Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis

ilustraciones, diagramas

Autores:: Rey Padilla, Diana Patricia

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
dc.title.translated.eng.fl_str_mv	In vivo and in vitro study of the antidiabetic effect of an extract of passiflora ligularis leaves
title	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
spellingShingle	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis Ciencias Farmacéuticas 540 - Química y ciencias afines 610 - Medicina y salud::615 - Farmacología y terapéutica Passiflora Diabetes Mellitus Tipo 2 Extractos Vegetales Diabetes Mellitus, Type 2 Plant Extracts Diabetes mellitus tipo 2 Dieta rica en grasa/estreptozotocina Astragalina Isoquercetina Señalización de calcio GLUT4 Passiflora ligularis Juss Type 2 diabetes mellitus High-fat diet/streptozotocin Astragalin Isoquercetin Calcium signaling
title_short	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
title_full	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
title_fullStr	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
title_full_unstemmed	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
title_sort	Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis
dc.creator.fl_str_mv	Rey Padilla, Diana Patricia
dc.contributor.advisor.none.fl_str_mv	Ospina Giraldo, Luis Fernando Mena Barreto Silva, Fátima Regina
dc.contributor.author.none.fl_str_mv	Rey Padilla, Diana Patricia
dc.contributor.researchgroup.spa.fl_str_mv	Principios Bioactivos en Plantas Medicinales Grupo de Investigación en Tecnología de Productos Naturales Tecprona
dc.contributor.orcid.spa.fl_str_mv	Diana Patricia Rey [000000034517631X]
dc.contributor.cvlac.spa.fl_str_mv	Diana Patricia Rey Padilla [0001395740]
dc.contributor.researchgate.spa.fl_str_mv	Diana Rey [Diana-Rey]
dc.contributor.googlescholar.spa.fl_str_mv	Diana Patricia Rey Padilla [3HljxewAAAAJ&hl=es]
dc.subject.ddc.spa.fl_str_mv	Ciencias Farmacéuticas 540 - Química y ciencias afines 610 - Medicina y salud::615 - Farmacología y terapéutica
topic	Ciencias Farmacéuticas 540 - Química y ciencias afines 610 - Medicina y salud::615 - Farmacología y terapéutica Passiflora Diabetes Mellitus Tipo 2 Extractos Vegetales Diabetes Mellitus, Type 2 Plant Extracts Diabetes mellitus tipo 2 Dieta rica en grasa/estreptozotocina Astragalina Isoquercetina Señalización de calcio GLUT4 Passiflora ligularis Juss Type 2 diabetes mellitus High-fat diet/streptozotocin Astragalin Isoquercetin Calcium signaling
dc.subject.decs.none.fl_str_mv	Passiflora
dc.subject.decs.spa.fl_str_mv	Diabetes Mellitus Tipo 2 Extractos Vegetales
dc.subject.decs.eng.fl_str_mv	Diabetes Mellitus, Type 2 Plant Extracts
dc.subject.proposal.spa.fl_str_mv	Diabetes mellitus tipo 2 Dieta rica en grasa/estreptozotocina Astragalina Isoquercetina Señalización de calcio
dc.subject.proposal.none.fl_str_mv	GLUT4 Passiflora ligularis Juss
dc.subject.proposal.eng.fl_str_mv	Type 2 diabetes mellitus High-fat diet/streptozotocin Astragalin Isoquercetin Calcium signaling
description	ilustraciones, diagramas
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-08-08T14:26:24Z
dc.date.available.none.fl_str_mv	2023-08-08T14:26:24Z
dc.date.issued.none.fl_str_mv	2023-10-31
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
format	http://purl.org/coar/resource_type/c_db06
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84473
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84473 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ospina Giraldo, Luis Fernandobfb3464e494e8bac88c6cb72a6754547600Mena Barreto Silva, Fátima Regina3d5c30b03563ffbe97734b3f2c0036c2Rey Padilla, Diana Patriciaa471ff60f9625596cc6bd780001052ed600Principios Bioactivos en Plantas MedicinalesGrupo de Investigación en Tecnología de Productos Naturales TecpronaDiana Patricia Rey [000000034517631X]Diana Patricia Rey Padilla [0001395740]Diana Rey [Diana-Rey]Diana Patricia Rey Padilla [3HljxewAAAAJ&hl=es]2023-08-08T14:26:24Z2023-08-08T14:26:24Z2023-10-31https://repositorio.unal.edu.co/handle/unal/84473Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasIntroducción: La diabetes mellitus tipo 2 es una enfermedad de alta prevalencia e incidencia a nivel mundial, se estima que la población afectada por esta enfermedad siga en aumento en el transcurso de los próximos años, esta patología se caracteriza por una hiperglicemia crónica que si no es controlada conlleva a complicaciones cardiovasculares, neuropáticas, neurológicas, entre otras. Aunque actualmente se cuenta con varios tratamientos para el control de la glicemia y prevenir la aparición de las complicaciones asociadas a la misma, se sigue en búsqueda de nuevos tratamientos. Gran parte de la población mundial acude a la utilización de plantas medicinales para el tratamiento de sus enfermedades y aunque se ha reportado en la literatura el efecto antidiabético de varias plantas medicinales, es necesario profundizar en estudios que permitan establecer su actividad terapéutica, una de las especies en las que se ha evidenciado esta actividad, es la Passiflora ligularis, sin embargo se desconoce los metabolitos asociados a este efecto y su mecanismo de acción por ello se plantearon los siguientes objetivos. Los objetivos planteados fueron: evaluar el efecto antidiabético de un extracto de hojas de Passiflora ligularis (P. ligularis), identificar los metabolitos responsables de la actividad antidiabética de dicho extracto y la dilucidar un posible mecanismo de acción de los metabolitos responsables de dicha actividad antidiabética. (Texto tomado de la fuente)Introduction: Type 2 diabetes mellitus is a disease of high prevalence and incidence worldwide, it is estimated that the population affected by this disease will continue to increase in the coming years, this pathology is characterized by chronic hyperglycemia that if not controlled leads to cardiovascular, neuropathic, neurological complications, among others. Although there are currently several treatments to control glycemia and prevent the appearance of complications associated with it, the search for new treatments continues. A large part of the world population resorts to the use of medicinal plants for the treatment of their diseases and although the antidiabetic effect of various medicinal plants has been reported in the literature, it is necessary to deepen studies that allow establishing their therapeutic activity, one of the species in which this activity has been evidenced, is Passiflora ligularis, however the metabolites associated with this effect and its mechanism of action are unknown, therefore the following objectives were set. The proposed objectives were: evaluate the antidiabetic effect of an extract of Passiflora ligularis (P. ligularis) leaves, to identify the metabolites responsible for the antidiabetic activity of said extract and to elucidate a possible mechanism of action of the metabolites responsible for said antidiabetic activity.DoctoradoDoctor en Ciencias Farmacéuticasse realizó la preparación tanto del extracto acuoso como de la fracción etanólica de hojas de Passiflora ligularis, luego, se cuantificaron los flavonoides presentes en tanto en estos dos, mediante cromatografía liquida de alta resolución (CLAR), en un sistema LC Agilent 1260 Infinity acoplado a un detector de matriz de diodos (DAD). Posteriormente se evaluó la actividad antidiabética en ratones con diabetes inducida por dieta rica en grasa y dosis baja de estreptozotocina, se determinó la glicemia a los 7, 14 y 21 días de tratamiento y luego de los 21 días se realizó un test de tolerancia oral a la glucosa (TTOG), la determinación de insulina sérica y el sacrificio de los animales. Posterior al sacrificio se realizó un análisis histopatológico en páncreas, hígado y riñón y se determinaron los parámetros de estrés oxidativo y perfil lipídico de los animales diabéticos tratados y no tratados. Posteriormente en ratas normoglicémicas se efectuó un TTOG para determinar el efecto antihiperglicemiante y el contenido de glucógeno hepático y muscular de diferentes dosis de la fracción etanólica, por último, se evaluó el efecto y el posible mecanismo de acción de la isoquercetina y astragalina en la captación de glucosa en músculo sóleo aislado y en el aumento del calcio intracelular en islotes β-pancreáticos aislados para aumentar la secreción de insulinaFarmacología experimentalxxi, 144 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias FarmacéuticasFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáCiencias Farmacéuticas540 - Química y ciencias afines610 - Medicina y salud::615 - Farmacología y terapéuticaPassifloraDiabetes Mellitus Tipo 2Extractos VegetalesDiabetes Mellitus, Type 2Plant ExtractsDiabetes mellitus tipo 2Dieta rica en grasa/estreptozotocinaAstragalinaIsoquercetinaSeñalización de calcioGLUT4Passiflora ligularis JussType 2 diabetes mellitusHigh-fat diet/streptozotocinAstragalinIsoquercetinCalcium signalingEstudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularisIn vivo and in vitro study of the antidiabetic effect of an extract of passiflora ligularis leavesTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDAbdelhameed, R. 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Phytochemical Analysis, 23(3), 232–239. https://doi.org/10.1002/pca.1348Contract .836–2017#305799/2019–3Fondo Nacional de Financiamiento para la Ciencia, la Tecnología y la Innovación, Francisco José de Caldas.CNPq-Brazil & CAPES-BrazilInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84473/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1014182296.2023.pdf1014182296.2023.pdfTesis de Doctorado en Ciencias Farmacéuticasapplication/pdf2193319https://repositorio.unal.edu.co/bitstream/unal/84473/2/1014182296.2023.pdf3d76d9cac5de9fe86d31c5779ccf4ec2MD52THUMBNAIL1014182296.2023.pdf.jpg1014182296.2023.pdf.jpgGenerated Thumbnailimage/jpeg4376https://repositorio.unal.edu.co/bitstream/unal/84473/3/1014182296.2023.pdf.jpg3cf7e381c5765d9a658b5acde3560fcfMD53unal/84473oai:repositorio.unal.edu.co:unal/844732024-07-19 23:32:17.856Repositorio Institucional Universidad Nacional de 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Estudio in vivo e in vitro del efecto antidiabético de un extracto de hojas de passiflora ligularis

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