Biochemical events related to glial response in spinal cord injury
Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that...
- Autores:
-
Lapuente-Chala, Catalina
Céspedes-Rubio, Angel
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/64964
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/64964
http://bdigital.unal.edu.co/65987/
- Palabra clave:
- 61 Ciencias médicas; Medicina / Medicine and health
Spinal Cord
Microglia
Gliosis
Inflammation
Oligodendrocytes
Médula espinal
Microglía
Gliosis
Inflamación
Oligodendrocitos
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Biochemical events related to glial response in spinal cord injury |
| title |
Biochemical events related to glial response in spinal cord injury |
| spellingShingle |
Biochemical events related to glial response in spinal cord injury 61 Ciencias médicas; Medicina / Medicine and health Spinal Cord Microglia Gliosis Inflammation Oligodendrocytes Médula espinal Microglía Gliosis Inflamación Oligodendrocitos |
| title_short |
Biochemical events related to glial response in spinal cord injury |
| title_full |
Biochemical events related to glial response in spinal cord injury |
| title_fullStr |
Biochemical events related to glial response in spinal cord injury |
| title_full_unstemmed |
Biochemical events related to glial response in spinal cord injury |
| title_sort |
Biochemical events related to glial response in spinal cord injury |
| dc.creator.fl_str_mv |
Lapuente-Chala, Catalina Céspedes-Rubio, Angel |
| dc.contributor.author.spa.fl_str_mv |
Lapuente-Chala, Catalina Céspedes-Rubio, Angel |
| dc.subject.ddc.spa.fl_str_mv |
61 Ciencias médicas; Medicina / Medicine and health |
| topic |
61 Ciencias médicas; Medicina / Medicine and health Spinal Cord Microglia Gliosis Inflammation Oligodendrocytes Médula espinal Microglía Gliosis Inflamación Oligodendrocitos |
| dc.subject.proposal.spa.fl_str_mv |
Spinal Cord Microglia Gliosis Inflammation Oligodendrocytes Médula espinal Microglía Gliosis Inflamación Oligodendrocitos |
| description |
Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that depend on the injured axonal tracts.Objective: To describe the most relevant sequential biochemical events of glial cells response after SCI.Materials and methods: A search of scientific publications released in the past 18 years was carried out in PubMed and Science Direct databases, with the terms spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar and chondroitin sulfate proteoglycans (CSPG).Results: The pathophysiological processes resulting from SCI are determinant for the neurological recovery of patients. Activation of glial cells plays an important role in promoting bioactive molecules and the formation of physical barriers that inhibit neural regeneration.Conclusion: Knowledge of neurobiological changes after SCI allows a greater understanding of the pathophysiology and favors the search for new therapeutic alternatives that limit the progression of the primary injury and minimize secondary damage, responsible for neurological dysfunction. |
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2018 |
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2018-04-01 |
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2019-07-02T23:37:42Z |
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2019-07-02T23:37:42Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Text |
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http://purl.org/redcol/resource_type/ART |
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ISSN: 2357-3848 |
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https://repositorio.unal.edu.co/handle/unal/64964 |
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http://bdigital.unal.edu.co/65987/ |
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ISSN: 2357-3848 |
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spa |
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spa |
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https://revistas.unal.edu.co/index.php/revfacmed/article/view/61701 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina Revista de la Facultad de Medicina |
| dc.relation.references.spa.fl_str_mv |
Lapuente-Chala, Catalina and Céspedes-Rubio, Angel (2018) Biochemical events related to glial response in spinal cord injury. Revista de la Facultad de Medicina, 66 (2). pp. 269-277. ISSN 2357-3848 |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lapuente-Chala, Catalinab6a76286-2697-4b35-8773-27bc0700041d300Céspedes-Rubio, Angelba7b4265-58cc-4aae-baec-1528c0fe5cd63002019-07-02T23:37:42Z2019-07-02T23:37:42Z2018-04-01ISSN: 2357-3848https://repositorio.unal.edu.co/handle/unal/64964http://bdigital.unal.edu.co/65987/Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that depend on the injured axonal tracts.Objective: To describe the most relevant sequential biochemical events of glial cells response after SCI.Materials and methods: A search of scientific publications released in the past 18 years was carried out in PubMed and Science Direct databases, with the terms spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar and chondroitin sulfate proteoglycans (CSPG).Results: The pathophysiological processes resulting from SCI are determinant for the neurological recovery of patients. Activation of glial cells plays an important role in promoting bioactive molecules and the formation of physical barriers that inhibit neural regeneration.Conclusion: Knowledge of neurobiological changes after SCI allows a greater understanding of the pathophysiology and favors the search for new therapeutic alternatives that limit the progression of the primary injury and minimize secondary damage, responsible for neurological dysfunction.Introducción. La lesión de la médula espinal (LME) es un evento devastador con implicaciones físicas, psicológicas y socioeconómicas. En el tejido cercano a la lesión se instauran cambios morfofisiológicos que determinan la recuperación funcional del segmento medular y de los órganos efectores dependientes de los tractos axonales lesionados.Objetivo. Describir los eventos bioquímicos secuenciales más relevantes de la respuesta de las células gliales posterior a la LME.Materiales y métodos. Se realizó una búsqueda de publicaciones científicas de los últimos 18 años en las bases de datos PubMed y ScienceDirect, bajo los términos en inglés spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar y chondroitin sulfate proteoglycans (CSPG).Resultados. Los procesos fisiopatológicos que se producen después de la LME determinan la recuperación neurológica de los pacientes. La activación de las células gliales juega un papel importante, ya que promueve la producción de moléculas bioactivas y la formación de barreras físicas que inhiben la regeneración neural.Conclusión. El conocimiento de los cambios neurobiológicos ocurridos tras la LME permite una mayor comprensión de la fisiopatología y favorece la búsqueda de nuevas alternativas terapéuticas que limiten la progresión de la lesión primaria y que minimicen el daño secundario responsable de la disfunción neurológica.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicinahttps://revistas.unal.edu.co/index.php/revfacmed/article/view/61701Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaLapuente-Chala, Catalina and Céspedes-Rubio, Angel (2018) Biochemical events related to glial response in spinal cord injury. Revista de la Facultad de Medicina, 66 (2). pp. 269-277. ISSN 2357-384861 Ciencias médicas; Medicina / Medicine and healthSpinal CordMicrogliaGliosisInflammationOligodendrocytesMédula espinalMicroglíaGliosisInflamaciónOligodendrocitosBiochemical events related to glial response in spinal cord injuryArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL61701-389467-1-PB.pdfapplication/pdf2582282https://repositorio.unal.edu.co/bitstream/unal/64964/1/61701-389467-1-PB.pdf3c1928b6c9335b50e6d19efdee7b96a4MD51THUMBNAIL61701-389467-1-PB.pdf.jpg61701-389467-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8083https://repositorio.unal.edu.co/bitstream/unal/64964/2/61701-389467-1-PB.pdf.jpg057bc43b83a180167c8b58faed2ca664MD52unal/64964oai:repositorio.unal.edu.co:unal/649642023-05-16 23:48:15.223Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |