Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas
ilustraciones, diagramas, fotografías
- Autores:
-
Darwich Cedeño, Mohamed Toufic
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86613
- Palabra clave:
- 570 - Biología::579 - Historia natural microorganismos, hongos, algas
620 - Ingeniería y operaciones afines::628 - Ingeniería sanitaria
570 - Biología::572 - Bioquímica
Metabolitos microbianos
Microbial metabolites
Demanda bioquímica de oxígeno
Biochemical oxygen demand
Cianobacterias
Anticarcinógenos
Cyanobacteria
Anticarcinogenic Agents
Microbiología de aguas residuales
Sewage - microbiology
Biotecnología
Cianobacterias
Metabolitos primarios
Depuración de aguas
Anticancerígenos
MG063
Promotores de crecimiento
HCT116
Biotechnology
Cyanobacteria
Wastewater treatment
Anticancer
Growth promoters
Synechococcales
Oscillatoriales
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| dc.title.translated.eng.fl_str_mv |
Biotechnological potential of colombian Synechococcales and Oscillatoriales (cyanobacteria) |
| title |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| spellingShingle |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas 570 - Biología::579 - Historia natural microorganismos, hongos, algas 620 - Ingeniería y operaciones afines::628 - Ingeniería sanitaria 570 - Biología::572 - Bioquímica Metabolitos microbianos Microbial metabolites Demanda bioquímica de oxígeno Biochemical oxygen demand Cianobacterias Anticarcinógenos Cyanobacteria Anticarcinogenic Agents Microbiología de aguas residuales Sewage - microbiology Biotecnología Cianobacterias Metabolitos primarios Depuración de aguas Anticancerígenos MG063 Promotores de crecimiento HCT116 Biotechnology Cyanobacteria Wastewater treatment Anticancer Growth promoters Synechococcales Oscillatoriales |
| title_short |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| title_full |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| title_fullStr |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| title_full_unstemmed |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| title_sort |
Potencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianas |
| dc.creator.fl_str_mv |
Darwich Cedeño, Mohamed Toufic |
| dc.contributor.advisor.none.fl_str_mv |
Montenegro Ruiz, Luis Carlos |
| dc.contributor.author.none.fl_str_mv |
Darwich Cedeño, Mohamed Toufic |
| dc.contributor.researchgroup.spa.fl_str_mv |
Fisiología del Estrés y Biodiversidad en Plantas y Microorganismos |
| dc.contributor.orcid.spa.fl_str_mv |
Darwich Cedeño, Mohamed Toufic [000900060989433X] |
| dc.contributor.cvlac.spa.fl_str_mv |
Darwich Cedeño, Mohamed Toufic [0000024464] |
| dc.subject.ddc.spa.fl_str_mv |
570 - Biología::579 - Historia natural microorganismos, hongos, algas 620 - Ingeniería y operaciones afines::628 - Ingeniería sanitaria 570 - Biología::572 - Bioquímica |
| topic |
570 - Biología::579 - Historia natural microorganismos, hongos, algas 620 - Ingeniería y operaciones afines::628 - Ingeniería sanitaria 570 - Biología::572 - Bioquímica Metabolitos microbianos Microbial metabolites Demanda bioquímica de oxígeno Biochemical oxygen demand Cianobacterias Anticarcinógenos Cyanobacteria Anticarcinogenic Agents Microbiología de aguas residuales Sewage - microbiology Biotecnología Cianobacterias Metabolitos primarios Depuración de aguas Anticancerígenos MG063 Promotores de crecimiento HCT116 Biotechnology Cyanobacteria Wastewater treatment Anticancer Growth promoters Synechococcales Oscillatoriales |
| dc.subject.other.spa.fl_str_mv |
Metabolitos microbianos |
| dc.subject.other.eng.fl_str_mv |
Microbial metabolites |
| dc.subject.agrovoc.spa.fl_str_mv |
Demanda bioquímica de oxígeno |
| dc.subject.agrovoc.eng.fl_str_mv |
Biochemical oxygen demand |
| dc.subject.decs.spa.fl_str_mv |
Cianobacterias Anticarcinógenos |
| dc.subject.decs.eng.fl_str_mv |
Cyanobacteria Anticarcinogenic Agents |
| dc.subject.lemb.spa.fl_str_mv |
Microbiología de aguas residuales |
| dc.subject.lemb.eng.fl_str_mv |
Sewage - microbiology |
| dc.subject.proposal.spa.fl_str_mv |
Biotecnología Cianobacterias Metabolitos primarios Depuración de aguas Anticancerígenos MG063 Promotores de crecimiento |
| dc.subject.proposal.zho.fl_str_mv |
HCT116 |
| dc.subject.proposal.eng.fl_str_mv |
Biotechnology Cyanobacteria Wastewater treatment Anticancer Growth promoters |
| dc.subject.wikidata.eng.fl_str_mv |
Synechococcales Oscillatoriales |
| description |
ilustraciones, diagramas, fotografías |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-24T20:54:48Z |
| dc.date.available.none.fl_str_mv |
2024-07-24T20:54:48Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Doctorado |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TD |
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http://purl.org/coar/resource_type/c_db06 |
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acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/86613 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/86613 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
| dc.relation.references.spa.fl_str_mv |
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Seaweed Market by Product and Application - Global Opportunity Analysis and Industry Forecast, 2018-2024. https://www.researchandmarkets.com/reports/4580612/seaweed-market-by-product-and-application Arencibia, D. F., Fernández Rosario, A., & Gámez Menéndez, R. (2014). Métodos generales de conservación de microorganismos. January 2008. Ayala, F. (2017). Búsqueda de compuestos con posible actividad a partir de cianobacterias marinas del Caribe colombiano. Tesis de Maestría. Bayona Maldonado, L. M. (2014). Estudio químico y evaluación de la actividad citotóxica de metabolitos secundarios provenientes de cianobacterias bentónicas arrecifales del Caribe colombiano. http://www.bdigital.unal.edu.co/20433/ Becerra, L. (2017). Evaluación del perfil metabólico de un consorcio de cianobacterias bentónicas arrecifales del Caribe colombiano bajo condiciones de cultivo. (Tesis de Maestría). https://repositorio.unal.edu.co/handle/unal/62324 Bioeconomía (Enero 17 de 2018). Pronostican un mercado mundial de algas de USD 3,318 millones para 2022., https://www.bioeconomia.info/2018/01/17/pronostican_mercado_mundial_de_algas_de_usd_3318_millones_para_2022/ Blunt, J., Copp, B., Keyzers, R., Munro, M., & Prinsep, M. (2009). Marine natural products. Natural Product Reports, 26(2), 170–244. https://doi.org/10.1016/j.bjp.2015.09.004 Bösch, N., Mariana, B., Greczmiel, U., Morinaka, B., Gugger, M., Oxenius, A., Vagstad, A. L., & Piel, J. (2020). Landornamides, antiviral ornithine‐containing ribosomal peptides discovered by proteusin mining. Angewandte Chemie. https://doi.org/10.1002/ange.201916321 Bravakos, P., Kotoulas, G., Skaraki, K., Pantazidou, A., & Economou-Amilli, A. (2016). A polyphasic taxonomic approach in isolated strains of Cyanobacteria from thermal springs of Greece. Molecular Phylogenetics and Evolution, 98, 147–160. https://doi.org/10.1016/j.ympev.2016.02.009 Brito, Â., Gaifem, J., Ramos, V., Glukhov, E., Dorrestein, P. C., Gerwick, W. 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(2018). Purificación de agua : eliminación de nitratos , nitritos y compuestos orgánicos utilizando catalizadores en polvo y estructurados. In Universidad Nacional Del Litoral (Vol. 1, Issue 4). www.univeersidaddellit.com Mondal, A., Bose, S., Banerjee, S., Patra, J. K., Malik, J., Mandal, S. K., Kilpatrick, K. L., Das, G., Kerry, R. G., Fimognari, C., & Bishayee, A. (2020). Marine cyanobacteria and microalgae metabolites—A rich source of potential anticancer drugs. Marine Drugs, 18(9). https://doi.org/10.3390/md18090476 Montalvão, S., Demirel, Z., Devi, P., Lombardi, V., Hongisto, V., Perälä, M., Hattara, J., Imamoglu, E., Tilvi, S. S., Turan, G., Dalay, M. C., & Tammela, P. (2016). Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea. New Biotechnology, 33(3), 399–406. https://doi.org/10.1016/j.nbt.2016.02.002 Musale, A. S., Kumar, G. R. K., Sapre, A., & Dasgupta, S. (2020). Marine Algae as a Natural Source for Antiviral Compounds. 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Increasing Phosphorus Uptake Efficiency by Phosphorus-Starved Microalgae for Municipal. Microorganisms, 9. Lin, Y., Koutsospyros, A., Braida, W., Christodoulatos, C., Terracciano, A., & Su, T. L. (2022). MicroAlgal Biofilm Reactor (MABR) – Evaluation of Biomass Support Materials and Nitrate Removal Performance. Environmental Processes, 9(2). https://doi.org/10.1007/s40710-022-00574-y Miranda, F. (2018). Purificación de agua : eliminación de nitratos , nitritos y compuestos orgánicos utilizando catalizadores en polvo y estructurados. In Universidad Nacional Del Litoral (Vol. 1, Issue 4). www.univeersidaddellit.com Mohsenpour, S. F., Hennige, S., Willoughby, N., Adeloye, A., & Gutierrez, T. (2021). Integrating micro-algae into wastewater treatment: A review. Science of the Total Environment, 752(September 2020), 142168. https://doi.org/10.1016/j.scitotenv.2020.142168 Mousavi, S. A., Sarshad Ghahfarokhi, M., & Soltani Koupaei, S. (2020). 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Petroleum & Coal, 57(2), 101–107. Torres-Valenzuela, L. S., Sanín-Villarrea, A., Arango-Ramírez, A., & Serna-Jiménez, J. A. (2019). Caracterización fisicoquímica y microbiológica de aguas mieles del beneficio del café. Revista ION, 32(2), 59–66. https://doi.org/10.18273/revion.v32n2-2019006 Wang, Y., Wang, S., Sun, L., Sun, Z., & Li, D. (2020). Screening of a Chlorella-bacteria consortium and research on piggery wastewater purification. Algal Research, 47(October 2019), 101840. https://doi.org/10.1016/j.algal.2020.101840 Watanabe, K., Takihana, N., Aoyagi, H., Hanada, S., Watanabe, Y., Ohmura, N., Saiki, H., & Tanaka, H. (2005). Symbiotic association in Chlorella culture. FEMS Microbiology Ecology, 51(2), 187–196. https://doi.org/10.1016/j.femsec.2004.08.004 Zhang, H., Chen, X., Song, L., Liu, S., & Li, P. (2022). The mechanism by which Enteromorpha Linza polysaccharide promotes Bacillus subtilis growth and nitrate removal. International Journal of Biological Macromolecules, 209(PA), 840–849. https://doi.org/10.1016/j.ijbiomac.2022.04.082 Andersen, R. A. (2005). Algal Culturing Techniques. In Elsevier (Vol. 1). Ayala, F. (2017). Búsqueda de compuestos con posible actividad a partir de cianobacterias marinas del Caribe colombiano. Tesis de Maestría. Bayona Maldonado, L. M. (2014). Estudio químico y evaluación de la actividad citotóxica de metabolitos secundarios provenientes de cianobacterias bentónicas arrecifales del Caribe colombiano. http://www.bdigital.unal.edu.co/20433/ Becerra, L. (2017). Evaluación del perfil metabólico de un consorcio de cianobacterias bentónicas arrecifales del Caribe colombiano bajo condiciones de cultivo. (Tesis de Maestría). https://repositorio.unal.edu.co/handle/unal/62324 Cano, J. (2018). Conservación in vitro y cultivo de Cyanoprocariotas bentónicas arrecifales de Providencia y Santa Catalina Islas, Colombia. Tesis de Maestría. In Universidad Nacional de Colombia. Charitos, G., Trafalis, D. T., Dalezis, P., Potamitis, C., Sarli, V., Zoumpoulakis, P., & Camoutsis, C. (2019). Synthesis and anticancer activity of novel 3,6-disubstituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives. Arabian Journal of Chemistry, 12(8), 4784–4794. https://doi.org/10.1016/j.arabjc.2016.09.015 Costa, M., Garcia, M., Costa-Rodrigues, J., Costa, M. S., Ribeiro, M. J., Fernandez, M. H., Barros, P., Barreiro, A., Vasconcelos, V., & Martins, R. (2014). Exploring Bioactive Properties of Marine Cyanobacteria Isolated from the Portuguese Coast: High Potential as a Source of Anticancer Compounds. Marine Drugs, 12(December 2013), 98–114. https://doi.org/10.3390/md12010098 Ferreira, L., Morais, J., Preto, M., Silva, R., Urbatzka, R., Vasconcelos, V., & Reis, M. (2021). Uncovering the bioactive potential of a cyanobacterial natural products library aided by untargeted metabolomics. Marine Drugs, 19(11). https://doi.org/10.3390/md19110633 Ferreira, L., Morais, J., Vasconcelos, V., & Reis, M. (2022). Discovery of a Novel Potent Cytotoxic Compound from Leptothoe sp. 778069, 46. https://doi.org/10.3390/blsf2022014046 Girão, M., Ribeiro, I., Ribeiro, T., Azevedo, I. C., Pereira, F., Urbatzka, R., Leão, P. N., & Carvalho, M. F. (2019). Actinobacteria isolated from laminaria ochroleuca: A source of new bioactive compounds. Frontiers in Microbiology, 10(APR), 1–13. https://doi.org/10.3389/fmicb.2019.00683 Grkovic, T., Akee, R. K., Thornburg, C. C., Trinh, S. K., Britt, J. R., Harris, M. J., Evans, J. R., Kang, U., Ensel, S., Henrich, C. J., Gustafson, K. R., Schneider, J. P., & O’Keefe, B. R. (2020). National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. 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Afloramientos de cianobacterias marinas bentónicas en San Andrés, Providencia y las Islas del Rosario (Caribe colombiano): Caracterización y evaluación de su posible papel ecológico. Quintana Bulla, J. I. (2011). Evaluación de la toxicidad y del potencial bioactivo de afloramientos de cianobacterias bentónicas arrecifales del Caribe Colombiano / Evaluation of toxicity and bioactive potential of benthic marine cyanobacteria from Colombian Caribbean Sea. http://www.bdigital.unal.edu.co/8094/ Robles-Bañuelos, B., Durán-Riveroll, L. M., Rangel-López, E., Pérez-López, H. I., & González-Maya, L. (2022). Marine Cyanobacteria as Sources of Lead Anticancer Compounds: A Review of Families of Metabolites with Cytotoxic, Antiproliferative, and Antineoplastic Effects. Molecules, 27(15). https://doi.org/10.3390/molecules27154814 Sousa, M. L. da S. (2020). Cyanobacterial bioactive metabolites for anticancer drug discovery: Characterization of new compounds and molecular mechanisms in physiologically relevant 3D cell culture. https://repositorio-aberto.up.pt/handle/10216/126888 Sousa, M. L., Preto, M., Vasconcelos, V., Linder, S., & Urbatzka, R. (2019). Antiproliferative effects of the natural oxadiazine nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation. Frontiers in Oncology, 9(APR), 1–13. https://doi.org/10.3389/fonc.2019.00224 Sousa, M. L., Ribeiro, T., Vasconcelos, V., Linder, S., & Urbatzka, R. (2020). Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours. Toxicon, 175, 49–56. https://doi.org/10.1016/j.toxicon.2019.12.159 Gkotsis, P., Peleka, E., & Zouboulis, A. (2020). The use of natural minerals in a pilot-scale MBR for membrane fouling mitigation. Separations, 7(2), 1–13. https://doi.org/10.3390/separations7020024 Suraraksa, B., Nopharatana, A., Chaiprasert, P., Bhumiratana, S., & Tanticharoen, M. (2017). Effect of Substrate Feeding Concentration on Initial Biofilm Development in Anaerobic Hybrid Reactor. ASEAN Journal on Science and Technology for Development, 20(3&4), 361–372. https://doi.org/10.29037/ajstd.357 Cegłowska, M., Kwiecień, P., Szubert, K., Brzuzan, P., Florczyk, M., Edwards, C., Kosakowska, A., & Mazur-Marzec, H. (2022). Biological Activity and Stability of Aeruginosamides from Cyanobacteria. Marine Drugs, 20(2). https://doi.org/10.3390/md20020093 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Montenegro Ruiz, Luis Carlos991f9b712cfdf53aecb21221300a7365Darwich Cedeño, Mohamed Toufic82c1a7653b4be18356c8eb12d1886191600Fisiología del Estrés y Biodiversidad en Plantas y MicroorganismosDarwich Cedeño, Mohamed Toufic [000900060989433X]Darwich Cedeño, Mohamed Toufic [0000024464]2024-07-24T20:54:48Z2024-07-24T20:54:48Z2023https://repositorio.unal.edu.co/handle/unal/86613Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasLas cianobacterias son de los organismos más antiguos del planeta, por tanto, han soportado múltiples presiones ambientales y biológicas que han impulsado a la aparición de moléculas que han garantizado su supervivencia. Partiendo de lo anterior, se buscó realizar una caracterización biotecnológica de las cianobacterias de la Colección de Algas y Cianobacterias LAUN, de la Universidad Nacional de Colombia. Se identificaron las cepas mediante análisis moleculares encontrando 7 posibles géneros nuevos. Se analizó la producción de metabolitos primarios, teniendo que la cepa LAUN 81 (Synechoccocales Cyanobacteria) presenta la mayor concentración de proteína (19.04% de proteína soluble), la cepa LAUN 34 (Pleurocapsa sp.) presenta la mayor concentración de carbohidratos (11.73% de carbohidratos solubles) y la cepa LAUN 74 (Synechoccocales Cyanobacteria) presenta la mayor concentración de lípidos (40.5% de lípidos del peso total de biomasa). Por otra parte, la cepa LAUN 71 (Leptolyngbya sp.) presentó los mejores porcentajes de remoción de contaminantes en agua residual sintética, 77.5% de nitratos y 98% de fosfatos, alcanzó un 85.40% de disminución de la DQO y 94.5% de la DBO5. Finalmente, se realizó el fraccionamiento por HPLC de extractos metanólicos de los géneros representativos de las cepas LAUN y se probaron las fracciones contra células cancerígenas de cáncer colorectal (HCT116) y osteosarcoma (MG063), teniendo que la fracción “D” de LAUN33 (Baaleninema sp.) y la fracción “A” de LAUN 74 la mayor toxicidad con rendimientos de 33.18% y 34.32% de supervivencia celular respectivamente, contra la línea HCT116 y las fracciones E y F de la cepa LAUN33, la fracción H de LAUN 55 (Synechoccocales Cyanobacteria) y la fracción F de LAUN74 presentaron la mayor toxicidad con rendimientos de 39.28%, 38.94%, 38.28% y 38.42% de supervivencia celular respectivamente, contra la línea MG063 (Texto tomado de la fuente).Cyanobacteria are among the oldest organisms on the planet; therefore, they have endured multiple environmental and biological pressures that have led to the appearance of molecules that guarantee their survival. Based on this, we sought to carry out a biotechnological characterization of the cyanobacteria from the LAUN Algae and Cyanobacteria Collection of the National University of Colombia. The strains were identified through molecular analysis, which revealed 7 possible new genera. The production of primary metabolites was analyzed, and it was found that the strain LAUN 81 (Synechoccocales Cyanobacteria) presents the highest concentration of protein (19.04% of soluble protein), the strain LAUN 34 (Pleurocapsa sp.) presents the highest concentration of carbohydrates (11.73% of soluble carbohydrates), and the strain LAUN 74 (Synechoccocales Cyanobacteria) presents the highest concentration of lipids (40.5% lipids of the total weight of biomass). On the other hand, the strain LAUN 71 (Leptolyngbya sp.) demonstrated the best percentages of pollutant removal in synthetic wastewater, with 77.5% nitrate and 98% phosphate removal, reaching an 85.40% reduction in COD (Chemical Oxygen Demand) and 94.5% reduction of the BOD5 (Biochemical Oxygen Demand). Finally, HPLC fractionation of methanolic extracts of the representative genera of the LAUN strains was carried out. The fractions were then tested against colorectal cancer cells (HCT116) and osteosarcoma cells (MG063). Fraction "D" of LAUN33 (Baaleninema sp.) and fraction "A" of LAUN 74 showed the highest toxicity with cell survival yields of 33.18% and 34.32%, respectively, against the HCT116 line. On the other hand, fractions E and F of strain LAUN33, fraction H of LAUN 55 (Synechoccocales Cyanobacteria), and fraction F of LAUN 74 presented the highest toxicity with cell survival yields of 39.28%, 38.94%, 38.28%, and 38.42%, respectively, against the MG063 line.DoctoradoDoctor en Ciencias - BiologíaBiotecnologíaxvii, 125 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::579 - Historia natural microorganismos, hongos, algas620 - Ingeniería y operaciones afines::628 - Ingeniería sanitaria570 - Biología::572 - BioquímicaMetabolitos microbianosMicrobial metabolitesDemanda bioquímica de oxígenoBiochemical oxygen demandCianobacteriasAnticarcinógenosCyanobacteriaAnticarcinogenic AgentsMicrobiología de aguas residualesSewage - microbiologyBiotecnologíaCianobacteriasMetabolitos primariosDepuración de aguasAnticancerígenosMG063Promotores de crecimientoHCT116BiotechnologyCyanobacteriaWastewater treatmentAnticancerGrowth promotersSynechococcalesOscillatorialesPotencial biotecnológico de Synechococcales y Oscillatoriales (cyanobacteria) colombianasBiotechnological potential of colombian Synechococcales and Oscillatoriales (cyanobacteria)Trabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDColombiaAbed, R. 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Marine Drugs, 20(2). https://doi.org/10.3390/md20020093EstudiantesInvestigadoresMaestrosPúblico generalORIGINAL1144054446.2023.pdf1144054446.2023.pdfTesis de Doctorado en Ciencias-Biologíaapplication/pdf1542715https://repositorio.unal.edu.co/bitstream/unal/86613/2/1144054446.2023.pdffa14c60366fca4bf244967c8d9b821d9MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86613/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53THUMBNAIL1144054446.2023.pdf.jpg1144054446.2023.pdf.jpgGenerated Thumbnailimage/jpeg5445https://repositorio.unal.edu.co/bitstream/unal/86613/4/1144054446.2023.pdf.jpg81b4deb01a91197c33caa08ced10435eMD54unal/86613oai:repositorio.unal.edu.co:unal/866132024-07-24 23:25:51.969Repositorio Institucional Universidad Nacional de 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