Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio

Este estudio fue diseñado para realizar el análisis de la equivalencia sustancial del maíz off patent (evento TC1507), que contiene los genes que codifican para las proteínas CRY1F y PAT, que le confieren resistencia a insectos lepidópteros y tolerancia al herbicida glufosinato de amonio. Se llevó a...

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Autores:: Suárez Rodríguez, Hernán Darío

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
dc.title.translated.none.fl_str_mv	Substantial equivalence analysis of off-patent corn (event TC1507) with insect resistance and glufosinate-ammonium herbicide tolerance
title	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
spellingShingle	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio 630 - Agricultura y tecnologías relacionadas Corn - breeding Mejoramiento selectivo del maíz Off patent Transgenic corn event Substantial equivalence Nutritional composition Compositional analysis Maíz transgénico Equivalencia sustancial Composición de nutrientes Análisis composicional
title_short	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
title_full	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
title_fullStr	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
title_full_unstemmed	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
title_sort	Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio
dc.creator.fl_str_mv	Suárez Rodríguez, Hernán Darío
dc.contributor.advisor.none.fl_str_mv	Chaparro Giraldo, Alejandro Acosta Losada, Orlando
dc.contributor.author.none.fl_str_mv	Suárez Rodríguez, Hernán Darío
dc.contributor.researchgroup.spa.fl_str_mv	Ingeniería Genética de Plantas
dc.subject.ddc.spa.fl_str_mv	630 - Agricultura y tecnologías relacionadas
topic	630 - Agricultura y tecnologías relacionadas Corn - breeding Mejoramiento selectivo del maíz Off patent Transgenic corn event Substantial equivalence Nutritional composition Compositional analysis Maíz transgénico Equivalencia sustancial Composición de nutrientes Análisis composicional
dc.subject.armarc.none.fl_str_mv	Corn - breeding
dc.subject.lemb.spa.fl_str_mv	Mejoramiento selectivo del maíz
dc.subject.proposal.eng.fl_str_mv	Off patent Transgenic corn event Substantial equivalence Nutritional composition Compositional analysis
dc.subject.proposal.spa.fl_str_mv	Maíz transgénico Equivalencia sustancial Composición de nutrientes Análisis composicional
description	Este estudio fue diseñado para realizar el análisis de la equivalencia sustancial del maíz off patent (evento TC1507), que contiene los genes que codifican para las proteínas CRY1F y PAT, que le confieren resistencia a insectos lepidópteros y tolerancia al herbicida glufosinato de amonio. Se llevó a cabo una revisión tecnológica para recopilar los estudios con los que se sustentó la equivalencia sustancial en Colombia y en las principales agencias regulatorias en el mundo el evento de maíz transgénico TC1507, junto con el análisis de la equivalencia sustancial que se realizó a partir de la comparación de los niveles de los componentes nutricionales de los analitos proximales en los tejidos de grano y forraje de los genotipos off patent de plantas de maíz transgénicas y genotipos de maíz convencional. Los niveles de los analitos evaluados en las plantas transgénicas se encontraron dentro de los rangos publicados en la literatura para el maíz no transgénico y fueron estadísticamente no significativos del maíz convencional del cual derivan (líneas elite de maíz). Estos resultados constituyeron una parte de la evidencia con la que se sustentaron y solicitaron ante las instituciones regulatorias nacionales, INVIMA e ICA, la autorización para consumo de seres humanos y animales en Colombia, del primer maíz transgénico en el mundo desarrollado con base en tecnologías que están en dominio público. (Texto tomado de la fuente)
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-11-25T22:32:07Z
dc.date.available.none.fl_str_mv	2021-11-25T22:32:07Z
dc.date.issued.none.fl_str_mv	2021
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	DataPaper Image Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80731
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80731 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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Consensus document on compositional considerations for new varieties of cotton (Gossypium hirsutum and Gossypium barbadense): key food and feed nutrients and anti-nutrients. In: Environmental Directorate: Joint meeting of Chemical Committee and the Working Party on Chemicals, Pesticides and Biotechnology: Series on the Safety of Novel Foods and Feeds. Organisation for Economic Co-operation and Development, Paris, France. OECD. (2007) Consensus document on safety information on transgenic plants expressing Bacillus thuringiensis-derived insect control proteins. Series on Harmonisation of Regulatory Oversight in Biotechnology, Number 42. ENV/JM/MONO(2007)14. Paris: Organisation for Economic Co-operation and Development Parrott, W., Chassy, B., Ligon, J., Meyer, L., Petrick, J., Zhou, J., Herman, R., Delaney, B., & Levine, M. (2010). Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops. 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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias Agrarias
dc.publisher.place.spa.fl_str_mv	Bogotá - Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Chaparro Giraldo, Alejandro0352f7295e6de906d5a65eadf07006feAcosta Losada, Orlando5619602ba505a71f9dae2a3abba1a96aSuárez Rodríguez, Hernán Darío9a3656515a77529ea8deecc9e86a9a2eIngeniería Genética de Plantas2021-11-25T22:32:07Z2021-11-25T22:32:07Z2021https://repositorio.unal.edu.co/handle/unal/80731Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Este estudio fue diseñado para realizar el análisis de la equivalencia sustancial del maíz off patent (evento TC1507), que contiene los genes que codifican para las proteínas CRY1F y PAT, que le confieren resistencia a insectos lepidópteros y tolerancia al herbicida glufosinato de amonio. Se llevó a cabo una revisión tecnológica para recopilar los estudios con los que se sustentó la equivalencia sustancial en Colombia y en las principales agencias regulatorias en el mundo el evento de maíz transgénico TC1507, junto con el análisis de la equivalencia sustancial que se realizó a partir de la comparación de los niveles de los componentes nutricionales de los analitos proximales en los tejidos de grano y forraje de los genotipos off patent de plantas de maíz transgénicas y genotipos de maíz convencional. Los niveles de los analitos evaluados en las plantas transgénicas se encontraron dentro de los rangos publicados en la literatura para el maíz no transgénico y fueron estadísticamente no significativos del maíz convencional del cual derivan (líneas elite de maíz). Estos resultados constituyeron una parte de la evidencia con la que se sustentaron y solicitaron ante las instituciones regulatorias nacionales, INVIMA e ICA, la autorización para consumo de seres humanos y animales en Colombia, del primer maíz transgénico en el mundo desarrollado con base en tecnologías que están en dominio público. (Texto tomado de la fuente)This study was designed to carry out the substantial equivalence analysis of the off patent corn event TC1507, which contains the genes that code for the CRY1F and PAT proteins, which confer resistance to lepidopteran insects and tolerance to the herbicide glufosinate ammonium, respectively. A review was carried out aimed at gathering information on the studies that supported substantial equivalence in Colombia and on those of the main regulatory agencies throughout the world about the transgenic corn event TC1507. Substantial equivalence analysis also included comparison of nutritional component levels from tests for proximate analytes present in grain and forage tissues from both transgenic off patent corn and conventional corn genotypes. Analyte levels assessed in transgenic plants were found within the ranges published in the literature for non-transgenic corn and were statistically indistinguishable from the conventional corn from which they were derived (elite corn lines). These results are part of the evidence that supported the application submitted to the national regulatory institutions INVIMA and ICA in order to obtain authorization for animal and human consumption. This is the first domestically developed corn genotype containing the off-patent event TC-1507, since the technology that made it possible is already in the public domain.MaestríaMagíster en Ciencias AgrariasGenética y Fitomejoramientoxi, 74 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias Agrarias - Maestría en Ciencias AgrariasEscuela de posgradosFacultad de Ciencias AgrariasBogotá - ColombiaUniversidad Nacional de Colombia - Sede Bogotá630 - Agricultura y tecnologías relacionadasCorn - breedingMejoramiento selectivo del maízOff patentTransgenic corn eventSubstantial equivalenceNutritional compositionCompositional analysisMaíz transgénicoEquivalencia sustancialComposición de nutrientesAnálisis composicionalAnálisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonioSubstantial equivalence analysis of off-patent corn (event TC1507) with insect resistance and glufosinate-ammonium herbicide toleranceTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionDataPaperImageTexthttp://purl.org/redcol/resource_type/TMAFSI (2020) Crop Composition Database, Version 8.0, Agriculture & Food Systems Institute www.cropcomposition.orgAnderson, J. A., Hong, B., Moellring, E., TeRonde, S., Walker, C., Wang, Y., & Maxwell, C. (2019). Composition of forage and grain from genetically modified DP202216 maize is equivalent to non-modified conventional maize ( Zea mays L.). GM Crops & Food, 10(2), 77-89. https://doi.org/10.1080/21645698.2019.1609849Anon. (2007). EPPO Guideline for the efficacy Evaluation of plant protection products: Design and Analysis of Efficacy Evaluation Trials, PP 1/152(3). EPPO/OEPP, Paris. pp. 139–145.Baker, J. M., Hawkins, N. D., Ward, J. L., Lovegrove, A., Napier, J. A., Shewry, P. R., & Beale, M. H. (2006). A metabolomic study of substantial equivalence of field-grown genetically modified wheat. Plant Biotechnology Journal, 4(4), 381-392. https://doi.org/10.1111/j.1467-7652.2006.00197.xBaktavachalam, G. B., Delaney, B., Fisher, T. L., Ladics, G. S., Layton, R. J., Locke, M. E., Schmidt, J., Anderson, J. A., Weber, N. N., Herman, R. A., & Evans, S. L. (2015). Transgenic maize event TC1507: Global status of food, feed, and environmental safety. GM Crops & Food, 6(2), 80-102. https://doi.org/10.1080/21645698.2015.1054093Bell, E., Nakai, S., & Burzio, L. A. (2018). Stacked Genetically Engineered Trait Products Produced by Conventional Breeding Reflect the Compositional Profiles of Their Component Single Trait Products. Journal of Agricultural and Food Chemistry, 66(29), 7794-7804. https://doi.org/10.1021/acs.jafc.8b02317Bevan, M., Flavell, R. B., and Chilton, M. D. (1983). A chimaeric antibiotic resistance gene as a selectable marker for plant cell transformation. Nature 304, 184–187. doi: 10.1038/304184a0Brent, P., Bittisnich, D., Brooke-Taylor, S., Galway, N., Graf, L., Healy, M., & Kelly, L. (2003). Regulation of genetically modified foods in Australia and New Zealand. Food Control, 14(6), 409-416. https://doi.org/10.1016/S0956-7135(03)00037-9Brookes, G. & Barfoot, P. (2018). Farm income and production impacts of using GM crop technology 1996–2016, GM Crops & Food, 9:2, 59-89Carpenter, J. E. (2010). Peer-reviewed surveys indicate positive impact of commercialized GM crops. Nat Biotech 28, 319–321.Cerdeira, A. L., Gazziero, D. L. P., Duke, S. O., & Matallo, M. B. (2011). Agricultural Impacts of Glyphosate-Resistant Soybean Cultivation in South America. Journal of Agricultural and Food Chemistry, 59(11), 5799-5807. https://doi.org/10.1021/jf102652yCheng, K. C., Beaulieu, J., Iquira, E., Belzile, F. J., Fortin, M. G., & Strömvik, M. V. (2008). Effect of Transgenes on Global Gene Expression in Soybean Is within the Natural Range of Variation of Conventional Cultivars. Journal of Agricultural and Food Chemistry, 56(9), 3057-3067. https://doi.org/10.1021/jf073505iChrispeels, M.J., (2014). Global production and consumption of genetically engineered crops. J. Huazhong Agric. Univ. 33, 120–132.Codex Alimentarius. (2003). Codex principles and guidelines on foods derived from biotechnology. Codex Alimentarius Commission, Joint FAO/WHO Food Standards Programme, FAO, Rome.Codex Alimentarius Commission (2013). Codex Standard for Named Vegetable Oils. Rome (Italy): Codex Alimentarius;. p. 16.Cong, B., Maxwell, C., Luck, S., Vespestad, D., Richard, K., Mickelson, J., & Zhong, C. (2015). Genotypic and Environmental Impact on Natural Variation of Nutrient Composition in 50 Non Genetically Modified Commercial Maize Hybrids in North America. Journal of Agricultural and Food Chemistry, 63(22), 5321-5334. https://doi.org/10.1021/acs.jafc.5b01764Duke, S. O. & Cerdeira, A. L. (2010). Transgenic crops for herbicide resistance, Vol. 2. Springer: Heidelberg, Germany.EFSA Application for renewal: Feed produced from 1507 maize. Summary of the application for renewal of authorisation of existing products according to article 23 of regulation (EC) no 1829/2003. Feed produced from genetically modified 1507 maize (DAS-Ø15Ø7-1). [internet] (2004). Disponible en: https://euginius.eu/euginius/api/literature/pdf/9095514491964051003EFSA Opinion of the scientific panel on genetically modified organisms on a request from the commission related to the notification (Reference C/NL/00/10) for the placing on the market of insect-tolerant genetically modified maize 1507, for import and processing, under Part C of Directive 2001/18/EC from Pioneer Hi-Bred International/ Mycogen Seeds (Question No EFSA-Q-2004-011). EFSA J (2004a); 124: 1–18; http://dx.doi.org/10.2903/j.efsa.2004.124EFSA Opinion of the Scientific Panel on Genetically Modified Organisms on an application (reference EFSA-GMO-NL-2004-02) for the placing on the market of insect-tolerant genetically modified maize 1507, for food use, under Regulation (EC) No 1829/2003 from Pioneer Hi-Bred International/Mycogen Seeds, The EFSA Journal (2005) 182, 1-22. [Internet]. Disponible en: https://euginius.eu/euginius/api/literature/pdf/-1436758519488164233EFSA Scientific Opinion of the Panel on Genetically Modified Organisms on an application (EFSA-GMO-RX-1507) for renewal of authorisation for the continued marketing of existing products produced from maize 1507 for feed use, under Regulation (EC) No 1829/2003 from Pioneer Hi-Bred International, Inc. / Mycogen Seeds. EFSA J (2009). a; 1138:1–11; http://dx.doi.org/10.2903/j.efsa.2009.1138EFSA GMO Panel (EFSA Panel on genetically modified organisms), Naegeli H, Birch AN, Casacuberta J, De Schrijver A, Gralak MA, Guerche P, Jones H, Manachini B, Messe an A, Nielsen EE, Nogue F, Robaglia C, Rostoks N, Sweet J, Tebbe C, Visioli F, Wal J-M , Alvarez F, Ardizzone M, Mestdagh S and Ramon M, 2017. Scientific opinion on an application for renewal of authorisation for continued marketing of maize 1507 and derived food and feed submitted under Articles 11 and 23 of Regulation (EC) No 1829/2003 by Pioneer Overseas Corporation and Dow AgroSciences LLC. EFSA Journal (2017);15(1):4659, 11 pp. doi:10.2903/j.efsa.2017.4659FAO/OMS. (1996). Biotecnología e inocuidad de los alimentos. Informe de una Consulta FAO/OMS, 30 de septiembre-4 de octubre de 1996. Organización de las Naciones Unidas para la Agricultura y la Alimentación, Roma y Organización Mundial de la Salud, Ginebra.FAO/OMS. (2000). Aspectos relativos a la inocuidad de los alimentos de origen vegetal modificados genéticamente. Organización de las Naciones Unidas para la Agricultura y la Alimentación, Roma, y Organización Mundial de la Salud, Ginebra.FAO. (2010). Food Quality and Standards Service has published GM food safety assessment: Tools for trainers’, Pesticide & Toxic Chemical News, no. 12Fraley, R. (2015). Presentation to the National Academy of Sciences. Disponible en:https://vimeo.com/album/3192610/video/115717420FSANZ. Food Standards Australia New Zealand. Food derived from insect-protected and glufosinate-ammonium tolerant corn line 1507. A safety assessment. Technical report series no. 32. [Internet]. 2004. Disponible en: https://www.foodstandards.gov.au/publications/documents/32_TRX%20A446%20-%20Corn%20line%201507.pdfFSANZ. Food Standards Australia New Zealand. Draft assessment. Report application a446 food derived from insect-protected and glufosinate-ammonium tolerant corn line 1507. [Internet]. 2002. Disponible en: https://www.foodstandards.gov.au/code/applications/documents/A446%20DAR%20-%20GM%20Corn.pdfFSANZ. Food Standards Australia New Zealand. Final assessment report application a446 insect-protected and glufosinate ammonium-tolerant corn line 1507. [Internet]. 2003. Disponible en: http://www.fao.org/fileadmin/user_upload/gmfp/docs/ACF18.pdfGoodman, R.E., (2014). Biosafety: evaluation and regulation of genetically modified (GM) crops in the United States. J. Huazhong Agric. Univ. 33, 85–114.Harlander, S. K. (2002). The evolution of modern agriculture and its future with biotechnology. J. Am. Coll. Nutr. 21, 161S165S.Harrigan, G. G., Glenn, K. C., & Ridley, W. P. (2010). Assessing the natural variability in crop composition. Regulatory Toxicology and Pharmacology, 58(3, Supplement), S13-S20. https://doi.org/10.1016/j.yrtph.2010.08.023Harrigan, G. G., Lundry, D., Drury, S., Berman, K., Riordan, S. G., Nemeth, M. A., Ridley, W. P., & Glenn, K. C. (2010a). Natural variation in crop composition and the impact of transgenesis. Nature Biotechnology, 28(5), 402-404. https://doi.org/10.1038/nbt0510-402Herman, R. A., & Price, W. D. (2013). Unintended Compositional Changes in Genetically Modified (GM) Crops: 20 Years of Research. Journal of Agricultural and Food Chemistry, 61(48), 11695-11701. https://doi.org/10.1021/jf400135rHerrera-Estrella, L., Depicker, A., Van Montagu, M., and Schell, J. (1983). Expression of chimeric genes transferred into plant cells using a Ti-plasmid derived vector. Nature 303, 209–213. doi: 10.1038/303209a0Hothorn L.A. and Oberdoerfer R. (2006). Statistical analysis used in the nutritional assessment of novel food using the proof of safety. Regulatory Toxicology and Pharmacology, 44: 125-135.ICA Instituto Colombiano Agropecuario. Resolución No. 003745 (15 de diciembre de 2006 ). Por la cual se establece que el maíz con la tecnología Herculex I®, evento TC 1507 es apto para consumo como alimento de animales domésticos en Colombia. Bogotá, Colombia. [Internet] Disponible en: https://www.ica.gov.co/getattachment/f1b4c01b-b802-4cff-ae51-db9787833a4d/3745.aspxICA Instituto Colombiano Agropecuario. Resolución 000879 (2008). Por la cual no se autoriza la importación de semillas de maíz MON- 88017-3 (CCR) al país. Bogotá, Colombia. [Internet] Disponible en: https://www.ica.gov.co/getattachment/fdbea15a-b473-4d08-bb1d-aec81acf405b/2008R879.aspxICA Instituto Colombiano Agropecuario. Resolución 003662 (2011). Por la cual se autoriza el empleo del maíz SmartStax TM (MON-89Ø34-3 x DAS- Ø15Ø7-1 x MON- 88Ø17-3 x DAS-59122-7), para consumo directo y/o como materia prima para la producción de alimentos para animales domésticos. Bogotá, Colombia. [Internet] Disponible en: https://www.ica.gov.co/getattachment/3bcf82f7-262e-4760-9218-71a08261e92b/2011R3662.aspxICA Instituto Colombiano Agropecuario. Resolución 003050 (2013). Por la cual se autoriza el uso del maíz MON89034 x 1507 x NK603 (MON-89Ø34-3 x DAS- Ø15Ø7-1 x MONØØ6Ø3-6) para consumo directo y/o como materia prima para la producción de alimentos para animales domésticos. Bogotá, Colombia. [Internet] Disponible en: https://www.ica.gov.co/getattachment/3b3a12fe-8289-4c02-88e4-a8998cb7bec4/2013R3050.aspxINVIMA Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Acta 05/06 (2006). Comisión revisora de medicamentos y productos biológicos, de alimentos y bebidas alcohólicas, de insumos para la salud y productos varios. Conceptuar sobre el empleo del producto: granos de maíz, provenientes de híbridos de maíz con tecnología Bt Herculex I. (2006). Bogotá, Colombia. [Internet]. Disponible en: http://bch.biodiv.org/database/attachedfile.aspx?id=1036INVIMA Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Resolución No. 2018027808 (2018). Por la cual se autoriza el uso de Maíz TC1507 x MIR604 x NK603 (DAS-01507-1 x SYN-IR604-5 x MON-00603-6) como materia prima para la producción de alimentos para consumo humano. Bogotá, Colombia. [Internet]. 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Searcher Magazine 16: 34-39.FENALCEEstudiantesInvestigadoresResponsables políticosLICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80731/3/license.txt8153f7789df02f0a4c9e079953658ab2MD53ORIGINALTesisMSc_hdsuarezr.pdfTesisMSc_hdsuarezr.pdfTesis de Maestría en Ciencias Agrariasapplication/pdf1399796https://repositorio.unal.edu.co/bitstream/unal/80731/4/TesisMSc_hdsuarezr.pdf5b5ab8cea361d7ef7d70a664c521c9eaMD54THUMBNAILTesisMSc_hdsuarezr.pdf.jpgTesisMSc_hdsuarezr.pdf.jpgGenerated Thumbnailimage/jpeg5699https://repositorio.unal.edu.co/bitstream/unal/80731/5/TesisMSc_hdsuarezr.pdf.jpg9d5c27885d04fac27655693d9ec252d8MD55unal/80731oai:repositorio.unal.edu.co:unal/807312024-08-01 23:10:35.515Repositorio Institucional Universidad Nacional de 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Análisis de la equivalencia sustancial de maíz off patent (evento TC1507) con resistencia a insectos y con tolerancia al herbicida glufosinato de amonio

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