Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020
ilustraciones, fotografías, gráficas, tablas
- Autores:
-
Barrero Flórez, Fabián Gonzalo
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/83417
- Palabra clave:
- 610 - Medicina y salud::616 - Enfermedades
Neoplasias de la Tiroides/patología
Enfermedades de la Tiroides/patología
Enfermedades de la Tiroides/epidemiología
Thyroid Neoplasms/pathology
Thyroid Diseases/pathology
Thyroid Diseases/epidemiology
Neoplasias de la tiroides
Patología
Carcinoma papilar
Informes de casos
Pathology
Carcinoma, Papillary
Case reports
Thyroid neoplasms
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
| dc.title.translated.eng.fl_str_mv |
Thyroid cancer: clinico-pathological features in a case series from Hospital Universitario Nacional 2017-2020 |
| title |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
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Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 610 - Medicina y salud::616 - Enfermedades Neoplasias de la Tiroides/patología Enfermedades de la Tiroides/patología Enfermedades de la Tiroides/epidemiología Thyroid Neoplasms/pathology Thyroid Diseases/pathology Thyroid Diseases/epidemiology Neoplasias de la tiroides Patología Carcinoma papilar Informes de casos Pathology Carcinoma, Papillary Case reports Thyroid neoplasms |
| title_short |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
| title_full |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
| title_fullStr |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
| title_full_unstemmed |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
| title_sort |
Cáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020 |
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Barrero Flórez, Fabián Gonzalo |
| dc.contributor.advisor.spa.fl_str_mv |
Acosta Forero, Bernarda Jinneth Ricaurte Guerrero, Orlando |
| dc.contributor.author.spa.fl_str_mv |
Barrero Flórez, Fabián Gonzalo |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::616 - Enfermedades |
| topic |
610 - Medicina y salud::616 - Enfermedades Neoplasias de la Tiroides/patología Enfermedades de la Tiroides/patología Enfermedades de la Tiroides/epidemiología Thyroid Neoplasms/pathology Thyroid Diseases/pathology Thyroid Diseases/epidemiology Neoplasias de la tiroides Patología Carcinoma papilar Informes de casos Pathology Carcinoma, Papillary Case reports Thyroid neoplasms |
| dc.subject.decs.spa.fl_str_mv |
Neoplasias de la Tiroides/patología Enfermedades de la Tiroides/patología Enfermedades de la Tiroides/epidemiología |
| dc.subject.decs.eng.fl_str_mv |
Thyroid Neoplasms/pathology Thyroid Diseases/pathology Thyroid Diseases/epidemiology |
| dc.subject.proposal.spa.fl_str_mv |
Neoplasias de la tiroides Patología Carcinoma papilar Informes de casos |
| dc.subject.proposal.eng.fl_str_mv |
Pathology Carcinoma, Papillary Case reports Thyroid neoplasms |
| description |
ilustraciones, fotografías, gráficas, tablas |
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2022 |
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2022 |
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2023-02-10T16:13:48Z |
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2023-02-10T16:13:48Z |
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Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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https://repositorio.unal.edu.co/handle/unal/83417 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/83417 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
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Bireme |
| dc.relation.references.spa.fl_str_mv |
Global Cancer Observatory (GLOBOCAN), Intenational agency for research on Cancer. Estimated age-standardized incidence rates (World) in 2018. LLoyd R, Osamura R, Klöppel G, Rosai J. WHO Classification of tumours of endocrine organs. International Agency for research on Cancer, 2016. Chapter 2. Pags 68-66. La Vecchia C, Malvezzi M, Bosetti C, Garavello W, Bertuccio P, Levi F, Negri E. Thyroid cancer mortality and incidence: A global overview. International Journal of Cancer.2014. 0:1-9 Seib C, Sosa J. Evolving Understanding of the Epidemiology of Thyroid Cancer.Endocrinology Metabolic Clinic North America 2018. p 1-13 Hernando V, Jorge H, Ivonne M, Valentina A. Thyroid Cancer – South American Experience. Thyroid Disorders. 2015. Ther 4:182 Da Mota A, Miranda-Filho A, Koifman S, Koifman J. Thyroid Cancer Incidences From Selected South America Population-Based Cancer Registries: An Age-Period-Cohort Study. Journal of Global Oncology. 2017.P 1-11 Romei C, Fugazzola L, Puxeddu E, et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years. Journal of Clinical Endocrinology and Metabolics 2012. 97(9):1758–1765 Cabanillas M, McFadden D, Durante C. Thyroid cancer. The Lancet. 2016. 388: 2783-2795. Haugen B, Alexander E, Bible K, et al. American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 26(1):1-92. Tessler R, Middleton W, Grant E, et al.ACR Thyroid Imaging, Reporting and DataSystem (TI-RADS): White Paper of the ACR TI-RADS Committee. Journal of the American College of Radiology.2017.14(5):587-595. Fernandez J. Clasificación TI-RADS de los nódulos tiroideos en base a una escala de puntuación modificada con respecto a los criterios ecográficos de malignidad. Revista Argentina de Radiología. 2014.78(3):138-148 Ali S, Cibas E. The Bethesda System for Reporting Thyroid Cytopathology, Second Edition.Springer International Publishing. 2018. Wang T, Sosa J. Thyroid surgery for differentiated thyroid cancer — recent advances and future directions. Nature reviews. 2018. 14: 670-683 Mete O, Seethala R, Asa S, et al. Protocol for the Examination of Specimens From Patients With Carcinomas of the Thyroid Gland. College of American Pathologists Templates (CAP).2020. P 1-22 Lemos M, Okoye E. Atlas of Surgical Pathology Grossing. Springer. 2019. Cap 3. P 16. Goldblum et al. Rosai and Ackerman’s Surgical Pathology. 11 edition, Elsevier. 2018. Cap 2. P 90-97 Ito Y, Miyauchi A, Kihara M, Higashiyama T, Kobayashi K, Miya A. Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid. 2014;24(1):27-34. doi:10.1089/thy.2013.0367 Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y. Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg. 2010;34(6):1222-1231. doi:10.1007/s00268-009-0359-x Lim H, Devesa S, Sosa J, Check D, Kitahara C. Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013.Journal of American Medical Association (JAMA). 2017. E1-E11 Romero A, Martínez J, Osorio K, Olaya N. Histological variants and prognostic factors of papillary thyroid carcinoma at the Colombian Instituto Nacional de Cancerología, 2006-2012. Revista Biomédica. 2015. 35:429-436. Akın Ş, Yazgan Aksoy D, Akın S, Kılıç M, Yetişir F, Bayraktar M. Prediction of central lymph node metastasis in patientswith thyroid papillary microcarcinoma. Turk J Med Sci. 2017;47(6):1723-1727. Published 2017 Dec 19. doi:10.3906/sag-1702-99 Zhao W, Chen S, Hou X, Liao Q, Chen G, Zhao Y. Predictive Factors of Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. Pathol Oncol Res. 2019;25(3):1245-1251. doi:10.1007/s12253-018-0511-8 |
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xviii, 71 páginas |
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2017-2020 |
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Universidad Nacional de Colombia |
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Bogotá - Medicina - Especialidad en Patología Anatómica y Clínica |
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Facultad de Medicina |
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Bogotá, Colombia |
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Universidad Nacional de Colombia - Sede Bogotá |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Acosta Forero, Bernarda Jinneth5c00c20085cc2446955539fac6cb0aa8Ricaurte Guerrero, Orlandoc67cb936cb7891759c7d917997db460dBarrero Flórez, Fabián Gonzalof17b08ea312cfbda4737ab555460680b2017-20202023-02-10T16:13:48Z2023-02-10T16:13:48Z2022https://repositorio.unal.edu.co/handle/unal/83417Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, gráficas, tablasObjetivos: Describir en una población con diagnóstico de cáncer de tiroides, las características patológicas relacionadas con comportamiento biológico y riesgo de recurrencia. Métodos: Se incluyeron casos con diagnóstico histopatológico de carcinoma de tiroides entre los años 2017 y 2020, cuyos reportes de patología fueron revisados para recopilar información respecto a las variables sociodemográficas y patológicas asociadas con recurrencia. Se registraron los datos y se cuantificaron medidas de frecuencia para la muestra en general y con las submuestras: microcarcinomas y tumores mayores de un 1 centímetro. Resultados: De los 959 casos, se presentaron con mayor frecuencia en mujeres (84.98%) y en edades entre los 40 a 59 años (46.71%), el tipo histológico más frecuente fue el papilar (95.93%), seguido por el medular (1.15%). El 40.46% de los casos correspondían a microcarcinomas, los cuales presentaban menor frecuencia de características asociadas a recurrencia en comparación con los tumores mayores de un centímetro: metástasis a ganglios linfáticos (38.15% vs 63.15%), extensión extratiroidea macroscópica (1.80% vs 8.95%), compromiso de los márgenes de sección (20.10% vs 44.04%). Dentro de los microcarcinomas con metástasis a ganglios linfáticos hay una mayor presentación a edades más tempranas y de tumores multifocales, en comparación con los que no presentan metástasis. Conclusiones: El carcinoma de tiroides es una entidad frecuente en Colombia, donde los microcarcinomas comprenden una importante proporción de los casos, y los cuales se caracterizan por presentar un comportamiento menos agresivo dado por una menor prevalencia de características asociadas a recurrencia, en comparación con tumores mayores de 1 centímetro.Objectives: In a case series with diagnosis of thyroid cancer, to make a description about the clinical and pathological features, especially those which are related to biological behavior and recurrence risk. Methods: A search was performed in the archives of the pathology´s laboratory at Hospital Universitario Nacional, the cases with pathological diagnosis of thyroid carcinoma between the years of 2017 and 2020 were selected. Each report of pathology was reviewed, and the information related to sociodemográfic and pathological features were recorded in a database, and statistical measures like percentage and absolute frequencies were calculated. The results were compared against researchs performed in other countries. Results: 959 cases of thyroid carcinoma were found, 84.98% were in female patients, the most common age was between 40 and 59 years (46.71%). The papillary carcinoma was the most common histologic type (95.93%), followed by medullary carcinoma (1.15%), 40.46% were microcarcinomas, which showed less prevalence versus larger carcinomas in variables such as: lymph node metastasis (38.15% vs 63.15%), gross extrathyroidal invasion (1.80% vs 8.95%) and positive surgical margins (20.10% vs 44.04%). The microcarcinomas with lymph node metastasis tends to occur frequently in younger people and when there are multifocal. Conclusions: In Colombia the thyroid carcinoma is a common entity, and microcarcinomas are frequently observed in our hospital, and show a less aggressive phenotype than larger tumors, when comparing presence of recurrence features.Especialidades MédicasEspecialista en Patología Anatómica y ClínicaEstudio descriptivo retrospectivoxviii, 71 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Patología Anatómica y ClínicaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesNeoplasias de la Tiroides/patologíaEnfermedades de la Tiroides/patologíaEnfermedades de la Tiroides/epidemiologíaThyroid Neoplasms/pathologyThyroid Diseases/pathologyThyroid Diseases/epidemiologyNeoplasias de la tiroidesPatologíaCarcinoma papilarInformes de casosPathologyCarcinoma, PapillaryCase reportsThyroid neoplasmsCáncer de tiroides: características clinicopatológicas en una serie de casos del Hospital Universitario Nacional 2017-2020Thyroid cancer: clinico-pathological features in a case series from Hospital Universitario Nacional 2017-2020Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeGlobal Cancer Observatory (GLOBOCAN), Intenational agency for research on Cancer. Estimated age-standardized incidence rates (World) in 2018.LLoyd R, Osamura R, Klöppel G, Rosai J. WHO Classification of tumours of endocrine organs. International Agency for research on Cancer, 2016. Chapter 2. Pags 68-66.La Vecchia C, Malvezzi M, Bosetti C, Garavello W, Bertuccio P, Levi F, Negri E. Thyroid cancer mortality and incidence: A global overview. International Journal of Cancer.2014. 0:1-9Seib C, Sosa J. Evolving Understanding of the Epidemiology of Thyroid Cancer.Endocrinology Metabolic Clinic North America 2018. p 1-13Hernando V, Jorge H, Ivonne M, Valentina A. Thyroid Cancer – South American Experience. Thyroid Disorders. 2015. Ther 4:182Da Mota A, Miranda-Filho A, Koifman S, Koifman J. Thyroid Cancer Incidences From Selected South America Population-Based Cancer Registries: An Age-Period-Cohort Study. Journal of Global Oncology. 2017.P 1-11Romei C, Fugazzola L, Puxeddu E, et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years. Journal of Clinical Endocrinology and Metabolics 2012. 97(9):1758–1765Cabanillas M, McFadden D, Durante C. Thyroid cancer. The Lancet. 2016. 388: 2783-2795.Haugen B, Alexander E, Bible K, et al. American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 26(1):1-92.Tessler R, Middleton W, Grant E, et al.ACR Thyroid Imaging, Reporting and DataSystem (TI-RADS): White Paper of the ACR TI-RADS Committee. Journal of the American College of Radiology.2017.14(5):587-595.Fernandez J. Clasificación TI-RADS de los nódulos tiroideos en base a una escala de puntuación modificada con respecto a los criterios ecográficos de malignidad. Revista Argentina de Radiología. 2014.78(3):138-148Ali S, Cibas E. The Bethesda System for Reporting Thyroid Cytopathology, Second Edition.Springer International Publishing. 2018.Wang T, Sosa J. Thyroid surgery for differentiated thyroid cancer — recent advances and future directions. Nature reviews. 2018. 14: 670-683Mete O, Seethala R, Asa S, et al. Protocol for the Examination of Specimens From Patients With Carcinomas of the Thyroid Gland. College of American Pathologists Templates (CAP).2020. P 1-22Lemos M, Okoye E. Atlas of Surgical Pathology Grossing. Springer. 2019. Cap 3. P 16.Goldblum et al. Rosai and Ackerman’s Surgical Pathology. 11 edition, Elsevier. 2018. Cap 2. P 90-97Ito Y, Miyauchi A, Kihara M, Higashiyama T, Kobayashi K, Miya A. Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid. 2014;24(1):27-34. doi:10.1089/thy.2013.0367Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y. Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg. 2010;34(6):1222-1231. doi:10.1007/s00268-009-0359-xLim H, Devesa S, Sosa J, Check D, Kitahara C. Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013.Journal of American Medical Association (JAMA). 2017. E1-E11Romero A, Martínez J, Osorio K, Olaya N. Histological variants and prognostic factors of papillary thyroid carcinoma at the Colombian Instituto Nacional de Cancerología, 2006-2012. Revista Biomédica. 2015. 35:429-436.Akın Ş, Yazgan Aksoy D, Akın S, Kılıç M, Yetişir F, Bayraktar M. Prediction of central lymph node metastasis in patientswith thyroid papillary microcarcinoma. Turk J Med Sci. 2017;47(6):1723-1727. Published 2017 Dec 19. doi:10.3906/sag-1702-99Zhao W, Chen S, Hou X, Liao Q, Chen G, Zhao Y. Predictive Factors of Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. Pathol Oncol Res. 2019;25(3):1245-1251. doi:10.1007/s12253-018-0511-8EstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83417/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1014246731.2022.pdf1014246731.2022.pdfTesis de Especialidad en Patología Anatómica y Clínicaapplication/pdf2718228https://repositorio.unal.edu.co/bitstream/unal/83417/2/1014246731.2022.pdf430f682b10f83b4bd37dc4d06b9bc36fMD52THUMBNAIL1014246731.2022.pdf.jpg1014246731.2022.pdf.jpgGenerated Thumbnailimage/jpeg6024https://repositorio.unal.edu.co/bitstream/unal/83417/3/1014246731.2022.pdf.jpg2f47853c145cf852ac37bf8f94e2e3e5MD53unal/83417oai:repositorio.unal.edu.co:unal/834172023-08-14 23:04:48.184Repositorio Institucional Universidad Nacional de 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