Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia
ilustraciones, diagramas, mapas
- Autores:
-
Rodriguez Castro, Leidy Katherine
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86765
- Palabra clave:
- 610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::615 - Farmacología y terapéutica
Neuropsiquiatría
Prueba Serológica para COVID-19
Pandemias
Coronavirus
Portador Sano
Variantes Farmacogenómicas
Neuropsychiatry
COVID-19 Serological Testing
Pandemics
Coronavirus
Carrier State
Pharmacogenomic Variants
COVID-19
SARS-CoV-2
Variante
Genética
Población
PCR
COVID-19
SARS-CoV-2
Variant
Genetic
Population
PCR
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.title.spa.fl_str_mv |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
dc.title.translated.eng.fl_str_mv |
Neuropsychiatric manifestations in people with positive SARS-CoV-2 test and their relationship with the variants rs430915 and rs11910678 in Bogotá, Colombia |
title |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
spellingShingle |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica Neuropsiquiatría Prueba Serológica para COVID-19 Pandemias Coronavirus Portador Sano Variantes Farmacogenómicas Neuropsychiatry COVID-19 Serological Testing Pandemics Coronavirus Carrier State Pharmacogenomic Variants COVID-19 SARS-CoV-2 Variante Genética Población PCR COVID-19 SARS-CoV-2 Variant Genetic Population PCR |
title_short |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
title_full |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
title_fullStr |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
title_full_unstemmed |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
title_sort |
Manifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, Colombia |
dc.creator.fl_str_mv |
Rodriguez Castro, Leidy Katherine |
dc.contributor.advisor.spa.fl_str_mv |
Arboleda Granados, Humberto |
dc.contributor.author.spa.fl_str_mv |
Rodriguez Castro, Leidy Katherine |
dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica |
topic |
610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica Neuropsiquiatría Prueba Serológica para COVID-19 Pandemias Coronavirus Portador Sano Variantes Farmacogenómicas Neuropsychiatry COVID-19 Serological Testing Pandemics Coronavirus Carrier State Pharmacogenomic Variants COVID-19 SARS-CoV-2 Variante Genética Población PCR COVID-19 SARS-CoV-2 Variant Genetic Population PCR |
dc.subject.decs.spa.fl_str_mv |
Neuropsiquiatría Prueba Serológica para COVID-19 Pandemias Coronavirus Portador Sano Variantes Farmacogenómicas |
dc.subject.decs.eng.fl_str_mv |
Neuropsychiatry COVID-19 Serological Testing Pandemics Coronavirus Carrier State Pharmacogenomic Variants |
dc.subject.proposal.spa.fl_str_mv |
COVID-19 SARS-CoV-2 Variante Genética Población PCR |
dc.subject.proposal.eng.fl_str_mv |
COVID-19 SARS-CoV-2 Variant Genetic Population PCR |
description |
ilustraciones, diagramas, mapas |
publishDate |
2024 |
dc.date.accessioned.none.fl_str_mv |
2024-09-02T13:10:48Z |
dc.date.available.none.fl_str_mv |
2024-09-02T13:10:48Z |
dc.date.issued.none.fl_str_mv |
2024 |
dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86765 |
dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
url |
https://repositorio.unal.edu.co/handle/unal/86765 https://repositorio.unal.edu.co/ |
identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
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Cerda, J.; Vera, C. & Rada, G.: , 2013; Odds ratio: aspectos teóricos y prácticos.; Revista médica de Chile; 141, 10; doi: https://dx.doi.org/10.4067/S0034-98872013001000014. Chen, Y.; Lee, M.and Lucht, A.; Chou, F.; Huang, W.; Havighurst, T.and Kim, K.; Wang, J.; Antalis, T.; Johnson, M. & Lin, C.: , 2010; Tmprss2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.; Am J Pathol. PMID: 20382709; PMCID: PMC2877858.; 176(6):2986-96; doi:doi:10.2353/ajpath.2010.090665. Chou, S. H.; Beghi, E.; Helbok, R.; Moro, E.; Sampson, J.; Altamirano, V. et al.: , 2021; Global incidence of neurological manifestations among patients hospitalized with covid-19-a report for the gcs-neurocovid consortium and the energy consortium; JAMA Netw Open; 4: 5. Cicero, A. & Phelan, A.: , 2024; A pandemic agreement is within reach; Science; 384, Issue 6695, p. 489; doi:DOI:10.1126/science. adq1055. Colling, M. E. & associated coagulopathy, K. Y. C.-.: , 2020; An exploration of mechanisms; Vasc Med; 25 (5): 471--8. Connors, J. M.; Brooks, M. M.; Sciurba, F. C.; Krishnan, J. A.; Bledsoe, J. R.; Kindzelski, A. et al.: , 2021; Effect of antithrombotic therapy on clinical outcomes in outpatients with clinically stable symptomatic covid-19: The activ-4b randomized clinical trial; JAMA; 326 (17): 1703--12. Consortium, T. U.: , 2022; Uniprot: the universal protein knowledgebase in 2023; Nucleic Acids Research; 51(D1-6), D523–D531; doi:https://doi.org/10.1093/nar/gkac1052. Coto, E.; Albaiceta, G. M.; Amado-Rodriguez, L.; Garcia-Clemente, M.; Cuesta-Llavona, E.; Vazquez-Coto, D. et al.: , 2022; Furin gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe covid-19; J Med Virol; 94 (8): 3589--95. Cotroneo, C.; Mangano, N.; Dragani, T. & Colombo, F.: , 2021; Lung expression of genes putatively involved in sars-cov-2 infection is modulated in cis by germline variants.; Eur J Hum Genet. 2021 Jun;29(6):1019-1026. PMID: 33649539; PMCID: PMC7917374.; doi:doi:10.1038/s41431-021-00831-y. Dominguez-Lara, S.: , 2018; El odds ratio y su interpretación como magnitud del efecto en investigación.; Educación Médica; 19, 1; doi:doi:10.1016/j.edumed.2017.01.008. Duman, N.; Tuncel, G.; Bisgin, A. & et al.: , 2022; Analysis of ace2 and tmprss2 coding variants as a risk factor for sars-cov-2 from 946 whole-exome sequencing data in the turkish population.; J Med Virol; 94: 5225-5243.; doi:doi:10.1002/jmv.27976. FJ., C.-A.: , 2020; Neurological complications of coronavirus and covid-19; Rev Neurol; 70 (9): 311--22. Fox, J.: , 2022; polycor: Polychoric and Polyserial Correlations; R; URL https://CRAN.R-project.org/package=polycor; r package version 0.8-1. Goncalves de Andrade, E.; Simoncicova, E.; Carrier, M.; Vecchiarelli, H. A.; Robert, M. E. & ME., T.: , 2021; Microglia fighting for neurological and mental health: On the central nervous system frontline of covid-19 pandemic; Front Cell Neurosci; 15 (64737): 8. Gupta, A.; Madhavan, M. V.; Sehgal, K.; Nair, N.; Mahajan, S.; Sehrawat, T. S. et al.: , 2020; Extrapulmonary manifestations of covid-19; Nat Med; 26 (7): 1017--32. Gupta, K.; Toelzer, C.; Williamson, M. K.; Shoemark, D. K.; Asf, O.; Matthews, D. A. et al.: , 2022; Structural insights in cell-type specific evolution of intra-host diversity by sars-cov-2; Nat Commun; 13: 1. Hampshire, A.; Trender, W.; Chamberlain, S. R.; Jolly, A. E.; Grant, J. E.; Patrick, F. et al.: , 2021; Cognitive deficits in people who have recovered from covid-19; EClinicalMedicine; 39 (10104): 4. Helms, J.; Kremer, S.; Merdji, H.; Clere-Jehl, R.; Schenck, M.; Kummerlen, C. et al.: , 2020; Neurologic features in severe sars-cov-2 infection; N Engl J Med; 382 (23): 2268--70. Herrmann, J.; Mori, V.; Jht, B. & Suki, B.: , 2020; Modeling lung perfusion abnormalities to explain early covid-19 hypoxemia; Nat Commun; 11: 1. Kanberg, N.; Simren, J.; Eden, A.; Andersson, L. M.; Nilsson, S.; Ashton, N. J. et al.: , 2021; Neurochemical signs of astrocytic and neuronal injury in acute covid-19 normalizes during long-term follow-up; EBioMedicine; 70 (10351): 2. Kouhpayeh, H. R.; Tabasi, F.; Dehvari, M.; Naderi, M.; Bahari, G.; Khalili, T. et al.: , 2021; Association between angiotensinogen (agt), angiotensin-converting enzyme (ace) and angiotensin-ii receptor 1 (agtr1) polymorphisms and covid-19 infection in the southeast of iran: a preliminary case-control study; Transl Med Commun; 6: 1. Li, F.; Han, M.; Dai, P.; Xu, W.; He, J.; Tao, X. et al.: , 2021a; Distinct mechanisms for tmprss2 expression explain organ-specific inhibition of sars-cov-2 infection by enzalutamide; Nat Commun; 12: 1. Li, Y.; Ke, Y.; Xia, X.; Wang, Y.; Cheng, F.; Liu, X.; Jin, X.; Li, B.; Xie, C.; Liu, S.; Chen, W.; Yang, C.; Niu, Y.; Jia, R.; Chen, Y.; Liu, X.; Wang, Z.; Zheng, F.; Jin, Y.; Li, Z.; Yang, N.; Cao, P.; Chen, H.; Ping, J. & Zhou, G.: , 2021b; Genome-wide association study of covid-19 severity among the chinese population.; Cell Discovery; 7, 76; doi: https://doi.org/10.1038/s41421-021-00318-6. Lin, Y.; Yang, B.; Cobey, S.; Ehy, L.; Adam, D. C.; Wong, J. Y. et al.: , 2022; Incorporating temporal distribution of population-level viral load enables real-time estimation of covid-19 transmission; Nat Commun; 13: 1. Liu, L.; Ni, S. Y.; Yan, W.; Lu, Q. D.; Zhao, Y. M.; Xu, Y. Y. et al.: , 2021; Mental and neurological disorders and risk of covid-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action; EClinicalMedicine; 40 (10111): 1. Manterola, C.; Quiroz, G.; Salazar, P. & García, N.: , 2019; Metodología de los tipos y diseños de estudio más frecuentemente utilizados en investigación clínica; Revista Médica Clínica Las Condes; 30, 1; doi:https://doi.org/10.1016/j.rmclc.2018.11.005. Mantilla-Morales, A.: , 2020; ¿la mayor susceptibilidad de los hombres a covid-19 se puede atribuir a la proteasa transmembrana de serina 2?; Gaceta médica de México; 156, 5; doi:https://doi.org/10.24875/gmm.20000504. Mao, L.; Jin, H.; Wang, M.; Hu, Y.; Chen, S.; He, Q. et al.: , 2020; Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in wuhan, china; JAMA Neurol; 77 (6): 683--90. Mazza, M. G.; Palladini, M.; De Lorenzo, R.; Magnaghi, C.; Poletti, S.; Furlan, R. et al.: , 2021; Persistent psychopathology and neurocognitive impairment in covid-19 survivors: Effect of inflammatory biomarkers at three-month follow-up; Brain Behav Immun; 94: 138--47. Meduri, A.; Oliverio, G. W.; Mancuso, G.; Giuffrida, A.; Guarneri, C.; Venanzi Rullo, E. et al.: , 2020; Ocular surface manifestation of covid-19 and tear film analysis; Sci Rep; 10: 1. Mehandru, S. & Merad, M.: , 2022; Pathological sequelae of long-haul covid; Nat Immunol; 23 (2): 194--202. Nadim, M. K.; Forni, L. G.; Mehta, R. L.; Mj; Liu, K. D.; Ostermann, M. et al.: , 2020; Covid-19-associated acute kidney injury: consensus report of the 25th acute disease quality initiative (adqi) workgroup; Nat Rev Nephrol; 16 (12): 747--64. NIH, N. I. o. H.: , 2023; Shining a light on long covid brain fog; URL https://covid19.nih.gov/news-and-stories/ shining-light-long-covid-brain-fog; news and Stories. NIH-NCBI: , 2024; Tmprss2 transmembrane serine protease 2 [ homo sapiens (human) ]; URL https://www.ncbi.nlm.nih.gov/gene/7113; gene ID: 7113, updated on 7-Jan-2024. of the International Committee on Taxonomy of V, C. S. G.: , 2020; The species severe acute respiratory syndrome-related coronavirus: classifying 2019-ncov and naming it sars-cov-2.; Nat Microbiol; 5 (4): 536--44. Pastrian-Soto, G.: , 2020; Bases genéticas y moleculares del covid-19 (sars-cov-2); Mecanismos de Patogénesis y de Respuesta Inmune. International journal of odontostomatology; 14: 331--7. Paul, S. & Lorin, E.: , 2021; Distribution of incubation periods of covid-19 in the canadian context; Sci Rep; 11: 1. Petrelis, A. M.; Stathopoulou, M. G.; Kafyra, M.; Murray, H.; Masson, C.; Lamont, J. et al.: , 2022; Vegf-a-related genetic variants protect against alzheimer’s disease; Aging (Albany NY); 14 (6): 2524--36. Pirraglia, M. P.; Ceccarelli, G.; Cerini, A.; Visioli, G.; d’Ettorre, G.; Mastroianni, C. M. et al.: , 2020; Retinal involvement and ocular findings in covid-19 pneumonia patients; Sci Rep; 10: 1. ProteinAtlas, T. H. P. A.: , 2023; Tmprss2; URL https://www.proteinatlas.org/ENSG00000184012-TMPRSS2/tissue; protein Atlas version 23.0, Release date: 2023.06.19, Ensembl version: 109. Purcell, S.; Neale, B.; Todd-Brown, K.; Thomas, L.; Ferreira, M.; Bender, D.; Maller, J.; Sklar, P.; de Bakker, P.; Daly, M. & Sham, P.: , 2007; Plink: a tool set for whole-genome association and population-based linkage analyses.; American Journal of Human Genetics; 81, 3; doi:https://doi.org/10.1086/519795. R Core Team: , 2023; R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing; Vienna, Austria; URL https://www.R-project.org/. Ramos-Casals, M.; Brito-Zeron, P. & and, M. X. S.: , 2021; and organ-specific immune-related manifestations of covid-19; Nat Rev Rheumatol; 17 (6): 315--32. Rando, H. M.; Bennett, T. D.; Byrd, J. B.; Bramante, C.; Callahan, T. J.; Chute, C. G. et al.: , 2021; Challenges in defining Long COVID: Striking differences across literature; Electronic Health Records and patient-reported information. medRxiv. Rodriguez-Quiroga, A.; Buiza, C.; Maa, M. & Quintero, J.: , 2020; [update on covid-19 and mental health]; Medicine (Madr); 13 (23): 1285--96. Sahebnasagh, A.; Nabavi, S. M.; Hrk, K.; Abdollahian, S.; Habtemariam, S. & agents, R. A. A.-V.: , 2021; As appealing targets in the setting of covid-19 treatment in critically ill patients; Int Immunopharmacol; 101. Senapati, S., K.-S. S. A. e. a.: , 2020; Assessment of risk conferred by coding and regulatory variations of tmprss2 and cd26 in susceptibility to sars-cov-2 infection in human.; Journal of Genetics; 99, 53; doi:https://doi.org/10.1007/s12041-020-01217-7. Sharma, A.; Ahmad-Farouk, I. & Lal, S.: , 2021a; Covid-19: A review on the novel coronavirus disease evolution, transmission, detection, control and prevention.; Viruses; 13(2) (202): 1--25. Sharma, A.; Ahmad Farouk, I. & Lal SK. Covid-19:, A.: , 2021b; Review on the novel coronavirus disease evolution, transmission, detection, control and prevention; Viruses; 13: 2. Stevenson, M.; Sergeant, E. & Firestone, S.: , 2024; epiR: Tools for the Analysis of Epidemiological Data; URL https: //CRAN.R-project.org/package=epiR; r package version 2.0.67. Takahashi, Y.; Hayakawa, A.; Sano, R.; Fukuda, H.; Harada, M.; Kubo, R. et al.: , 2021; Histone deacetylase inhibitors suppress ace2 and abo simultaneously, suggesting a preventive potential against covid-19; Sci Rep; 11: 1. Wang, W.; Tang, J. & Wei, F.: , 2020; Updated understanding of the outbreak of 2019 novel coronavirus (2019-ncov) in wuhan, china; J Med Virol; 92 (4): 441--7. Wettstein, L.; Kirchhoff, F. & Münch, J.: , 2022; The transmembrane protease tmprss2 as a therapeutic target for covid-19 treatment.; Int J Mol Sci. PMID: 35163273; PMCID: PMC8836196.; 25;23(3):1351.; doi:doi:10.3390/ijms23031351. Wickman, H.: , 2016; ggplot2: Elegant Graphics for Data Analysis.; Springer-Verlag, New York. isbn 978-3-319-24277-4.; URL https://ggplot2.tidyverse.org. Xie, Y.; Xu, E.; Bowe, B. & Al-Aly, Z.: , 2022; Long-term cardiovascular outcomes of covid-19; Nat Med; 28 (3): 583--90. Yende, S. & and, P. C. L. C.: , 2021; and kidney disease; Nat Rev Nephrol; 17 (12): 792--3. Yuan, Y.; Cao, D.; Zhang, Y.; Ma, J.; Qi, J.; Wang, Q. et al.: , 2017; Cryo-em structures of mers-cov and sars-cov spike glycoproteins reveal the dynamic receptor binding domains; Nature Communications; 8: 15092. Zepeda-Cervantes, J.; Martínez-Flores, D.; Ramírez-Jarquín, J. O.; Tecalco-Cruz, C.; Alavez-Pérez, N. S.; Vaca, L. & Sarmiento-Silva, R. E.: , 2022; Implications of the immune polymorphisms of the host and the genetic variability of sars-cov-2 in the development of covid-19.; Viruses; 14; doi:https://doi.org/10.3390/v14010094. |
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ix, 68 páginas |
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Bogotá |
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Colombia |
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Universidad Nacional de Colombia |
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Bogotá - Medicina - Maestría en Neurociencias |
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Facultad de Medicina |
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Bogotá, Colombia |
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Universidad Nacional de Colombia - Sede Bogotá |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Arboleda Granados, Humberto9912a1c0969400ecbcae3ab2b5478d0eRodriguez Castro, Leidy Katherine317071fa173e149c0f26581627ddba922024-09-02T13:10:48Z2024-09-02T13:10:48Z2024https://repositorio.unal.edu.co/handle/unal/86765Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, mapasEl SARS-CoV-2, descubierto en Wuhan, China, en diciembre de 2019, es el virus responsable de la COVID-19. Esta enfermedad se convirtió rápidamente en una pandemia global, cobrando millones de vidas en todo el mundo. Aunque los síntomas primarios están asociados con los sistemas respiratorio y circulatorio, como pérdida del olfato o del gusto, fiebre, tos seca, dolor de cabeza, neumonía grave y trastornos de la coagulación, se ha observado que el virus también afecta a otros sistemas del cuerpo humano, esto se debe a la alta expresión de ACE2, proteína receptora que permite la entrada del coronavirus. Se ha observado la incidencia del virus en distintos sistemas, además del respiratorio, lo cual es algo de gran relevancia biomédica. Por lo tanto, es crucial investigar los cuadros Clínicos en diferentes sistemas del cuerpo humano y ver cómo pueden contribuir a diferentes manifestaciones neuropsiquiátricas. En este estudio se explorara la relación entre las variantes del gen TMPRSS2 (rs430915, 11910678) y la susceptibilidad de contraer COVID-19, así como su relación con diversas manifestaciones clínicas, especialmente a nivel neurológico, para esto se analizaron dos grupos de 43 individuos mayores de 18 años en Bogotá D.C: uno con prueba PCR COVID-19 positiva y otro sin síntomas ni prueba positiva para COVID-19 en las últimas 4 semanas. Los individuos positivos para SARS-CoV-2 se clasificarán en casos asintomáticos, leves y severos. A ambos grupos se les realizó una batería neuropsicológica y se les tomarán muestras de sangre para genotipificación mediante técnicas de biología molecular, buscando identificar la relación genética de las variantes del gen TMPRSS2 con contraer COVID-19, sintomatologías y el riesgo de desarrollar LONG-COVID (Texto tomado de la fuente).The SARS-CoV-2, discovered in Wuhan, China, in December 2019, is the virus responsible for COVID-19. This disease quickly became a global pandemic, claiming millions of lives worldwide. Although the primary symptoms are associated with the respiratory and circulatory systems, such as loss of smell or taste, fever, dry cough, headache, severe pneumonia, and coagulation disorders, it has been observed that the virus also affects other human body systems. This is due to the high expression of ACE2, the receptor protein that allows the entry of the coronavirus. The incidence of the virus in different systems, in addition to the respiratory system, is of great biomedical relevance. Therefore, it is crucial to investigate the clinical pictures in different human body systems and see how they can contribute to different neuropsychiatric manifestations. This study will explore the relationship between the variants of the TMPRSS2 gene (rs430915, 11910678) and the susceptibility to contract COVID-19, as well as its relationship with various clinical manifestations, especially at the neurological level. For this, two groups of 43 individuals over 18 years old in Bogotá D.C were analyzed: one with a positive PCR COVID-19 test and another without symptoms or a positive test for COVID-19 in the last 4 weeks. Individuals positive for SARS-CoV-2 will be classified into asymptomatic, mild, and severe cases. Both groups underwent a neuropsychological battery and blood samples will be taken for genotyping using molecular biology techniques, seeking to identify the genetic relationship of the TMPRSS2 gene variants with contracting COVID-19, symptoms, and the risk of developing LONG-COVID.MaestríaMagíster en NeurocienciasSe llevó a cabo un estudio observacional retrospectivo a conveniencia en un Grupo de Casos (antecedente de infección por SARS-CoV-2) y Grupo Control (sin antecedente de infección por SARS-CoV-2) con el objetivo de describir manifestaciones clínicas, con énfasis en síntomas de tipo neuropsiquiátrico, que puedan corresponder al LONG COVID (mediante pruebas de tamizaje y una batería neurocognitiva). Adicionalmente, se identificarán y correlacionarán variantes genéticas de TMPRSS2 (rs430915 y 11910678) en muestras de sangre venosa periférica de los participantes.Neurociencias Línea Neurogenéticaix, 68 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en NeurocienciasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - Enfermedades610 - Medicina y salud::615 - Farmacología y terapéuticaNeuropsiquiatríaPrueba Serológica para COVID-19PandemiasCoronavirusPortador SanoVariantes FarmacogenómicasNeuropsychiatryCOVID-19 Serological TestingPandemicsCoronavirusCarrier StatePharmacogenomic VariantsCOVID-19SARS-CoV-2VarianteGenéticaPoblaciónPCRCOVID-19SARS-CoV-2VariantGeneticPopulationPCRManifestaciones neuropsiquiátricas en personas con prueba SARS-CoV-2 positiva y su relación con las variantes rs430915 y rs11910678 en Bogotá, ColombiaNeuropsychiatric manifestations in people with positive SARS-CoV-2 test and their relationship with the variants rs430915 and rs11910678 in Bogotá, ColombiaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotáColombiaAdimulam, T.; Thilona, A.; Anmol, G. & Veron, R.: , 2023; Genetic variants within sars-cov-2 human receptor genes may contribute to variable disease outcomes in different ethnicities.; International Journal of Molecular Sciences; 24, no. 10: 8711; doi:https://doi.org/10.3390/ijms24108711.Albtoosh, A.S., T. 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E.: , 2022; Implications of the immune polymorphisms of the host and the genetic variability of sars-cov-2 in the development of covid-19.; Viruses; 14; doi:https://doi.org/10.3390/v14010094.EstudiantesGrupos comunitariosInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86765/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINALTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfTesis de Maestría en Neurocienciasapplication/pdf13735729https://repositorio.unal.edu.co/bitstream/unal/86765/2/Tesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdfd5d051b6a61d4924b1a3dcc82c01210cMD52THUMBNAILTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdf.jpgTesis_Trabajo_Final_UNAL_Leidy_Katherine_Rodriguez_Castro_2024.pdf.jpgGenerated 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