One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science

In 1913, around 100 years ago, the Harvard University sent an expedition to Peru, led by Richard Strong, to investigate Carrion’s disease. This paper provides a critical review of the scientific research carried out in this expedition.Richard Strong was a physician who performed unethical human expe...

Full description

Autores:
Salinas-Flores, David
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/65205
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/65205
http://bdigital.unal.edu.co/66228/
Palabra clave:
61 Ciencias médicas; Medicina / Medicine and health
Enfermedad de Carrion
Infecciones por Bartonella
Fiebre de Oroya
Verruga Peruana
Bioética
Carrion’s Disease
Bartonella Infections
Oroya Fever
Bioethics
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_6f15706e09ce51504049f3f7e352a531
oai_identifier_str oai:repositorio.unal.edu.co:unal/65205
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
title One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
spellingShingle One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
61 Ciencias médicas; Medicina / Medicine and health
Enfermedad de Carrion
Infecciones por Bartonella
Fiebre de Oroya
Verruga Peruana
Bioética
Carrion’s Disease
Bartonella Infections
Oroya Fever
Bioethics
title_short One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
title_full One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
title_fullStr One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
title_full_unstemmed One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
title_sort One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science
dc.creator.fl_str_mv Salinas-Flores, David
dc.contributor.author.spa.fl_str_mv Salinas-Flores, David
dc.subject.ddc.spa.fl_str_mv 61 Ciencias médicas; Medicina / Medicine and health
topic 61 Ciencias médicas; Medicina / Medicine and health
Enfermedad de Carrion
Infecciones por Bartonella
Fiebre de Oroya
Verruga Peruana
Bioética
Carrion’s Disease
Bartonella Infections
Oroya Fever
Bioethics
dc.subject.proposal.spa.fl_str_mv Enfermedad de Carrion
Infecciones por Bartonella
Fiebre de Oroya
Verruga Peruana
Bioética
Carrion’s Disease
Bartonella Infections
Oroya Fever
Bioethics
description In 1913, around 100 years ago, the Harvard University sent an expedition to Peru, led by Richard Strong, to investigate Carrion’s disease. This paper provides a critical review of the scientific research carried out in this expedition.Richard Strong was a physician who performed unethical human experimentation in the Philippines and China. In Peru, Strong conducted experiments on humans to inoculate wart secretions to a psychiatric patient, which led him to replicate the Peruvian wart in this individual, although he could not replicate Oroya fever. Based on this experiment, and without taking into account epidemiological and clinical evidence, the Harvard expedition erroneously concluded that Oroya fever and Peruvian wart were two different diseases.A retrospective review of the scientific work conducted by the expedition in Peru allows drawing the following lessons for science: a) disapproving unethical human experimentation conducted by the expedition; b) to determine the cause of infectious diseases, it is necessary to obtain the best scientific, experimental and observational evidence, and c) to acknowledge that, despite the poor infrastructure, researchers in developing countries are able to produce high-quality scientific knowledge that may surpass the knowledge generated by researchers in developed countries.
publishDate 2016
dc.date.issued.spa.fl_str_mv 2016-07-01
dc.date.accessioned.spa.fl_str_mv 2019-07-02T23:59:09Z
dc.date.available.spa.fl_str_mv 2019-07-02T23:59:09Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/ART
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.issn.spa.fl_str_mv ISSN: 2357-3848
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/65205
dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/66228/
identifier_str_mv ISSN: 2357-3848
url https://repositorio.unal.edu.co/handle/unal/65205
http://bdigital.unal.edu.co/66228/
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.spa.fl_str_mv https://revistas.unal.edu.co/index.php/revfacmed/article/view/55059
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina
Revista de la Facultad de Medicina
dc.relation.references.spa.fl_str_mv Salinas-Flores, David (2016) One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science. Revista de la Facultad de Medicina, 64 (3). pp. 517-524. ISSN 2357-3848
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/65205/1/55059-315310-1-PB.pdf
https://repositorio.unal.edu.co/bitstream/unal/65205/2/55059-315310-1-PB.pdf.jpg
bitstream.checksum.fl_str_mv 9276e050c477d816751b9839facef711
c36e6a471818e49b63458211d945f002
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
repository.mail.fl_str_mv repositorio_nal@unal.edu.co
_version_ 1814089907176472576
spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Salinas-Flores, David83b6bf7e-b995-4d61-ba91-09c741c6b9923002019-07-02T23:59:09Z2019-07-02T23:59:09Z2016-07-01ISSN: 2357-3848https://repositorio.unal.edu.co/handle/unal/65205http://bdigital.unal.edu.co/66228/In 1913, around 100 years ago, the Harvard University sent an expedition to Peru, led by Richard Strong, to investigate Carrion’s disease. This paper provides a critical review of the scientific research carried out in this expedition.Richard Strong was a physician who performed unethical human experimentation in the Philippines and China. In Peru, Strong conducted experiments on humans to inoculate wart secretions to a psychiatric patient, which led him to replicate the Peruvian wart in this individual, although he could not replicate Oroya fever. Based on this experiment, and without taking into account epidemiological and clinical evidence, the Harvard expedition erroneously concluded that Oroya fever and Peruvian wart were two different diseases.A retrospective review of the scientific work conducted by the expedition in Peru allows drawing the following lessons for science: a) disapproving unethical human experimentation conducted by the expedition; b) to determine the cause of infectious diseases, it is necessary to obtain the best scientific, experimental and observational evidence, and c) to acknowledge that, despite the poor infrastructure, researchers in developing countries are able to produce high-quality scientific knowledge that may surpass the knowledge generated by researchers in developed countries.Hace poco se cumplieron 100 años de la expedición de la Universidad de Harvard a Perú, liderada por Richard Strong, para investigar la enfermedad de Carrion. El presente estudio realizó una revisión crítica de la investigación científica de dicha expedición.Richard Strong era un médico con antecedentes relacionados con la realización de experimentaciones humanas antiéticas en Filipinas y China. En Perú, Strong realizó experimentación humana al inocular secreciones de verruga en un paciente psiquiátrico, logrando reproducir en este la verruga peruana, pero no la fiebre de la Oroya; con base en este experimento, y sin considerar la evidencia epidemiológica y clínica, la expedición de Harvard concluyó erróneamente que la fiebre de la Oroya y la verruga peruana eran dos enfermedades diferentes.Una visión retrospectiva de la labor científica de la expedición de Harvard en Perú lleva a extraer las siguientes lecciones para la ciencia: a) se debe condenar la antiética experimentación humana realizada por la expedición de Harvard; b) es necesario obtener la mejor evidencia científica, experimental y observacional en la causalidad de las enfermedades infecciosas, y c) es necesario reconocer que en países subdesarrollados se puede generar conocimiento científico de alta calidad y que, pese a la escasa infraestructura, puede ser mejor al de los países desarrollados.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicinahttps://revistas.unal.edu.co/index.php/revfacmed/article/view/55059Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaSalinas-Flores, David (2016) One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science. Revista de la Facultad de Medicina, 64 (3). pp. 517-524. ISSN 2357-384861 Ciencias médicas; Medicina / Medicine and healthEnfermedad de CarrionInfecciones por BartonellaFiebre de OroyaVerruga PeruanaBioéticaCarrion’s DiseaseBartonella InfectionsOroya FeverBioethicsOne hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for scienceArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL55059-315310-1-PB.pdfapplication/pdf886586https://repositorio.unal.edu.co/bitstream/unal/65205/1/55059-315310-1-PB.pdf9276e050c477d816751b9839facef711MD51THUMBNAIL55059-315310-1-PB.pdf.jpg55059-315310-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8634https://repositorio.unal.edu.co/bitstream/unal/65205/2/55059-315310-1-PB.pdf.jpgc36e6a471818e49b63458211d945f002MD52unal/65205oai:repositorio.unal.edu.co:unal/652052024-05-09 23:09:09.754Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co

Publicaciones similares