Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia

ilustraciones, diagramas, mapas

Autores:
Rodriguez Castro, Leidy Katherine
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86765
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86765
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::615 - Farmacología y terapéutica
Neuropsiquiatría
Prueba Serológica para COVID-19
Pandemias
Coronavirus
Portador Sano
Variantes Farmacogenómicas
Neuropsychiatry
COVID-19 Serological Testing
Pandemics
Coronavirus
Carrier State
Pharmacogenomic Variants
COVID-19
SARS-CoV-2
Variante
Genética
Población
PCR
COVID-19
SARS-CoV-2
Variant
Genetic
Population
PCR
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_61a6b172bd647e5865871bdd800ec889
oai_identifier_str oai:repositorio.unal.edu.co:unal/86765
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
dc.title.translated.eng.fl_str_mv Neuropsychiatric manifestations in people with positive SARS-CoV-2 test and their relationship with the variants rs430915 and rs11910678 in Bogotá, Colombia
title Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
spellingShingle Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::615 - Farmacología y terapéutica
Neuropsiquiatría
Prueba Serológica para COVID-19
Pandemias
Coronavirus
Portador Sano
Variantes Farmacogenómicas
Neuropsychiatry
COVID-19 Serological Testing
Pandemics
Coronavirus
Carrier State
Pharmacogenomic Variants
COVID-19
SARS-CoV-2
Variante
Genética
Población
PCR
COVID-19
SARS-CoV-2
Variant
Genetic
Population
PCR
title_short Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
title_full Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
title_fullStr Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
title_full_unstemmed Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
title_sort Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
dc.creator.fl_str_mv Rodriguez Castro, Leidy Katherine
dc.contributor.advisor.spa.fl_str_mv Arboleda Granados, Humberto
dc.contributor.author.spa.fl_str_mv Rodriguez Castro, Leidy Katherine
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::615 - Farmacología y terapéutica
topic 610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::615 - Farmacología y terapéutica
Neuropsiquiatría
Prueba Serológica para COVID-19
Pandemias
Coronavirus
Portador Sano
Variantes Farmacogenómicas
Neuropsychiatry
COVID-19 Serological Testing
Pandemics
Coronavirus
Carrier State
Pharmacogenomic Variants
COVID-19
SARS-CoV-2
Variante
Genética
Población
PCR
COVID-19
SARS-CoV-2
Variant
Genetic
Population
PCR
dc.subject.decs.spa.fl_str_mv Neuropsiquiatría
Prueba Serológica para COVID-19
Pandemias
Coronavirus
Portador Sano
Variantes Farmacogenómicas
dc.subject.decs.eng.fl_str_mv Neuropsychiatry
COVID-19 Serological Testing
Pandemics
Coronavirus
Carrier State
Pharmacogenomic Variants
dc.subject.proposal.spa.fl_str_mv COVID-19
SARS-CoV-2
Variante
Genética
Población
PCR
dc.subject.proposal.eng.fl_str_mv COVID-19
SARS-CoV-2
Variant
Genetic
Population
PCR
description ilustraciones, diagramas, mapas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-09-02T13:10:48Z
dc.date.available.none.fl_str_mv 2024-09-02T13:10:48Z
dc.date.issued.none.fl_str_mv 2024
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86765
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86765
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
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dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Arboleda Granados, Humberto9912a1c0969400ecbcae3ab2b5478d0eRodriguez Castro, Leidy Katherine317071fa173e149c0f26581627ddba922024-09-02T13:10:48Z2024-09-02T13:10:48Z2024https://repositorio.unal.edu.co/handle/unal/86765Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, mapasEl SARS-CoV-2, descubierto en Wuhan, China, en diciembre de 2019, es el virus responsable de la COVID-19. Esta enfermedad se convirtió rápidamente en una pandemia global, cobrando millones de vidas en todo el mundo. Aunque los síntomas primarios están asociados con los sistemas respiratorio y circulatorio, como pérdida del olfato o del gusto, fiebre, tos seca, dolor de cabeza, neumonía grave y trastornos de la coagulación, se ha observado que el virus también afecta a otros sistemas del cuerpo humano, esto se debe a la alta expresión de ACE2, proteína receptora que permite la entrada del coronavirus. Se ha observado la incidencia del virus en distintos sistemas, además del respiratorio, lo cual es algo de gran relevancia biomédica. Por lo tanto, es crucial investigar los cuadros Clínicos en diferentes sistemas del cuerpo humano y ver cómo pueden contribuir a diferentes manifestaciones neuropsiquiátricas. En este estudio se explorara la relación entre las variantes del gen TMPRSS2 (rs430915, 11910678) y la susceptibilidad de contraer COVID-19, así como su relación con diversas manifestaciones clínicas, especialmente a nivel neurológico, para esto se analizaron dos grupos de 43 individuos mayores de 18 años en Bogotá D.C: uno con prueba PCR COVID-19 positiva y otro sin síntomas ni prueba positiva para COVID-19 en las últimas 4 semanas. Los individuos positivos para SARS-CoV-2 se clasificarán en casos asintomáticos, leves y severos. A ambos grupos se les realizó una batería neuropsicológica y se les tomarán muestras de sangre para genotipificación mediante técnicas de biología molecular, buscando identificar la relación genética de las variantes del gen TMPRSS2 con contraer COVID-19, sintomatologías y el riesgo de desarrollar LONG-COVID (Texto tomado de la fuente).The SARS-CoV-2, discovered in Wuhan, China, in December 2019, is the virus responsible for COVID-19. This disease quickly became a global pandemic, claiming millions of lives worldwide. Although the primary symptoms are associated with the respiratory and circulatory systems, such as loss of smell or taste, fever, dry cough, headache, severe pneumonia, and coagulation disorders, it has been observed that the virus also affects other human body systems. This is due to the high expression of ACE2, the receptor protein that allows the entry of the coronavirus. The incidence of the virus in different systems, in addition to the respiratory system, is of great biomedical relevance. Therefore, it is crucial to investigate the clinical pictures in different human body systems and see how they can contribute to different neuropsychiatric manifestations. This study will explore the relationship between the variants of the TMPRSS2 gene (rs430915, 11910678) and the susceptibility to contract COVID-19, as well as its relationship with various clinical manifestations, especially at the neurological level. For this, two groups of 43 individuals over 18 years old in Bogotá D.C were analyzed: one with a positive PCR COVID-19 test and another without symptoms or a positive test for COVID-19 in the last 4 weeks. Individuals positive for SARS-CoV-2 will be classified into asymptomatic, mild, and severe cases. Both groups underwent a neuropsychological battery and blood samples will be taken for genotyping using molecular biology techniques, seeking to identify the genetic relationship of the TMPRSS2 gene variants with contracting COVID-19, symptoms, and the risk of developing LONG-COVID.MaestríaMagíster en NeurocienciasSe llevó a cabo un estudio observacional retrospectivo a conveniencia en un Grupo de Casos (antecedente de infección por SARS-CoV-2) y Grupo Control (sin antecedente de infección por SARS-CoV-2) con el objetivo de describir manifestaciones clínicas, con énfasis en síntomas de tipo neuropsiquiátrico, que puedan corresponder al LONG COVID (mediante pruebas de tamizaje y una batería neurocognitiva). Adicionalmente, se identificarán y correlacionarán variantes genéticas de TMPRSS2 (rs430915 y 11910678) en muestras de sangre venosa periférica de los participantes.Neurociencias Línea Neurogenéticaix, 68 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en NeurocienciasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - Enfermedades610 - Medicina y salud::615 - Farmacología y terapéuticaNeuropsiquiatríaPrueba Serológica para COVID-19PandemiasCoronavirusPortador SanoVariantes FarmacogenómicasNeuropsychiatryCOVID-19 Serological TestingPandemicsCoronavirusCarrier StatePharmacogenomic VariantsCOVID-19SARS-CoV-2VarianteGenéticaPoblaciónPCRCOVID-19SARS-CoV-2VariantGeneticPopulationPCRManifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, ColombiaNeuropsychiatric manifestations in people with positive SARS-CoV-2 test and their relationship with the variants rs430915 and rs11910678 in Bogotá, ColombiaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotáColombiaAdimulam, T.; Thilona, A.; Anmol, G. & Veron, R.: , 2023; Genetic variants within sars-cov-2 human receptor genes may contribute to variable disease outcomes in different ethnicities.; International Journal of Molecular Sciences; 24, no. 10: 8711; doi:https://doi.org/10.3390/ijms24108711.Albtoosh, A.S., T. 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E.: , 2022; Implications of the immune polymorphisms of the host and the genetic variability of sars-cov-2 in the development of covid-19.; Viruses; 14; doi:https://doi.org/10.3390/v14010094.EstudiantesGrupos comunitariosInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86765/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINALTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfTesis de Maestría en Neurocienciasapplication/pdf13735729https://repositorio.unal.edu.co/bitstream/unal/86765/2/Tesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfd5d051b6a61d4924b1a3dcc82c01210cMD52THUMBNAILTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdf.jpgTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdf.jpgGenerated 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