Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53

ilustraciones, fotografías a color

Autores:: Londoño Montoya, Gregorio

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
dc.title.translated.eng.fl_str_mv	Clinicopathological characterization of a series of cases of squamous cell carcinoma of the oral cavity and oropharynx, determination of p16 and p53
title	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
spellingShingle	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53 610 - Medicina y salud Diagnóstico por Imagen Métodos Diagnostic Imaging Methods Carcinoma escamocelular Orofaringe Cavidad oral Alcohol Tabaco p16 p53 Squamous cell carcinoma Oropharynx Oral cavity Alcohol Tabacco p16 p53
title_short	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
title_full	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
title_fullStr	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
title_full_unstemmed	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
title_sort	Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53
dc.creator.fl_str_mv	Londoño Montoya, Gregorio
dc.contributor.advisor.none.fl_str_mv	Acosta Forero, Bernarda Jinneth
dc.contributor.author.none.fl_str_mv	Londoño Montoya, Gregorio
dc.contributor.cvlac.spa.fl_str_mv	Londoño Montoya, Gregorio
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud
topic	610 - Medicina y salud Diagnóstico por Imagen Métodos Diagnostic Imaging Methods Carcinoma escamocelular Orofaringe Cavidad oral Alcohol Tabaco p16 p53 Squamous cell carcinoma Oropharynx Oral cavity Alcohol Tabacco p16 p53
dc.subject.decs.spa.fl_str_mv	Diagnóstico por Imagen Métodos
dc.subject.decs.eng.fl_str_mv	Diagnostic Imaging
dc.subject.lemb.eng.fl_str_mv	Methods
dc.subject.proposal.spa.fl_str_mv	Carcinoma escamocelular Orofaringe Cavidad oral Alcohol Tabaco p16 p53
dc.subject.proposal.eng.fl_str_mv	Squamous cell carcinoma Oropharynx Oral cavity Alcohol Tabacco p16 p53
description	ilustraciones, fotografías a color
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-10-06
dc.date.accessioned.none.fl_str_mv	2023-02-03T19:47:40Z
dc.date.available.none.fl_str_mv	2023-02-03T19:47:40Z
dc.type.spa.fl_str_mv	Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
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url	https://repositorio.unal.edu.co/handle/unal/83293 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	1. Kristen B. Pytynia, Dahlstrom KR, Sturgis EM. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol. May; 50(5): 380–386, 2014. 2. AK Chaturvedi, EA Engels, RM Pfeiffer, BY Hernandez, W Xiao, E Kim, B Jiang, MT Goodman, M Sibug-Saber, W Cozen, L Liu, CF Lynch, N Wentzensen, R C Jordan, S Altekruse, WF Anderson, PS Rosenberg, ML Gillison. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. Nov 10 2011. 3. C Pardo, A Suárez, JA Acosta, JJ Pérez. Atlas de mortalidad por cáncer en Colombia cuarta edición. Instituto nacional de cancerología, Dic 2017. 4. C Pardo , R Cendales. Incidencia, mortalidad y prevalencia de cáncer en Colombia, 2007-2011. Primera edición. Bogotá. D.C. Instituto Nacional de Cancerología, v.1. p. 148, 2015. 5. NJ Fischbein, N Lee. Leibel and Phillips Textbook of Radiation Oncology (Third Edition), 2010. 6. BW Neville, TA Day. Oral Cancer and Precancerous Lesions. CA Cancer J Clin ;52:195-215 2002. 7. SS Hetch. Lung Carcinogenesis by Tobacco Smoke Int J Cancer. 2012 8. Wilson D, Wakefield M, Owen N, Roberts L. Characteristics of heavy smokers. Preventive Medicine, 21(3), 311–319, 1992. 9. G PÖschl, HK Seitz. Alcohol & Alcoholism Vol. 39, No. 3, pp. 155–165, 2004. 10. HK Seitz, F Stickel,N Homann. Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics. International Journal of Cancer, 108, 483–487, 2004. 11. JA Theruvathu, P Jaruga, RG Nath, M Dizdaroglu, P J Brooks. Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Research Vol. 33, No. 11 3513–3520, 2005. 12. M Taberna, M Mena, MA Pavón, L Alemany , ML Gillison, R MesÍa. Human papillomavirus-related oropharyngeal cancer. Annals of Oncology 28: 2386–2398, 2017. 13. K Sonawane, R Suk, EY Chiao, J Chhatwal, P Qiu, T Wilkin, AG Nyitray, AG Sikora, AA Deshmukh. Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014. Ann Intern Med. 2017. 14. A Erira, LA Motta, A Chala, A Moreno, F Gamboa, DA García. Genotipificación, niveles de expresión y estado físico del virus del papiloma humano en pacientes colombianos con cáncer de células escamosas en la cavidad oral. Biomédica 2016. 15. AK. EI-Naggar, JKC Chan, JR. Grandis, T Takata, PJ. Slootweg. WHO Classification of Head and Neck Tumours. International Agency for Research on Cancer, 2017. 16. S Syrjänen, K Syrjänen. HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?. Acta Cytologica, 2019. 17. K Quintero, GA Giraldo, ML Uribe, A Baena, AC López, E Alvarez, GI Sánchez. Human papillomavirus types in cases of squamous cell carcinoma of head and neck in Colombia. Braz J Otorhinolaryngol;79(3):375-81, 2013. 18. American Joint committee on cancer. AJCC Cancer staging Manual 8th edition, Springer, Chicago 2017. 19. M Robinson, A Schache, P Sloan, S Thavaraj. HPV Specific Testing: A Requirement for Oropharyngeal Squamous Cell Carcinoma Patients. Head and Neck Pathol 2012. 20. JE Lewis, Beth Beadle, JA Bishop, RD Chernock, C Colasacco, C Lacchetti, JT Moncur, JW Rocco, MR Schwartz, RR Seethala, NE Thomas, WH Westra, WC Faquin. Human Papillomavirus Testing in Head and Neck Carcinomas. College of American Pathologists. 2017. 21. AA Hashmi, ZF Hussain, SK Hashmi,M Irfan, EY Khan, N Faridi, A Khan, MM Edhi. Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance. l. BMC Res Notes 11:433, 2016. 22. NF Schlecht, M Masika, A Diaz. Risk of Oral Human Papillomavirus Infection Among Sexually Active Female Adolescents Receiving the Quadrivalent Vaccine. JAMA Network Open, 2019. 23. G Zhou, Z Liu, JN Myers. TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response. J Cell Biochem, 117(12): 2682–2692, 2016. 24. D Taylor, WM Koch, M Zahurak, K Shah, D Sidransky, WH Westra. Immunohistochemical Detection of p53 Protein Accumulation in Head and Neck Cancer: Correlation with p53 Gene Alterations. Human Pathology Vol 30, No. 10, 1999. 25. M Orsaria, S Marzinotto, L De MarchI, V Giacomarra, S Boria, C Rubini, AP Londero, C Di Loreto, L Mariuzzi. HPV-related Oropharyngeal Squamous Cell Carcinoma: p16INK4A Immunohistochemistry or HPV Genotyping? Anticancer research 35: 4733-4740, 2015. 26. L Amlani, E Bellile, M Spector, J Smith, C Brenner, L Rozek, A Nguyen, K Zarins, D Thomas, J McHugh, J Taylor, G Wolf. Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Int J Cancer Clin Res, 2019. 27. L Alos, M Castillo, A Nadal, M Caballero, C Mallofre, A Palacin, A Cardesa. Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases. Histopathology 44, 570–579, 2004. 28. RP Masand, SK El-Mofty, X-J Ma, Y Luo, JJ Flanagan, JS Lewis. Adenosquamous Carcinoma of the Head and Neck: Relationship to Human Papillomavirus and Review of the Literature. Head and Neck Pathol 5:108–116, 2011. 29. AA Hashmi, N Younus , S Naz. P16 Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma: Association With Prognostic Parameters, Cureus 12(6), 2020. 30. PT Hennessey , WH Westra, JA Califano. Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications. J Dent Res 88(4):300-306, 2009. 31. M Ralli, S Singh, SPS Yadav, N Sharma, R Verma, R Sen. Assessment and clinicopathological correlation of p16 expression in head and neck squamous cell carcinoma. Journal of Cancer Research and Therapeutics, Vol 12 Iss1, 2016. 32. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature 351: 453-456, 1991. 33. Wong, K. S., Krane, J. F., & Jo, V. Y. Heterogeneity of p16 immunohistochemistry and increased sensitivity of RNA in situ hybridization in cytology specimens of HPV‐related head and neck squamous cell carcinoma. In Cancer Cytopathology Vol. 127, Issue 10, pp. 632–642, 2019. 34. Yepez MC, Uribe C, Arias N, Navarro E, de Vries E, Gamboa O, Gil OF, Pardo C. Sistema de información de cáncer en Colombia -SICC (Versión 1.0). [Internet]. Bogotá, Colombia: Instituto Nacional de Cancerología -INC 2017. Disponible de: http://www.infocancer.co, fecha de acceso 2022. 35. Johnson, D. E, Burtness, B, Leemans, C. R., Lui, V. W. Y, Bauman, J. E., & Grandis, J. R. Head and neck squamous cell carcinoma. In Nature Reviews Disease Primers (Vol. 6, Issue 1). Springer Science and Business Media LLC, 2020. 36. Salinas-Sánchez, A. S., Atienzar-Tobarra, M., Lorenzo-Romero, J. G., Sánchez-Sánchez, F., Giménez-Bachs, J. M., Donate-Moreno, M. J., Pastor-Navarro, H., Hernández-Millán, I., Segura-Martín, M., & Escribano-Martínez, J. Sensitivity and Specificity of P53 Protein Detection by Immunohistochemistry in Patients with Urothelial Bladder Carcinoma. In Urologia Internationalis (Vol. 79, Issue 4, pp. 321–327), 2007. 37. Thompson, E.F., Chen, J., Huvila, J. et al. p53 Immunohistochemical patterns in HPV-related neoplasms of the female lower genital tract can be mistaken for TP53 null or missense mutational patterns. Mod Pathol 33, 1649–1659, 2020. 38. Köbel, M., Ronnett, B. M., Singh, N., Soslow, R. A., Gilks, C. B., & McCluggage, W. G. Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas. In International Journal of Gynecological Pathology (Vol. 38, pp. S123–S131). Ovid Technologies, 2019. 39. Hwang, H. J., Nam, S. K., Park, H., Park, Y., Koh, J., Na, H. Y., Kwak, Y., Kim, W. H., & Lee, H. S. Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer. In Journal of Pathology and Translational Medicine (Vol. 54, Issue 5, pp. 378–386). The Korean Society of Pathologists and The Korean Society for Cytopathology,2020. 40. Heckl, M., Schmoeckel, E., Hertlein, L., Rottmann, M., Jeschke, U., & Mayr, D. (2018). The ARID1A, p53 and ß-Catenin statuses are strong prognosticators in clear cell and endometrioid carcinoma of the ovary and the endometrium. In E. Asselin (Ed.), PLOS ONE Vol. 13, Issue 2, p. e0192881, 2018. 41. Beynon, R. A., Lang, S., Schimansky, S., Penfold, C. M., Waylen, A., Thomas, S. J., Pawlita, M., Waterboer, T., Martin, R. M., May, M., & Ness, A. R. Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all-cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer. In International Journal of Cancer Vol. 143, Issue 5, pp. 1114–1127.2018. 42. López, A. F., & Sanabria Quiroga, Á. E. Características clínicas y administrativas que se relacionan con el retraso en el diagnóstico y tratamiento de los pacientes con cáncer de cabeza y cuello. In Revista Colombiana de Cirugía (Vol. 35, Issue 1, pp. 66–74), 2020. 43. Ministerio de Justicia y del Derecho, Observatorio de Drogas de Colombia. Estudio Nacional de Consumo de Sustancias Psicoactivas Colombia 2019. Bogotá DC,2019. 44. Rettig, E., Kiess, A. P., & Fakhry, C. The role of sexual behavior in head and neck cancer: implications for prevention and therapy. In Expert Review of Anticancer Therapy (Vol. 15, Issue 1, pp. 35–49), 2014. 45. Benzerdjeb, N., Tantot, J., Blanchet, C., Philouze, P., Mekki, Y., Lopez, J., & Devouassoux‐Shisheboran, M. Oropharyngeal squamous cell carcinoma: p16/p53 immunohistochemistry as a strong predictor of HPV tumour status. Histopathology (Vol. 79, Issue 3, pp. 381–390), 2021.
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dc.format.extent.spa.fl_str_mv	35 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina - Especialidad en Patología Anatómica y Clínica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Acosta Forero, Bernarda Jinneth5c00c20085cc2446955539fac6cb0aa8Londoño Montoya, Gregorio0e7edb16cef19601b091aa2fa8a8d724Londoño Montoya, Gregorio2023-02-03T19:47:40Z2023-02-03T19:47:40Z2022-10-06https://repositorio.unal.edu.co/handle/unal/83293Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías a colorIntroducción El carcinoma escamocelular de cabeza y cuello es una neoplasia maligna de pronóstico intermedio con un incremento en el número de casos en los últimos años. En cavidad orofaringe se describen dos tipos: aquellos relacionados con la infección del virus del papiloma humano (VPH) relacionado con la variante histológica basaloide y aquellos que no, los cuales a su vez se relacionan con otros factores de riesgo como el uso de tabaco y el consumo de alcohol, además de la variante histológica convencional . El carcinoma relacionado con VPH usualmente tiene un mejor pronóstico incluso en etapas avanzadas debido a que inicialmente no posee la mutación para el gen TP53 a diferencia del no relacionado con VPH que la tiene. Materiales y métodos El objetivo de este proyecto es encontrar las diferencias en la expresión por inmunohistoquímica de un marcador subrogado para la infección por VPH (p16) y de la expresión de p53, utilizando escalas aceptadas, así como su asociación con factores de riesgo y variables histológicas, en pacientes con carcinoma escamocelular de cavidad oral y orofaringe del Hospital Universitario Nacional entre los años 2017-2021 . Resultados Se encontraron 50 pacientes con carcinoma escamocelular (18 [36%] mujeres, 32[64%] hombres) con una edad promedio de 64 años, en 27 (54%) cavidad oral con una prevalencia del variante convencional de 18(66%) y 23 (46%) en orofaringe con 12 (52%) de la variante basaloide. Para la marcación con inmunohistoquímica el 19 (38%) fueron positivos para p16 en orofarínge y 21 (40%) positivos para p53 en cavidad oral, la distribución para factores de riesgo fue en p16, el 1 (5%) con consumo de alcohol únicamente, 3 (15%) uso exclusivo de tabaco y 4 (20%) uso de ambos; para p53 3 (30%) pacientes con uso de tabaco exclusivamente, 3 (30%) con consumo de alcohol exclusivamente y 4 (40%) con uso de ambos Conclusión La asociación con infección por VPH es más común en orofaringe con variante basaloide, el consumo de alcohol y tabaco es más común en cavidad oral, con variante histológica convencional, por otra parte, la marcación para p16 acorde a lo esperado, sin embargo, la marcación para p53 fue heterogénea con algunos datos inesperados como marcación doble (p16 y p53). (Texto tomado de la fuente)Introduction Squamous cell carcinoma of the head and neck is a malignant neoplasm of intermediate prognosis with an increase in the number of cases in recent years. Two types are described in the oropharynx cavity: those related to human papillomavirus (HPV) infection related to the basaloid histological variant and those that are not, which in turn are related to other risk factors such as tobacco use and alcohol consumption, and usually present with a conventional histological variant. HPV-related carcinoma usually has a better prognosis even in advanced stages because it does not initially have the TP53 gene mutation, unlike non-HPV-related carcinoma that does. Materials and methods The objective of this project is to find the differences in the expression by immunohistochemistry of a surrogate marker for HPV infection (p16) and the expression of p53, using accepted scales, as well as their association with risk factors and histological variants, in patients with squamous cell carcinoma of the oral cavity and oropharynx at the Hospital Universitario Nacional between the years 2017-2021. Results Fifty patients with squamous cell carcinoma (18 [36%] women, 32 [64%] men) with a mean age of 64 years were found. 27 (54%) in oral cavity with a prevalence of the conventional variant of 18 (66%). 23 (46%) in the oropharynx with 12 (52%) of the basaloid variant. For immunohistochemical staining, 19 (38%) were positive for p16 in the oropharynx and 21 (40%) positive for p53 in the oral cavity, the distribution for risk factors was in p16, 1 (5%) with only alcohol consumption, 3 (15%) exclusive use of tobacco and 4 (20%) use of both; for p53, 3 (30%) patients used tobacco exclusively, 3 (30%) used alcohol exclusively, and 4 (40%) used both. Conclusion The association with HPV infection is more common in the oropharynx with a basaloid variant, alcohol and tobacco consumption is more common in the oral cavity, with a conventional histological variant. On the other hand, p16 staining is as expected, however, p53 staining was heterogeneous with some unexpected data such as double (p16 and p53) labelling.Especialidades MédicasEspecialista en Patología Anatómica y Clínica35 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Patología Anatómica y ClínicaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludDiagnóstico por ImagenMétodosDiagnostic ImagingMethodsCarcinoma escamocelularOrofaringeCavidad oralAlcoholTabacop16p53Squamous cell carcinomaOropharynxOral cavityAlcoholTabaccop16p53Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53Clinicopathological characterization of a series of cases of squamous cell carcinoma of the oral cavity and oropharynx, determination of p16 and p53Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TM1. Kristen B. Pytynia, Dahlstrom KR, Sturgis EM. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol. May; 50(5): 380–386, 2014.2. AK Chaturvedi, EA Engels, RM Pfeiffer, BY Hernandez, W Xiao, E Kim, B Jiang, MT Goodman, M Sibug-Saber, W Cozen, L Liu, CF Lynch, N Wentzensen, R C Jordan, S Altekruse, WF Anderson, PS Rosenberg, ML Gillison. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. Nov 10 2011.3. C Pardo, A Suárez, JA Acosta, JJ Pérez. Atlas de mortalidad por cáncer en Colombia cuarta edición. Instituto nacional de cancerología, Dic 2017.4. C Pardo , R Cendales. Incidencia, mortalidad y prevalencia de cáncer en Colombia, 2007-2011. Primera edición. Bogotá. D.C. Instituto Nacional de Cancerología, v.1. p. 148, 2015.5. NJ Fischbein, N Lee. Leibel and Phillips Textbook of Radiation Oncology (Third Edition), 2010.6. BW Neville, TA Day. Oral Cancer and Precancerous Lesions. CA Cancer J Clin ;52:195-215 2002.7. SS Hetch. Lung Carcinogenesis by Tobacco Smoke Int J Cancer. 20128. Wilson D, Wakefield M, Owen N, Roberts L. Characteristics of heavy smokers. Preventive Medicine, 21(3), 311–319, 1992.9. G PÖschl, HK Seitz. Alcohol & Alcoholism Vol. 39, No. 3, pp. 155–165, 2004.10. HK Seitz, F Stickel,N Homann. Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics. International Journal of Cancer, 108, 483–487, 2004.11. JA Theruvathu, P Jaruga, RG Nath, M Dizdaroglu, P J Brooks. Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde. Nucleic Acids Research Vol. 33, No. 11 3513–3520, 2005.12. M Taberna, M Mena, MA Pavón, L Alemany , ML Gillison, R MesÍa. Human papillomavirus-related oropharyngeal cancer. Annals of Oncology 28: 2386–2398, 2017.13. K Sonawane, R Suk, EY Chiao, J Chhatwal, P Qiu, T Wilkin, AG Nyitray, AG Sikora, AA Deshmukh. Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014. Ann Intern Med. 2017.14. A Erira, LA Motta, A Chala, A Moreno, F Gamboa, DA García. Genotipificación, niveles de expresión y estado físico del virus del papiloma humano en pacientes colombianos con cáncer de células escamosas en la cavidad oral. Biomédica 2016.15. AK. EI-Naggar, JKC Chan, JR. Grandis, T Takata, PJ. Slootweg. WHO Classification of Head and Neck Tumours. International Agency for Research on Cancer, 2017.16. S Syrjänen, K Syrjänen. HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?. Acta Cytologica, 2019.17. K Quintero, GA Giraldo, ML Uribe, A Baena, AC López, E Alvarez, GI Sánchez. Human papillomavirus types in cases of squamous cell carcinoma of head and neck in Colombia. Braz J Otorhinolaryngol;79(3):375-81, 2013.18. American Joint committee on cancer. AJCC Cancer staging Manual 8th edition, Springer, Chicago 2017.19. M Robinson, A Schache, P Sloan, S Thavaraj. HPV Specific Testing: A Requirement for Oropharyngeal Squamous Cell Carcinoma Patients. Head and Neck Pathol 2012.20. JE Lewis, Beth Beadle, JA Bishop, RD Chernock, C Colasacco, C Lacchetti, JT Moncur, JW Rocco, MR Schwartz, RR Seethala, NE Thomas, WH Westra, WC Faquin. Human Papillomavirus Testing in Head and Neck Carcinomas. College of American Pathologists. 2017.21. AA Hashmi, ZF Hussain, SK Hashmi,M Irfan, EY Khan, N Faridi, A Khan, MM Edhi. Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance. l. BMC Res Notes 11:433, 2016.22. NF Schlecht, M Masika, A Diaz. Risk of Oral Human Papillomavirus Infection Among Sexually Active Female Adolescents Receiving the Quadrivalent Vaccine. JAMA Network Open, 2019.23. G Zhou, Z Liu, JN Myers. 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Histopathology (Vol. 79, Issue 3, pp. 381–390), 2021.EstudiantesLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83293/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53ORIGINAL1094884952.2022.pdf1094884952.2022.pdfEspecialidad Médica en Patología Anatómica y Clínicaapplication/pdf883853https://repositorio.unal.edu.co/bitstream/unal/83293/4/1094884952.2022.pdf791ef8c38a3cec0c76e350ea42d29cd6MD54THUMBNAIL1094884952.2022.pdf.jpg1094884952.2022.pdf.jpgGenerated Thumbnailimage/jpeg5492https://repositorio.unal.edu.co/bitstream/unal/83293/5/1094884952.2022.pdf.jpg16172445eb52c0c1053e96428b167ff4MD55unal/83293oai:repositorio.unal.edu.co:unal/832932023-08-15 23:04:13.961Repositorio Institucional Universidad Nacional de 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Caracterización clínico-patológica de una serie de casos de carcinoma escamocelular de cavidad oral y orofaringe, determinación de p16 y p53

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