Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c

ilustraciones (algunas a color), diagramas

Autores:
Chivatá Avila, Jaime Alexander
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86491
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86491
https://repositorio.unal.edu.co/
Palabra clave:
540 - Química y ciencias afines
Trastornos del neurodesarrollo
Neurociencia cognitiva
Infección por el virus Zika
Neurodevelopmental disorders
Cognitive neuroscience
Zika virus infection
Virus del tumor murino
Mouse mammary tumor virus
Modelo de infección
desordenes del neurodesarrollo (NDDs)
Expresión diferencial
Enriquecimiento funcional
Transcriptómica
Infection model
Neurodevelopmental disorders (NDDs)
Differential expression
Functional enrichment
Transcriptomics
Transcriptómica
Transcriptome
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_593016cb329b85b6f6d7e5d7ab6c884d
oai_identifier_str oai:repositorio.unal.edu.co:unal/86491
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
dc.title.translated.eng.fl_str_mv Identification of genes associated with neurobehavioral changes due to zika virus infection in BALB/c mice
title Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
spellingShingle Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
540 - Química y ciencias afines
Trastornos del neurodesarrollo
Neurociencia cognitiva
Infección por el virus Zika
Neurodevelopmental disorders
Cognitive neuroscience
Zika virus infection
Virus del tumor murino
Mouse mammary tumor virus
Modelo de infección
desordenes del neurodesarrollo (NDDs)
Expresión diferencial
Enriquecimiento funcional
Transcriptómica
Infection model
Neurodevelopmental disorders (NDDs)
Differential expression
Functional enrichment
Transcriptomics
Transcriptómica
Transcriptome
title_short Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
title_full Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
title_fullStr Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
title_full_unstemmed Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
title_sort Identificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/c
dc.creator.fl_str_mv Chivatá Avila, Jaime Alexander
dc.contributor.advisor.spa.fl_str_mv Álvarez Diaz, Diego Alejandro
Lozano Moreno, José Manuel
dc.contributor.author.spa.fl_str_mv Chivatá Avila, Jaime Alexander
dc.contributor.researchgroup.spa.fl_str_mv Genómica de Microorganismos Emergentes
dc.contributor.cvlac.spa.fl_str_mv Chivatá Avila, Jaime Alexander [0001692043]
dc.subject.ddc.spa.fl_str_mv 540 - Química y ciencias afines
topic 540 - Química y ciencias afines
Trastornos del neurodesarrollo
Neurociencia cognitiva
Infección por el virus Zika
Neurodevelopmental disorders
Cognitive neuroscience
Zika virus infection
Virus del tumor murino
Mouse mammary tumor virus
Modelo de infección
desordenes del neurodesarrollo (NDDs)
Expresión diferencial
Enriquecimiento funcional
Transcriptómica
Infection model
Neurodevelopmental disorders (NDDs)
Differential expression
Functional enrichment
Transcriptomics
Transcriptómica
Transcriptome
dc.subject.decs.spa.fl_str_mv Trastornos del neurodesarrollo
Neurociencia cognitiva
Infección por el virus Zika
dc.subject.decs.eng.fl_str_mv Neurodevelopmental disorders
Cognitive neuroscience
Zika virus infection
dc.subject.lemb.spa.fl_str_mv Virus del tumor murino
dc.subject.lemb.eng.fl_str_mv Mouse mammary tumor virus
dc.subject.proposal.spa.fl_str_mv Modelo de infección
desordenes del neurodesarrollo (NDDs)
Expresión diferencial
Enriquecimiento funcional
Transcriptómica
dc.subject.proposal.eng.fl_str_mv Infection model
Neurodevelopmental disorders (NDDs)
Differential expression
Functional enrichment
Transcriptomics
dc.subject.wikidata.spa.fl_str_mv Transcriptómica
dc.subject.wikidata.eng.fl_str_mv Transcriptome
description ilustraciones (algunas a color), diagramas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-16T21:18:41Z
dc.date.available.none.fl_str_mv 2024-07-16T21:18:41Z
dc.date.issued.none.fl_str_mv 2024-01
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86491
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86491
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Álvarez Diaz, Diego Alejandrod0a756464256e51f82e12994d9061a7dLozano Moreno, José Manueldcbd854266c63b771557dc4006002e04600Chivatá Avila, Jaime Alexanderfe36cbb53722d31f10016f047caee3d6Genómica de Microorganismos EmergentesChivatá Avila, Jaime Alexander [0001692043]2024-07-16T21:18:41Z2024-07-16T21:18:41Z2024-01https://repositorio.unal.edu.co/handle/unal/86491Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones (algunas a color), diagramasEl virus Zika (ZIKV) es un arbovirus causante del “Síndrome de zika congénito”, asociado con diversos desórdenes del neurodesarrollo (NDDs) donde la microcefalia es una de las manifestaciones más severas. Existen NDDs más leves que pueden pasar desapercibidos en neonatos, como trastornos del espectro autista, retrasos en el desarrollo neuropsicomotor y del lenguaje que resultan en dificultades sociales y académicas. Los modelos murinos de infección por ZIKV reproducen defectos motores y cognitivos reportados en humanos los cuales pueden evaluarse mediante dispositivos comportamentales para su posterior contraste con perfiles de expresión genética, útiles en la caracterización de NDDs por ZIKV. Este estudio se enfocó en identificar genes asociados a cambios comportamentales por la infección con virus Zika en ratones BALB/c juveniles. Se inocularon por vía subcutánea con ZIKV (MH544701.2) ratones con dosis de 6.8x103 PFU al 1 día post-natal (DPN). La presencia del virus en cerebelo y corteza se verificó y cuantificó a los 10 y 30 días post-nfección (DPI) mediante RT-qPCR, los potenciales déficits neuroconductuales se evaluaron a los 30 DPI mediante las pruebas de laberinto en T, rotarod y campo abierto para posteriormente secuenciar y obtener listas genes diferencialmente expresados (DEG) así como categorías funcionales mediante análisis de enriquecimiento de conjunto de genes (GSEA). Se obtuvo un modelo de infección por ZIKV con capacidad de infectar para infectar cerebro, permitir la sobrevida más allá del 30 DPI y causar alteraciones comportamentales leves relacionadas con la actividad cognitiva, pero no con la motora o motivacional, asociada a una fuerte subregulación de genes relacionados con la sinapsis y con funciones estructurales en axones, dendritas y recubrimiento de mielina. En conjunto, estos datos proporcionan nueva información sobre los genes y las posibles vías moleculares que se ven alteradas en un proceso de infección leve y sugiere genes candidatos para futuras investigaciones. (Texto tomado de la fuente)The Zika virus (ZIKV) is an arbovirus responsible for the "Congenital Zika Syndrome," associated with various neurodevelopmental disorders (NDDs), where microcephaly is one of the most severe manifestations. Milder NDDs, including autism spectrum disorders and delays in neuropsychomotor and language development, may go unnoticed in neonates, resulting in social and academic challenges. Murine models of ZIKV infection replicate motor and cognitive defects reported in humans, assessable through behavioural devices for subsequent comparison with gene expression profiles, valuable in characterizing ZIKV-induced NDDs. This study aimed to identify genes associated with behavioral changes in Zika virus infection in juvenile BALB/c mice. Mice were subcutaneously inoculated with ZIKV (MH544701.2) at 1 day postnatal (DPN) with a dose of 6.8x103 PFU. Virus presence in cerebellum and cortex was verified and quantified at 10 and 30 days post-infection (DPI) using RT-qPCR. Potential neurobehavioral deficits were evaluated at 30 DPI through T-maze, rotarod, and open-field tests, followed by sequencing to obtain lists of differentially expressed genes (DEGs) and functional categories through gene set enrichment analysis (GSEA). A ZIKV infection model was established with the ability to infect the brain, allow survival beyond 30 DPI, and induce mild behavioral alterations related to cognitive activity but not motor or motivational aspects. This was associated with a strong downregulation of genes related to synapses and structural functions in axons, dendrites, and myelin sheaths. Overall, these data provide new insights into genes and potential molecular pathways altered in a mild infection process, suggesting candidate genes for future investigations. (Texto tomado de la fuente)MaestríaMagíster en Ciencias - BioquímicaBiología celular y patogénesis de los agentes emergentes y reemergentes causantes de enfermedades transmisibles.89 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BioquímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afinesTrastornos del neurodesarrolloNeurociencia cognitivaInfección por el virus ZikaNeurodevelopmental disordersCognitive neuroscienceZika virus infectionVirus del tumor murinoMouse mammary tumor virusModelo de infeccióndesordenes del neurodesarrollo (NDDs)Expresión diferencialEnriquecimiento funcionalTranscriptómicaInfection modelNeurodevelopmental disorders (NDDs)Differential expressionFunctional enrichmentTranscriptomicsTranscriptómicaTranscriptomeIdentificación de genes asociados a cambios neurocomportamentales por la infección con virus Zika en ratones BALB/cIdentification of genes associated with neurobehavioral changes due to zika virus infection in BALB/c miceTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TME. 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CNS Drug Discov., vol. 1, no. 2, pp. 219–230, 2006, doi: 10.2174/157488906777452776.Instituto Nacional de SaludInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86491/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1014260488.2024.pdf1014260488.2024.pdfTesis de Maestría en Ciencias - Bioquímicaapplication/pdf2505328https://repositorio.unal.edu.co/bitstream/unal/86491/2/1014260488.2024.pdf3a18c216ed5e83b705ff3ca481e34e17MD52THUMBNAIL1014260488.2024.pdf.jpg1014260488.2024.pdf.jpgGenerated Thumbnailimage/jpeg5314https://repositorio.unal.edu.co/bitstream/unal/86491/3/1014260488.2024.pdf.jpg012a9b8ecb01f7a29bf5924f8df2e7a2MD53unal/86491oai:repositorio.unal.edu.co:unal/864912024-07-16 23:05:11.86Repositorio Institucional Universidad Nacional de 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