Clinical markers associated with acute laboratory-confirmed Dengue infection: results of a national epidemiological surveillance system

ABSTRACTObjective To evaluate the association of several clinical markers with acute laboratory-positive Dengue Virus infection.Methods A hospital-based case-control study was conducted in the state of Colima, Mexico, by using information from the National System of Epidemiological Surveillance (Sistema Nacional de Vigilancia Epidemiológica [SINAVE]) for Dengue. Data from 2 732 cases and 2 775 frequency-matched controls were analyzed. Odds Ratio (OR) and the 95 % Confidence Interval (CI), estimated by means of logistic regression models, were used.Results The presence of skin rash (OR=1,7; 95 % CI 1,5–2,1), persisting vomiting (OR=1,8; 95 % CI 1,5–2,3) and increased capillary fragility (petechiae, ecchymosis, hematoma or positive tourniquet test; OR=1,8; 95 % CI 1,2–2,6) were associated with laboratory-positive infection.Conclusions Three clinical markers were significantly associated with an increased risk of acute laboratory-confirmed dengue infection. These findings would support accurate and timely diagnosis of dengue in laboratory-limited settings.

• Autores: Murillo-Zamora, Efrén; Medina-González, Alfredo; Trujillo-Hernández, Benjamín; Mendoza-Cano, Oliver; Guzmán-Esquivel, José; Higareda-Almaraz, Martha Alicia; Higareda-Almaraz, Enrique
• Tipo de recurso: Article of journal
• Fecha de publicación: 2017
• Institución: Universidad Nacional de Colombia
• Repositorio: Universidad Nacional de Colombia
• Idioma: spa
• OAI Identifier: oai:repositorio.unal.edu.co:unal/65447
• Acceso en línea: https://repositorio.unal.edu.co/handle/unal/65447; http://bdigital.unal.edu.co/66470/
• Palabra clave: 36 Problemas y servicios sociales, asociaciones / Social problems and social services; 61 Ciencias médicas; Medicina / Medicine and health; Dengue; Epidemiología; Vigilancia de la Población; Enfermedades Transmisibles; Estudios de Casos y Controles.; Dengue; Epidemiology; Population Surveillance; Communicable diseases; Case-Control Studies.
• Rights: openAccess
• License: Atribución-NoComercial 4.0 Internacional