Identificación de genes asociados a la producción de withanólidos en Physalideae

ilustraciones, diagramas

Autores:
Perez Moreno, Santiago
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86466
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86466
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología::576 - Genética y evolución
570 - Biología::572 - Bioquímica
Lactona
Physalis
genómica
lactones
Physalis
genomics
Withanolidos
Biosíntesis de withanolidos
Genómica vegetal
Metabolitos secundarios
Evolución metabólica
Solanaceae
Withanolides
Secondary metabolites
Metabolic evolution
Withanolide biosynthesis
Plant genomics
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_669228443183bdf5462c7e9059cff0dc
oai_identifier_str oai:repositorio.unal.edu.co:unal/86466
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Identificación de genes asociados a la producción de withanólidos en Physalideae
dc.title.translated.eng.fl_str_mv Identification of Genes Associated with the Production of Withanolides in Physalideae
title Identificación de genes asociados a la producción de withanólidos en Physalideae
spellingShingle Identificación de genes asociados a la producción de withanólidos en Physalideae
570 - Biología::576 - Genética y evolución
570 - Biología::572 - Bioquímica
Lactona
Physalis
genómica
lactones
Physalis
genomics
Withanolidos
Biosíntesis de withanolidos
Genómica vegetal
Metabolitos secundarios
Evolución metabólica
Solanaceae
Withanolides
Secondary metabolites
Metabolic evolution
Withanolide biosynthesis
Plant genomics
title_short Identificación de genes asociados a la producción de withanólidos en Physalideae
title_full Identificación de genes asociados a la producción de withanólidos en Physalideae
title_fullStr Identificación de genes asociados a la producción de withanólidos en Physalideae
title_full_unstemmed Identificación de genes asociados a la producción de withanólidos en Physalideae
title_sort Identificación de genes asociados a la producción de withanólidos en Physalideae
dc.creator.fl_str_mv Perez Moreno, Santiago
dc.contributor.advisor.spa.fl_str_mv Roda Fornaguera, Federico
dc.contributor.author.spa.fl_str_mv Perez Moreno, Santiago
dc.contributor.researchgroup.spa.fl_str_mv Genómica Evolutiva del Metabolismo Secundario (GEME)
dc.subject.ddc.spa.fl_str_mv 570 - Biología::576 - Genética y evolución
570 - Biología::572 - Bioquímica
topic 570 - Biología::576 - Genética y evolución
570 - Biología::572 - Bioquímica
Lactona
Physalis
genómica
lactones
Physalis
genomics
Withanolidos
Biosíntesis de withanolidos
Genómica vegetal
Metabolitos secundarios
Evolución metabólica
Solanaceae
Withanolides
Secondary metabolites
Metabolic evolution
Withanolide biosynthesis
Plant genomics
dc.subject.agrovoc.spa.fl_str_mv Lactona
Physalis
genómica
dc.subject.agrovoc.eng.fl_str_mv lactones
Physalis
genomics
dc.subject.proposal.spa.fl_str_mv Withanolidos
Biosíntesis de withanolidos
Genómica vegetal
Metabolitos secundarios
Evolución metabólica
dc.subject.proposal.other.fl_str_mv Solanaceae
dc.subject.proposal.eng.fl_str_mv Withanolides
Secondary metabolites
Metabolic evolution
Withanolide biosynthesis
dc.subject.proposal.fra.fl_str_mv Plant genomics
description ilustraciones, diagramas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-16T18:26:49Z
dc.date.available.none.fl_str_mv 2024-07-16T18:26:49Z
dc.date.issued.none.fl_str_mv 2024
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86466
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86466
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Agrosavia
Agrovoc
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dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.extent.spa.fl_str_mv 132 páginas + 1 anexo
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Ciencias - Maestría en Ciencias - Biología
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Roda Fornaguera, Federico4d61953eec7a0e32909a2521dbd7a5adPerez Moreno, Santiago4cb94960f1b707b41fe64e15e3f73cb6Genómica Evolutiva del Metabolismo Secundario (GEME)2024-07-16T18:26:49Z2024-07-16T18:26:49Z2024https://repositorio.unal.edu.co/handle/unal/86466Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEsta tesis explora la biosíntesis y regulación de los withanolidos en la familia Solanaceae, específicamente en la tribu Physalideae, arrojando luz sobre los complejos procesos bioquímicos y genéticos que conforman su diversidad y evolución. El estudio analiza cómo se sintetizan los withanolidos, destacando la importancia de procesos bioquímicos específicos y la interacción de rutas metabólicas clave. Se enfatiza el papel crucial de ciertos procesos biológicos y genes en la modulación de la síntesis de estos compuestos, resaltando la significativa coexpresión de genes vinculados a funciones esenciales en la planta. El papel de las enzimas citocromo P450, genes específicos y clústeres biosintéticos como el propuesto WBC se examinan en profundidad, proporcionando una comprensión más profunda de la regulación genética en la producción de withanolidos. La investigación también revela interesantes interacciones entre diferentes vías metabólicas y muestra cómo la variación genética podría influir en la presencia o ausencia de ciertos withanolidos entre las especies de Solanaceae. Finalmente, la tesis ofrece una mirada a la regulación y los factores de transcripción involucrados en la producción de withanolidos, subrayando el descubrimiento de patrones de expresión genética que podrían ser fundamentales para futuras investigaciones en biotecnología vegetal y desarrollo farmacológico. Este trabajo representa un avance significativo en el conocimiento de la fitoquímica y la biología evolutiva de las plantas, destacando la complejidad y el dinamismo del mundo vegetal. (Texto tomado de la fuente).This thesis explores the biosynthesis and regulation of withanolidos in the Solanaceae family, specifically in the Physalideae tribe, shedding light on the complex biochemicaland genetic processes that shape their diversity and evolution. The study examines howwithanolidos are synthesized, highlighting the importance of specific biochemical processes and the interaction of key metabolic pathways. The crucial role of biologicalprocesses and genes, particularly cytochrome P450 enzymes, specific genes, and proposed biosynthetic clusters like WBC, is examined in depth, providing a deeper understanding of genetic regulation in withanolide production. The research also revealsintriguing interactions between different metabolic pathways and shows how genetic variation might influence the presence or absence of certain withanolidos among Solanaceae species. Finally, the thesis offers insights into the regulation and transcription factors involved in withanolide production, emphasizing the discovery of gene expression patterns that could be key for future research in plant biotechnology and pharmacological development. This work represents a significant advancement in the understanding of plant phytochemistry and evolutionary biology, highlighting the complexity and dynamism of the plant world.El proyecto "Identificación de genes asociados a la producción de withanólidos en Physalideae" recibió apoyo financiero y de recursos del Grupo de investigación de Genómica y fue patrocinado por el Tandem de Max Planck del Metabolismo Especializado (GEME). Este apoyo incluyó financiamiento y recursos necesarios para la investigaciónMaestríaMagíster en Ciencias - BiologíaGenómica evolutiva132 páginas + 1 anexoapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::576 - Genética y evolución570 - Biología::572 - BioquímicaLactonaPhysalisgenómicalactonesPhysalisgenomicsWithanolidosBiosíntesis de withanolidosGenómica vegetalMetabolitos secundariosEvolución metabólicaSolanaceaeWithanolidesSecondary metabolitesMetabolic evolutionWithanolide biosynthesisPlant genomicsIdentificación de genes asociados a la producción de withanólidos en PhysalideaeIdentification of Genes Associated with the Production of Withanolides in PhysalideaeTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAgrosaviaAgrovocAgarwal, A. 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A comparative study of quantification measures for the analysis of RNA-seq data from the NCI patient- derived models repository. Journal of translational medicine, 19(1), 1-15.Grupo Genómica Evolutiva del Metabolismo EspecializadoInvestigadoresORIGINAL1032465939.2024.pdf1032465939.2024.pdfTesis de Mestría en Ciencias - Biologíaapplication/pdf3070358https://repositorio.unal.edu.co/bitstream/unal/86466/7/1032465939.2024.pdfa4fb1f00f468ef4b808c832250d2eedfMD57Anexo3.txtAnexo3.txtAnexotext/plain19135693https://repositorio.unal.edu.co/bitstream/unal/86466/3/Anexo3.txt2b1de1629fbdf630c8276c621a5beda7MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86466/4/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD54THUMBNAIL1032465939.2024.pdf.jpg1032465939.2024.pdf.jpgGenerated Thumbnailimage/jpeg4597https://repositorio.unal.edu.co/bitstream/unal/86466/6/1032465939.2024.pdf.jpg20c54c7f0a2395ad864763a4ff9ae5fdMD56unal/86466oai:repositorio.unal.edu.co:unal/864662024-07-17 14:26:08.912Repositorio Institucional Universidad Nacional de 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