Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos

gráficas, ilustraciones, tablas

Autores:: Otálora Otálora, Juan Martín

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
dc.title.translated.eng.fl_str_mv	Effect of autologous cell trasplantation olfactory ensheathing glial in clinical cases spinal cord injury in canines
title	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
spellingShingle	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos Neurociencias Transplantation of organs, tissues, etc Trasplante de órganos, tejidos, etc. Trasplante celular Cell--transplantation Lesión medular Células de la glía envolvente olfactoria Trasplante autólogo Spinal cord injury olfactory ensheathing glial cells Autologous trasplant
title_short	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
title_full	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
title_fullStr	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
title_full_unstemmed	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
title_sort	Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
dc.creator.fl_str_mv	Otálora Otálora, Juan Martín
dc.contributor.advisor.none.fl_str_mv	Botero Espinosa, Lucía Ghome Ghotme, Kemel
dc.contributor.author.none.fl_str_mv	Otálora Otálora, Juan Martín
dc.contributor.other.none.fl_str_mv	Ghotme Ghotme, Kemel
dc.subject.ddc.spa.fl_str_mv	Neurociencias
topic	Neurociencias Transplantation of organs, tissues, etc Trasplante de órganos, tejidos, etc. Trasplante celular Cell--transplantation Lesión medular Células de la glía envolvente olfactoria Trasplante autólogo Spinal cord injury olfactory ensheathing glial cells Autologous trasplant
dc.subject.lemb.none.fl_str_mv	Transplantation of organs, tissues, etc Trasplante de órganos, tejidos, etc. Trasplante celular Cell--transplantation
dc.subject.proposal.spa.fl_str_mv	Lesión medular Células de la glía envolvente olfactoria Trasplante autólogo
dc.subject.proposal.eng.fl_str_mv	Spinal cord injury olfactory ensheathing glial cells Autologous trasplant
description	gráficas, ilustraciones, tablas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-08-25T19:58:32Z
dc.date.available.none.fl_str_mv	2021-08-25T19:58:32Z
dc.date.issued.none.fl_str_mv	2021
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80016
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80016 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.format.extent.spa.fl_str_mv	XXII, 132 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina - Maestría en Neurociencias
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Botero Espinosa, Lucía2708e5b88997141c20524d894c6027bfGhome Ghotme, Kemel542ab33e46a4d1d51503e04b9281ff11Otálora Otálora, Juan Martín7c78977ca303f99db89db9daa42edabcGhotme Ghotme, Kemel2021-08-25T19:58:32Z2021-08-25T19:58:32Z2021https://repositorio.unal.edu.co/handle/unal/80016Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/gráficas, ilustraciones, tablasSpinal cord injury is an unfortunate event that generally involves a condition that in the short, medium and long term has multiple implications not only for the person suffering from it but also for their family nucleus and society in general (DeVivo and Chen, 2011; Angeli et al., 2018). For its treatment with cell therapy, a variety of cells have been used, among which the transplantation of ensheathing glial cells (CGEO). Specifically in canines, CGEO of the olfactory bulb and olfactory mucosa have been used, obtained through moderately invasive surgical procedures. In this research we innovate in taking the sample endoscopically in the nasal cavity avoiding the surgical approach to the nasal sinus and we also innovate by performing the transplant with a percutaneous technique with ultrasound guidance for the introduction of the needle and the deposit of cells intramedullary level without the need for an invasive surgical procedure involving laminectomy or myelotomy. We use magnetic resonance imaging to identify the exact site of the injury to perform the transplant. We measured the effect of non-purified CGEO transplantation (containing an average of 45% CGEO) in a sample of 8 companion dogs that presented chronic traumatic spinal cord injury in the city of Bogotá. Neurological tests and gait evaluation were performed using the Olby scale in pre-transplantation and monthly post-transplantation for three months, finding significant changes in some of the variables analyzed. Therefore, we were able to conclude that the effect of CGEO transplantation in clinical cases of spinal cord injury in canines is safe and brought beneficial effects in some of the patients. It is worth clarifying that there were no recoveries in the general proprioception tests or in postural reactions, so we think that the observed improvements were possibly due to local changes in spinal circuits and not to a recovery of movement that depends on long ascending and long tracts descending.La lesión medular es un infortunado evento que generalmente implica un padecimiento que a corto, mediano y largo plazo tiene múltiples implicaciones no solo para quien la padece sino además para su núcleo familiar y la sociedad en general (DeVivo and Chen, 2011; Angeli et al., 2018). Para su tratamiento con terapia celular se han utilizado variedad de células entre las que se destacan el trasplante de células de la glía envolvente olfatoria (CGEO). Específicamente en caninos se han utilizado CGEO del bulbo olfatorio y de la mucosa olfatoria, obtenidas mediante procedimientos quirúrgicos medianamente invasivos. En esta investigación innovamos en la toma de la muestra por vía endoscópica en la cavidad nasal evitando el abordaje quirúrgico del seno nasal e innovamos también al realizar el trasplante con una técnica percutánea con guía ecográfica para la introducción de la aguja y el depósito de las células a nivel intramedular sin necesidad de realizar un procedimiento quirúrgico invasivo que implicara laminectomía y mielotomía. Utilizamos imágenes de resonancia magnética para identificar el sitio exacto de la lesión para realizar el trasplante. Medimos el efecto del trasplante de CGEO no purificadas (conteniendo en promedio un 45% de CGEO) en una muestra de 8 perros de compañía que presentaron lesión medular traumática crónica en la ciudad de Bogotá. Se realizaron pruebas neurológicas y evaluación de la marcha utilizando la escala Olby en pre-trasplante y mensuales pos-trasplante por tres meses encontrando cambios significativos en algunas de las variables analizadas. Por lo que pudimos concluir que el efecto del trasplante de CGEO en casos clínicos de lesión medular en caninos es seguro y trajo efectos benéficos en algunos de los pacientes. Es de aclarar que no se presentaron recuperaciones en las pruebas de propiocepción general ni en reacciones posturales por lo que pensamos que las mejoras observadas se debieron posiblemente a cambios locales en circuitos medulares y no a una recuperación del movimiento que depende de tractos largos tanto ascendentes como descendentes (Texto tomado de la fuente)MaestríaMagister en NeurocienciasXXII, 132 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en NeurocienciasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáNeurocienciasTransplantation of organs, tissues, etcTrasplante de órganos, tejidos, etc.Trasplante celularCell--transplantationLesión medularCélulas de la glía envolvente olfactoriaTrasplante autólogoSpinal cord injuryolfactory ensheathing glial cellsAutologous trasplantEfecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninosEffect of autologous cell trasplantation olfactory ensheathing glial in clinical cases spinal cord injury in caninesTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMWyndaele M, Wyndaele JJ. 2006. 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