Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos

ilustraciones, fotografías, graficas

Autores:
Sánchez Santamaría, Katherine Johanna
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82222
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82222
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Accidente Cerebrovascular
Stroke
GUSS
ECV
CVD
Acelerometría deglutoria
Trastorno de la deglución
Tamizaje deglutorio
Swallowing accelerometry
Swallowing disorder
Swallowing screening
Rights
openAccess
License
Reconocimiento 4.0 Internacional
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oai_identifier_str oai:repositorio.unal.edu.co:unal/82222
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network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
dc.title.translated.eng.fl_str_mv Screening of swallowing in patients with Cerebrovascular Disease (CVD) by means of the GUSS Test and swallowing accelerometry in relation to healthy patients.
title Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
spellingShingle Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
610 - Medicina y salud::616 - Enfermedades
Accidente Cerebrovascular
Stroke
GUSS
ECV
CVD
Acelerometría deglutoria
Trastorno de la deglución
Tamizaje deglutorio
Swallowing accelerometry
Swallowing disorder
Swallowing screening
title_short Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
title_full Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
title_fullStr Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
title_full_unstemmed Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
title_sort Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos
dc.creator.fl_str_mv Sánchez Santamaría, Katherine Johanna
dc.contributor.advisor.none.fl_str_mv Angel Gordillo, Luisa Fernanda
dc.contributor.author.none.fl_str_mv Sánchez Santamaría, Katherine Johanna
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Accidente Cerebrovascular
Stroke
GUSS
ECV
CVD
Acelerometría deglutoria
Trastorno de la deglución
Tamizaje deglutorio
Swallowing accelerometry
Swallowing disorder
Swallowing screening
dc.subject.lemb.spa.fl_str_mv Accidente Cerebrovascular
dc.subject.lemb.eng.fl_str_mv Stroke
dc.subject.proposal.none.fl_str_mv GUSS
ECV
CVD
dc.subject.proposal.spa.fl_str_mv Acelerometría deglutoria
Trastorno de la deglución
Tamizaje deglutorio
dc.subject.proposal.eng.fl_str_mv Swallowing accelerometry
Swallowing disorder
Swallowing screening
description ilustraciones, fotografías, graficas
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-08-31T18:27:53Z
dc.date.available.none.fl_str_mv 2022-08-31T18:27:53Z
dc.date.issued.none.fl_str_mv 2022
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82222
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82222
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv RedCol
LaReferencia
dc.relation.references.spa.fl_str_mv Zuercher P, Moret CS, Dziewas R, Schefold JC. Dysphagia in the intensive care unit: Epidemiology, mechanisms, and clinical management. Crit Care. 2019;23(1):1–11.
Brown CVR, Hejl K, Mandaville AD, Chaney PE, Stevenson G, Smith C. Swallowing dysfunction after mechanical ventilation in trauma patients. J Crit Care [Internet]. 2011;26(1):108.e9-108.e13. Available from: http://dx.doi.org/10.1016/j.jcrc.2010.05.036
Wang X, Zheng G, Su M, Chen Y, Xie H, Han W, et al. Biting force and tongue muscle strength as useful indicators for eating and swallowing capability assessment among elderly patients. Food Sci Hum Wellness [Internet]. 2019;8(2):149–55. Available from: https://doi.org/10.1016/j.fshw.2019.03.009
Fernández-Carmona A, Peñas-Maldonado L, Yuste-Osorio E, Díaz-Redondo A. Exploración y abordaje de disfagia secundaria a vía aérea artificial. Med Intensiva. 2012;36(6):423–33.
Warnecke T, Im S, Kaiser C, Hamacher C, Oelenberg S, Dziewas R. Aspiration and dysphagia screening in acute stroke – the Gugging Swallowing Screen revisited. Eur J Neurol. 2017 Apr 1;24(4):594–601.
Crary MA, Carnaby GD, Sia I, Khanna A, Waters MF, Crary MA, et al. Spontaneous Swallowing Frequency Has Potential to Identify. 2014;3452–7.
Trapl M, Enderle P, Nowotny M, Teuschl Y, Matz K, Dachenhausen A, et al. Dysphagia bedside screening for acute-stroke patients: The gugging swallowing screen. Stroke. 2007 Nov;38(11):2948–52.
Antonios N, Carnaby-Mann G, Crary M, Miller L, Hubbard H, Hood K, et al. Analysis of a Physician Tool for Evaluating Dysphagia on an Inpatient Stroke Unit: The Modified Mann Assessment of Swallowing Ability. J Stroke Cerebrovasc Dis [Internet]. 2010;19(1):49–57. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2009.03.007
Takizawa C, Gemmell E, Kenworthy J, Speyer R. A Systematic Review of the Prevalence of Oropharyngeal Dysphagia in Stroke, Parkinson’s Disease, Alzheimer’s Disease, Head Injury, and Pneumonia. Dysphagia. 2016;31(3):434–4
Ferreira A, Pierdevara L, Ventura I, Gracias A, Marques J, Reis M. The Gugging Swallowing Screen: A contribution to the cultural and linguistic validationfor the Portuguese context. Rev Enferm Ref. 2018 Mar 31;IV Série(No16):85–94.
Edmiaston J, Connor LT, Steger-May K, Ford AL. A simple bedside stroke dysphagia screen, validated against videofluoroscopy, detects dysphagia and aspiration with high sensitivity. J Stroke Cerebrovasc Dis [Internet]. 2014;23(4):712–6. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.030
Borders JC, Fink D, Levitt JE, McKeehan J, McNally E, Rubio A, et al. Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure. Dysphagia [Internet]. 2019;34(4):521–8. Available from: https://doi.org/10.1007/s00455-019-09980-1
Byeon H, Koh HW. Comparison of treatment effect of neuromuscular electrical stimulation and thermal-tactile stimulation on patients with sub-acute dysphagia caused by stroke. J Phys Ther Sci. 2016;28(6):1809–12.
Castellini, H.; Cerderira, H.; Romanelli L. Simetrias en osciladores caoticos acoplados y su relacion con el generador central de patrones en animales. An AFA. 2003;15:302–6.
Bermúdez de Alvear RM, Martínez Arquero AG. Estrategias para potenciar el aprendizaje motor en el tratamiento vocal de las enfermedades neurodegenerativas. Rev Logop Foniatr y Audiol [Internet]. 2013;33(1):13–24. Available from: http://dx.doi.org/10.1016/j.rlfa.2012.07.004
Logemann J. Evaluation and treatment of swallowing disorders. ASHA J. 1998;38–50.
Acosta NB, Freitas Cardoso MC de A. Vista do Presbifagia: estado da arte da deglutição do idoso. Rev Bras Ciências Do Envelhec Hum [Internet]. 2013 Mar 27 [cited 2021 Oct 18];9(1):143–54. Available from: http://seer.upf.br/index.php/rbceh/article/view/1504/pdf
Murray, T., Carrau, R., & Chan K. Clinical management of swallowing disorders. Plural Publishing; 2016.
Lo WL, Leu HB, Yang MC, Wang DH, Hsu ML. Dysphagia and risk of aspiration pneumonia: A nonrandomized, pair-matched cohort study. J Dent Sci [Internet]. 2019;14(3):241–7. Available from: https://doi.org/10.1016/j.jds.2019.01.005
Padovani AR, Moraes DP, Sassi FC, de Andrade CRF. Clinical swallowing assessment in intensive care unit. Codas. 2013;25(1):1–7.
María A, Lodeiro Á, Polanco SF. GRAO EN ENFERMERÍA Comunicación con el paciente en ventilación mecánica invasiva: revisión bibliográfica. ESCOLA UNIVERSITARIA DE ENFERMARÍA A CORUÑA UNIVERSIDADE DA CORUÑA [Internet]. 2018 [cited 2020 Sep 23]. Available from: https://ruc.udc.es/dspace/handle/2183/25253
PEDRAZA OL, DÍAZ R, SÁNCHEZ E I. Enfermedad Cerebrovascular. Guia Neurológica. :47–70.
Rodríguez López JM, Bayona Ortiz HF MC. Prevalencia de enfermedad carotidea posterior a ACV en un hospital universitario de bogotá. Univ Med [Internet] 1 de abril de 2021 [citado 20 de julio de 2021]; 2021;62(1).
Rodriguez-Garcia, J.; Peñaloza-Quintero R. A-LJ. 2017 Estimación de la carga global de enfermedad en Colombia 2012_ nuevos aspectos metodológicos.pdf. Rev Salud Pública. 2017;19(2):235–40.
Silva, M.; Sandoval, D.; Durán J. 2021 caracterización de ECV isquemica aguda.pdf. Repert Med y Cirugía. 2021;29(3):173–8.
Martin-Schild S, Albright KC, Tanksley J, Pandav V, Jones EB, Grotta JC, et al. Zero on the NIHSS Does Not Equal the Absence of Stroke. YMEM [Internet]. 2010 [cited 2021 Nov 10];57:42–5. Available from: www.annemergmed.com.
Ortiz GA, Sacco RL, Faha F. NATIONAL INSTITUTES OF HEALTH STROKE SCALE (NIHSS). [cited 2021 Nov 9]; Available from: www.ninds.nih.gov.
Cheung W, Clayton N, Li F, Tan J, Milliss D, Thanakrishnan G, et al. The effect of endotracheal tube size on voice and swallowing function in patients with thermal burn injury: An evaluation using the Australian Therapy Outcome Measures (AusTOMS). Int J Speech Lang Pathol. 2013;15(2):216–20.
Dang, P.; Nguyen, M.; Mai, X.; Pham, D.; Dang, M.; Nguyen, D.; Bui, V.; Mai, D.; Do, N.; Go D. 2020 Comparison of the NIHSS and GUSS en predicion de neumonia asociada a Stroke..pdf. Ther Clin Risk Manag. 2020;16:445–50.
Kuhlemeier K V, Palmer JB, Rosenberg D. Effect of Liquid Bolus Consistency and Delivery Method on Aspiration and Pharyngeal Retention in Dysphagia Patients. Dysphagia. 2001;16(2):119–112.
Ibarra NB. Métodos de prueba del marco de la IDDSI Documento traducido al español por [Internet]. Available from: https://ftp.iddsi.org/Documents/Metodos_de_prueba_del_marco_de_la_IDDSI_Final.pdf
Terré R. Oropharyngeal dysphagia in stroke: Diagnostic and therapeutic aspects. Rev Neurol. 2020 Jun 16;70(12):444–52.
Kim SY, Kim TU, Hyun JK, Lee SJ. Differences in videofluoroscopic swallowing study (VFSS) findings according to the vascular territory involved in stroke. Dysphagia. 2014;29(4):444–9.
Scheel R, Pisegna JM, McNally E, Noordzij JP, Langmore SE. Endoscopic Assessment of Swallowing after Prolonged Intubation in the ICU Setting. Ann Otol Rhinol Laryngol. 2016;125(1):43–52.
Teuschl Y, Trapl M, Ratajczak P, Matz K, Dachenhausen A, Brainin M. Systematic dysphagia screening and dietary modifications to reduce stroke-associated pneumonia rates in a stroke-unit. PLoS One. 2018 Feb 1;13(2).
Ojo O, Brooke J. The use of enteral nutrition in the management of stroke. Nutrients. 2016 Dec 20;8(12).
Mao S, Zhang Z, Khalifa Y, Donohue C, Coyle JL, Sejdic E. Neck sensor-supported hyoid bone movement tracking during swallowing. R Soc Open Sci. 2019;6(7).
Movahedi F, Kurosu A, Coyle JL, Perera S, Sejdić E. Anatomical directional dissimilarities in tri-axial swallowing accelerometry signals. IEEE Trans Neural Syst Rehabil Eng. 2017;25(5):447–58.
Mamun KA, Steele CM, Chau T. Swallowing accelerometry signal feature variations with sensor displacement. Med Eng Phys [Internet]. 2015;37(7):665–73. Available from: http://dx.doi.org/10.1016/j.medengphy.2015.04.007
Dudik JM, Jestrović I, Luan B, Coyle JL, Sejdić E. A comparative analysis of swallowing accelerometry and sounds during saliva swallows. Biomed Eng Online. 2015;14(1):1–15.
Marmouset F, Hammoudi K, Bobillier C, Morinière S. Fisiología de la deglución normal. EMC - Otorrinolaringol. 2015;44(3):1–12.
Zoratto DCB. Hyolaryngeal excursion as the physiological source of swallowing accelerometry signals Hyolaryngeal excursion as the physiological source of swallowing accelerometry signals. 2010;
Lee J, Steele CM, Chau T. Artificial Intelligence in Medicine Classification of healthy and abnormal swallows based on accelerometry and nasal airflow signals. Artif Intell Med [Internet]. 2011;52(1):17–25. Available from: http://dx.doi.org/10.1016/j.artmed.2011.03.002
Lazareck LJ, Moussavi Z. Swallowing Sound Characteristics in Healthy and Dysphagic Individuals. 2004;3820–3.
Dudik JM, Kurosu A, Coyle JL, Sejdi E. A comparative analysis of DBSCAN , K-means , and quadratic variation algorithms for automatic identi fi cation of swallows from swallowing accelerometry signals. 2015;59:10–8.
Steele CM, Chau T, Sejdic E. Understanding the statistical persistence of dual-axis swallowing accelerometry signals. 2010;40:839–44.
Ochagavía A, Baigorri F, Mesquida J, Ayuela JM, Ferrándiz A, García X, et al. Monitorización hemodinámica en el paciente crítico. Recomendaciones del Grupo de Trabajo de Cuidados Intensivos Cardiológicos y RCP de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias. Med Intensiva [Internet]. 2014;38(3):154–69. Available from: http://dx.doi.org/10.1016/j.medin.2013.10.006
Screen S, En G, Con A, Araucanía RDELA. “ VALIDACIÓN DE LA ESCALA GUGGING ACCIDENTE CEREBROVASCULAR ( ACV ) EN LA. 2017.
Bunn A, Korpela M. An Introduction to dplR. 2019 [cited 2020 Mar 9]; Available from: http://doi.org/10.1016/j.dendro.2008.01.002
CRAN - Package agricolae [Internet]. [cited 2020 Mar 9]. Available from: https://cran.r-project.org/web/packages/agricolae/index.html
Pardo CE, César P, Campo D. Combination of Factorial Methods and Cluster Analysis in R: The Package FactoClass [Internet]. 2007 [cited 2020 Mar 9]. Available from: http://www.miktex.org/
Kori-Lindner C. Ethical principles for medical research involving human subjects: World medical association declaration of Helsinki. Vol. 11, Klinische Pharmakologie Aktuell. 2000. p. 26–8.
Vallotton MB. Council for international organizations of medical sciences perspectives: protecting persons through international ethics guidelines. Int J Integr Care [Internet]. 2010 Jan 29 [cited 2021 Nov 24];10(5). Available from: http://www.ijic.org/articles/10.5334/ijic.478/
Salud M de. Hoja 1 de 1 [Internet]. Resolución 8430 de 1993 Colombia; 1993. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESOLUCION-8430-DE-1993.PDF
Jorge E. Machado-Alba1 MEM-D. Artículo Original CARDIOVASCULAR RISK FACTORS PREVALENCE AMONG PATIENTS. Rev Peru Med Exp Salud Publica. 2013;30(2):205–11.
Sung SF, Hsieh CY, Lin HJ, Chen YW, Yang YHK, Li CY. Validation of algorithms to identify stroke risk factors in patients with acute ischemic stroke, transient ischemic attack, or intracerebral hemorrhage in an administrative claims database. Int J Cardiol. 2016 Jul 15;215:277–82.
Roquer J, Ana ;, Campello R, Gomis M. Sex Differences in First-Ever Acute Stroke. 2003; Available from: http://ahajournals.org
José Medrano Albero M, Boix Martínez R, Cerrato Crespán E, Ramírez Santa-Pau M. INCIDENCIA Y PREVALENCIA DE CARDIOPATÍA ISQUÉMICA Y ENFERMEDAD CEREBROVASCULAR EN ESPAÑA: REVISIÓN SISTEMÁTICA DE LA LITERATURA (*).
Haast RA, Gustafson DR, Kiliaan AJ. Sex differences in stroke. J Cereb Blood Flow Metab [Internet]. 2012 [cited 2022 Jan 20];32:2100–7. Available from: www.jcbfm.com
Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA - J Am Med Assoc. 2010 Jun 9;303(22):2280–6.
Kolapo KO, Ogun SA, Danesi MA, Osalusi BS, Odusote KA. Validation study of the Siriraj stroke score in African Nigerians and evaluation of the discriminant values of its parameters: A preliminary prospective CT scan study. Stroke [Internet]. 2006 Aug [cited 2022 Jan 20];37(8):1997–2000. Available from: http://ahajournals.org
Geisler F, Wesirow M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, et al. Probability assessment of intracerebral hemorrhage in prehospital emergency patients. Available from: https://doi.org/10.1186/s42466-020-00100-1
Gonzalez-Fernandez M, Kleinman JT, Ky PKS, Palmer JB, Hillis AE. Supratentorial Regions of Acute Ischemia Associated With Clinically Important Swallowing Disorders A Pilot Study. 2008; Available from: http://stroke.ahajournals.org
Beharry A, Michel P, Faouzi M, Kuntzer T, Schweizer V, Diserens K. Predictive Factors of Swallowing Disorders and Bronchopneumonia in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019 Aug 1;28(8):2148–54.
Goldstein LB, Simel DL. Is this patient having a stroke? J Am Med Assoc. 2005;293(19):2391–402.
Ribeiro PW, Cola PC, Gatto AR, Silva RG, Luvizutto GJ, Braga GP, et al. Relationship Between Dysphagia , National Institutes of Health Stroke Scale Score , and Predictors of Pneumonia After Ischemic Stroke. J Stroke Cerebrovasc Dis [Internet]. 2015;1–7. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.05.009
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Medicina - Maestría en Fisiología
dc.publisher.department.spa.fl_str_mv Departamento de Ciencias Fisiológicas
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Angel Gordillo, Luisa Fernandad1db48ac5f6a1d49879f40be3754cdb6Sánchez Santamaría, Katherine Johanna681cb2724058b44fa5735f84da2b0d382022-08-31T18:27:53Z2022-08-31T18:27:53Z2022https://repositorio.unal.edu.co/handle/unal/82222Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, graficasAntecedentes: La deglución compuesta por diferentes fases es un proceso complejo que implica la coordinación entre varios subprocesos e involucra diversas estructuras anatómicas que van desde la corteza cerebral hasta la periferia. El compromiso de cualquiera de esos subprocesos puede suponer la aparición de un trastorno deglutorio o disfagia. En los pacientes con enfermedad cerebrovascular (ECV) se reporta una incidencia de disfagia del 78% en su fase aguda, con lo cual, la evaluación temprana y la implementación pronta de estrategias de alimentación acordes a las dificultades del sujeto disminuyen el riesgo de complicaciones en la condición de salud relacionadas con la neumonía aspirativa. Dicha evaluación puede ser de tipo clínico observacional por medio de escalas de tamizaje deglutorio, tales como el test GUSS, o puede ser de tipo objetivo instrumental. Objetivo: comparar pacientes con antecedente de ECV con pacientes sanos mediante el Test GUSS para tamizaje deglutorio adaptado a población colombiana y la acelerometría deglutoria como medida fisiológica objetiva no invasiva. Método: Este estudio observacional analítico incluyó 19 personas con ECV y 15 personas sanas como grupo control emparejado por edad y sexo. La evaluación de la deglución se realizó en simultáneo con el test GUSS para tamizaje de la deglución y la acelerometría deglutoria como medida fisiológica para registro de la movilidad laríngea. Resultados: los resultados no encontraron una diferencia significativa en la magnitud de aceleración laríngea de los pacientes con ECV respecto al grupo control, sin embargo, si existe una diferencia en cuanto al tiempo de respuesta deglutoria para alcanzar ése rango máximo de aceleración laríngea, lo cual determina que la variación se encuentra en el tiempo de la respuesta deglutoria refleja, más que en la aceleración de la laringe durante la deglución. Conclusión: Se identifica diferencia en las medidas fisiológicas entre los pacientes con ECV y los pacientes sanos en relación al desempeño deglutorio según la consistencia, no se evidencia diferencia en la magnitud de aceleración laríngea de ambos grupos, y existe una relación inversamente proporcional entre la puntuación de la escala NIHSS y el test GUSS. (Texto tomado de la fuente)Background: Swallowing, composed of different phases, is a complex process that involves the coordination between several threads and involves various anatomical structures that range from the cerebral cortex to the periphery. The compromise of any of these threads can lead to the appearance of a swallowing disorder or dysphagia. In patients with Stroke an incidence of dysphagia of 78% is reported in its acute phase, with which, early evaluation and prompt implementation of feeding strategies according to the difficulties of the subject reduce the risk of complications in health condition related to aspiration pneumonia. This evaluation can be of an observational clinical type by means of swallowing screening scales, such as the GUSS test, or it can be of an objective instrumental type. Objective: to compare patients with a history of Stroke with healthy patients using the GUSS Test for swallowing screening adapted to the Colombian population and swallowing accelerometry as a non-invasive objective physiological measure. Method: This analytical observational study included 19 people with stroke and 15 healthy people as a control group matched for age and sex. Swallowing evaluation was performed simultaneously with the GUSS test for swallowing screening and swallowing accelerometry as a physiological measure to record laryngeal mobility. Results: the results did not find a significant difference in the magnitude of laryngeal acceleration of patients with Stroke compared to the control group, however, there is a difference in the swallowing response time to reach that maximum range of laryngeal acceleration, which determined that the variation is found in the time of the reflex swallowing response, rather than in the acceleration of the larynx during swallowing. Conclusion: A difference is identified in the physiological measurements between patients with Stroke and healthy patients in relation to swallowing performance according to consistency, there is no difference in the magnitude of laryngeal acceleration in both groups, and there is an inversely proportional relationship between the scale score NIHSS and the GUSS test.MaestríaMagíster en FisiologíaEstudio observacional analítico de tipo cohorte transversal. Los individuos convocados para el estudio fueron personas con diagnóstico inicial de ECV que cursan con disfagia, adicional a un grupo de personas control sin diagnóstico de disfagia ni antecedente de ECV, las cuales fueron pareadas por edad y sexo. El reclutamiento se hizo dentro de las instalaciones del Hospital Universitario Nacional, donde no fue necesario realizar una convocatoria de participación abierta de forma extra institucional86 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en FisiologíaDepartamento de Ciencias FisiológicasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesAccidente CerebrovascularStrokeGUSSECVCVDAcelerometría deglutoriaTrastorno de la degluciónTamizaje deglutorioSwallowing accelerometrySwallowing disorderSwallowing screeningTamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanosScreening of swallowing in patients with Cerebrovascular Disease (CVD) by means of the GUSS Test and swallowing accelerometry in relation to healthy patients.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMRedColLaReferenciaZuercher P, Moret CS, Dziewas R, Schefold JC. Dysphagia in the intensive care unit: Epidemiology, mechanisms, and clinical management. Crit Care. 2019;23(1):1–11.Brown CVR, Hejl K, Mandaville AD, Chaney PE, Stevenson G, Smith C. Swallowing dysfunction after mechanical ventilation in trauma patients. J Crit Care [Internet]. 2011;26(1):108.e9-108.e13. Available from: http://dx.doi.org/10.1016/j.jcrc.2010.05.036Wang X, Zheng G, Su M, Chen Y, Xie H, Han W, et al. Biting force and tongue muscle strength as useful indicators for eating and swallowing capability assessment among elderly patients. Food Sci Hum Wellness [Internet]. 2019;8(2):149–55. Available from: https://doi.org/10.1016/j.fshw.2019.03.009Fernández-Carmona A, Peñas-Maldonado L, Yuste-Osorio E, Díaz-Redondo A. Exploración y abordaje de disfagia secundaria a vía aérea artificial. Med Intensiva. 2012;36(6):423–33.Warnecke T, Im S, Kaiser C, Hamacher C, Oelenberg S, Dziewas R. Aspiration and dysphagia screening in acute stroke – the Gugging Swallowing Screen revisited. Eur J Neurol. 2017 Apr 1;24(4):594–601.Crary MA, Carnaby GD, Sia I, Khanna A, Waters MF, Crary MA, et al. Spontaneous Swallowing Frequency Has Potential to Identify. 2014;3452–7.Trapl M, Enderle P, Nowotny M, Teuschl Y, Matz K, Dachenhausen A, et al. Dysphagia bedside screening for acute-stroke patients: The gugging swallowing screen. Stroke. 2007 Nov;38(11):2948–52.Antonios N, Carnaby-Mann G, Crary M, Miller L, Hubbard H, Hood K, et al. Analysis of a Physician Tool for Evaluating Dysphagia on an Inpatient Stroke Unit: The Modified Mann Assessment of Swallowing Ability. J Stroke Cerebrovasc Dis [Internet]. 2010;19(1):49–57. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2009.03.007Takizawa C, Gemmell E, Kenworthy J, Speyer R. A Systematic Review of the Prevalence of Oropharyngeal Dysphagia in Stroke, Parkinson’s Disease, Alzheimer’s Disease, Head Injury, and Pneumonia. Dysphagia. 2016;31(3):434–4Ferreira A, Pierdevara L, Ventura I, Gracias A, Marques J, Reis M. The Gugging Swallowing Screen: A contribution to the cultural and linguistic validationfor the Portuguese context. Rev Enferm Ref. 2018 Mar 31;IV Série(No16):85–94.Edmiaston J, Connor LT, Steger-May K, Ford AL. A simple bedside stroke dysphagia screen, validated against videofluoroscopy, detects dysphagia and aspiration with high sensitivity. J Stroke Cerebrovasc Dis [Internet]. 2014;23(4):712–6. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.030Borders JC, Fink D, Levitt JE, McKeehan J, McNally E, Rubio A, et al. Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure. Dysphagia [Internet]. 2019;34(4):521–8. Available from: https://doi.org/10.1007/s00455-019-09980-1Byeon H, Koh HW. Comparison of treatment effect of neuromuscular electrical stimulation and thermal-tactile stimulation on patients with sub-acute dysphagia caused by stroke. J Phys Ther Sci. 2016;28(6):1809–12.Castellini, H.; Cerderira, H.; Romanelli L. Simetrias en osciladores caoticos acoplados y su relacion con el generador central de patrones en animales. An AFA. 2003;15:302–6.Bermúdez de Alvear RM, Martínez Arquero AG. Estrategias para potenciar el aprendizaje motor en el tratamiento vocal de las enfermedades neurodegenerativas. Rev Logop Foniatr y Audiol [Internet]. 2013;33(1):13–24. Available from: http://dx.doi.org/10.1016/j.rlfa.2012.07.004Logemann J. Evaluation and treatment of swallowing disorders. ASHA J. 1998;38–50.Acosta NB, Freitas Cardoso MC de A. Vista do Presbifagia: estado da arte da deglutição do idoso. Rev Bras Ciências Do Envelhec Hum [Internet]. 2013 Mar 27 [cited 2021 Oct 18];9(1):143–54. Available from: http://seer.upf.br/index.php/rbceh/article/view/1504/pdfMurray, T., Carrau, R., & Chan K. Clinical management of swallowing disorders. Plural Publishing; 2016.Lo WL, Leu HB, Yang MC, Wang DH, Hsu ML. Dysphagia and risk of aspiration pneumonia: A nonrandomized, pair-matched cohort study. J Dent Sci [Internet]. 2019;14(3):241–7. Available from: https://doi.org/10.1016/j.jds.2019.01.005Padovani AR, Moraes DP, Sassi FC, de Andrade CRF. Clinical swallowing assessment in intensive care unit. Codas. 2013;25(1):1–7.María A, Lodeiro Á, Polanco SF. GRAO EN ENFERMERÍA Comunicación con el paciente en ventilación mecánica invasiva: revisión bibliográfica. ESCOLA UNIVERSITARIA DE ENFERMARÍA A CORUÑA UNIVERSIDADE DA CORUÑA [Internet]. 2018 [cited 2020 Sep 23]. Available from: https://ruc.udc.es/dspace/handle/2183/25253PEDRAZA OL, DÍAZ R, SÁNCHEZ E I. Enfermedad Cerebrovascular. Guia Neurológica. :47–70.Rodríguez López JM, Bayona Ortiz HF MC. Prevalencia de enfermedad carotidea posterior a ACV en un hospital universitario de bogotá. Univ Med [Internet] 1 de abril de 2021 [citado 20 de julio de 2021]; 2021;62(1).Rodriguez-Garcia, J.; Peñaloza-Quintero R. A-LJ. 2017 Estimación de la carga global de enfermedad en Colombia 2012_ nuevos aspectos metodológicos.pdf. Rev Salud Pública. 2017;19(2):235–40.Silva, M.; Sandoval, D.; Durán J. 2021 caracterización de ECV isquemica aguda.pdf. Repert Med y Cirugía. 2021;29(3):173–8.Martin-Schild S, Albright KC, Tanksley J, Pandav V, Jones EB, Grotta JC, et al. Zero on the NIHSS Does Not Equal the Absence of Stroke. YMEM [Internet]. 2010 [cited 2021 Nov 10];57:42–5. Available from: www.annemergmed.com.Ortiz GA, Sacco RL, Faha F. NATIONAL INSTITUTES OF HEALTH STROKE SCALE (NIHSS). [cited 2021 Nov 9]; Available from: www.ninds.nih.gov.Cheung W, Clayton N, Li F, Tan J, Milliss D, Thanakrishnan G, et al. The effect of endotracheal tube size on voice and swallowing function in patients with thermal burn injury: An evaluation using the Australian Therapy Outcome Measures (AusTOMS). Int J Speech Lang Pathol. 2013;15(2):216–20.Dang, P.; Nguyen, M.; Mai, X.; Pham, D.; Dang, M.; Nguyen, D.; Bui, V.; Mai, D.; Do, N.; Go D. 2020 Comparison of the NIHSS and GUSS en predicion de neumonia asociada a Stroke..pdf. Ther Clin Risk Manag. 2020;16:445–50.Kuhlemeier K V, Palmer JB, Rosenberg D. Effect of Liquid Bolus Consistency and Delivery Method on Aspiration and Pharyngeal Retention in Dysphagia Patients. Dysphagia. 2001;16(2):119–112.Ibarra NB. Métodos de prueba del marco de la IDDSI Documento traducido al español por [Internet]. Available from: https://ftp.iddsi.org/Documents/Metodos_de_prueba_del_marco_de_la_IDDSI_Final.pdfTerré R. Oropharyngeal dysphagia in stroke: Diagnostic and therapeutic aspects. Rev Neurol. 2020 Jun 16;70(12):444–52.Kim SY, Kim TU, Hyun JK, Lee SJ. Differences in videofluoroscopic swallowing study (VFSS) findings according to the vascular territory involved in stroke. Dysphagia. 2014;29(4):444–9.Scheel R, Pisegna JM, McNally E, Noordzij JP, Langmore SE. Endoscopic Assessment of Swallowing after Prolonged Intubation in the ICU Setting. Ann Otol Rhinol Laryngol. 2016;125(1):43–52.Teuschl Y, Trapl M, Ratajczak P, Matz K, Dachenhausen A, Brainin M. Systematic dysphagia screening and dietary modifications to reduce stroke-associated pneumonia rates in a stroke-unit. PLoS One. 2018 Feb 1;13(2).Ojo O, Brooke J. The use of enteral nutrition in the management of stroke. Nutrients. 2016 Dec 20;8(12).Mao S, Zhang Z, Khalifa Y, Donohue C, Coyle JL, Sejdic E. Neck sensor-supported hyoid bone movement tracking during swallowing. R Soc Open Sci. 2019;6(7).Movahedi F, Kurosu A, Coyle JL, Perera S, Sejdić E. Anatomical directional dissimilarities in tri-axial swallowing accelerometry signals. IEEE Trans Neural Syst Rehabil Eng. 2017;25(5):447–58.Mamun KA, Steele CM, Chau T. Swallowing accelerometry signal feature variations with sensor displacement. Med Eng Phys [Internet]. 2015;37(7):665–73. Available from: http://dx.doi.org/10.1016/j.medengphy.2015.04.007Dudik JM, Jestrović I, Luan B, Coyle JL, Sejdić E. A comparative analysis of swallowing accelerometry and sounds during saliva swallows. Biomed Eng Online. 2015;14(1):1–15.Marmouset F, Hammoudi K, Bobillier C, Morinière S. Fisiología de la deglución normal. EMC - Otorrinolaringol. 2015;44(3):1–12.Zoratto DCB. Hyolaryngeal excursion as the physiological source of swallowing accelerometry signals Hyolaryngeal excursion as the physiological source of swallowing accelerometry signals. 2010;Lee J, Steele CM, Chau T. Artificial Intelligence in Medicine Classification of healthy and abnormal swallows based on accelerometry and nasal airflow signals. Artif Intell Med [Internet]. 2011;52(1):17–25. Available from: http://dx.doi.org/10.1016/j.artmed.2011.03.002Lazareck LJ, Moussavi Z. Swallowing Sound Characteristics in Healthy and Dysphagic Individuals. 2004;3820–3.Dudik JM, Kurosu A, Coyle JL, Sejdi E. A comparative analysis of DBSCAN , K-means , and quadratic variation algorithms for automatic identi fi cation of swallows from swallowing accelerometry signals. 2015;59:10–8.Steele CM, Chau T, Sejdic E. Understanding the statistical persistence of dual-axis swallowing accelerometry signals. 2010;40:839–44.Ochagavía A, Baigorri F, Mesquida J, Ayuela JM, Ferrándiz A, García X, et al. Monitorización hemodinámica en el paciente crítico. Recomendaciones del Grupo de Trabajo de Cuidados Intensivos Cardiológicos y RCP de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias. Med Intensiva [Internet]. 2014;38(3):154–69. Available from: http://dx.doi.org/10.1016/j.medin.2013.10.006Screen S, En G, Con A, Araucanía RDELA. “ VALIDACIÓN DE LA ESCALA GUGGING ACCIDENTE CEREBROVASCULAR ( ACV ) EN LA. 2017.Bunn A, Korpela M. An Introduction to dplR. 2019 [cited 2020 Mar 9]; Available from: http://doi.org/10.1016/j.dendro.2008.01.002CRAN - Package agricolae [Internet]. [cited 2020 Mar 9]. Available from: https://cran.r-project.org/web/packages/agricolae/index.htmlPardo CE, César P, Campo D. Combination of Factorial Methods and Cluster Analysis in R: The Package FactoClass [Internet]. 2007 [cited 2020 Mar 9]. Available from: http://www.miktex.org/Kori-Lindner C. Ethical principles for medical research involving human subjects: World medical association declaration of Helsinki. Vol. 11, Klinische Pharmakologie Aktuell. 2000. p. 26–8.Vallotton MB. Council for international organizations of medical sciences perspectives: protecting persons through international ethics guidelines. Int J Integr Care [Internet]. 2010 Jan 29 [cited 2021 Nov 24];10(5). Available from: http://www.ijic.org/articles/10.5334/ijic.478/Salud M de. Hoja 1 de 1 [Internet]. Resolución 8430 de 1993 Colombia; 1993. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESOLUCION-8430-DE-1993.PDFJorge E. Machado-Alba1 MEM-D. Artículo Original CARDIOVASCULAR RISK FACTORS PREVALENCE AMONG PATIENTS. Rev Peru Med Exp Salud Publica. 2013;30(2):205–11.Sung SF, Hsieh CY, Lin HJ, Chen YW, Yang YHK, Li CY. Validation of algorithms to identify stroke risk factors in patients with acute ischemic stroke, transient ischemic attack, or intracerebral hemorrhage in an administrative claims database. Int J Cardiol. 2016 Jul 15;215:277–82.Roquer J, Ana ;, Campello R, Gomis M. Sex Differences in First-Ever Acute Stroke. 2003; Available from: http://ahajournals.orgJosé Medrano Albero M, Boix Martínez R, Cerrato Crespán E, Ramírez Santa-Pau M. INCIDENCIA Y PREVALENCIA DE CARDIOPATÍA ISQUÉMICA Y ENFERMEDAD CEREBROVASCULAR EN ESPAÑA: REVISIÓN SISTEMÁTICA DE LA LITERATURA (*).Haast RA, Gustafson DR, Kiliaan AJ. Sex differences in stroke. J Cereb Blood Flow Metab [Internet]. 2012 [cited 2022 Jan 20];32:2100–7. Available from: www.jcbfm.comRunchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA - J Am Med Assoc. 2010 Jun 9;303(22):2280–6.Kolapo KO, Ogun SA, Danesi MA, Osalusi BS, Odusote KA. Validation study of the Siriraj stroke score in African Nigerians and evaluation of the discriminant values of its parameters: A preliminary prospective CT scan study. Stroke [Internet]. 2006 Aug [cited 2022 Jan 20];37(8):1997–2000. Available from: http://ahajournals.orgGeisler F, Wesirow M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, et al. Probability assessment of intracerebral hemorrhage in prehospital emergency patients. Available from: https://doi.org/10.1186/s42466-020-00100-1Gonzalez-Fernandez M, Kleinman JT, Ky PKS, Palmer JB, Hillis AE. Supratentorial Regions of Acute Ischemia Associated With Clinically Important Swallowing Disorders A Pilot Study. 2008; Available from: http://stroke.ahajournals.orgBeharry A, Michel P, Faouzi M, Kuntzer T, Schweizer V, Diserens K. Predictive Factors of Swallowing Disorders and Bronchopneumonia in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019 Aug 1;28(8):2148–54.Goldstein LB, Simel DL. Is this patient having a stroke? J Am Med Assoc. 2005;293(19):2391–402.Ribeiro PW, Cola PC, Gatto AR, Silva RG, Luvizutto GJ, Braga GP, et al. Relationship Between Dysphagia , National Institutes of Health Stroke Scale Score , and Predictors of Pneumonia After Ischemic Stroke. J Stroke Cerebrovasc Dis [Internet]. 2015;1–7. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.05.009BibliotecariosEstudiantesInvestigadoresMaestrosMedios de comunicaciónPadres y familiasPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unal.edu.co/bitstream/unal/82222/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALTesis_Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos..pdfTesis_Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos..pdfTesis de Maestría en Fisiologíaapplication/pdf2281215https://repositorio.unal.edu.co/bitstream/unal/82222/2/Tesis_Tamizaje%20de%20la%20degluci%c3%b3n%20en%20pacientes%20con%20Enfermedad%20Cerebrovascular%20%28ECV%29%20por%20medio%20del%20Test%20GUSS%20y%20acelerometr%c3%ada%20deglutoria%20en%20relaci%c3%b3n%20con%20pacientes%20sanos..pdf376c4b420ba14a1fbe977a0404e187ceMD52THUMBNAILTesis_Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos..pdf.jpgTesis_Tamizaje de la deglución en pacientes con Enfermedad Cerebrovascular (ECV) por medio del Test GUSS y acelerometría deglutoria en relación con pacientes sanos..pdf.jpgGenerated Thumbnailimage/jpeg5563https://repositorio.unal.edu.co/bitstream/unal/82222/3/Tesis_Tamizaje%20de%20la%20degluci%c3%b3n%20en%20pacientes%20con%20Enfermedad%20Cerebrovascular%20%28ECV%29%20por%20medio%20del%20Test%20GUSS%20y%20acelerometr%c3%ada%20deglutoria%20en%20relaci%c3%b3n%20con%20pacientes%20sanos..pdf.jpg10814d76dd7a2df786a2f9d37a467f46MD53unal/82222oai:repositorio.unal.edu.co:unal/822222023-08-08 23:04:11.448Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=