb.none.fl_str_mv	Modelado biológico Biological models
dc.subject.proposal.eng.fl_str_mv	Elbow Finite element method Limb development Joint morphogenesis Reaction-diffusion
dc.subject.proposal.spa.fl_str_mv	Codo Desarrollo de extremidades Método de los elementos finitos Morfogénesis articular Reacción-difusión
description	ilustraciones, tablas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-07-26T15:23:27Z
dc.date.available.none.fl_str_mv	2021-07-26T15:23:27Z
dc.date.issued.none.fl_str_mv	2021
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/79845
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/79845 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	eng
language	eng
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spelling	Atribución-NoComercial-SinDerivadas 4.0 InternacionalDerechos reservados al autor, 2021http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garzón Alvarado, Diego Alexanderd5e7b2061f3b824fc0ee4a3bdafc95d3600Márquez Flórez, Kalenia María9c6b0737fed05a78fc9359e089202090600Millán Claro, Luis Felipeaff52a943a215ef09d02a81213fab5d1600GNUM - Grupo de Modelado y Métodos Numericos en Ingeniería2021-07-26T15:23:27Z2021-07-26T15:23:27Z2021https://repositorio.unal.edu.co/handle/unal/79845Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, tablasIn this study, two computational models were developed, the first one predicts the appearance, location, and development of the mesenchymal condensation within the upper limb as it grows. Biochemical events were modeled with reaction-diffusion equations of generic molecules. The results obtained showed that patterns generated by molecules that behave as Fgf8, Fgf10 and Wnt3a, can predict the shape of the mesenchymal condensation. Simple diffusive patterns were adequate to explain the areas where sox9 is expressed and how they are affected by the shape and size of the signaling zones and the ectoderm. Furthermore, our results suggest that Grem1 and Wnt3a have the same effect on Sox9 expression, and that Tgf-β expression could be due to inhibition of RA. The second model analyze how mechanical and biochemical stimuli affect joint morphogenesis. For this, it was assumed that cartilage growth was controlled by cyclic hydrostatic stress and inhibited by octahedral shear stress. In addition, the effect of molecules that promote chondrocyte proliferation such as PTHrP-Ihh and Wnt was included. The results obtained through the model suggest that the initial morphogenesis of the elbow joint is influenced by hydrostatic stresses together with biochemical stimulation. To solve the systems of partial differential equations in both models, the finite element method was applied. It should be noted that this document also presents a conceptual background of the biological processes before and during the development of the elbow, as well as a brief mention of what the principal characteristics of the elbow is and some pathologies associated, moreover, it is also included a brief explanation of the finite element method and the solution of the elasticity and reaction-diffusion equations through this method. (Text taken from source)En este estudio se desarrollaron dos modelos computacionales, el primero predice la apariencia, ubicación y desarrollo de la condensación mesenquimal mientras crece parte de extremidad superior. Los eventos bioquímicos se modelaron con ecuaciones de reacción-difusión con moléculas genéricas. Los resultados obtenidos mostraron que los patrones de Fgf8, Fgf10 y Wnt3a pueden predecir la forma de la condensación mesenquimal mientras crece la extremidad. Los patrones difusivos simples fueron adecuados para explicar las áreas donde se expresa sox9 y cómo se ven afectadas por la forma y el tamaño de las zonas de señalización y el ectodermo. Además, nuestros resultados sugieren que Grem1 y Wnt3a tienen el mismo efecto sobre la expresión de Sox9, y que la expresión de Tgf-β podría deberse a la inhibición de la AR. El segundo modelo analiza cómo estímulos mecánicos y bioquímicos afectan la morfogénesis articular. Para ello se asumió que el crecimiento del cartílago estaba controlado por el estrés hidrostático cíclico e inhibido por el esfuerzo cortante octaédrico. Además, se incluyó el efecto de moléculas que promueven la proliferación de condrocitos tales como PTHrP-Ihh y Wnt. Los resultados obtenidos a través del modelo sugieren que la morfogénesis de la articulación del codo está influenciada en gran medida por las tensiones hidrostáticas junto con la estimulación bioquímica. Para resolver los sistemas de ecuaciones diferenciales parciales en ambos modelos se aplicó el método de los elementos finitos. Cabe destacar que dentro de este documento también se presenta un marco conceptual de los procesos biológicos durante y antes del desarrollo del codo, una breve mención de qué es el codo y algunas enfermedades, así como una breve explicación del método de los elementos finitos y la solución de las ecuaciones de elasticidad y reacción-difusión a través de este método. (Texto tomado de la fuente)MaestríaMagíster en Ingeniería BiomédicaBiomecánica computacional108 páginasapplication/pdfengUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Ingeniería BiomédicaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaArticulación del CodoElbow JointMorfogénesisMorphogenesisModelado biológicoBiological modelsElbowFinite element methodLimb developmentJoint morphogenesisReaction-diffusionCodoDesarrollo de extremidadesMétodo de los elementos finitosMorfogénesis articularReacción-difusiónBiomechanical computational model of the elbow developmentModelo computacional biomecánico de la formación del codoTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMP. Susan Standring DSc, Gray’s anatomy 41st edition: The anatomical basis of clinical practice. 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

Biomechanical computational model of the elbow development

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