Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes
ilustraciones, diagramas, figuras
- Autores:
-
Martin Neira, Valentyna
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/85489
- Palabra clave:
- 150 - Psicología::152 - Percepción sensorial, movimiento, emociones, impulsos fisiológicos
150 - Psicología::155 - Psicología diferencial y del desarrollo
300 - Ciencias sociales::302 - Interacción social
570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
590 - Animales::599 - Mamíferos
Interacción social
Aprendizaje -- Aspectos fisiológicos
Neuropsicología
Social interaction
Learning-Physiological aspects
Neuropsychology
Receptores de Oxitocina
Neurociencia Cognitiva
Receptors, Oxytocin
Cognitive Neuroscience
Psicología aplicada
Pruebas psicológicas para animales
Diagnóstico conductual
Neuropsicología-Pruebas
Psychology, applied
Animals - psychological testing
Neuropsychology - testing
Aislamiento
Oxitocina
Tirosina Hidroxilasa
Interacción social
Isolation
Oxytocin
Tyrosine Hydroxylase
Social Interaction
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| dc.title.translated.eng.fl_str_mv |
Effects of early social isolation on brain reward circuit activity and social interaction in adolescent rats |
| title |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| spellingShingle |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes 150 - Psicología::152 - Percepción sensorial, movimiento, emociones, impulsos fisiológicos 150 - Psicología::155 - Psicología diferencial y del desarrollo 300 - Ciencias sociales::302 - Interacción social 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales 590 - Animales::599 - Mamíferos Interacción social Aprendizaje -- Aspectos fisiológicos Neuropsicología Social interaction Learning-Physiological aspects Neuropsychology Receptores de Oxitocina Neurociencia Cognitiva Receptors, Oxytocin Cognitive Neuroscience Psicología aplicada Pruebas psicológicas para animales Diagnóstico conductual Neuropsicología-Pruebas Psychology, applied Animals - psychological testing Neuropsychology - testing Aislamiento Oxitocina Tirosina Hidroxilasa Interacción social Isolation Oxytocin Tyrosine Hydroxylase Social Interaction |
| title_short |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| title_full |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| title_fullStr |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| title_full_unstemmed |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| title_sort |
Efectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentes |
| dc.creator.fl_str_mv |
Martin Neira, Valentyna |
| dc.contributor.advisor.none.fl_str_mv |
Lamprea Rodríguez, Marisol Cortes Patiño, Diana Milena |
| dc.contributor.author.none.fl_str_mv |
Martin Neira, Valentyna |
| dc.contributor.researchgroup.spa.fl_str_mv |
Neuropsicología básica y cognoscitiva |
| dc.contributor.orcid.spa.fl_str_mv |
Martin Neira, Valentyna [0000000217116929] |
| dc.subject.ddc.spa.fl_str_mv |
150 - Psicología::152 - Percepción sensorial, movimiento, emociones, impulsos fisiológicos 150 - Psicología::155 - Psicología diferencial y del desarrollo 300 - Ciencias sociales::302 - Interacción social 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales 590 - Animales::599 - Mamíferos |
| topic |
150 - Psicología::152 - Percepción sensorial, movimiento, emociones, impulsos fisiológicos 150 - Psicología::155 - Psicología diferencial y del desarrollo 300 - Ciencias sociales::302 - Interacción social 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales 590 - Animales::599 - Mamíferos Interacción social Aprendizaje -- Aspectos fisiológicos Neuropsicología Social interaction Learning-Physiological aspects Neuropsychology Receptores de Oxitocina Neurociencia Cognitiva Receptors, Oxytocin Cognitive Neuroscience Psicología aplicada Pruebas psicológicas para animales Diagnóstico conductual Neuropsicología-Pruebas Psychology, applied Animals - psychological testing Neuropsychology - testing Aislamiento Oxitocina Tirosina Hidroxilasa Interacción social Isolation Oxytocin Tyrosine Hydroxylase Social Interaction |
| dc.subject.lcc.spa.fl_str_mv |
Interacción social Aprendizaje -- Aspectos fisiológicos Neuropsicología |
| dc.subject.lcc.eng.fl_str_mv |
Social interaction Learning-Physiological aspects Neuropsychology |
| dc.subject.decs.spa.fl_str_mv |
Receptores de Oxitocina Neurociencia Cognitiva |
| dc.subject.decs.eng.fl_str_mv |
Receptors, Oxytocin Cognitive Neuroscience |
| dc.subject.lemb.spa.fl_str_mv |
Psicología aplicada Pruebas psicológicas para animales Diagnóstico conductual Neuropsicología-Pruebas |
| dc.subject.lemb.eng.fl_str_mv |
Psychology, applied Animals - psychological testing Neuropsychology - testing |
| dc.subject.proposal.spa.fl_str_mv |
Aislamiento Oxitocina Tirosina Hidroxilasa Interacción social |
| dc.subject.proposal.eng.fl_str_mv |
Isolation Oxytocin Tyrosine Hydroxylase Social Interaction |
| description |
ilustraciones, diagramas, figuras |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2024-01-29T19:16:24Z |
| dc.date.available.none.fl_str_mv |
2024-01-29T19:16:24Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/85489 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/85489 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
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Proceedings of the National Academy of Sciences of the United States of America, 106, 7281-7288. |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lamprea Rodríguez, Marisola14f7906338f9d662885067f2e6abfe0Cortes Patiño, Diana Milenaa51b40b176c12ba318da04a51cc191e6Martin Neira, Valentyna90af0794efd1570676c05d44c961d678Neuropsicología básica y cognoscitivaMartin Neira, Valentyna [0000000217116929]2024-01-29T19:16:24Z2024-01-29T19:16:24Z2023https://repositorio.unal.edu.co/handle/unal/85489Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, figurasSe ha demostrado que el circuito de recompensa cerebral continúa en desarrollo durante la adolescencia y es sensible al estrés y las condiciones ambientales a las que son expuestos los animales. El aislamiento social temprano ha mostrado afectar el adecuado desarrollo cerebral de los individuos y aumentar la sensibilidad a las propiedades de incentivo de la interacción social. El presente estudio tuvo como objetivo determinar los efectos del aislamiento social posterior al destete en la actividad de la dopamina y la oxitocina cerebral y en el establecimiento de la preferencia de lugar condicionada por interacción social en ratas macho adolescentes. Se criaron 63 ratas Wistar en la condición de grupo o aislamiento social, y se entrenaron en el paradigma de preferencia de lugar condicionado, utilizando el acceso a interacción social como incentivo. Para las medidas fisiológicas, se obtuvo el tejido cerebral de un grupo de animales el último día de entrenamiento y se evalúo mediante inmunofluorescencia la actividad de la dopamina cerebral con el indicador de Tirosina Hidroxilasa en el Área Tegmental ventral y la actividad de la oxitocina cerebral en el Núcleo Paraventricular del Hipotálamo. Se encontró que los animales alojados en aislamiento mostraron mayor preferencia por lugares asociados a la interacción social y aumentaron el tiempo dedicado a las conductas de juego social. Por otro lado, el aislamiento social disminuyó la cantidad de células positivas para oxitocina en el núcleo paraventricular del hipotálamo y aumentó la cantidad de tirosina hidroxilasa disponible en el área tegmental ventral. Nuestros resultados sugieren que la crianza en aislamiento social aumentó la sensibilidad de los animales a las propiedades de incentivó de la interacción social y alteró los patrones de interacción social, aumentando el juego y disminuyendo la investigación social. Sugerimos que el aumento en las conductas de juego y en sensibilidad a las propiedades de incentivo de la interacción social podría deberse al aumento en la cantidad de tirosina hidroxilasa en el VTA y la disminución en las conductas de investigación podría deberse a la reducción de la actividad de la oxitocina cerebral. (Texto tomado de la fuente)It has been demonstrated that the brain's reward circuitry continues to develop during adolescence and is sensitive to stress and environmental conditions to which animals are exposed. Early social isolation has been shown to affect the proper brain development of individuals and increase sensitivity to the rewarding properties of social interaction. The present study aimed to determine the effects of post-weaning social isolation on dopamine and brain oxytocin activity, as well as on the establishment of socially conditioned place preference in adolescent male rats. Sixty-three Wistar rats were raised either in group conditions or subjected to social isolation. They were trained in a conditioned place preference paradigm using access to social interaction as the incentive stimulus. For physiological measurements, brain tissue was obtained from a group of animals on the last day of training, and the activity of brain dopamine was assessed using Tyrosine Hydroxylase immunofluorescence in the Ventral Tegmental Area, and the activity of brain oxytocin was evaluated in the Paraventricular Nucleus of the Hypothalamus. It was found that animals housed in isolation exhibited a stronger preference for locations associated with social interaction and increased the time dedicated to social play behaviors. Conversely, social isolation reduced the number of oxytocin-positive cells in the paraventricular nucleus of the hypothalamus and increased the amount of available tyrosine hydroxylase in the ventral tegmental area. Our findings suggest that upbringing in social isolation heightened animals' sensitivity to the rewarding properties of social interaction and altered patterns of social engagement, promoting more play, and decreasing social investigation behaviors. We propose that the increase in play behaviors and sensitivity to the rewarding properties of social interaction could be attributed to the elevated levels of tyrosine hydroxylase in the ventral tegmental area, while the decrease in investigative behaviors might be linked to reduced brain oxytocin activity.Ministerio de Ciencia, Tecnología e Innovación (Minciencias #835/2019)Universidad Nacional de ColombiaMaestríaMagíster en PsicologíaExperimentalPsicología Básicax, 102 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias Humanas - Maestría en PsicologíaFacultad de Ciencias HumanasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá150 - Psicología::152 - Percepción sensorial, movimiento, emociones, impulsos fisiológicos150 - Psicología::155 - Psicología diferencial y del desarrollo300 - Ciencias sociales::302 - Interacción social570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales590 - Animales::599 - MamíferosInteracción socialAprendizaje -- Aspectos fisiológicosNeuropsicologíaSocial interactionLearning-Physiological aspectsNeuropsychologyReceptores de OxitocinaNeurociencia CognitivaReceptors, OxytocinCognitive NeurosciencePsicología aplicadaPruebas psicológicas para animalesDiagnóstico conductualNeuropsicología-PruebasPsychology, appliedAnimals - psychological testingNeuropsychology - testingAislamientoOxitocinaTirosina HidroxilasaInteracción socialIsolationOxytocinTyrosine HydroxylaseSocial InteractionEfectos del aislamiento social temprano sobre la actividad del circuito de recompensa cerebral y la interacción social en ratas adolescentesEffects of early social isolation on brain reward circuit activity and social interaction in adolescent ratsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMColombiaAdvani, T., Hensler, J. 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Proceedings of the National Academy of Sciences of the United States of America, 106, 7281-7288.Evaluación conductual y neurobiológica del estrés social temprano como modulador de la interacción entre nicotina y refuerzo social en ratas adolescentesMinisterio de Ciencia, Tecnología e InnovaciónEstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85489/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53ORIGINAL1013679673.2023.pdf1013679673.2023.pdfTesis de Maestría en Psicologíaapplication/pdf1885888https://repositorio.unal.edu.co/bitstream/unal/85489/4/1013679673.2023.pdff9930d80ec011c1f76b6b914391d6b64MD54THUMBNAIL1013679673.2023.pdf.jpg1013679673.2023.pdf.jpgGenerated Thumbnailimage/jpeg3868https://repositorio.unal.edu.co/bitstream/unal/85489/5/1013679673.2023.pdf.jpgcbdc6b526bea534b0679ac13b8aa24a8MD55unal/85489oai:repositorio.unal.edu.co:unal/854892024-01-29 23:03:52.238Repositorio Institucional Universidad Nacional de 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