Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m

ilustraciones, diagramas

Autores:: Villamil Parra, Wilder Andres

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
dc.title.translated.eng.fl_str_mv	Responses to physical exercise mediated by HIF-1 in patients with COPD residing at 2600 m
title	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
spellingShingle	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m 610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::616 - Enfermedades 570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::572 - Bioquímica Hipoxia Medicina deportiva Hypoxia Sports Medicine Enfermedad pulmonar obstructiva crónica Ejercicio físico Hipoxia Factor 1 inducible por hipoxia Aptitud física Chronic obstructive pulmonary disease Physical exercise Hypoxia Hypoxia-inducible factor 1
title_short	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
title_full	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
title_fullStr	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
title_full_unstemmed	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
title_sort	Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m
dc.creator.fl_str_mv	Villamil Parra, Wilder Andres
dc.contributor.advisor.none.fl_str_mv	Mancera Soto, Erica Mabel Cristancho Mejía, Édgar Emigdio
dc.contributor.author.none.fl_str_mv	Villamil Parra, Wilder Andres
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigacion en Adaptaciones Al Ejercicio y A la Hipoxia
dc.contributor.orcid.spa.fl_str_mv	0000-0002-1717-1020
dc.contributor.cvlac.spa.fl_str_mv	Villamil Parra, Wilder Andrés
dc.contributor.scopus.spa.fl_str_mv	Villamil Parra, Wilder Andrés
dc.contributor.researchgate.spa.fl_str_mv	Wilder Villamil Parra
dc.contributor.googlescholar.spa.fl_str_mv	Wilder Andres Villamil-Parra
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::616 - Enfermedades 570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::572 - Bioquímica
topic	610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::616 - Enfermedades 570 - Biología::571 - Fisiología y temas relacionados 570 - Biología::572 - Bioquímica Hipoxia Medicina deportiva Hypoxia Sports Medicine Enfermedad pulmonar obstructiva crónica Ejercicio físico Hipoxia Factor 1 inducible por hipoxia Aptitud física Chronic obstructive pulmonary disease Physical exercise Hypoxia Hypoxia-inducible factor 1
dc.subject.decs.spa.fl_str_mv	Hipoxia Medicina deportiva
dc.subject.decs.eng.fl_str_mv	Hypoxia Sports Medicine
dc.subject.proposal.spa.fl_str_mv	Enfermedad pulmonar obstructiva crónica Ejercicio físico Hipoxia Factor 1 inducible por hipoxia Aptitud física
dc.subject.proposal.eng.fl_str_mv	Chronic obstructive pulmonary disease Physical exercise Hypoxia Hypoxia-inducible factor 1
description	ilustraciones, diagramas
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-10-17T14:21:12Z
dc.date.available.none.fl_str_mv	2023-10-17T14:21:12Z
dc.date.issued.none.fl_str_mv	2023
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
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status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84803
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84803 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional De Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Doctorado en Ciencias - Biología
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mancera Soto, Erica Mabel78c6f6706f764e0fdc069d4c5643e56eCristancho Mejía, Édgar Emigdiof125293cd4072443d0266142aa1a074dVillamil Parra, Wilder Andres90212f29e70cfaccd551064aa6df8535Grupo de Investigacion en Adaptaciones Al Ejercicio y A la Hipoxia0000-0002-1717-1020Villamil Parra, Wilder AndrésVillamil Parra, Wilder AndrésWilder Villamil ParraWilder Andres Villamil-Parra2023-10-17T14:21:12Z2023-10-17T14:21:12Z2023https://repositorio.unal.edu.co/handle/unal/84803Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasAntecedentes: A pesar del conocimiento sobre la Enfermedad Pulmonar Obstructiva Crónica (EPOC) y los mecanismos celulares de reacción a la hipoxia, se desconocen cuáles los niveles de referencia del HIF-1 en EPOC a gran altitud y su relación con el Factor de crecimiento endotelial vascular (VEGF) y de la Eritropoyetina (EPO) antes y después del ejercicio físico. Objetivo: Determinar los efectos del ejercicio sobre la vía de señalización de HIF-1α, la función cardiopulmonar y la calidad de vida en pacientes con EPOC residentes a gran altitud. Métodos: Pacientes con EPOC físicamente inactivas residentes en gran altitud, comparados con sujetos control sanos. Intervención: programa de ejercicio físico domiciliar multimodal de 8 semanas (8-WVP) compuesto por ejercicio respiratorios, resistencia cardiopulmonar, fuerza resistencia, flexibilidad y sesiones de educación en salud. Variables primarias: concentración plasmática de HIF-1α, EPO y VEGF en reposo, 30 minutos y 24 horas después de ergoespirometría. Variables secundarias: espirometría, hemograma, rendimiento físico, test funcionales de aptitud física y calidad de vida asociada a la salud. Resultados: Los niveles de HIF-1α fueron más altos en los pacientes EPOC que en los controles. El ejercicio disminuyó los niveles de HIF-1α en 25 %, aumentó el nivel de VEGF en 34 % y la EPO en 23 % en pacientes con EPOC. Existe una correlación negativa entre HIF-1α y el V̇O2pico, VE, CVF, FEF 25-75%, MCV y MCH. El rendimiento físico de los EPOC aumentó en todas las pruebas de aptitud física. Conclusión: Los niveles de HIF-1α en los EPOC fueron significativamente más altos que en personas sanas antes del ejercicio. Los niveles de VEGF y EPO aumentaron a pesar de la disminución de HIF-1 posterior al ejercicio. Registro del ensayo: NCT04955977 [ClinicalTrials.gov, WHOICRTP] (Texto tomado de la fuente)Background: Despite the knowledge about Chronic Obstructive Pulmonary Disease (COPD) and the cellular mechanisms of reaction to hypoxia, the levels of HIF-1 in COPD at high altitudes and its relationship with the Vascular Endothelial Growth Factor (VEGF), and Erythropoietin (EPO) before and after physical exercise. Objective: To determine the effects of exercise on the HIF-1α signaling pathway, cardiopulmonary function, and quality of life in high-altitude residents with COPD. Methods: Physically inactive COPD patients residing at high altitude, compared with healthy control subjects. Intervention: 8-week multimodal home physical exercise program (8-WVP) composed of respiratory exercise, cardiopulmonary resistance, strength resistance, flexibility and health education sessions. Primary variables: plasma concentration of HIF-1α, EPO and VEGF at rest, 30 minutes and 24 hours after ergospirometry. Secondary variables: spirometry, blood count, physical performance, functional physical fitness tests, and quality of life associated with health. Results: HIF-1α levels were higher in COPD than in controls. Exercise will increase HIF-1α levels by 25%, increase VEGF level by 34%, and EPO by 23% in COPD patients. There is a negative connection between HIF-1α and V̇O2peak, VE, FVC, FEF 25-75%, MCV and MCH. EPOCs' physical performance increased in all physical fitness tests. Conclusion: HIF-1α levels in COPDs were significantly higher than in healthy people before exercise. VEGF and EPO levels increased despite the post-exercise HIF-1 decrease. Trial Registry: NCT04955977 [ClinicalTrials.gov, WHOICRTP]Investigación financiada por la Universidad Nacional de Colombia – Sede Bogotá, a través de la “Convocatoria para el apoyo a proyectos de investigación y creación artística de la sede Bogotá de la Universidad Nacional de Colombia - 2019, código HERMES, 47970).Beca asistente docente – Facultad de medicina. Otorgada por la Dirección académica de Bogotá – UN. (Acuerdo 028/10 del Consejo Superior Universitario) 2020-1S.Pasantía internacional (Laboratorio de fisiología en inmunología celular de la UB. Apoyo económico complementario para estudiantes en movilidad académica saliente nacional correspondiente a la convocatoria 2023-177 - DRE UNALDoctoradoDoctor en Ciencias - BiologíaSe realizó un ensayo clínico cuasi-experimental con análisis longitudinal de medidas repetidas, con comparaciones intra e inter grupos, en tres momentos diferentes antes (B) y después (A) de la intervención y a los cuales se referencia de la siguiente manera: 1. Reposo (R), 1 hora antes de la CPET, 2. Ejercicio (E), 30 minutos después de finalizar la CPET, 3. Post-ejercicio (P), 24 horas después de CPET. En cada uno de estos tiempos se obtuvieron diferentes medidas moleculares, hematológicas, ventilatorias y de esfuerzo físico. Las mediciones se realizaron en el Laboratorio de Fisiología del Ejercicio de la Facultad de Medicina y el Laboratorio de investigación básica en Bioquímica de la Universidad Nacional de Colombia – Bogotá. El enfoque del protocolo del estudio se ha desarrollado siguiendo las pautas y recomendaciones para los ensayos intervencionistas SPIRIT. Se tuvieron como sujetos de estudio a pacientes con EPOC físicamente inactivas residentes en gran altitud, comparados con sujetos control sanos. Intervención: programa de ejercicio físico domiciliar multimodal de 8 semanas (8-Week Variant Program) compuesto por ejercicio respiratorios, resistencia cardiopulmonar, fuerza resistencia, flexibilidad y sesiones de educación en salud. Las variables de resultados fueron: 1. Variables primarias: concentración plasmática de HIF-1α, EPO y VEGF en reposo, 30 minutos y 24 horas después de ergoespirometría, 2. Variables secundarias: espirometría, hemograma, rendimiento físico, test funcionales de aptitud física y calidad de vida asociada a la saludFisiología y bioquímica aplicada a la actividad física, el ejercicio y el deporteRegistro del ensayo ClinicalTrials.gov: NCT04955977 Registro del ensayo WHO-ICRTP: NCT04955977 [xx, 186 páginasapplication/pdfspaUniversidad Nacional De ColombiaBogotá - Ciencias - Doctorado en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::612 - Fisiología humana610 - Medicina y salud::616 - Enfermedades570 - Biología::571 - Fisiología y temas relacionados570 - Biología::572 - BioquímicaHipoxiaMedicina deportivaHypoxiaSports MedicineEnfermedad pulmonar obstructiva crónicaEjercicio físicoHipoxiaFactor 1 inducible por hipoxiaAptitud físicaChronic obstructive pulmonary diseasePhysical exerciseHypoxiaHypoxia-inducible factor 1Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.mResponses to physical exercise mediated by HIF-1 in patients with COPD residing at 2600 mTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDAgustí A, Vogelmeier C, Faner R. 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DOI: 10.1186/s12890-021-01585-5Efectos de un programa de ejercicio físico terapéutico sobre las variables hematológicas, el rendimiento físico y la calidad de vida en personas con EPOC residentes a 2600m - HERMES Nº 47970Universidad Nacional de Colombia - Sede BogotáEstudiantesInvestigadoresMaestrosPúblico generalResponsables políticosTHUMBNAIL1.018.423.914.2023.pdf.jpg1.018.423.914.2023.pdf.jpgGenerated Thumbnailimage/jpeg4987https://repositorio.unal.edu.co/bitstream/unal/84803/3/1.018.423.914.2023.pdf.jpgaf1f33393561432976bae97b49c4f746MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84803/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1.018.423.914.2023.pdf1.018.423.914.2023.pdfTesis de Doctorado en Ciencias - Biología.application/pdf5366797https://repositorio.unal.edu.co/bitstream/unal/84803/2/1.018.423.914.2023.pdf2149761a06eec1dc68087b73901067beMD52unal/84803oai:repositorio.unal.edu.co:unal/848032023-10-17 23:04:07.876Repositorio Institucional Universidad Nacional de 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Respuestas al ejercicio físico mediadas por HIF-1 en pacientes con EPOC residentes a 2600 m.s.n.m

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