Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia

fotografías a color, gráficos, ilustraciones, tablas

Autores:
Bonilla Moncada, Jennifer Marcela
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82260
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82260
https://repositorio.unal.edu.co/
Palabra clave:
Beauty, personal
Cosmética
Belleza personal
Beauty culture
Biopolímeros
Infecciones
Autoinmunidad
Subpoblaciones celulares
BAFF
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_603e7a3c641693080102778f080045d8
oai_identifier_str oai:repositorio.unal.edu.co:unal/82260
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
dc.title.translated.eng.fl_str_mv Identification of infections and immunological changes in patients with adverse with adverse reactions to the use of modeling substances in the city of cali city of Cali, Colombia
title Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
spellingShingle Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
Beauty, personal
Cosmética
Belleza personal
Beauty culture
Biopolímeros
Infecciones
Autoinmunidad
Subpoblaciones celulares
BAFF
title_short Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
title_full Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
title_fullStr Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
title_full_unstemmed Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
title_sort Identificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali Colombia
dc.creator.fl_str_mv Bonilla Moncada, Jennifer Marcela
dc.contributor.advisor.none.fl_str_mv Moreno Castañeda, Jaime Enrique
Leal Castro, Aura Lucia
Arturo, Jhan
dc.contributor.author.none.fl_str_mv Bonilla Moncada, Jennifer Marcela
dc.contributor.researchgroup.spa.fl_str_mv Microbiología Instituto Nacional de Salud
dc.subject.armarc.eng.fl_str_mv Beauty, personal
topic Beauty, personal
Cosmética
Belleza personal
Beauty culture
Biopolímeros
Infecciones
Autoinmunidad
Subpoblaciones celulares
BAFF
dc.subject.lemb.spa.fl_str_mv Cosmética
Belleza personal
dc.subject.lemb.eng.fl_str_mv Beauty culture
dc.subject.proposal.spa.fl_str_mv Biopolímeros
Infecciones
Autoinmunidad
Subpoblaciones celulares
BAFF
description fotografías a color, gráficos, ilustraciones, tablas
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-09-06T15:35:44Z
dc.date.available.none.fl_str_mv 2022-09-06T15:35:44Z
dc.date.issued.none.fl_str_mv 2022-08-17
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82260
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82260
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Riascos A., “Las tragedias diarias de pacientes por uso de biopolímeros en Cali”. Diario el tiempo, Bogotá. 26.07.2018. 29.10.2019. Disponible en: https://www.eltiempo.com/colombia/cali/los-repetidos-dramas-de-pacientes-por-uso- de- biopolimeros-en-cali-248100
Coiffman F. Alogenosis iatrogénica. Una nueva enfermedad. Cir Plast Ibero-Latinoamericana. 2008;34(1):1–8.
Stanford, N., & Montealegre, G. (2013). Alogenosis iatrogénica, hallazgos de una enfermedad reumática. Revista Colombiana de Cirugía Plástica y Reconstructiva, 19(1),28–38
Ricaurte AI, Forense M, Castaño DA, Castro JA, Paz DA De, Echeverry DA. Alogenosis iatrogénica vs . alogenosis secundaria en Cali , Colombia . 2016;0684.
Gordillo-Hernández J., Alegre-Tamez E., Torres-Baltazar I., Mendieta-EspinosaM.J., Sastré-Ortiz N.. Abordaje ultidisciplinario de la enfermedad humana por infiltración de sustancias modelantes. Cir. plást. iberolatinoam. [Internet]. 2013 Sep [citado 2021 Nov 18] ; 39( 3 ): 269-277. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376- 78922013000300009&lng=es. https://dx.doi.org/10.4321/S0376-78922013000300009.
Castro Claudia Marcela, Ríos Carlos Alberto, López Carlos Alejandro, Ospina Martha Lucía, Ortiz Yamileth. Efectos adversos de las sustancias modelantes en Cali, Colombia. Biomed. 2021. https://doi.org/10.7705/biomedica.5707.
Informe de ponencia para primer debate al proyecto de ley 158 de 2016 cámara. Legis. 07.11.2019. Disponible en: http://www.legisaldia.com/BancoMedios/Archivos/pl-158- 16c-infponencia1debate-regulacioncirugiasesteticas.pdf
"En Cali nació la primera fundación de Colombia que lucha contra los biopolímeros”. Caracol noticias web. Cali. 12.04.2016. 28.09.2019. Disponible en: https://noticias.caracoltv.com/cali/en-cali-nacio-la-primera-fundacion-de-colombia-que- lucha-contra-los-biopolímeros
Tejero Garcia P. Efectos secundarios de los implantes tisulares: situación actual, protocolo de prevención y tratamiento. (Tesis Doctorado en medicina). Universidad Complutense de Madrid; 2012.
Sanz-Barriga Helen Amelia, Eróstegui Revilla Carlos Pedro. Alogenosis Iatrogénica, el Gran Peligro de los Biopolímeros. 2010; 13 (1): 31-34. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1817- 74332010000100010&lng=es.
Chiang YZ, Pierone G, Al-Niaimi F. Dermal fillers: pathophysiology, prevention and treatment of complications. J Eur Acad Dermatol Venereol. 2017;31(3):405-413. doi:10.1111/jdv.13977
Dermal Fillers Soft tissue. FDA U.S FOOD & DRUG ADMINISTRATION. 26.10.2021. Disponible en: https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal-fillers-soft-tissue-fillers
Sánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. Materiales de relleno: tipos, indicaciones y complicaciones. Actas Dermosifiliogr. 2010;101(5):381–93.
Fernández-Cossío S, León-Mateos A, Sampedro FG, Oreja MTC. Biocompatibility of agarose gel as a dermal filler: histologic evaluation of subcutaneous implants. Plast Reconstr Surg. 2007;120(5):1161-1169. doi:10.1097/01.prs.0000279475.99934.71
Gómez DBT, Vargas RB, Ramírez GM, Blancas RBP. Instrumento para evaluar y estadificar el daño producido por la infiltración de sustancias modelantes [Internet]. Medigraphic.com. 2010 [citado el 18 de noviembre de 2020]. Disponible en: https://www.medigraphic.com/pdfs/cplast/cp-2010/cp103b.pdf
Castro LFG, Rueda JDA, de Jesús Cano Calle H. Análisis infrarrojo del hialucorp, metacorp y silicona líquida en el marco de la alogenosis iatrogénica. Revista Colombiana de Cirugía Plástica y Reconstructiva [Internet]. 2017 [citado el 18 de noviembre de 2020];23(1). Disponible en: https://www.ciplastica.com/ojs/index.php/rccp/article/view/37
Donis AA, Gutiérrez PG, Domínguez NR, Moreno GS, Ávila JR. Filler Materials: A Review [Internet]. Medigraphic.com. [citado el 14 de noviembre de 2021]. Disponible en: https://www.medigraphic.com/pdfs/cosmetica/dcm-2015/dcm151l.pdf.
Steven H. Dayan, MD, Benjamin A. Bassichis, MD, Facial Dermal Fillers: Selection of Appropriate Products and Techniques, Aesthetic Surgery Journal, Volume 28, Issue 3, May 2008, Pages 335–347, https://doi.org/10.1016/j.asj.2008.03.004
Broder, K. W., & Cohen, S. R. (2006). An overview of permanent and semipermanent fillers. Plastic and reconstructive surgery, 118(3 Suppl), 7S–14S. https://doi.org/10.1097/01.prs.0000234900.26676.0b
Alijotas-Reig J, Esteve-Valverde E, Gil-Aliberas N, Garcia-Gimenez V. Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials:analysis of 45 cases an d comprehensive review of the literature. Immunol Res. 2018;66(1):120-140. doi:10.1007/s12026-017-8980-5
González DMG. INFORME DE BIOSEGURIDAD INMUNOLÓGICA DE BIOIMPLANTES: ACIDO HIALURÓNICO [Internet]. Seme.org. [citado el 18 de noviembre de 2021]. Disponible en: https://old.seme.org/docs/Informe-Bioseguridad-Inmunologica- Bioimplantes.pdf?it=docs/Informe-Bioseguridad-Inmunologica-Bioimplantes.pdf
Tejero P, López Pitalúa JA, Tuffet J, Anido J. Protocolos de práctica clínica en la utilización de materiales de relleno. SEME. 2009; 21:40-47
Alimoradi J, Novaa K. (Complications in connection with injection of dermal fillers). Ugeskrift for Laeger. 2019 Mar;181(12). PMID: 30931884.https://doi.org/10.1016/j.jdds.2016.01.001.
Murillo J, Torres J, Bofill L, et al. Skin and Wound Infection by Rapidly Growing Mycobacteria: An Unexpected Complication of Liposuction and Liposculpture. Arch Dermatol. 2000;136(11):1347–1352. doi:10.1001/archderm.136.11.1347
Ananth-Shenoy, P., Vishwanath, S., Targain, R., Shetty, S., Sunil-Rodrigues, G., Mukhopadhyay, C., & Chawla, K. (2016). Anaerobic infections in surgical wards: a two year study. Iranian journal of microbiology, 8(3), 181–186
Esposito, Silvano & Ascione, Tiziana & Pagliano, Pasquale. (2018). Management of bacterial skin and skin structure infections with polymicrobial etiology. Expert Review of Anti- infective Therapy. 17. 10.1080/14787210.2019.1552518.
Murray JL, Connell JL, Stacy A, Turner KH, Whiteley M. Mechanisms of synergy in polymicrobial infections. J Microbiol. 2014;52(3):188–99. https://doi.org/10.1007/s12275- 014-4067-3
Gravante G, Caruso R, Araco A, Cervelli V. Infections after plastic procedures: incidences, etiologies, risk factors, and antibiotic prophylaxis. Aesthetic Plast Surg. 2008;32(2):243-251. doi:10.1007/s00266-007-9068-8
Ferneini EM, Beauvais D, Aronin SI. An Overview of Infections Associated With Soft Tissue Facial Fillers: Identification, Prevention, and Treatment. J Oral Maxillofac Surg. 2017;75(1):160-166. doi:10.1016/j.joms.2016.09.004
Gonzalez-Santiago TM, Drage LA. Nontuberculous Mycobacteria: Skin and Soft Tissue Infections. Dermatol Clin. 2015;33(3):563-577. doi:10.1016/j.det.2015.03.017
Franco-Paredes C, Marcos LA, Henao-Martínez AF, et al. Cutaneous Mycobacterial Infections. Clin Microbiol Rev. 2018;32(1):e00069-18. Published 2018 Nov 14. doi:10.1128/CMR.00069-18
Douglas, Raymond S. M.D., Ph.D.; Cook, Todd M.D.; Shorr, Norman M.D. Lumps and Bumps:, Plastic and Reconstructive Surgery: December 2003 - Volume 112 - Issue 7 - p 1923-1928. https://doi.org/10.1097/01.PRS.0000091423.45859.BD
Rodriguez JM, Xie YL, Winthrop KL, et al. Mycobacterium chelonae facial infections following injection of dermal filler. Aesthet Surg J. 2013;33(2):265-269. doi:10.1177/1090820X12471944
Alcaide F, Esteban J. Infecciones cutáneas y de partes blandas por micobacterias no tuberculosas. Enferm Infecc Microbiol Clin. 2010;28 Suppl 1:46–50.
Alijotas-Reig J, Miró-Mur F, Planells-Romeu I, Garcia-Aranda N, Garcia-Gimenez V, Vilardell-Tarrés M. Are bacterial growth and/or chemotaxis increased by filler injections? Implications for the pathogenesis and treatment of filler-related granulomas. Dermatology. 2010;221(4):356–64.
Ader, Florence & Bernard, Louis. Physiopathologie des infections sur matériel orthopédique. Presse Medicale. 2005 ;34. 533-536.Doi:10.1016/S0755-4982(05)83967-3
Schierholz JM, Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect. 2001;49(2):87-93. doi:10.1053/jhin.2001.1052
Christensen L, Breiting V, Janssen M, Vuust J, Hogdall E. Adverse reactions to injectable soft tissue permanent fillers. Aesthetic Plast Surg. 2005;29(1):34-48. doi:10.1007/s00266-004-0113-6
Goldan O, Georgiou I, Grabov-Nardini G, et al. Early and late complications after a nonabsorbable hydrogel polymer injection: a series of 14 patients and novel management. Dermatol Surg. 2007;33 Suppl 2:S199-S206. doi:10.1111/j.1524- 4725.2007.33361.x
Pittet B, Montandon D, Pittet D: Infection in breast implants. Lancet Infect Dis 2005;5:94–106.
Christensen L. Host Tissue Interaction, Fate, and Risks of Degradable and Nondegradable Gel Fillers (2009) Dermatologic Surgery Volume: 35, Issue: 2, pp 1612- 1619 DOI: 10.1111/J.1524-4725.2009.01338.X
Decates T, Kadouch J, Velthuis P, Rustemeyer T. Immediate nor delayed type hypersensitivity plays a role in late inflammatory reactions after hyaluronic acid filler injections. Clin Cosmet Investig Dermatol. 2021;14:581–9.
López C, Manchola JF, Medina-Cárdenas S, Moreno S. Reacción granulomatosa de tipo cuerpo extraño secundaria a biomateriales y su respuesta inmunológica: Revisión sistemática de la literatura. Salut Sci Spirit [Internet]. 2016 [citado el 18 de noviembre de 2021];2(1). Disponible en: https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1385.
Kindt TJ, Goldsby RA, Osborne BA, Martínez RP. Inmunología de Kuby [Internet]. McGraw-Hill; 2007. Available from: https://books.google.com.co/books?id=2xpqMwAACAAJ
Micheels P. Human anti-hyaluronic acid antibodies: is it possible?. Dermatol Surg. 2001;27(2):185-191. doi:10.1046/j.1524-4725.2001.00248.xB
Bigatà X, Ribera M, Bielsa I, Ferrándiz C. Adverse granulomatous reaction after cosmetic dermal silicone injection. Dermatol Surg. 2001;27(2):198-200. doi:10.1046/j.1524- 4725.2001.00020.x
Lowe NJ, Maxwell CA, Lowe P, Duick MG, Shah K. Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol. 2001;45(6):930-933. doi:10.1067/mjd.2001.117381.
Jones P, Mempin M, Hu H, et al. The Functional Influence of Breast Implant Outer Shell Morphology on Bacterial Attachment and Growth. Plast Reconstr Surg. 2018;142(4):837-849. doi:10.1097/PRS.0000000000004801
Lee JM, Kim YJ. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg. 2015;42(2):232-239. doi:10.5999/aps.2015.42.2.232
Bhojani-Lynch, Tahera MRCOphth, CertLRS, MBCAM, DipCS Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers, Plastic and Reconstructive Surgery - Global Open: December 2017 - Volume 5 - Issue 12 - p e1532 doi: 10.1097/GOX.0000000000001532
Ercilla González G. (2010). Informe de bioseguridad inmunológica de implantes: ácido hialurónico. SEME; 24:7-13
Yel L, Chen W, Gupta S. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004;92(1):88-91. doi:10.1016/S1081-1206(10)61716-4
Alijotas-Reig J, Fernández-Figueras MT, Puig L. Late-onset inflammatory adverse reactions related to soft tissue filler injections. Clin Rev Allergy Immunol. 2013;45(1):97-108. doi:10.1007/s12016-012-8348-5
Ledon JA, Savas JA, Yang S, Franca K, Camacho I, Nouri K. Inflammatory nodules following soft tissue filler use: a review of causative agents, pathology and treatment options. Am J Clin Dermatol. 2013;14(5):401-411. doi:10.1007/s40257-013-0043-7
Montealegre G, Uribe R, Martínez-Ceballos MA, Rojas-Villarraga A. ASIA syndrome symptoms induced by gluteal biopolymer injections: Case-series and narrative review. Toxicol Rep. 2021;8:303-314. Published 2021 Jan 27. doi:10.1016/j.toxrep.2021.01.011
Tamayo Carbón AM, Castellanos Prada AR, Aveiro-Róbalo TR. Alogenosis Iatrogénica Y Enfermedades Reumáticas. Rev cuba reumatol. 2018;20(2):18.
Ameratunga R, Gillis D, Gold M, Linneberg A, Elwood JM. Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). J Allergy Clin Immunol Pract. 2017;5(6):1551-1555.e1. doi:10.1016/j.jaip.2017.06.033
Watad A, Quaresma M, Brown S, et al. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome) - An update. Lupus. 2017;26(7):675-681. doi:10.1177/0961203316686406
Ferrer-Cosme B, Téllez-Martínez D, Batista-Duharte A. inflamatorio inducido por adyuvantes. ¿Una nueva entidad clínica? [Internet]. Medigraphic.com. [citado el 18 de noviembre de 2021]. Disponible en: https://www.medigraphic.com/pdfs/imss/im- 2017/im173n.
Nunes E Silva D, Gründler C, Spengler MDGMT, et al. Autoimmune Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Augmentation Surgery. Plast Reconstr Surg Glob Open. 2017;5(9):e1487. Published 2017 Sep 25. doi:10.1097/GOX.0000000000001487
Cappellano G, Ploner C, Lobenwein S, et al. Immunophenotypic characterization of human T cells after in vitro exposure to different silicone breast implant surfaces. PLoS One. 2018;13(2):e0192108. Published 2018 Feb 8. doi:10.1371/journal.pone.0192108
Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus. 2009;18(13):1217-1225. doi:10.1177/0961203309345724.
Fernández de Vega F, Moreno J, González J, Palacios J. Procedimientos en microbiología Clínica Recomendaciones de la Sociedad Española de enfermedades Infecciosas y Microbiología Clínica. 2005. ISBN: 84-609-7032-9
Dingle TC, Butler-Wu SM. Maldi-tof mass spectrometry for microorganism identification. Clin Lab Med. 2013;33(3):589-609. doi:10.1016/j.cll.2013.03.001
Abu-Zhayia, E.R., Khoury-Haddad, H., Guttmann-Raviv, N. et al. A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. Sci Rep 7, 1002 (2017). https://doi.org/10.1038/s41598-017-01185-6
World Health Organization & Centers for Disease Control and Prevention (U.S.). (2011). Laboratory methods for the diagnosis of meningitis caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae : WHO manual, 2nd ed. World Health Organization. https://apps.who.int/iris/handle/10665/70765
Church DL, Cerutti L, Gürtler A, Griener T, Zelazny A, Emler S. Performance and Application of 16S rRNA Gene Cycle Sequencing for Routine Identification of Bacteria in the Clinical Microbiology Laboratory. Clin Microbiol Rev. 2020;33(4):e00053-19. Published 2020 Sep 9. doi:10.1128/CMR.00053-19
Jo J-H, Kennedy EA, Kong HH. Research techniques made simple: Bacterial 16S ribosomal RNA gene sequencing in cutaneous research. J Invest Dermatol. 2016;136(3):e23–7.
Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology (Reading). 2002;148(Pt 1):257-266. doi:10.1099/00221287-148-1-257
Edwards KJ, Logan JMJ, Langham S, Swift C, Gharbia SE. Utility of real-time amplification of selected 16S rRNA gene sequences as a tool for detection and identification of microbial signatures directly from clinical samples. J Med Microbiol. 2012;61(Pt 5):645-652. doi:10.1099/jmm.0.041764-0
Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology (Reading). 2002;148(Pt 1):257-266. doi:10.1099/00221287-148-1-257
Wu YD, Li W, Wei Y, Gao HH, Shang SQ, Du LZ. Rapid and Sensitive Identification of Bacterial Infection and Bacteria Gram Types in Pleural Fluid of Children. Glob Pediatr Health. 2015; 2:2333794X15569302. Published 2015 Jan 30. doi:10.1177/2333794X15569302
DEVALLOIS A, GOH K.S, RASTOGI N. Rapid identification of mycobacteria to species level by PCR-restriction fragment length polymorphism analysis of the hsp65 gene and proposition of an algorithm to differentiate 34 mycobacterial species. J Clin Microbiol 1997; 35:2969-2973
Häfner B, Haag H, Geiss HK, Nolte O. Different molecular methods for the identification of rarely isolated non-tuberculous mycobacteria and description of new hsp65 restriction fragment length polymorphism patterns. Mol Cell Probes. 2004;18(1):59-65. doi: 10.1016/j.mcp.2003.09.003
Telenti A, Marchesi F, Balz M, Bally F, Böttger EC, Bodmer T. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol. 1993;31(2):175-178. doi:10.1128/jcm.31.2.175- 178.1993
Zhang HJ, Pan Z, Wei JC, et al. Optimization of Pulsed-field Gel Electrophoresis Procedure for Bacillus cereus. Biomed Environ Sci. 2016;29(3):233-237. doi:10.3967/bes2016.030
Neoh HM, Tan XE, Sapri HF, Tan TL. Pulsed-field gel electrophoresis (PFGE): A review of the "gold standard" for bacteria typing and current alternatives. Infect Genet Evol. 2019;74:103935. doi: 10.1016/j.meegid.2019.103935
Kaminska PS, Fiedoruk K, Jankowska D, et al. One-day pulsed-field gel electrophoresis protocol for rapid determination of emetic Bacillus cereus isolates. Electrophoresis. 2015;36(7-8):1051-1054. doi:10.1002/elps.201400552
Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233-2239. doi:10.1128/jcm.33.9.2233- 2239.1995
Kwong JC, McCallum N, Sintchenko V, Howden BP. Whole genome sequencing in clinical and public health microbiology. Pathology. 2015;47(3):199-210. doi:10.1097/PAT.0000000000000235
Bianco A, Capozzi L, Monno MR, et al. Characterization of Bacillus cereus Group Isolates From Human Bacteremia by Whole-Genome Sequencing. Front Microbiol. 2021;11:599524. Published 2021 Jan 12. doi:10.3389/fmicb.2020.599524
Cossarizza A, Chang HD, Radbruch A, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019;49(10):1457-1973. doi:10.1002/eji.201970107
Mendez-Rayo, Tatiana, Ochoa-Zárate, Laura, Posso-Osorio, Iván, Ortiz, Eliana, Naranjo-Escobar, Juan, & Tdbón, Gabriel J.. (2018). Interpretación de los autoanticuerpos en enfermedades reumatológicas. Revista Colombiana de Reumatología, 25(2), 112-125. https://doi.org/10.1016/j.rcreu.2018.02.004
Kryštůfková O, Hulejová H, Mann HF, et al. Serum levels of B-cell activating factorof the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis. Arthritis Res Ther. 2018;20(1):158. Published 2018 Jul 27.doi:10.1186/s13075-018-1650-8
Reyes L., León F., Rozas F., Gonzalez P., Naves R., BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide. Rev. méd. Chile (online). 2006, vol.134, n.9, pp.1175-1184. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872006000900014.
Smulski CR, Eibel H. BAFF and BAFF-Receptor in B Cell Selection and Survival. Front Immunol. 2018;9:2285. Published 2018 Oct 8.doi:10.3389/fimmu.2018.02285
Pisetsky D. S. (2017). Antinuclear antibody testing - misunderstood or misbegotten?. Nature reviews. Rheumatology, 13(8), 495–502. https://doi.org/10.1038/nrrheum.2017.74
Geetha D, Jefferson JA. ANCA-Associated Vasculitis: Core Curriculum 2020. Am J Kidney Dis. 2020;75(1):124-137. doi:10.1053/j.ajkd.2019.04.031
Thieblemont N,Wright HL, Edwards SW,Witko-Sarsat V. Human neutrophils in auto- immunity. Semin Immunol. 2016;28(2):159–73.
Nakazawa D, Masuda S, Tomaru U, Ishizu A. Pathogenesis and therapeutic interventions for ANCA-associated vasculitis [published correction appears in Nat Rev Rheumatol. 2019 Jan 17]. Nat Rev Rheumatol. 2019;15(2):91-101. doi:10.1038/s41584-018-0145-y
Mendez-Rayo, Tatiana, Ochoa-Zárate, Laura, Posso-Osorio, Iván, Ortiz, Eliana, Naranjo-Escobar, Juan, & Tdbón, Gabriel J.. (2018). Interpretación de los autoanticuerpos en enfermedades reumatológicas. Revista Colombiana de Reumatología, 25(2), 112-125. https://doi.org/10.1016/j.rcreu.2018.02.004
González Rodríguez, C., Aparicio Hernández, M. & Alarcón Torres, I. (2021). Actualización y manejo clínico de los anticuerpos anti-ácido desoxirribonucleico. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, 2(3), 322- 331. https://doi.org/10.1515/almed-2020-0067
Gómez-Puerta, J. A., Burlingame, R. W., & Cervera, R.(2006). Anti-chromatin (anti- nucleosome) antibodies. Lupus, 15(7), 408–411. https://doi.org/10.1191/0961203306lu2325oa
Cozzani, E., Drosera, M., Gasparini, G., & Parodi, A. (2014). Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects. Autoimmune diseases, 2014, 321359. https://doi.org/10.1155/2014/321359
Mahler M. (2011). Sm peptides in differentiation of autoimmune diseases. Advances in clinical chemistry, 54, 109–128. https://doi.org/10.1016/b978-0-12-387025- 4.00005-4
Ohzeki, J. I., Otake, K., & Masumoto, H. (2020). Human artificial chromosome: Chromatin assembly mechanisms and CENP-B. Experimental cellresearch, 389(2), 111900. https://doi.org/10.1016/j.yexcr.2020.111900
Koenig, M., Dieudé, M., & Senécal, J. L. (2008). Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies. Autoimmunity reviews, 7(8), 588–593. https://doi.org/10.1016/j.autrev.2008.06.010
Chatterjee, S., & Prayson, R. A. (2020). Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Seminars in arthritis and rheumatism, 50(3), 498–502. https://doi.org/10.1016/j.semarthrit.2019.11.008
Ghirardello, A., Zampieri, S., Iaccarino, L., Tarricone, E., Bendo, R., Gambari, P. F., & Doria, A. (2005). Anti-Mi-2 antibodies. Autoimmunity, 38(1), 79–83. https://doi.org/10.1080/08916930400022681
Belizna, C., Henrion, D., Beucher, A., Lavigne, C., Ghaali, A., & Lévesque, H. (2010). Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmunity reviews, 9(10), 691–694. https://doi.org/10.1016/j.autrev.2010.05.020
Franceschini, F., & Cavazzana, I. (2005). Anti-Ro/SSA and La/SSB antibodies. Autoimmunity, 38(1), 55–63. https://doi.org/10.1080/08916930400022954
Kattah NH, Kattah MG, Utz PJ. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol Rev. 2010;233(1):126- 145. doi:10.1111/j.0105-2896.2009.00863.x
Zampieri S, Ghirardello A, Iaccarino L, Tarricone E, Gambari PF, Doria A. Anti-Jo-1 antibodies. Autoimmunity. 2005;38(1):73-78. doi:10.1080/08916930400022640
Rodríguez EC, Díaz-Guevara P, Moreno J, Bautista A, Montaño L, Realpe ME, Della Gaspera A, Wiesner M. Laboratory surveillance of Salmonella enterica from human clinical cases in Colombia 2005-2011. Enferm Infecc Microbiol Clin. 2017 Aug- Sep;35(7):417-425. English, Spanish. doi: 10.1016/j.eimc.2016.02.023. Epub 2016 Mar 30. PMID: 27038678.
Comans-Bitter WM, de Groot R, van den Beemd R, Neijens HJ, Hop WC, Groeneveld K, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr 1997; 130: 388-93.
Christensen L, Breiting V, Bjarnsholt T, Eickhardt S, Høgdall E, Janssen M, et al. Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis. 2013;56(10):1438–44.
Meneghetti KL, do Canto Canabarro M, Otton LM, Dos Santos Hain T, Geimba MP, Corção G. Bacterial contamination of human skin allografts and antimicrobial resistance: a skin bank problem. BMC Microbiol. 2018;18(1):121. Published 2018 Sep 24. doi:10.1186/s12866-018-1261-1
Dominguez-Zambrano A., Haddad-Tame J.L., Torres-Baltazar I., Jiménez- Muñoz G., Satré-Ortíz N., Espinosa-Maceda S.. Enfermedad por modelantes: problemática actual en México y presentación de casos. Cir. plást. iberolatinoam. [Internet]. 2013 Dic [citado 2021 Nov 18] ; 39( 4 ): 399-405. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S037678922013000400010 &lng=es. https://dx.doi.org/10.4321/S0376-
Busscher HJ, van der Mei HC, Subbiahdoss G, et al. Biomaterial-associated infection: locating the finish line in the race for the surface. Sci Transl Med. 2012;4(153):153rv10. doi:10.1126/scitranslmed.3004528
Yel L, Chen W, Gupta S. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004;92(1):88-91. doi:10.1016/S1081-1206(10)61716-4
Dubouix A, Bonnet E, Alvarez M, et al. Bacillus cereus infections in Traumatology- Orthopaedics Department: retrospective investigation and improvement of healthcare practices. J Infect. 2005;50(1):22-30. doi:10.1016/j.jinf.2004.05.012
Wang, Y., Leng, V., Patel, V. et al. Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures. Sci Rep 7, 45070 (2017). https://doi.org/10.1038/srep45070
Ehling-Schulz M, Lereclus D, Koehler TM. The Bacillus cereus Group: Bacillus Species with Pathogenic Potential. Microbiol Spectr. 2019;7(3):10.1128/microbiolspec.GPP3-0032-2018. doi:10.1128/microbiolspec.GPP3-0032-2018
Thomas MS,Wigneshweraraj S. Regulation of virulence gene expression. Virulence. 2014;5(8):832-834. doi:10.1080/21505594.2014.995573
Marculescu CE, Berbari EF, Cockerill FR 3rd, Osmon DR. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res. 2006;451:55-63. doi:10.1097/01.blo.0000229317.43631.81
Brown MM, Horswill AR. Staphylococcus epidermidis-Skin friend or foe?. PLoS Pathog. 2020;16(11):e1009026. Published 2020 Nov 12. doi:10.1371/journal.ppat.1009026
Marculescu CE, Berbari EF, Cockerill FR 3rd, Osmon DR. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res. 2006;451:55-63. doi:10.1097/01.blo.0000229317.43631.81
Månsson E, Hellmark B, Sundqvist M, Söderquist B. Sequence types of Staphylococcus epidermidis associated with prosthetic joint infections are not present in the laminar airflow during prosthetic joint surgery. APMIS. 2015;123(7):589-595. doi:10.1111/apm.12392
Otto M. Staphylococcus epidermidis--the 'accidental' pathogen. Nat Rev Microbiol. 2009;7(8):555-567. doi:10.1038/nrmicro2182
Heldt Manica LA, Cohen PR. Staphylococcus lugdunensis infections of the skin and soft tissue: A case series and review. Dermatol Ther (Heidelb). 2017;7(4):555–62.
Tevell S, Hellmark B, Nilsdotter-Augustinsson Å, Söderquist B. Staphylococcus capitis isolated from prosthetic joint infections. Eur J Clin Microbiol Infect Dis. 2017;36(1):115-122. doi:10.1007/s10096-016-2777-7
Leonel C, Sena IFG, Silva WN, et al. Staphylococcus epidermidis role in the skin microenvironment. J Cell Mol Med. 2019;23(9):5949-5955. doi:10.1111/jcmm.14415
Choi M, Cheon JS, Choi WY, Son KM, Ki JS, Kim Y. An outbreak of Pseudomonas stutzeri bacterial isolation caused by sterile dressing products. J Wound Manag Res. 2017;13(1):24–7.
Ospina Fabio Enrique, Betancur Juan Felipe, Suso Juan Pablo, Muñoz-Buitro Evelyn, Cañas Carlos Alberto, Tobón Gabriel J.. Papel de la citocina BAFF en las enfermedades autoinmunes: rol fisiopatológico y estrategias terapéuticas. Rev.Colomb.Reumatol; 23( 3 ): 177-194. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121- 81232016000300006&lng=en. https://doi.org/10.1016/j.rcreu.2016.06.003
Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241-258. doi:10.1016/j.semarthrit.2013.02.001
Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241-258. doi:10.1016/j.semarthrit.2013.02.001
Maijers MC, de Blok CJ, Niessen FB, et al. Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study. Neth J Med. 2013;71(10):534- 540.
Psianou K, Panagoulias I, Papanastasiou AD, et al. Clinical and immunological parameters of Sjögren's syndrome. Autoimmun Rev. 2018;17(10):1053-1064. doi:10.1016/j.autrev.2018.05.005
Belizna C, Henrion D, Beucher A, Lavigne C, Ghaali A, Lévesque H. Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmun Rev. 2010;9(10):691-694. doi:10.1016/j.autrev.2010.05.020
Chatterjee S, Prayson RA. Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Semin Arthritis Rheum. 2020;50(3):498-502. doi:10.1016/j.semarthrit.2019.11.008
Chatterjee S, Prayson RA. Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Semin Arthritis Rheum. 2020;50(3):498-502. doi:10.1016/j.semarthrit.2019.11.008
Schmidt J. Current Classification and Management of Inflammatory Myopathies. J Neuromuscul Dis. 2018;5(2):109-129. doi:10.3233/JND-180308
Pisetsky DS, Lipsky PE. New insights into the role of antinuclear antibodies in systemic lupus erythematosus. Nat Rev Rheumatol. 2020;16(10):565-579. doi:10.1038/s41584-020-0480-7
Sapkota B, Al Khalili Y. Mixed connective tissue disease. En: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.
Strzepa A, Pritchard KA, Dittel BN. Myeloperoxidase: A new player in autoimmunity. Cell Immunol. 2017;317:1-8. doi:10.1016/j.cellimm.2017.05.002
Ripalda A, Loja A, Víctor L, Herrera P, Freites P. Consecuencias Clínicas Del Uso De Biopolímeros Como Prácticas De Auto-Atención En El Proceso De Trasformación Corporal En Personas Transexuales. // Clinical Consequences of the Use of Biopolymers As Self- Attention Practices in the Process of Body Transfor. Facsalud-Unemi [Internet]. 2018;2(2):46–52. Available from: http://ojs.unemi.edu.ec/index.php/facsalud- unemi/article/view/723/0.
International Society of Aesthetic Plastic Surgery. International Survey on Aesthetic/Cosmetic., Procedures Performed in 2015. Fecha de consulta: 28.09.2019. Disponible en: https://www.isaps.org/wp-content/uploads/2018/10/2017-Global-Survey- Press-Release-Demand-for-Cosmetic-Surgery-Procedures-Around-The-World-Continues- To-Skyrocket_2_RW.pdf
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dc.publisher.department.spa.fl_str_mv Departamento de Geociencias
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Moreno Castañeda, Jaime Enriquec2d555e042c9520fc04928dd6a820f60Leal Castro, Aura Luciab2235314a4de0cbfb8d19498eb44f1cfArturo, Jhand8453f1e32fcea9bae8ecc85209ec27fBonilla Moncada, Jennifer Marcela42a54ecba5fadb8375b45e1526a4eac3Microbiología Instituto Nacional de Salud2022-09-06T15:35:44Z2022-09-06T15:35:44Z2022-08-17https://repositorio.unal.edu.co/handle/unal/82260Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/fotografías a color, gráficos, ilustraciones, tablasEn la búsqueda de sustancias modelantes (biopolímeros) capaces de proporcionar volumen y generar cambios estéticos sin intervención quirúrgica se han empleado diversos materiales, como sustancias químicas derivadas del petróleo, de origen vegetal y sintético los cuales pueden producir reacciones adversas como procesos infecciosos, inflamatorios y autoinmunes. Objetivo: Identificar las infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali. Metodología: Es un estudio transversal y descriptivo en el cual se procesaron muestras de tejido para análisis microbiológicos y muestras de sangre total y suero para análisis inmunológicos de 113 pacientes con eventos adversos al uso de biopolímeros en la ciudad de Cali durante 2019-2021. Resultados: Se identificaron aislamientos microbianos en 22 pacientes (19,4 %), 15 (13,2 %) presentaron infecciones mono-microbianas y 7 (6,19 %) pacientes presentaron infecciones polimicrobianas, la frecuencia de los aislamientos identificados fue de Bacillus cereus (n=8, 36,3 %), Mycobacterium fortuitum tipo 2 (n=5, 22,7 %) y Pseudomonas stutzeri (n=3, 13,6 %). Se evidenció un aumento de células T CD4+ en la población de estudio, sin embargo, el promedio del fenotipo celular se encontró por debajo del promedio comparado con el valor de referencia lo que sugiere una tendencia a inmunosupresión con la expresión de autoanticuerpos en 78 (69,0%) pacientes de los cuales SS-B/La (n=32, 60,3%), anti- Ku (n= 22, 28,2 %) y anti -PM-Scl (n=14, 17,9%) anti MPO (n=51, 91,0%) fueron los más frecuentes. La asociación de microorganismos, inflamación y autoinmunidadal uso de sustancias modelantes son hallazgos relevantes para su control. (Texto tomado de la fuente)In the search for modeling substances (biopolymers) capable of providing volume and generating aesthetic changes without surgical intervention, various materials have been used, such as chemical substances derived from petroleum, of vegetable and synthetic origin; which can produce adverse reactions such as infectious, inflammatory and autoimmune processes. Objective: To identify infections and immunological changes in patients with adverse reactions to the use of modeling substances in the city of Cali. Methodology: This is a cross-sectional and descriptive studyin whichtissu e samples were processed for microbiological analysis and whole blood and serum samples for immunological analysis of 113 patients with adverse events to the use of biopolymers in the city of Cali during 2019-2021. Results: Microbial isolates were identified in 22 patients (19.4%), 15 (13.2 %) presented mono-microbial infections and 7 (6.19 %) patients presented polymicrobial infections, the frequency of identified isolates was Bacillus cereus (n=8, 36,3 %), Mycobacterium fortuitum tipo 2 (n=5, 22,7 %) and Pseudomonas stutzeri (n=3, 13,6 %). An increase of CD4+ T cells was evidenced in the study population, however, the average cell phenotype was found below average compared to the reference value suggesting a tendency to immunosuppression with autoantibody expression in 78 (69.0%) patients of which SS-B/La (n=32, 60.3%), anti- Ku (n= 22, 28.2 %) and anti -PM-Scl (n=14, 17.9%) anti MPO (n=51, 91.0%) were the most frequent. The association of microorganisms, inflammation and autoimmunity to the use of modeling substances are relevant findings for their control.MaestríaMagíster en Ciencias - MicrobiologíaInvestigación en Salud pública105 páginasapplication/pdfspaInstituto Nacional de SaludInmugen CorporationBogotá - Ciencias - Maestría en Ciencias - MicrobiologíaDepartamento de GeocienciasFacultad de CienciasUniversidad Nacional de Colombia - Sede BogotáIdentificación de infecciones y cambios inmunológicos en pacientes con reacciones adversas al uso de sustancias modelantes en la ciudad de Cali ColombiaIdentification of infections and immunological changes in patients with adverse with adverse reactions to the use of modeling substances in the city of cali city of Cali, ColombiaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMCali - ColombiaRiascos A., “Las tragedias diarias de pacientes por uso de biopolímeros en Cali”. Diario el tiempo, Bogotá. 26.07.2018. 29.10.2019. Disponible en: https://www.eltiempo.com/colombia/cali/los-repetidos-dramas-de-pacientes-por-uso- de- biopolimeros-en-cali-248100Coiffman F. Alogenosis iatrogénica. Una nueva enfermedad. Cir Plast Ibero-Latinoamericana. 2008;34(1):1–8.Stanford, N., & Montealegre, G. (2013). Alogenosis iatrogénica, hallazgos de una enfermedad reumática. Revista Colombiana de Cirugía Plástica y Reconstructiva, 19(1),28–38Ricaurte AI, Forense M, Castaño DA, Castro JA, Paz DA De, Echeverry DA. Alogenosis iatrogénica vs . alogenosis secundaria en Cali , Colombia . 2016;0684.Gordillo-Hernández J., Alegre-Tamez E., Torres-Baltazar I., Mendieta-EspinosaM.J., Sastré-Ortiz N.. Abordaje ultidisciplinario de la enfermedad humana por infiltración de sustancias modelantes. Cir. plást. iberolatinoam. [Internet]. 2013 Sep [citado 2021 Nov 18] ; 39( 3 ): 269-277. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376- 78922013000300009&lng=es. https://dx.doi.org/10.4321/S0376-78922013000300009.Castro Claudia Marcela, Ríos Carlos Alberto, López Carlos Alejandro, Ospina Martha Lucía, Ortiz Yamileth. Efectos adversos de las sustancias modelantes en Cali, Colombia. Biomed. 2021. https://doi.org/10.7705/biomedica.5707.Informe de ponencia para primer debate al proyecto de ley 158 de 2016 cámara. Legis. 07.11.2019. Disponible en: http://www.legisaldia.com/BancoMedios/Archivos/pl-158- 16c-infponencia1debate-regulacioncirugiasesteticas.pdf"En Cali nació la primera fundación de Colombia que lucha contra los biopolímeros”. Caracol noticias web. Cali. 12.04.2016. 28.09.2019. Disponible en: https://noticias.caracoltv.com/cali/en-cali-nacio-la-primera-fundacion-de-colombia-que- lucha-contra-los-biopolímerosTejero Garcia P. Efectos secundarios de los implantes tisulares: situación actual, protocolo de prevención y tratamiento. (Tesis Doctorado en medicina). Universidad Complutense de Madrid; 2012.Sanz-Barriga Helen Amelia, Eróstegui Revilla Carlos Pedro. Alogenosis Iatrogénica, el Gran Peligro de los Biopolímeros. 2010; 13 (1): 31-34. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1817- 74332010000100010&lng=es.Chiang YZ, Pierone G, Al-Niaimi F. Dermal fillers: pathophysiology, prevention and treatment of complications. J Eur Acad Dermatol Venereol. 2017;31(3):405-413. doi:10.1111/jdv.13977Dermal Fillers Soft tissue. FDA U.S FOOD & DRUG ADMINISTRATION. 26.10.2021. Disponible en: https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal-fillers-soft-tissue-fillersSánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. Materiales de relleno: tipos, indicaciones y complicaciones. Actas Dermosifiliogr. 2010;101(5):381–93.Fernández-Cossío S, León-Mateos A, Sampedro FG, Oreja MTC. Biocompatibility of agarose gel as a dermal filler: histologic evaluation of subcutaneous implants. Plast Reconstr Surg. 2007;120(5):1161-1169. doi:10.1097/01.prs.0000279475.99934.71Gómez DBT, Vargas RB, Ramírez GM, Blancas RBP. Instrumento para evaluar y estadificar el daño producido por la infiltración de sustancias modelantes [Internet]. Medigraphic.com. 2010 [citado el 18 de noviembre de 2020]. Disponible en: https://www.medigraphic.com/pdfs/cplast/cp-2010/cp103b.pdfCastro LFG, Rueda JDA, de Jesús Cano Calle H. Análisis infrarrojo del hialucorp, metacorp y silicona líquida en el marco de la alogenosis iatrogénica. Revista Colombiana de Cirugía Plástica y Reconstructiva [Internet]. 2017 [citado el 18 de noviembre de 2020];23(1). Disponible en: https://www.ciplastica.com/ojs/index.php/rccp/article/view/37Donis AA, Gutiérrez PG, Domínguez NR, Moreno GS, Ávila JR. Filler Materials: A Review [Internet]. Medigraphic.com. [citado el 14 de noviembre de 2021]. Disponible en: https://www.medigraphic.com/pdfs/cosmetica/dcm-2015/dcm151l.pdf.Steven H. Dayan, MD, Benjamin A. Bassichis, MD, Facial Dermal Fillers: Selection of Appropriate Products and Techniques, Aesthetic Surgery Journal, Volume 28, Issue 3, May 2008, Pages 335–347, https://doi.org/10.1016/j.asj.2008.03.004Broder, K. W., & Cohen, S. R. (2006). An overview of permanent and semipermanent fillers. Plastic and reconstructive surgery, 118(3 Suppl), 7S–14S. https://doi.org/10.1097/01.prs.0000234900.26676.0bAlijotas-Reig J, Esteve-Valverde E, Gil-Aliberas N, Garcia-Gimenez V. Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials:analysis of 45 cases an d comprehensive review of the literature. Immunol Res. 2018;66(1):120-140. doi:10.1007/s12026-017-8980-5González DMG. INFORME DE BIOSEGURIDAD INMUNOLÓGICA DE BIOIMPLANTES: ACIDO HIALURÓNICO [Internet]. Seme.org. [citado el 18 de noviembre de 2021]. Disponible en: https://old.seme.org/docs/Informe-Bioseguridad-Inmunologica- Bioimplantes.pdf?it=docs/Informe-Bioseguridad-Inmunologica-Bioimplantes.pdfTejero P, López Pitalúa JA, Tuffet J, Anido J. Protocolos de práctica clínica en la utilización de materiales de relleno. SEME. 2009; 21:40-47Alimoradi J, Novaa K. (Complications in connection with injection of dermal fillers). Ugeskrift for Laeger. 2019 Mar;181(12). PMID: 30931884.https://doi.org/10.1016/j.jdds.2016.01.001.Murillo J, Torres J, Bofill L, et al. Skin and Wound Infection by Rapidly Growing Mycobacteria: An Unexpected Complication of Liposuction and Liposculpture. Arch Dermatol. 2000;136(11):1347–1352. doi:10.1001/archderm.136.11.1347Ananth-Shenoy, P., Vishwanath, S., Targain, R., Shetty, S., Sunil-Rodrigues, G., Mukhopadhyay, C., & Chawla, K. (2016). Anaerobic infections in surgical wards: a two year study. Iranian journal of microbiology, 8(3), 181–186Esposito, Silvano & Ascione, Tiziana & Pagliano, Pasquale. (2018). Management of bacterial skin and skin structure infections with polymicrobial etiology. Expert Review of Anti- infective Therapy. 17. 10.1080/14787210.2019.1552518.Murray JL, Connell JL, Stacy A, Turner KH, Whiteley M. Mechanisms of synergy in polymicrobial infections. J Microbiol. 2014;52(3):188–99. https://doi.org/10.1007/s12275- 014-4067-3Gravante G, Caruso R, Araco A, Cervelli V. Infections after plastic procedures: incidences, etiologies, risk factors, and antibiotic prophylaxis. Aesthetic Plast Surg. 2008;32(2):243-251. doi:10.1007/s00266-007-9068-8Ferneini EM, Beauvais D, Aronin SI. An Overview of Infections Associated With Soft Tissue Facial Fillers: Identification, Prevention, and Treatment. J Oral Maxillofac Surg. 2017;75(1):160-166. doi:10.1016/j.joms.2016.09.004Gonzalez-Santiago TM, Drage LA. Nontuberculous Mycobacteria: Skin and Soft Tissue Infections. Dermatol Clin. 2015;33(3):563-577. doi:10.1016/j.det.2015.03.017Franco-Paredes C, Marcos LA, Henao-Martínez AF, et al. Cutaneous Mycobacterial Infections. Clin Microbiol Rev. 2018;32(1):e00069-18. Published 2018 Nov 14. doi:10.1128/CMR.00069-18Douglas, Raymond S. M.D., Ph.D.; Cook, Todd M.D.; Shorr, Norman M.D. Lumps and Bumps:, Plastic and Reconstructive Surgery: December 2003 - Volume 112 - Issue 7 - p 1923-1928. https://doi.org/10.1097/01.PRS.0000091423.45859.BDRodriguez JM, Xie YL, Winthrop KL, et al. Mycobacterium chelonae facial infections following injection of dermal filler. Aesthet Surg J. 2013;33(2):265-269. doi:10.1177/1090820X12471944Alcaide F, Esteban J. Infecciones cutáneas y de partes blandas por micobacterias no tuberculosas. Enferm Infecc Microbiol Clin. 2010;28 Suppl 1:46–50.Alijotas-Reig J, Miró-Mur F, Planells-Romeu I, Garcia-Aranda N, Garcia-Gimenez V, Vilardell-Tarrés M. Are bacterial growth and/or chemotaxis increased by filler injections? Implications for the pathogenesis and treatment of filler-related granulomas. Dermatology. 2010;221(4):356–64.Ader, Florence & Bernard, Louis. Physiopathologie des infections sur matériel orthopédique. Presse Medicale. 2005 ;34. 533-536.Doi:10.1016/S0755-4982(05)83967-3Schierholz JM, Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect. 2001;49(2):87-93. doi:10.1053/jhin.2001.1052Christensen L, Breiting V, Janssen M, Vuust J, Hogdall E. Adverse reactions to injectable soft tissue permanent fillers. Aesthetic Plast Surg. 2005;29(1):34-48. doi:10.1007/s00266-004-0113-6Goldan O, Georgiou I, Grabov-Nardini G, et al. Early and late complications after a nonabsorbable hydrogel polymer injection: a series of 14 patients and novel management. Dermatol Surg. 2007;33 Suppl 2:S199-S206. doi:10.1111/j.1524- 4725.2007.33361.xPittet B, Montandon D, Pittet D: Infection in breast implants. Lancet Infect Dis 2005;5:94–106.Christensen L. Host Tissue Interaction, Fate, and Risks of Degradable and Nondegradable Gel Fillers (2009) Dermatologic Surgery Volume: 35, Issue: 2, pp 1612- 1619 DOI: 10.1111/J.1524-4725.2009.01338.XDecates T, Kadouch J, Velthuis P, Rustemeyer T. Immediate nor delayed type hypersensitivity plays a role in late inflammatory reactions after hyaluronic acid filler injections. Clin Cosmet Investig Dermatol. 2021;14:581–9.López C, Manchola JF, Medina-Cárdenas S, Moreno S. Reacción granulomatosa de tipo cuerpo extraño secundaria a biomateriales y su respuesta inmunológica: Revisión sistemática de la literatura. Salut Sci Spirit [Internet]. 2016 [citado el 18 de noviembre de 2021];2(1). Disponible en: https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/1385.Kindt TJ, Goldsby RA, Osborne BA, Martínez RP. Inmunología de Kuby [Internet]. McGraw-Hill; 2007. Available from: https://books.google.com.co/books?id=2xpqMwAACAAJMicheels P. Human anti-hyaluronic acid antibodies: is it possible?. Dermatol Surg. 2001;27(2):185-191. doi:10.1046/j.1524-4725.2001.00248.xBBigatà X, Ribera M, Bielsa I, Ferrándiz C. Adverse granulomatous reaction after cosmetic dermal silicone injection. Dermatol Surg. 2001;27(2):198-200. doi:10.1046/j.1524- 4725.2001.00020.xLowe NJ, Maxwell CA, Lowe P, Duick MG, Shah K. Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol. 2001;45(6):930-933. doi:10.1067/mjd.2001.117381.Jones P, Mempin M, Hu H, et al. The Functional Influence of Breast Implant Outer Shell Morphology on Bacterial Attachment and Growth. Plast Reconstr Surg. 2018;142(4):837-849. doi:10.1097/PRS.0000000000004801Lee JM, Kim YJ. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg. 2015;42(2):232-239. doi:10.5999/aps.2015.42.2.232Bhojani-Lynch, Tahera MRCOphth, CertLRS, MBCAM, DipCS Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers, Plastic and Reconstructive Surgery - Global Open: December 2017 - Volume 5 - Issue 12 - p e1532 doi: 10.1097/GOX.0000000000001532Ercilla González G. (2010). Informe de bioseguridad inmunológica de implantes: ácido hialurónico. SEME; 24:7-13Yel L, Chen W, Gupta S. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004;92(1):88-91. doi:10.1016/S1081-1206(10)61716-4Alijotas-Reig J, Fernández-Figueras MT, Puig L. Late-onset inflammatory adverse reactions related to soft tissue filler injections. Clin Rev Allergy Immunol. 2013;45(1):97-108. doi:10.1007/s12016-012-8348-5Ledon JA, Savas JA, Yang S, Franca K, Camacho I, Nouri K. Inflammatory nodules following soft tissue filler use: a review of causative agents, pathology and treatment options. Am J Clin Dermatol. 2013;14(5):401-411. doi:10.1007/s40257-013-0043-7Montealegre G, Uribe R, Martínez-Ceballos MA, Rojas-Villarraga A. ASIA syndrome symptoms induced by gluteal biopolymer injections: Case-series and narrative review. Toxicol Rep. 2021;8:303-314. Published 2021 Jan 27. doi:10.1016/j.toxrep.2021.01.011Tamayo Carbón AM, Castellanos Prada AR, Aveiro-Róbalo TR. Alogenosis Iatrogénica Y Enfermedades Reumáticas. Rev cuba reumatol. 2018;20(2):18.Ameratunga R, Gillis D, Gold M, Linneberg A, Elwood JM. Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). J Allergy Clin Immunol Pract. 2017;5(6):1551-1555.e1. doi:10.1016/j.jaip.2017.06.033Watad A, Quaresma M, Brown S, et al. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome) - An update. Lupus. 2017;26(7):675-681. doi:10.1177/0961203316686406Ferrer-Cosme B, Téllez-Martínez D, Batista-Duharte A. inflamatorio inducido por adyuvantes. ¿Una nueva entidad clínica? [Internet]. Medigraphic.com. [citado el 18 de noviembre de 2021]. Disponible en: https://www.medigraphic.com/pdfs/imss/im- 2017/im173n.Nunes E Silva D, Gründler C, Spengler MDGMT, et al. Autoimmune Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Augmentation Surgery. Plast Reconstr Surg Glob Open. 2017;5(9):e1487. Published 2017 Sep 25. doi:10.1097/GOX.0000000000001487Cappellano G, Ploner C, Lobenwein S, et al. Immunophenotypic characterization of human T cells after in vitro exposure to different silicone breast implant surfaces. PLoS One. 2018;13(2):e0192108. Published 2018 Feb 8. doi:10.1371/journal.pone.0192108Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus. 2009;18(13):1217-1225. doi:10.1177/0961203309345724.Fernández de Vega F, Moreno J, González J, Palacios J. Procedimientos en microbiología Clínica Recomendaciones de la Sociedad Española de enfermedades Infecciosas y Microbiología Clínica. 2005. ISBN: 84-609-7032-9Dingle TC, Butler-Wu SM. Maldi-tof mass spectrometry for microorganism identification. Clin Lab Med. 2013;33(3):589-609. doi:10.1016/j.cll.2013.03.001Abu-Zhayia, E.R., Khoury-Haddad, H., Guttmann-Raviv, N. et al. A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. Sci Rep 7, 1002 (2017). https://doi.org/10.1038/s41598-017-01185-6World Health Organization & Centers for Disease Control and Prevention (U.S.). (2011). Laboratory methods for the diagnosis of meningitis caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae : WHO manual, 2nd ed. World Health Organization. https://apps.who.int/iris/handle/10665/70765Church DL, Cerutti L, Gürtler A, Griener T, Zelazny A, Emler S. Performance and Application of 16S rRNA Gene Cycle Sequencing for Routine Identification of Bacteria in the Clinical Microbiology Laboratory. Clin Microbiol Rev. 2020;33(4):e00053-19. Published 2020 Sep 9. doi:10.1128/CMR.00053-19Jo J-H, Kennedy EA, Kong HH. Research techniques made simple: Bacterial 16S ribosomal RNA gene sequencing in cutaneous research. J Invest Dermatol. 2016;136(3):e23–7.Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology (Reading). 2002;148(Pt 1):257-266. doi:10.1099/00221287-148-1-257Edwards KJ, Logan JMJ, Langham S, Swift C, Gharbia SE. Utility of real-time amplification of selected 16S rRNA gene sequences as a tool for detection and identification of microbial signatures directly from clinical samples. J Med Microbiol. 2012;61(Pt 5):645-652. doi:10.1099/jmm.0.041764-0Nadkarni MA, Martin FE, Jacques NA, Hunter N. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology (Reading). 2002;148(Pt 1):257-266. doi:10.1099/00221287-148-1-257Wu YD, Li W, Wei Y, Gao HH, Shang SQ, Du LZ. Rapid and Sensitive Identification of Bacterial Infection and Bacteria Gram Types in Pleural Fluid of Children. Glob Pediatr Health. 2015; 2:2333794X15569302. Published 2015 Jan 30. doi:10.1177/2333794X15569302DEVALLOIS A, GOH K.S, RASTOGI N. Rapid identification of mycobacteria to species level by PCR-restriction fragment length polymorphism analysis of the hsp65 gene and proposition of an algorithm to differentiate 34 mycobacterial species. J Clin Microbiol 1997; 35:2969-2973Häfner B, Haag H, Geiss HK, Nolte O. Different molecular methods for the identification of rarely isolated non-tuberculous mycobacteria and description of new hsp65 restriction fragment length polymorphism patterns. Mol Cell Probes. 2004;18(1):59-65. doi: 10.1016/j.mcp.2003.09.003Telenti A, Marchesi F, Balz M, Bally F, Böttger EC, Bodmer T. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol. 1993;31(2):175-178. doi:10.1128/jcm.31.2.175- 178.1993Zhang HJ, Pan Z, Wei JC, et al. Optimization of Pulsed-field Gel Electrophoresis Procedure for Bacillus cereus. Biomed Environ Sci. 2016;29(3):233-237. doi:10.3967/bes2016.030Neoh HM, Tan XE, Sapri HF, Tan TL. Pulsed-field gel electrophoresis (PFGE): A review of the "gold standard" for bacteria typing and current alternatives. Infect Genet Evol. 2019;74:103935. doi: 10.1016/j.meegid.2019.103935Kaminska PS, Fiedoruk K, Jankowska D, et al. One-day pulsed-field gel electrophoresis protocol for rapid determination of emetic Bacillus cereus isolates. Electrophoresis. 2015;36(7-8):1051-1054. doi:10.1002/elps.201400552Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233-2239. doi:10.1128/jcm.33.9.2233- 2239.1995Kwong JC, McCallum N, Sintchenko V, Howden BP. Whole genome sequencing in clinical and public health microbiology. Pathology. 2015;47(3):199-210. doi:10.1097/PAT.0000000000000235Bianco A, Capozzi L, Monno MR, et al. Characterization of Bacillus cereus Group Isolates From Human Bacteremia by Whole-Genome Sequencing. Front Microbiol. 2021;11:599524. Published 2021 Jan 12. doi:10.3389/fmicb.2020.599524Cossarizza A, Chang HD, Radbruch A, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019;49(10):1457-1973. doi:10.1002/eji.201970107Mendez-Rayo, Tatiana, Ochoa-Zárate, Laura, Posso-Osorio, Iván, Ortiz, Eliana, Naranjo-Escobar, Juan, & Tdbón, Gabriel J.. (2018). Interpretación de los autoanticuerpos en enfermedades reumatológicas. Revista Colombiana de Reumatología, 25(2), 112-125. https://doi.org/10.1016/j.rcreu.2018.02.004Kryštůfková O, Hulejová H, Mann HF, et al. Serum levels of B-cell activating factorof the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis. Arthritis Res Ther. 2018;20(1):158. Published 2018 Jul 27.doi:10.1186/s13075-018-1650-8Reyes L., León F., Rozas F., Gonzalez P., Naves R., BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide. Rev. méd. Chile (online). 2006, vol.134, n.9, pp.1175-1184. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872006000900014.Smulski CR, Eibel H. BAFF and BAFF-Receptor in B Cell Selection and Survival. Front Immunol. 2018;9:2285. Published 2018 Oct 8.doi:10.3389/fimmu.2018.02285Pisetsky D. S. (2017). Antinuclear antibody testing - misunderstood or misbegotten?. Nature reviews. Rheumatology, 13(8), 495–502. https://doi.org/10.1038/nrrheum.2017.74Geetha D, Jefferson JA. ANCA-Associated Vasculitis: Core Curriculum 2020. Am J Kidney Dis. 2020;75(1):124-137. doi:10.1053/j.ajkd.2019.04.031Thieblemont N,Wright HL, Edwards SW,Witko-Sarsat V. Human neutrophils in auto- immunity. Semin Immunol. 2016;28(2):159–73.Nakazawa D, Masuda S, Tomaru U, Ishizu A. Pathogenesis and therapeutic interventions for ANCA-associated vasculitis [published correction appears in Nat Rev Rheumatol. 2019 Jan 17]. Nat Rev Rheumatol. 2019;15(2):91-101. doi:10.1038/s41584-018-0145-yMendez-Rayo, Tatiana, Ochoa-Zárate, Laura, Posso-Osorio, Iván, Ortiz, Eliana, Naranjo-Escobar, Juan, & Tdbón, Gabriel J.. (2018). Interpretación de los autoanticuerpos en enfermedades reumatológicas. Revista Colombiana de Reumatología, 25(2), 112-125. https://doi.org/10.1016/j.rcreu.2018.02.004González Rodríguez, C., Aparicio Hernández, M. & Alarcón Torres, I. (2021). Actualización y manejo clínico de los anticuerpos anti-ácido desoxirribonucleico. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, 2(3), 322- 331. https://doi.org/10.1515/almed-2020-0067Gómez-Puerta, J. A., Burlingame, R. W., & Cervera, R.(2006). Anti-chromatin (anti- nucleosome) antibodies. Lupus, 15(7), 408–411. https://doi.org/10.1191/0961203306lu2325oaCozzani, E., Drosera, M., Gasparini, G., & Parodi, A. (2014). Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects. Autoimmune diseases, 2014, 321359. https://doi.org/10.1155/2014/321359Mahler M. (2011). Sm peptides in differentiation of autoimmune diseases. Advances in clinical chemistry, 54, 109–128. https://doi.org/10.1016/b978-0-12-387025- 4.00005-4Ohzeki, J. I., Otake, K., & Masumoto, H. (2020). Human artificial chromosome: Chromatin assembly mechanisms and CENP-B. Experimental cellresearch, 389(2), 111900. https://doi.org/10.1016/j.yexcr.2020.111900Koenig, M., Dieudé, M., & Senécal, J. L. (2008). Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies. Autoimmunity reviews, 7(8), 588–593. https://doi.org/10.1016/j.autrev.2008.06.010Chatterjee, S., & Prayson, R. A. (2020). Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Seminars in arthritis and rheumatism, 50(3), 498–502. https://doi.org/10.1016/j.semarthrit.2019.11.008Ghirardello, A., Zampieri, S., Iaccarino, L., Tarricone, E., Bendo, R., Gambari, P. F., & Doria, A. (2005). Anti-Mi-2 antibodies. Autoimmunity, 38(1), 79–83. https://doi.org/10.1080/08916930400022681Belizna, C., Henrion, D., Beucher, A., Lavigne, C., Ghaali, A., & Lévesque, H. (2010). Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmunity reviews, 9(10), 691–694. https://doi.org/10.1016/j.autrev.2010.05.020Franceschini, F., & Cavazzana, I. (2005). Anti-Ro/SSA and La/SSB antibodies. Autoimmunity, 38(1), 55–63. https://doi.org/10.1080/08916930400022954Kattah NH, Kattah MG, Utz PJ. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol Rev. 2010;233(1):126- 145. doi:10.1111/j.0105-2896.2009.00863.xZampieri S, Ghirardello A, Iaccarino L, Tarricone E, Gambari PF, Doria A. Anti-Jo-1 antibodies. Autoimmunity. 2005;38(1):73-78. doi:10.1080/08916930400022640Rodríguez EC, Díaz-Guevara P, Moreno J, Bautista A, Montaño L, Realpe ME, Della Gaspera A, Wiesner M. Laboratory surveillance of Salmonella enterica from human clinical cases in Colombia 2005-2011. Enferm Infecc Microbiol Clin. 2017 Aug- Sep;35(7):417-425. English, Spanish. doi: 10.1016/j.eimc.2016.02.023. Epub 2016 Mar 30. PMID: 27038678.Comans-Bitter WM, de Groot R, van den Beemd R, Neijens HJ, Hop WC, Groeneveld K, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr 1997; 130: 388-93.Christensen L, Breiting V, Bjarnsholt T, Eickhardt S, Høgdall E, Janssen M, et al. Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis. 2013;56(10):1438–44.Meneghetti KL, do Canto Canabarro M, Otton LM, Dos Santos Hain T, Geimba MP, Corção G. Bacterial contamination of human skin allografts and antimicrobial resistance: a skin bank problem. BMC Microbiol. 2018;18(1):121. Published 2018 Sep 24. doi:10.1186/s12866-018-1261-1Dominguez-Zambrano A., Haddad-Tame J.L., Torres-Baltazar I., Jiménez- Muñoz G., Satré-Ortíz N., Espinosa-Maceda S.. Enfermedad por modelantes: problemática actual en México y presentación de casos. Cir. plást. iberolatinoam. [Internet]. 2013 Dic [citado 2021 Nov 18] ; 39( 4 ): 399-405. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S037678922013000400010 &lng=es. https://dx.doi.org/10.4321/S0376-Busscher HJ, van der Mei HC, Subbiahdoss G, et al. Biomaterial-associated infection: locating the finish line in the race for the surface. Sci Transl Med. 2012;4(153):153rv10. doi:10.1126/scitranslmed.3004528Yel L, Chen W, Gupta S. Cellular immunodeficiency and autoimmunity in long-term mineral oil administration. Ann Allergy Asthma Immunol. 2004;92(1):88-91. doi:10.1016/S1081-1206(10)61716-4Dubouix A, Bonnet E, Alvarez M, et al. Bacillus cereus infections in Traumatology- Orthopaedics Department: retrospective investigation and improvement of healthcare practices. J Infect. 2005;50(1):22-30. doi:10.1016/j.jinf.2004.05.012Wang, Y., Leng, V., Patel, V. et al. Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures. Sci Rep 7, 45070 (2017). https://doi.org/10.1038/srep45070Ehling-Schulz M, Lereclus D, Koehler TM. The Bacillus cereus Group: Bacillus Species with Pathogenic Potential. Microbiol Spectr. 2019;7(3):10.1128/microbiolspec.GPP3-0032-2018. doi:10.1128/microbiolspec.GPP3-0032-2018Thomas MS,Wigneshweraraj S. Regulation of virulence gene expression. Virulence. 2014;5(8):832-834. doi:10.1080/21505594.2014.995573Marculescu CE, Berbari EF, Cockerill FR 3rd, Osmon DR. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res. 2006;451:55-63. doi:10.1097/01.blo.0000229317.43631.81Brown MM, Horswill AR. Staphylococcus epidermidis-Skin friend or foe?. PLoS Pathog. 2020;16(11):e1009026. Published 2020 Nov 12. doi:10.1371/journal.ppat.1009026Marculescu CE, Berbari EF, Cockerill FR 3rd, Osmon DR. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections. Clin Orthop Relat Res. 2006;451:55-63. doi:10.1097/01.blo.0000229317.43631.81Månsson E, Hellmark B, Sundqvist M, Söderquist B. Sequence types of Staphylococcus epidermidis associated with prosthetic joint infections are not present in the laminar airflow during prosthetic joint surgery. APMIS. 2015;123(7):589-595. doi:10.1111/apm.12392Otto M. Staphylococcus epidermidis--the 'accidental' pathogen. Nat Rev Microbiol. 2009;7(8):555-567. doi:10.1038/nrmicro2182Heldt Manica LA, Cohen PR. Staphylococcus lugdunensis infections of the skin and soft tissue: A case series and review. Dermatol Ther (Heidelb). 2017;7(4):555–62.Tevell S, Hellmark B, Nilsdotter-Augustinsson Å, Söderquist B. Staphylococcus capitis isolated from prosthetic joint infections. Eur J Clin Microbiol Infect Dis. 2017;36(1):115-122. doi:10.1007/s10096-016-2777-7Leonel C, Sena IFG, Silva WN, et al. Staphylococcus epidermidis role in the skin microenvironment. J Cell Mol Med. 2019;23(9):5949-5955. doi:10.1111/jcmm.14415Choi M, Cheon JS, Choi WY, Son KM, Ki JS, Kim Y. An outbreak of Pseudomonas stutzeri bacterial isolation caused by sterile dressing products. J Wound Manag Res. 2017;13(1):24–7.Ospina Fabio Enrique, Betancur Juan Felipe, Suso Juan Pablo, Muñoz-Buitro Evelyn, Cañas Carlos Alberto, Tobón Gabriel J.. Papel de la citocina BAFF en las enfermedades autoinmunes: rol fisiopatológico y estrategias terapéuticas. Rev.Colomb.Reumatol; 23( 3 ): 177-194. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121- 81232016000300006&lng=en. https://doi.org/10.1016/j.rcreu.2016.06.003Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241-258. doi:10.1016/j.semarthrit.2013.02.001Alijotas-Reig J, Fernández-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43(2):241-258. doi:10.1016/j.semarthrit.2013.02.001Maijers MC, de Blok CJ, Niessen FB, et al. Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study. Neth J Med. 2013;71(10):534- 540.Psianou K, Panagoulias I, Papanastasiou AD, et al. Clinical and immunological parameters of Sjögren's syndrome. Autoimmun Rev. 2018;17(10):1053-1064. doi:10.1016/j.autrev.2018.05.005Belizna C, Henrion D, Beucher A, Lavigne C, Ghaali A, Lévesque H. Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmun Rev. 2010;9(10):691-694. doi:10.1016/j.autrev.2010.05.020Chatterjee S, Prayson RA. Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Semin Arthritis Rheum. 2020;50(3):498-502. doi:10.1016/j.semarthrit.2019.11.008Chatterjee S, Prayson RA. Concurrent anti-PM-Scl antibody-associated systemic sclerosis and inclusion body myositis - report of two cases and review of the literature. Semin Arthritis Rheum. 2020;50(3):498-502. doi:10.1016/j.semarthrit.2019.11.008Schmidt J. Current Classification and Management of Inflammatory Myopathies. J Neuromuscul Dis. 2018;5(2):109-129. doi:10.3233/JND-180308Pisetsky DS, Lipsky PE. New insights into the role of antinuclear antibodies in systemic lupus erythematosus. Nat Rev Rheumatol. 2020;16(10):565-579. doi:10.1038/s41584-020-0480-7Sapkota B, Al Khalili Y. Mixed connective tissue disease. En: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021.Strzepa A, Pritchard KA, Dittel BN. Myeloperoxidase: A new player in autoimmunity. Cell Immunol. 2017;317:1-8. doi:10.1016/j.cellimm.2017.05.002Ripalda A, Loja A, Víctor L, Herrera P, Freites P. Consecuencias Clínicas Del Uso De Biopolímeros Como Prácticas De Auto-Atención En El Proceso De Trasformación Corporal En Personas Transexuales. // Clinical Consequences of the Use of Biopolymers As Self- Attention Practices in the Process of Body Transfor. Facsalud-Unemi [Internet]. 2018;2(2):46–52. Available from: http://ojs.unemi.edu.ec/index.php/facsalud- unemi/article/view/723/0.International Society of Aesthetic Plastic Surgery. International Survey on Aesthetic/Cosmetic., Procedures Performed in 2015. Fecha de consulta: 28.09.2019. 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