One hundred years after the expedition by Harvard University to Peru to investigate Carrion’s disease. Lessons for science

In 1913, around 100 years ago, the Harvard University sent an expedition to Peru, led by Richard Strong, to investigate Carrion’s disease. This paper provides a critical review of the scientific research carried out in this expedition.Richard Strong was a physician who performed unethical human expe...

Full description

Autores:
Salinas-Flores, David
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/65205
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/65205
http://bdigital.unal.edu.co/66228/
Palabra clave:
61 Ciencias médicas; Medicina / Medicine and health
Enfermedad de Carrion
Infecciones por Bartonella
Fiebre de Oroya
Verruga Peruana
Bioética
Carrion’s Disease
Bartonella Infections
Oroya Fever
Bioethics
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
Description
Summary:In 1913, around 100 years ago, the Harvard University sent an expedition to Peru, led by Richard Strong, to investigate Carrion’s disease. This paper provides a critical review of the scientific research carried out in this expedition.Richard Strong was a physician who performed unethical human experimentation in the Philippines and China. In Peru, Strong conducted experiments on humans to inoculate wart secretions to a psychiatric patient, which led him to replicate the Peruvian wart in this individual, although he could not replicate Oroya fever. Based on this experiment, and without taking into account epidemiological and clinical evidence, the Harvard expedition erroneously concluded that Oroya fever and Peruvian wart were two different diseases.A retrospective review of the scientific work conducted by the expedition in Peru allows drawing the following lessons for science: a) disapproving unethical human experimentation conducted by the expedition; b) to determine the cause of infectious diseases, it is necessary to obtain the best scientific, experimental and observational evidence, and c) to acknowledge that, despite the poor infrastructure, researchers in developing countries are able to produce high-quality scientific knowledge that may surpass the knowledge generated by researchers in developed countries.