Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications

Ilustraciones

Autores:: Hernández Montes, Vanessa

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2024

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: eng

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dc.title.eng.fl_str_mv	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
dc.title.translated.spa.fl_str_mv	Desarrollo de recubrimientos de hidroxietilcelulosa-aminada modificada con óxido de cerio para aleaciones de magnesio para uso en aplicaciones biomédicas.
title	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
spellingShingle	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería 660 - Ingeniería química::669 - Metalurgia Revestimientos metálicos Aleaciones de magnesio Oxidación electrolítica Corrosión electrolítica Biotecnología Bioingeniería Materiales biomédicos Implantes ortopédicos Magnesium alloys Surface modification Dip coating Electrolytic plasma oxidation Aminated hydroxyethyl cellulose Polylactic acid Corrosion resistance Biocompatibility Aleaciones de magnesio Modificación de superficies Recubrimiento por inmersión Oxidación electrolítica por plasma hidroxietilcelulosa aminada Ácido poliláctico Resistencia a la corrosión Biocompatibilidad
title_short	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
title_full	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
title_fullStr	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
title_full_unstemmed	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
title_sort	Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications
dc.creator.fl_str_mv	Hernández Montes, Vanessa
dc.contributor.advisor.none.fl_str_mv	Santa Marín, Juan Felipe Buitrago Sierra, Robison
dc.contributor.author.none.fl_str_mv	Hernández Montes, Vanessa
dc.contributor.orcid.spa.fl_str_mv	Hernández Montes, Vanessa [0000-0002-4692-3623]
dc.subject.ddc.spa.fl_str_mv	620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería 660 - Ingeniería química::669 - Metalurgia
topic	620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería 660 - Ingeniería química::669 - Metalurgia Revestimientos metálicos Aleaciones de magnesio Oxidación electrolítica Corrosión electrolítica Biotecnología Bioingeniería Materiales biomédicos Implantes ortopédicos Magnesium alloys Surface modification Dip coating Electrolytic plasma oxidation Aminated hydroxyethyl cellulose Polylactic acid Corrosion resistance Biocompatibility Aleaciones de magnesio Modificación de superficies Recubrimiento por inmersión Oxidación electrolítica por plasma hidroxietilcelulosa aminada Ácido poliláctico Resistencia a la corrosión Biocompatibilidad
dc.subject.lemb.none.fl_str_mv	Revestimientos metálicos Aleaciones de magnesio Oxidación electrolítica Corrosión electrolítica Biotecnología Bioingeniería Materiales biomédicos Implantes ortopédicos
dc.subject.proposal.eng.fl_str_mv	Magnesium alloys Surface modification Dip coating Electrolytic plasma oxidation Aminated hydroxyethyl cellulose Polylactic acid Corrosion resistance Biocompatibility
dc.subject.proposal.spa.fl_str_mv	Aleaciones de magnesio Modificación de superficies Recubrimiento por inmersión Oxidación electrolítica por plasma hidroxietilcelulosa aminada Ácido poliláctico Resistencia a la corrosión Biocompatibilidad
description	Ilustraciones
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-07-16T13:13:38Z
dc.date.available.none.fl_str_mv	2024-07-16T13:13:38Z
dc.date.issued.none.fl_str_mv	2024-07-12
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
format	http://purl.org/coar/resource_type/c_db06
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/86445
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/86445 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	eng
language	eng
dc.relation.indexed.spa.fl_str_mv	LaReferencia
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.format.extent.spa.fl_str_mv	171 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Medellín - Minas - Doctorado en Ingeniería - Ciencia y Tecnología de Materiales
dc.publisher.faculty.spa.fl_str_mv	Facultad de Minas
dc.publisher.place.spa.fl_str_mv	Medellín, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Medellín
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Santa Marín, Juan Felipe30f321423032a600a1187f1d8ce07534Buitrago Sierra, Robison44944f4ec6fd91249162ea2198a5505fHernández Montes, Vanessac0287d2303b4c579a48cfbff02669151Hernández Montes, Vanessa [0000-0002-4692-3623]2024-07-16T13:13:38Z2024-07-16T13:13:38Z2024-07-12https://repositorio.unal.edu.co/handle/unal/86445Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/IlustracionesMagnesium alloys have emerged as promising candidates for use in orthopedic implants due to their biodegradability, the lack of need for secondary excisional surgery, and the potential to reduce the cost of hospital care. AZ31 and ZK60 magnesium alloys are susceptible to biodegradation under in vivo conditions without completing the time required for bone implant stabilization. In this work, two magnesium alloys were with the purpose of improving their corrosion resistance and cytocompatibility. For this, the surfaces of the magnesium alloys ZK60 and AZ31 were modified using two different techniques. 1. Dip-coating to obtain coatings with PLA-AHEC-CeO2 with possible corrosion inhibition properties. For this purpose, a thin coating of polylactic acid (PLA) was first obtained by immersing the metal samples in a solution of PLA and dichloromethane, using an immersion and extraction speed of 65 mm/min. Subsequently, the AHEC-CeO2 film was deposited using the dip-coating technique in a solution containing AHEC and 1000 ppm of CeO2 nanoparticles. Finally, the coatings were dried at room temperature. The cerium nanoparticles were synthesized in the laboratory using a green synthesis route. 2. Plasma electrolytic oxidation (PEO) and PLA coating. The PEO coating was used as a physical barrier to prevent corrosion, thus slowing the corrosion process of the magnesium alloys. The PLA coating was applied to seal the pores within the PEO coating. The PEO coatings were applied to the magnesium alloys in an electrolyte based on sodium metasilicate and potassium hydroxide. A dip coating method was used to deposit PLA thin films on AZ31 and ZK60 Mg alloys. For the two surface modification methods, a physical-chemical characterization was conducted. The corrosion resistance was evaluated through hydrogen evolution and potentiodynamic polarization tests, and in-vitro cellular response through direct and indirect tests was also evaluated. All assays were performed in triplicate to ensure the reliability of the results. The results demonstrated that it was possible to obtain coatings using the proposed methodology. The proposed coatings showed a reduction in the corrosion rate of up to two orders of magnitude was achieved. The hydrogen evolution results and the potentiodynamic polarization tests allow us to identify that both the coatings composed of PLA-AHEC-CeO₂ and PEO-PLA were good candidates for implementation in anti-corrosion applications. However, the best results were found for the AZ31 and ZK60 samples modified with PEO-PLA with regard to cell viability and proliferation. Furthermore, MC3T3 pre-osteoblastic cells showed good adhesion on the surface of the ZK60-PEO-PLA and AZ31-PEO-PLA coatings. Consequently, PEO-PLA films have been proposed as a physical barrier to provide good corrosion protection in biomedical application. (Tomado de la fuente)Las aleaciones de magnesio se han convertido en candidatos prometedores para su uso en implantes ortopédicos debido a su biodegradabilidad, la falta de necesidad de cirugía de escisión secundaria y el potencial de reducir el costo de la atención hospitalaria. Las aleaciones de magnesio son susceptibles a la biodegradación en condiciones in vivo sin completar el tiempo necesario para la estabilización del implante óseo. En este trabajo se han recubierto dos aleaciones de magnesio con el propósito de mejorar su resistencia a la corrosión y su citocompatibilidad. Para esto, las superficies de las aleaciones de magnesio ZK60 y AZ31, fueron modificadas mediante dos técnicas distintas: 1. Dip-coating para obtener recubrimientos con PLA-AHEC-CeO2 con posibles propiedades de inhibición de corrosión. Para tal fin se obtuvo primero un recubrimiento delgado de ácido polilactico (PLA) a través de la inmersión de las muestras metálicas en una solución de PLA y diclorometano, utilizando una velocidad de inmersión y de extracción de 65 mm/min. Posteriormente, fue depositada la película de AHEC-CeO2 usando la técnica de dip-coating, en una solución que contenía AHEC y 1000 ppm de nanopartículas de CeO2. Finalmente, los recubrimientos fueron secados a temperatura ambiente. Las nanopartículas de cerio fueron sintetizadas en el laboratorio siguiendo una ruta de síntesis verde. 2. Recubrimiento por oxidación electrolítica por plasma (PEO) y PLA. El recubrimiento por PEO se obtuvo para que funcionara como una barrera física contra el medio corrosivo y de esta manera retardar el proceso de corrosión de las superficies de las aleaciones de magnesio. El PLA fue depositado con el fin de sellar los poros presentes en el recubrimiento PEO. Los recubrimientos con PEO fueron obtenidos sobre la superficie de las aleaciones de magnesio en un electrolito a base de metasilicato de sodio e hidróxido de potasio. Se utilizó un método de recubrimiento por inmersión para depositar películas delgadas de PLA sobre aleaciones de Mg AZ31 y ZK60. Para los dos métodos de modificación superficial se realizó una caracterización físico-química, se evaluó la resistencia a la corrosión mediante evolución de hidrógeno y pruebas de polarización potenciodinámica y la respuesta celular in vitro mediante ensayos directos e indirectos también fue evaluada. Todos los ensayos se realizaron por triplicado para garantizar la confiabilidad de los resultados. Los resultados mostraron que fue posible obtener recubrimientos utilizando la metodología propuesta. De forma importante para todos los recubrimientos propuestos se logró una reducción de la tasa de corrosión de hasta dos órdenes de magnitud. Los resultados de evolución de evolución de hidrógeno y las pruebas de polarización potenciodinámica permiten identificar que tanto los recubrimientos compuestos por PLA-AHEC-CeO2 y PEO-PLA son buenos candidatos para ser implementados en aplicaciones de anticorrosión. Sin embargo, los mejores resultados de viabilidad y proliferación celular fueron encontrados para las muestras de AZ31 y ZK60 modificadas con PEO-PLA. Además, celulas pre-osteoblasticas MC3T3, evidenciaron una buena adhesión sobre la superficie de los recubrimientos ZK60-PEO-PLA y AZ31-PEO-PLA. En consecuencia, las películas de PEO-PLA se han propuesto como barrera física para proporcionar una buena protección contra la corrosión en aplicaciones biomédicas.DoctoradoDoctor en Ingeniería -Ciencia y Tecnología de MaterialesMateriales Y Nanotecnología.Sede Medellín171 páginasapplication/pdfengUniversidad Nacional de ColombiaMedellín - Minas - Doctorado en Ingeniería - Ciencia y Tecnología de MaterialesFacultad de MinasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería660 - Ingeniería química::669 - MetalurgiaRevestimientos metálicosAleaciones de magnesioOxidación electrolíticaCorrosión electrolíticaBiotecnologíaBioingenieríaMateriales biomédicosImplantes ortopédicosMagnesium alloysSurface modificationDip coatingElectrolytic plasma oxidationAminated hydroxyethyl cellulosePolylactic acidCorrosion resistanceBiocompatibilityAleaciones de magnesioModificación de superficiesRecubrimiento por inmersiónOxidación electrolítica por plasmahidroxietilcelulosa aminadaÁcido polilácticoResistencia a la corrosiónBiocompatibilidadDevelopment of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applicationsDesarrollo de recubrimientos de hidroxietilcelulosa-aminada modificada con óxido de cerio para aleaciones de magnesio para uso en aplicaciones biomédicas.Trabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDLaReferencia[1] N. 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Castañeda-Rodríguez et al., “Recent advances in modified poly (lactic acid) as tissue engineering materials,” Journal of Biological Engineering 2023 17:1, vol. 17, no. 1, pp. 1–20, Mar. 2023, doi: 10.1186/S13036-023-00338-8.Ministerio de Ciencia, Tecnología e Innovación -MincienciasInvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86445/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1152200333.2024.pdf1152200333.2024.pdfTesis de doctorado en ingenieria Ciencia y Tecnología de Materialesapplication/pdf6552266https://repositorio.unal.edu.co/bitstream/unal/86445/2/1152200333.2024.pdfadb92b8391018821f4c17b8a622cf42eMD52CC-LICENSEU.FT.09.006.004 Licencia para publicación de obras en el Repositorio Institucional UNAL v4 (1) (1).pdfU.FT.09.006.004 Licencia para publicación de obras en el Repositorio Institucional UNAL v4 (1) 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Development of aminated-hydroxyethyl cellulose coatings modified with cerium oxide for magnesium alloys for biomedical applications

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