Export and trafficking of plasmodium proteins within the host erythrocyte
The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicom...
- Autores:
-
Wiser, Mark F.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2007
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/39088
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/39088
http://bdigital.unal.edu.co/29185/
- Palabra clave:
- Ciencias Bilógicas
Bilogía
Medicina
Vía Secretoria
Serca
Tráfico De Proteínas
Malaria
Plasmodium
Ciencias Bilógicas
Bilogía
Medicina
Secretory Pathway
Serca
Protein Trafficking
Malaria
Plasmodium
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| title |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| spellingShingle |
Export and trafficking of plasmodium proteins within the host erythrocyte Ciencias Bilógicas Bilogía Medicina Vía Secretoria Serca Tráfico De Proteínas Malaria Plasmodium Ciencias Bilógicas Bilogía Medicina Secretory Pathway Serca Protein Trafficking Malaria Plasmodium |
| title_short |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| title_full |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| title_fullStr |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| title_full_unstemmed |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| title_sort |
Export and trafficking of plasmodium proteins within the host erythrocyte |
| dc.creator.fl_str_mv |
Wiser, Mark F. |
| dc.contributor.author.spa.fl_str_mv |
Wiser, Mark F. |
| dc.subject.proposal.spa.fl_str_mv |
Ciencias Bilógicas Bilogía Medicina Vía Secretoria Serca Tráfico De Proteínas Malaria Plasmodium Ciencias Bilógicas Bilogía Medicina Secretory Pathway Serca Protein Trafficking Malaria Plasmodium |
| topic |
Ciencias Bilógicas Bilogía Medicina Vía Secretoria Serca Tráfico De Proteínas Malaria Plasmodium Ciencias Bilógicas Bilogía Medicina Secretory Pathway Serca Protein Trafficking Malaria Plasmodium |
| description |
The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmic-endoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element,PEXEL, may play a role in targeting proteins to this parasite export compartment. Exported proteins are then proposed to move into the parasit ophorous vacuoleand those destined for the host erythrocyte are transported to the erythrocytecytoplasm as soluble proteins. Chaperones probably play a role in escorting parasite proteins to their final destinations and assembly on the erythrocyte membrane. |
| publishDate |
2007 |
| dc.date.issued.spa.fl_str_mv |
2007 |
| dc.date.accessioned.spa.fl_str_mv |
2019-06-28T03:21:38Z |
| dc.date.available.spa.fl_str_mv |
2019-06-28T03:21:38Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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publishedVersion |
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https://repositorio.unal.edu.co/handle/unal/39088 |
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http://bdigital.unal.edu.co/29185/ |
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https://repositorio.unal.edu.co/handle/unal/39088 http://bdigital.unal.edu.co/29185/ |
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spa |
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spa |
| dc.relation.spa.fl_str_mv |
http://revistas.unal.edu.co/index.php/actabiol/article/view/27190 |
| dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Acta Biológica Colombiana Acta Biológica Colombiana |
| dc.relation.ispartofseries.none.fl_str_mv |
Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 1900-1649 0120-548X |
| dc.relation.references.spa.fl_str_mv |
Wiser, Mark F. (2007) Export and trafficking of plasmodium proteins within the host erythrocyte. Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 1900-1649 0120-548X . |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología |
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https://repositorio.unal.edu.co/bitstream/unal/39088/1/27190-95382-1-PB.pdf https://repositorio.unal.edu.co/bitstream/unal/39088/2/27190-95382-1-PB.pdf.jpg |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Wiser, Mark F.b9a3dbf7-4e6f-461a-853a-b5d562f6605f3002019-06-28T03:21:38Z2019-06-28T03:21:38Z2007https://repositorio.unal.edu.co/handle/unal/39088http://bdigital.unal.edu.co/29185/The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmic-endoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element,PEXEL, may play a role in targeting proteins to this parasite export compartment. Exported proteins are then proposed to move into the parasit ophorous vacuoleand those destined for the host erythrocyte are transported to the erythrocytecytoplasm as soluble proteins. Chaperones probably play a role in escorting parasite proteins to their final destinations and assembly on the erythrocyte membrane.El tráfico y exportación de proteínas del parásito dentro del citoplasma del eritrocito es un proceso complejo, que no es bien comprendido. Inicialmente se especuló sobre la manera como el parásito exporta éstas proteínas y se involucró un compartimiento que se denominó retículo endoplasmático secundario de los Apicomplexa (sERA). En este trabajo se revisan las propiedades de este compartimiento exportador de acuerdo con las observaciones más recientes del tráfico de proteínas de Plasmodium al salir del parásito. La discusión se enmarca dentro del contexto de este único compartimiento exportador relacionado con una ATPasa de calcio única de los Apicomplexa que presenta homología con la ATPasa de calcio del retículo endoplasmático sarcoplásmico (SERCA). Además, se especula que Plasmodium exporta elementos PEXEL, que podrían estar asociados con el direccionamiento de proteínas de Plasmodium hacia el compartimiento exportador y se propone que éstas proteínas van posteriormente a la vacuolaparasitófora, y aquellas cuyo destino es la célula hospedera se transportan al citoplasma del eritrocito como proteínas solubles. Las chaperonas posiblemente escoltan las proteínasdel parásito hasta su destino final y se ensamblan en la membrana del eritrocito.application/pdfspaUniversidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biologíahttp://revistas.unal.edu.co/index.php/actabiol/article/view/27190Universidad Nacional de Colombia Revistas electrónicas UN Acta Biológica ColombianaActa Biológica ColombianaActa Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 1900-1649 0120-548XWiser, Mark F. (2007) Export and trafficking of plasmodium proteins within the host erythrocyte. Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 Acta Biológica Colombiana; Vol. 12, núm. 2 (2007); 3-18 1900-1649 0120-548X .Export and trafficking of plasmodium proteins within the host erythrocyteArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTCiencias BilógicasBilogíaMedicinaVía SecretoriaSercaTráfico De ProteínasMalariaPlasmodiumCiencias BilógicasBilogíaMedicinaSecretory PathwaySercaProtein TraffickingMalariaPlasmodiumORIGINAL27190-95382-1-PB.pdfapplication/pdf5150771https://repositorio.unal.edu.co/bitstream/unal/39088/1/27190-95382-1-PB.pdfbeb05276f1e69fa332ecc45dc615f5fbMD51THUMBNAIL27190-95382-1-PB.pdf.jpg27190-95382-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg7959https://repositorio.unal.edu.co/bitstream/unal/39088/2/27190-95382-1-PB.pdf.jpg364aa49225b4530691245beced93b10aMD52unal/39088oai:repositorio.unal.edu.co:unal/390882023-01-22 23:03:41.457Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |