Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo

Tesis doctoral.

Autores:
Madrid Garcés, Tomás Antonio
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2020
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/79600
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/79600
https://repositorio.unal.edu.co/
Palabra clave:
660 - Ingeniería química
Extractos vegetales
Industria avícola
Avicultura
Fitobioticos
Microbioma
Aceite esencial de oregano
Dysbiosis
Growth promoters
Phytobiotics
Growth Promoting Antibiotics
Oregano essential oil
Antibióticos Promotores de Crecimiento
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_6dbc7a926e483c96aae48f43dacac989
oai_identifier_str oai:repositorio.unal.edu.co:unal/79600
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
dc.title.translated.eng.fl_str_mv Microbiome and intestinal, metabolic and zootechnical parameters of chickens fed with oregano essential oil (Lippia origanoides) in a model of intestinal inflammation in vivo
title Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
spellingShingle Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
660 - Ingeniería química
Extractos vegetales
Industria avícola
Avicultura
Fitobioticos
Microbioma
Aceite esencial de oregano
Dysbiosis
Growth promoters
Phytobiotics
Growth Promoting Antibiotics
Oregano essential oil
Antibióticos Promotores de Crecimiento
title_short Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
title_full Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
title_fullStr Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
title_full_unstemmed Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
title_sort Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo
dc.creator.fl_str_mv Madrid Garcés, Tomás Antonio
dc.contributor.advisor.none.fl_str_mv Parra Suescún, Jaime Eduardo
López Herrera, Albeiro
dc.contributor.author.none.fl_str_mv Madrid Garcés, Tomás Antonio
dc.subject.ddc.spa.fl_str_mv 660 - Ingeniería química
topic 660 - Ingeniería química
Extractos vegetales
Industria avícola
Avicultura
Fitobioticos
Microbioma
Aceite esencial de oregano
Dysbiosis
Growth promoters
Phytobiotics
Growth Promoting Antibiotics
Oregano essential oil
Antibióticos Promotores de Crecimiento
dc.subject.lemb.none.fl_str_mv Extractos vegetales
Industria avícola
dc.subject.proposal.spa.fl_str_mv Avicultura
Fitobioticos
Microbioma
Aceite esencial de oregano
dc.subject.proposal.eng.fl_str_mv Dysbiosis
Growth promoters
Phytobiotics
Growth Promoting Antibiotics
Oregano essential oil
dc.subject.proposal.zho.fl_str_mv Antibióticos Promotores de Crecimiento
description Tesis doctoral.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020
dc.date.accessioned.none.fl_str_mv 2021-06-02T19:03:35Z
dc.date.available.none.fl_str_mv 2021-06-02T19:03:35Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/79600
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/79600
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.publisher.program.spa.fl_str_mv Medellín - Ciencias - Doctorado en Biotecnología
dc.publisher.department.spa.fl_str_mv Escuela de biociencias
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv Medellín
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Medellín
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Parra Suescún, Jaime Eduardocab0d57f56ba12bfa3f0e75ea778fcf8López Herrera, Albeiro9b77ca9307c68dda3ffafbf09cfd2294Madrid Garcés, Tomás Antonio6f6c82db98adde3d9536618599f54f6e2021-06-02T19:03:35Z2021-06-02T19:03:35Z2020https://repositorio.unal.edu.co/handle/unal/79600Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Tesis doctoral.La producción agropecuaria actual es muy exigente en aspectos de calidad que se traduce en alimentos más seguros para los consumidores. En la avicultura se usan los antibióticos de manera profiláctica, conocidos como Antibióticos Promotores de Crecimiento (APC) con excelentes resultados productivos, pero con grandes dudas frente al tema de seguridad alimentaria por la proliferación de resistencia antimicrobiona y la llegada de estos microrganismos a la cadena alimenticia. Los fitobióticos se han presentado como una de las alternativas más efectivas a la hora de reemplazar los APC, dentro de estos extractos de plantas se encuentra el Aceite esencial de oregano (AEO) de Lippia origanoides, que viene demostrando sus propiedades en diferentes aspectos dentro de la producción avícola. El presente trabajo pretende estudiar el efecto de la adición de AEO sobre variables productivas, metabólicas, morfometría digestiva, células caliciformes, expresión molecular de enzimas y transportadores, y microbiota intestinal de pollos en un modelo de inflamación in vivo logrado mediante LPS de e coli. Se logró evidenciar que la adición de AEO mejora las variables zootécnicas (Ganancia acumulada de peso), metabolitos sanguíneos (glucosa, fosforo, calcio, colesterol, triglicéridos), morfometría digestiva (altura de vellosidades y profundad de criptas), células caliciformes (tipo de tinción), expresión molecular de enzimas y transportadores (MgA: maltasa-glucoamilasa; SI: sacarasa-isomaltasa; SGLT-1: sodium-glucose transporter; GLUT-5: glucose transporter-5; GLUT-2: glucose transporter-2) y modula positivamente la microbiota intestinal de pollos de engorde en un modelo inflación in vivo. El AEO se proyecta como un promotor nutricional de crecimiento con capacidad de reemplazar los APC.Current agricultural production is very demanding in terms of quality, which translates into safer food for consumers. In poultry, antibiotics are used prophylactically, known as Growth Promoting Antibiotics (GAP) with excellent productive results, but with great doubts regarding the issue of food safety due to the proliferation of antimicrobial resistance and the arrival of these microorganisms to the chain food. Phytobiotics have been presented as one of the most effective alternatives when it comes to replacing GAP, within these plant extracts is the Essential Oil of oregano (AEO) from Lippia origanoides, which has been demonstrating its properties in different aspects within poultry production. The present study aims to study the effect of the addition of AEO on productive and metabolic variables, digestive morphometry, goblet cells, molecular expression of enzymes and transporters, and intestinal microbiota of chickens in an in vivo model of inflammation achieved by e coli LPS. It was possible to show that the addition of AEO improves the zootechnical variables (accumulated weight gain), blood metabolites (glucose, phosphorus, calcium, cholesterol, triglycerides), digestive morphometry (height of villi and depth of crypts), goblet cells (type of staining), molecular expression of enzymes and transporters (MgA: maltaseglucoamylase; SI: sucrase-isomaltase; SGLT-1: sodium-glucose transporter; GLUT-5: glucose transporter-5; GLUT-2: glucose transporter-2) and positively modulates the gut microbiota of broilers in an in vivo inflation model. AEO is projected as a nutritional growth promoter with the ability to replace GAPsConvocatoria 757 de Colciencias operada por Colfuturo.DoctoradoDoctor en BiotecnologíaBiotecnología aplicada a la producción animal: microbioma intestinal.application/pdfspaUniversidad Nacional de Colombia - Sede MedellínMedellín - Ciencias - Doctorado en BiotecnologíaEscuela de biocienciasFacultad de CienciasMedellínUniversidad Nacional de Colombia - Sede Medellín660 - Ingeniería químicaExtractos vegetalesIndustria avícolaAviculturaFitobioticosMicrobiomaAceite esencial de oreganoDysbiosisGrowth promotersPhytobioticsGrowth Promoting AntibioticsOregano essential oilAntibióticos Promotores de CrecimientoMicrobioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivoMicrobiome and intestinal, metabolic and zootechnical parameters of chickens fed with oregano essential oil (Lippia origanoides) in a model of intestinal inflammation in vivoTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDAbbas, G., Iqbal, M. 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Proceedings of the National Academy of Sciences of the United States of America, 102(31), 11070–11075. https://doi.org/10.1073/pnas.0504978102“Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo”ColcienciasLICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/79600/4/license.txtcccfe52f796b7c63423298c2d3365fc6MD54CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.unal.edu.co/bitstream/unal/79600/6/license_rdf4460e5956bc1d1639be9ae6146a50347MD56ORIGINAL1035856496.2021.pdf1035856496.2021.pdfTesis Doctorado en Biotecnologíaapplication/pdf2868374https://repositorio.unal.edu.co/bitstream/unal/79600/5/1035856496.2021.pdf7cdd6681ece9ed70e1c081db6afa690aMD55THUMBNAIL1035856496.2021.pdf.jpg1035856496.2021.pdf.jpgGenerated 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