Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum

ilustraciones, gráficas, mapas, tablas

Autores:
Gaitán Albarracín, Felipe Andrés
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86037
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86037
https://repositorio.unal.edu.co/
Palabra clave:
570 - Biología::572 - Bioquímica
Deficiencia de Proteína
Leishmania
Gastrointestinal Tract
Protein Deficiency
Tracto Gastrointestinal
IgA
Leishmania infantum
Duodeno
Inflamación
Malnutrición
leishmaniasis visceral
GUT
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_4da7146c1099650ccac1ddb127ab56c7
oai_identifier_str oai:repositorio.unal.edu.co:unal/86037
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
dc.title.translated.eng.fl_str_mv Effect of protein restriction as a modulator of the immune response of the gastrointestinal tract of BALB/c mice infected with Leishmania infantum
title Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
spellingShingle Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
570 - Biología::572 - Bioquímica
Deficiencia de Proteína
Leishmania
Gastrointestinal Tract
Protein Deficiency
Tracto Gastrointestinal
IgA
Leishmania infantum
Duodeno
Inflamación
Malnutrición
leishmaniasis visceral
GUT
title_short Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
title_full Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
title_fullStr Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
title_full_unstemmed Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
title_sort Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
dc.creator.fl_str_mv Gaitán Albarracín, Felipe Andrés
dc.contributor.advisor.none.fl_str_mv Umaña Péres, Yadi Adriana
dc.contributor.author.none.fl_str_mv Gaitán Albarracín, Felipe Andrés
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Hormonas
dc.subject.ddc.spa.fl_str_mv 570 - Biología::572 - Bioquímica
topic 570 - Biología::572 - Bioquímica
Deficiencia de Proteína
Leishmania
Gastrointestinal Tract
Protein Deficiency
Tracto Gastrointestinal
IgA
Leishmania infantum
Duodeno
Inflamación
Malnutrición
leishmaniasis visceral
GUT
dc.subject.decs.spa.fl_str_mv Deficiencia de Proteína
Leishmania
Gastrointestinal Tract
dc.subject.decs.eng.fl_str_mv Protein Deficiency
Tracto Gastrointestinal
dc.subject.proposal.spa.fl_str_mv IgA
Leishmania infantum
Duodeno
Inflamación
Malnutrición
leishmaniasis visceral
dc.subject.proposal.eng.fl_str_mv GUT
description ilustraciones, gráficas, mapas, tablas
publishDate 2022
dc.date.issued.none.fl_str_mv 2022
dc.date.accessioned.none.fl_str_mv 2024-05-07T13:31:49Z
dc.date.available.none.fl_str_mv 2024-05-07T13:31:49Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86037
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86037
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados al autor, 2024http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Umaña Péres, Yadi Adriana55c0b64bb19a1dfda82dd09ebc9fd087Gaitán Albarracín, Felipe Andrés9b0f07ed3f4abd94a50e9df2d90503b2Grupo de Investigación en Hormonas2024-05-07T13:31:49Z2024-05-07T13:31:49Z2022https://repositorio.unal.edu.co/handle/unal/86037Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, mapas, tablasLa desnutrición proteica es la causa más frecuente de inmunodeficiencia secundaria que conlleva a alteraciones del sistema inmune innato y adaptativo, generando la colonización y proliferación de agentes patogénicos, convirtiéndose en uno de los principales factores de riesgo para el desarrollo de formas clínicas de leishmania visceral (LV). Usando como modelo biológico ratones BALB/c, nuestro grupo de investigación mostró que animales sometidos a restricción proteica e infección con L. infantum, presentan graves atrofias en órganos linfoides, alteraciones en las subpoblaciones de linfocitos T y en niveles de expresión de factores quimiotácticos en timo y bazo. Esas alteraciones sugieren que una precondición de desnutrición proteica afecta la respuesta inmune frente a L. infantum, modificando la migración de células T y la capacidad de controlar la proliferación de parásitos. Aunque un patrón diseminación y respuesta inmune órgano especifica aún no ha sido claramente elucidado para el tracto gastrointestinal, algunos estudios reportan la aparición de estos parásitos en mucosa intestinal. Nuestro objetivo fue evaluar la influencia de la restricción proteica en la respuesta inmune en tracto gastrointestinal de ratones BALB/c frente a la infección con L. infantum, observando como la infección y desnutrición generaron alteraciones inmunes en función del reclutamiento linfocitario tisular, alteraciones estructurales del tejido intestinal y alteraciones en la respuesta inmune adaptativa celular mediada por citoquinas y humoral a través de la secreción de Inmunoglobulina A de forma diferencial para el intestino delgado y grueso. (Texto tomado de la fuente)Protein malnutrition is the most frequent cause of secondary immunodeficiency that leads to alterations of the innate and adaptive immune system, generating the colonization and proliferation of pathogenic agents, becoming one of the main risk factors for the development of clinical forms of visceral leishmania (LV). Using BALB/c mice as a biological model, our research group showed that animals subjected to protein restriction and infection with L. infantum present severe atrophies in lymphoid organs, alterations in T lymphocyte subpopulations and in expression levels of chemotactic factors in thymus and spleen. These alterations suggest that a precondition of protein malnutrition affects the immune response against L. infantum, modifying the migration of T cells and the ability to control the proliferation of parasites. Although a pattern of dissemination and organ-specific immune response has not yet been clearly elucidated for the gastrointestinal tract, some studies report the appearance of these parasites in the intestinal mucosa. Our objective was to evaluate the influence of protein restriction on the immune response in the gastrointestinal tract of BALB/c mice against infection with L. infantum, observing how infection and malnutrition generated immune alterations based on tissue lymphocyte recruitment, structural alterations of the intestinal tissue and alterations in the cellular adaptive immune response mediated by cytokines and humoral through the secretion of Immunoglobulin A differentially for the small and large intestine.DoctoradoDoctor en Ciencias - BioquímicaEje GH/IGF-I y Nutriciónxii, 74 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - EstadísticaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::572 - BioquímicaDeficiencia de ProteínaLeishmaniaGastrointestinal TractProtein DeficiencyTracto GastrointestinalIgALeishmania infantumDuodenoInflamaciónMalnutriciónleishmaniasis visceralGUTEfecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntumEffect of protein restriction as a modulator of the immune response of the gastrointestinal tract of BALB/c mice infected with Leishmania infantumTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TD1. 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Trends Mol Med, 2012. 18(6): p. 328-36.EstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86037/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL80865742.2024.pdf80865742.2024.pdfTesis de Doctorados en Ciencias - Bioquímicaapplication/pdf2208226https://repositorio.unal.edu.co/bitstream/unal/86037/2/80865742.2024.pdf7d38d671b7c75b1974dfe9e62dd73d70MD52THUMBNAIL80865742.2024.pdf.jpg80865742.2024.pdf.jpgGenerated Thumbnailimage/jpeg6007https://repositorio.unal.edu.co/bitstream/unal/86037/3/80865742.2024.pdf.jpgd1e0c8736d649d322a19d1e7e27f3024MD53unal/86037oai:repositorio.unal.edu.co:unal/860372024-05-07 23:04:36.38Repositorio Institucional Universidad Nacional de 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