Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)

For millennia humans have been using plants for medicinal purposes to treat, cure, or prevent diseases, including cancer. Brazilian ecosystem has a high diversity of plant species. From this perspective, a species found in the Cerrado, Salacia crassifolia (Celastraceae), was selected, for an initial...

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Autores:: Rodrigues de Oliveira, Clayton
Severo Menezes, Antânio Calos
O. de Moraes, Manoel
de Melo Vieira, Letícia
Gomes Pereira, Adriana
Silva Lima, Rosa
dos Santos, Mirley Luciene

Tipo de recurso:: Article of journal

Fecha de publicación:: 2012

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
title	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
spellingShingle	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae) Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (cólon-humano) e SF-295 (sistema nervoso central) Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (human-colon) and SF-295 (CNS)
title_short	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
title_full	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
title_fullStr	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
title_full_unstemmed	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
title_sort	Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
dc.creator.fl_str_mv	Rodrigues de Oliveira, Clayton Severo Menezes, Antânio Calos O. de Moraes, Manoel de Melo Vieira, Letícia Gomes Pereira, Adriana Silva Lima, Rosa dos Santos, Mirley Luciene
dc.contributor.author.spa.fl_str_mv	Rodrigues de Oliveira, Clayton Severo Menezes, Antânio Calos O. de Moraes, Manoel de Melo Vieira, Letícia Gomes Pereira, Adriana Silva Lima, Rosa dos Santos, Mirley Luciene
dc.subject.proposal.spa.fl_str_mv	Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (cólon-humano) e SF-295 (sistema nervoso central) Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (human-colon) and SF-295 (CNS)
topic	Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (cólon-humano) e SF-295 (sistema nervoso central) Salacia crassifolia MDA-MB-435 (melanoma) HCT-8 (human-colon) and SF-295 (CNS)
description	For millennia humans have been using plants for medicinal purposes to treat, cure, or prevent diseases, including cancer. Brazilian ecosystem has a high diversity of plant species. From this perspective, a species found in the Cerrado, Salacia crassifolia (Celastraceae), was selected, for an initial screening to determine the cytotoxic potential of this species "in vitro". S. crassifolia has been widely used in traditional medicine to treat kidney diseases, chronic cough, headaches, healing, ulcerogenic, and for treatment of malaria. The fractions: hydroalcoholic (SCCcM-W), dichloromethane(SCCcM-D), hexane (SCCcM-H) and ethyl acetate (SCCcM-A) from the stem bark were tested for cytotoxicity "in vitro" to within MDA -MB-435(melanoma), HCT-8 (human-colon), and SF-295 (CNS) using the MTT colorimetric method. The hexane (SCCcM-H) and ethyl acetate (SCCcM-A) fractions were those that provided significant cytotoxicity against analyzed tumor cells.
publishDate	2012
dc.date.issued.spa.fl_str_mv	2012
dc.date.accessioned.spa.fl_str_mv	2019-06-29T08:34:38Z
dc.date.available.spa.fl_str_mv	2019-06-29T08:34:38Z
dc.type.spa.fl_str_mv	Artículo de revista
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dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/49309
dc.identifier.eprints.spa.fl_str_mv	http://bdigital.unal.edu.co/42766/ http://bdigital.unal.edu.co/42766/2/
url	https://repositorio.unal.edu.co/handle/unal/49309 http://bdigital.unal.edu.co/42766/ http://bdigital.unal.edu.co/42766/2/
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.spa.fl_str_mv	http://revistas.unal.edu.co/index.php/rccquifa/article/view/45092
dc.relation.ispartof.spa.fl_str_mv	Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.ispartofseries.none.fl_str_mv	Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356
dc.relation.references.spa.fl_str_mv	Rodrigues de Oliveira, Clayton and Severo Menezes, Antânio Calos and O. de Moraes, Manoel and de Melo Vieira, Letícia and Gomes Pereira, Adriana and Silva Lima, Rosa and dos Santos, Mirley Luciene (2012) Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae). Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356 .
dc.rights.spa.fl_str_mv	Derechos reservados - Universidad Nacional de Colombia
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial 4.0 Internacional
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rights_invalid_str_mv	Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
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dc.publisher.spa.fl_str_mv	Revista Colombiana de Ciencias Químico Farmacéuticas
institution	Universidad Nacional de Colombia
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repository.name.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rodrigues de Oliveira, Claytonbefd87b9-d978-46bd-b861-40a63b085e03300Severo Menezes, Antânio Calos241870dc-2198-46b7-b09a-0a84f43ee669300O. de Moraes, Manoela68363f5-e9b4-45b3-9915-c395af2eeb57300de Melo Vieira, Letícia9239efbe-4e17-40ed-a8b1-e3075ca3344d300Gomes Pereira, Adrianaa6df5f05-42a1-4eca-91be-67a7b0e76ad5300Silva Lima, Rosa6134a809-f4c4-44ef-8209-47cd5cb504e1300dos Santos, Mirley Luciene0fc8e7e1-dd42-4a45-8ed6-4653271e6a693002019-06-29T08:34:38Z2019-06-29T08:34:38Z2012https://repositorio.unal.edu.co/handle/unal/49309http://bdigital.unal.edu.co/42766/http://bdigital.unal.edu.co/42766/2/For millennia humans have been using plants for medicinal purposes to treat, cure, or prevent diseases, including cancer. Brazilian ecosystem has a high diversity of plant species. From this perspective, a species found in the Cerrado, Salacia crassifolia (Celastraceae), was selected, for an initial screening to determine the cytotoxic potential of this species "in vitro". S. crassifolia has been widely used in traditional medicine to treat kidney diseases, chronic cough, headaches, healing, ulcerogenic, and for treatment of malaria. The fractions: hydroalcoholic (SCCcM-W), dichloromethane(SCCcM-D), hexane (SCCcM-H) and ethyl acetate (SCCcM-A) from the stem bark were tested for cytotoxicity "in vitro" to within MDA -MB-435(melanoma), HCT-8 (human-colon), and SF-295 (CNS) using the MTT colorimetric method. The hexane (SCCcM-H) and ethyl acetate (SCCcM-A) fractions were those that provided significant cytotoxicity against analyzed tumor cells.A utilização de plantas pela humanidade com fins medicinais é uma das formas mais antigas para tratamento, cura e prevenção de doenças, dentre elas o câncer, cujas espécies vegetais são encontradas em elevada diversidade no ecossistema. Com essa perspectiva, se optou por um arbusto típico do Cerrado, Salacia crassifolia (Celastraceae), para um screening inicial na determinação do potencial citotóxico desta espécie in vitro. Na medicina popular, S. crassifoliaé utilizada no tratamento de problemas renais, tosse crônica, dores de cabeça, cicatrizantes, ulcerogênicas e na terapia da malaria. As frações: hidroalcoólica (SCCcM-W), diclorometânica(SCCcM-D), hexânica (SCCcM-H) e acetato de etila (SCCcM-A) da casca do caule foram submetidas a testes de citotoxicidade in vitro frente às linhagens MDA-MB-435(melanoma), HCT-8 (cólon-humano) e SF-295 (sistema nervoso central) utilizando o método colorimétrico MTT. As frações hexânica (SCCcM-H) e de acetato de etila(SCCcM-A) foram aquelas que proporcionaram citotoxicidade significativas frente às células tumorais analisadas.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/45092Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356Rodrigues de Oliveira, Clayton and Severo Menezes, Antânio Calos and O. de Moraes, Manoel and de Melo Vieira, Letícia and Gomes Pereira, Adriana and Silva Lima, Rosa and dos Santos, Mirley Luciene (2012) Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae). Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356 .Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTSalacia crassifoliaMDA-MB-435 (melanoma)HCT-8 (cólon-humano) e SF-295 (sistema nervoso central)Salacia crassifoliaMDA-MB-435 (melanoma)HCT-8 (human-colon)and SF-295 (CNS)ORIGINAL45092-216199-1-SM.pdfapplication/pdf374167https://repositorio.unal.edu.co/bitstream/unal/49309/1/45092-216199-1-SM.pdf6d19cf62e7116e443e874ddd9d58f8a3MD51THUMBNAIL45092-216199-1-SM.pdf.jpg45092-216199-1-SM.pdf.jpgGenerated Thumbnailimage/jpeg6237https://repositorio.unal.edu.co/bitstream/unal/49309/2/45092-216199-1-SM.pdf.jpg3eb0ac0ed5bfa51011dc67f97dc79682MD52unal/49309oai:repositorio.unal.edu.co:unal/493092023-12-09 23:05:54.978Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co

Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)

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