Biochemical events related to glial response in spinal cord injury

Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that...

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Autores:
Lapuente-Chala, Catalina
Céspedes-Rubio, Angel
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/64964
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/64964
http://bdigital.unal.edu.co/65987/
Palabra clave:
61 Ciencias médicas; Medicina / Medicine and health
Spinal Cord
Microglia
Gliosis
Inflammation
Oligodendrocytes
Médula espinal
Microglía
Gliosis
Inflamación
Oligodendrocitos
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_67d695b66810a9abdad3761b37e38872
oai_identifier_str oai:repositorio.unal.edu.co:unal/64964
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Biochemical events related to glial response in spinal cord injury
title Biochemical events related to glial response in spinal cord injury
spellingShingle Biochemical events related to glial response in spinal cord injury
61 Ciencias médicas; Medicina / Medicine and health
Spinal Cord
Microglia
Gliosis
Inflammation
Oligodendrocytes
Médula espinal
Microglía
Gliosis
Inflamación
Oligodendrocitos
title_short Biochemical events related to glial response in spinal cord injury
title_full Biochemical events related to glial response in spinal cord injury
title_fullStr Biochemical events related to glial response in spinal cord injury
title_full_unstemmed Biochemical events related to glial response in spinal cord injury
title_sort Biochemical events related to glial response in spinal cord injury
dc.creator.fl_str_mv Lapuente-Chala, Catalina
Céspedes-Rubio, Angel
dc.contributor.author.spa.fl_str_mv Lapuente-Chala, Catalina
Céspedes-Rubio, Angel
dc.subject.ddc.spa.fl_str_mv 61 Ciencias médicas; Medicina / Medicine and health
topic 61 Ciencias médicas; Medicina / Medicine and health
Spinal Cord
Microglia
Gliosis
Inflammation
Oligodendrocytes
Médula espinal
Microglía
Gliosis
Inflamación
Oligodendrocitos
dc.subject.proposal.spa.fl_str_mv Spinal Cord
Microglia
Gliosis
Inflammation
Oligodendrocytes
Médula espinal
Microglía
Gliosis
Inflamación
Oligodendrocitos
description Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that depend on the injured axonal tracts.Objective: To describe the most relevant sequential biochemical events of glial cells response after SCI.Materials and methods: A search of scientific publications released in the past 18 years was carried out in PubMed and Science Direct databases, with the terms spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar and chondroitin sulfate proteoglycans (CSPG).Results: The pathophysiological processes resulting from SCI are determinant for the neurological recovery of patients. Activation of glial cells plays an important role in promoting bioactive molecules and the formation of physical barriers that inhibit neural regeneration.Conclusion: Knowledge of neurobiological changes after SCI allows a greater understanding of the pathophysiology and favors the search for new therapeutic alternatives that limit the progression of the primary injury and minimize secondary damage, responsible for neurological dysfunction.
publishDate 2018
dc.date.issued.spa.fl_str_mv 2018-04-01
dc.date.accessioned.spa.fl_str_mv 2019-07-02T23:37:42Z
dc.date.available.spa.fl_str_mv 2019-07-02T23:37:42Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.issn.spa.fl_str_mv ISSN: 2357-3848
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identifier_str_mv ISSN: 2357-3848
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dc.language.iso.spa.fl_str_mv spa
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dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina
Revista de la Facultad de Medicina
dc.relation.references.spa.fl_str_mv Lapuente-Chala, Catalina and Céspedes-Rubio, Angel (2018) Biochemical events related to glial response in spinal cord injury. Revista de la Facultad de Medicina, 66 (2). pp. 269-277. ISSN 2357-3848
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/64964/1/61701-389467-1-PB.pdf
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repository.name.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lapuente-Chala, Catalinab6a76286-2697-4b35-8773-27bc0700041d300Céspedes-Rubio, Angelba7b4265-58cc-4aae-baec-1528c0fe5cd63002019-07-02T23:37:42Z2019-07-02T23:37:42Z2018-04-01ISSN: 2357-3848https://repositorio.unal.edu.co/handle/unal/64964http://bdigital.unal.edu.co/65987/Introduction: Spinal cord injury (SCI) is a devastating event with physical, psychological and socioeconomic implications. Morphophysiological changes are observed in the tissue close to the injury, which allow determining the functional recovery of the medullary segment and the effector organs that depend on the injured axonal tracts.Objective: To describe the most relevant sequential biochemical events of glial cells response after SCI.Materials and methods: A search of scientific publications released in the past 18 years was carried out in PubMed and Science Direct databases, with the terms spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar and chondroitin sulfate proteoglycans (CSPG).Results: The pathophysiological processes resulting from SCI are determinant for the neurological recovery of patients. Activation of glial cells plays an important role in promoting bioactive molecules and the formation of physical barriers that inhibit neural regeneration.Conclusion: Knowledge of neurobiological changes after SCI allows a greater understanding of the pathophysiology and favors the search for new therapeutic alternatives that limit the progression of the primary injury and minimize secondary damage, responsible for neurological dysfunction.Introducción. La lesión de la médula espinal (LME) es un evento devastador con implicaciones físicas, psicológicas y socioeconómicas. En el tejido cercano a la lesión se instauran cambios morfofisiológicos que determinan la recuperación funcional del segmento medular y de los órganos efectores dependientes de los tractos axonales lesionados.Objetivo. Describir los eventos bioquímicos secuenciales más relevantes de la respuesta de las células gliales posterior a la LME.Materiales y métodos. Se realizó una búsqueda de publicaciones científicas de los últimos 18 años en las bases de datos PubMed y ScienceDirect, bajo los términos en inglés spinal cord injury (SCI), SCI pathophysiology, SCI inflammation, microglia in SCI, glial scar y chondroitin sulfate proteoglycans (CSPG).Resultados. Los procesos fisiopatológicos que se producen después de la LME determinan la recuperación neurológica de los pacientes. La activación de las células gliales juega un papel importante, ya que promueve la producción de moléculas bioactivas y la formación de barreras físicas que inhiben la regeneración neural.Conclusión. El conocimiento de los cambios neurobiológicos ocurridos tras la LME permite una mayor comprensión de la fisiopatología y favorece la búsqueda de nuevas alternativas terapéuticas que limiten la progresión de la lesión primaria y que minimicen el daño secundario responsable de la disfunción neurológica.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicinahttps://revistas.unal.edu.co/index.php/revfacmed/article/view/61701Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaLapuente-Chala, Catalina and Céspedes-Rubio, Angel (2018) Biochemical events related to glial response in spinal cord injury. Revista de la Facultad de Medicina, 66 (2). pp. 269-277. ISSN 2357-384861 Ciencias médicas; Medicina / Medicine and healthSpinal CordMicrogliaGliosisInflammationOligodendrocytesMédula espinalMicroglíaGliosisInflamaciónOligodendrocitosBiochemical events related to glial response in spinal cord injuryArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL61701-389467-1-PB.pdfapplication/pdf2582282https://repositorio.unal.edu.co/bitstream/unal/64964/1/61701-389467-1-PB.pdf3c1928b6c9335b50e6d19efdee7b96a4MD51THUMBNAIL61701-389467-1-PB.pdf.jpg61701-389467-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8083https://repositorio.unal.edu.co/bitstream/unal/64964/2/61701-389467-1-PB.pdf.jpg057bc43b83a180167c8b58faed2ca664MD52unal/64964oai:repositorio.unal.edu.co:unal/649642023-05-16 23:48:15.223Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co