Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora
ilustraciones, diagramas, fotografías
- Autores:
-
Torres Vargas, David Gilberto
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86142
- Palabra clave:
- 540 - Química y ciencias afines::547 - Química orgánica
Bioprospección
Líquenes
Propiedades antioxidantes
bioprospecting
lichens
antioxidant properties
Bioprospección
Fotoprotección
Lobariella sipmanii
Hongos liquenizados
Páramo
Photoprotection
Bioprospection
Lobariella sipmanii
Lichenized fungi
Paramo
Bioprospektion
Fotoprotektion
Lobariella sipmanii
Lizenzierte Pilze
Paramo
photoprotection
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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UNACIONAL2 |
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Universidad Nacional de Colombia |
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| dc.title.spa.fl_str_mv |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| dc.title.translated.eng.fl_str_mv |
Bioprospection of lichenized fungi from páramo de Sumapaz (Bogotá - Colombia) as promising sources of antioxidant and photoprotective dual drugs |
| dc.title.translated.deu.fl_str_mv |
Bioprospektion von lichenisierten Pilzen aus dem Sumapaz-Páramo (Bogotá - Kolumbien) als vielversprechende Quelle für duale Arzneimittel mit antioxidativer und lichtschützender Wirkung |
| title |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| spellingShingle |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora 540 - Química y ciencias afines::547 - Química orgánica Bioprospección Líquenes Propiedades antioxidantes bioprospecting lichens antioxidant properties Bioprospección Fotoprotección Lobariella sipmanii Hongos liquenizados Páramo Photoprotection Bioprospection Lobariella sipmanii Lichenized fungi Paramo Bioprospektion Fotoprotektion Lobariella sipmanii Lizenzierte Pilze Paramo photoprotection |
| title_short |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| title_full |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| title_fullStr |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| title_full_unstemmed |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| title_sort |
Bioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectora |
| dc.creator.fl_str_mv |
Torres Vargas, David Gilberto |
| dc.contributor.advisor.spa.fl_str_mv |
Aguirre Ceballos, Jaime |
| dc.contributor.author.spa.fl_str_mv |
Torres Vargas, David Gilberto |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Estudios Biológicos y Fisicoquímicos de Líquenes Colombianos Grupo de Investigación en Química Medicinal |
| dc.contributor.orcid.spa.fl_str_mv |
0000-0001-5374-5784 |
| dc.contributor.researchgate.spa.fl_str_mv |
https://www.researchgate.net/profile/David-Torres-Vargas |
| dc.subject.ddc.spa.fl_str_mv |
540 - Química y ciencias afines::547 - Química orgánica |
| topic |
540 - Química y ciencias afines::547 - Química orgánica Bioprospección Líquenes Propiedades antioxidantes bioprospecting lichens antioxidant properties Bioprospección Fotoprotección Lobariella sipmanii Hongos liquenizados Páramo Photoprotection Bioprospection Lobariella sipmanii Lichenized fungi Paramo Bioprospektion Fotoprotektion Lobariella sipmanii Lizenzierte Pilze Paramo photoprotection |
| dc.subject.agrovoc.spa.fl_str_mv |
Bioprospección Líquenes Propiedades antioxidantes |
| dc.subject.agrovoc.eng.fl_str_mv |
bioprospecting lichens antioxidant properties |
| dc.subject.proposal.spa.fl_str_mv |
Bioprospección Fotoprotección Lobariella sipmanii Hongos liquenizados Páramo |
| dc.subject.proposal.eng.fl_str_mv |
Photoprotection Bioprospection Lobariella sipmanii Lichenized fungi Paramo |
| dc.subject.proposal.deu.fl_str_mv |
Bioprospektion Fotoprotektion Lobariella sipmanii Lizenzierte Pilze Paramo |
| dc.subject.wikidata.eng.fl_str_mv |
photoprotection |
| description |
ilustraciones, diagramas, fotografías |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023-11-29 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-22T22:35:02Z |
| dc.date.available.none.fl_str_mv |
2024-05-22T22:35:02Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86142 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/86142 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
| dc.relation.references.spa.fl_str_mv |
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A systematic review; Pharmaceutical Biology; 54 (1): 1--17; doi:10.3109/13880209.2014.1003354; URL http://www.tandfonline.com/doi/full/10.3109/13880209.2014.1003354 Garoli, D.; Pelizzo, M. G.; Bernardini, B.; Nicolosi, P. & Alaibac, M.: , 2008; Sunscreen tests: Correspondence between in vitro data and values reported by the manufacturers; Journal of Dermatological Science; 52 (3): 193--204; doi:10.1016/j.jdermsci.2008.06. 010 Gaspar, L. R.; Tharmann, J.; Maia Campos, P. M. & Liebsch, M.: , 2012; Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate; Toxicology in Vitro; 27 (1): 418--425; doi:10.1016/j.tiv.2012.08. 006; URL http://dx.doi.org/10.1016/j.tiv.2012.08.006 Gasparro, F. 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S. & Kim, H.: , 2017; The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis; Scientific Reports; 7 (1): 1--13; doi:10.1038/s41598-017-08225-1; URL http://dx.doi.org/10.1038/s41598-017-08225-1 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aguirre Ceballos, Jaimea16c4252b55ca358d6171713d565eeedTorres Vargas, David Gilberto930519eacf60f8fe52fde96f1ebad3c9600Grupo de Investigación en Estudios Biológicos y Fisicoquímicos de Líquenes ColombianosGrupo de Investigación en Química Medicinal0000-0001-5374-5784https://www.researchgate.net/profile/David-Torres-Vargas2024-05-22T22:35:02Z2024-05-22T22:35:02Z2023-11-29https://repositorio.unal.edu.co/handle/unal/86142Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasLos páramos son biomas de alta montaña sui generis localizados en el neotrópico, cuyos organismos están expuestos de forma constante a bajas temperaturas y alta irradiación. La radiación solar en su conjunto, pero en especial la radiación ultravioleta e infrarroja cercana, ha sido identificada como el factor etiológico de problemas de la piel, tales como el fotoenvejecimiento y diversos tipos de cáncer de piel (CP). Los productos naturales derivados de la flora de los páramos, en particular los hongos liquenizados (HL), han sido poco explorados; no obstante, debido a que los compuestos de líquenes no solo absorben la radiación UV sino que tienen actividad antioxidante, es posible proponerlos como una fuente original de compuestos que protejan de la radiación solar. Se evaluó la actividad antioxidante y fotoprotectora de varios extractos de HL del páramo de Sumapaz, donde el extracto de Lobariella sipmanii fue uno de los más activos y con mayor variedad de compuestos. De este HL se obtuvieron 3 compuestos, reportados por primera vez para la especie. Pseudociferelina A (1), 2,4-dihidroxi-3,5,6-trimetilbenzoato de metilo (2) y orselinato de metilo (3). De ellos, los compuestos monoaromáticos (2 y 3) presentaron absorción UV-B (FPS = 21,86 +/- 0,09 y 38,41 +/- 0,26 a 200 ug/mL respectivamente) y baja amplitud espectral (Longitud de onda crítica = 333,9 nm y 319,5 nm). Además, sus espectros de infrarrojo cercano son similares a los filtros solares comerciales usados como control y ofrecen protección para esta región del espectro electromagnético. Mientras que el compuesto 1 presentó un FPS de 9,82 +/- 0,58 a 200 ug/mL y mayor amplitud espectral (Longitud de onda crítica = 365,8 nm) similar a la de filtros de amplio espectro como el bemotrizinol (Longitud de onda crítica = 374,2 nm). Los compuestos 1 y 2 tuvieron actividad captadora de radicales libres (CE50 = 217,1 uM y 342,3uM respectivamente) y presentaron un porcentaje de inhibición de la peroxidación lipídica a 24 horas comparable con el BHT (p > 0,05), mientras que el compuesto 3 no presentó actividad antioxidante. Dado que el estrés oxidativo es uno de los factores que aceleran el desarrollo del CP y otros problemas cutáneos, la actividad captadora de radicales libres, el poder reductor férrico y la inhibición de la peroxidación lipídica de dos de los compuestos aislados (1 y 2) constituyen ventajas con respecto a los filtros solares comerciales disponibles actualmente. Asimismo, los compuestos aislados presentan menor potencial de causar alergias, menor toxicidad y más bajo potencial de bioacumulación para los organismos acuáticos in silico y están dentro de los parámetros de seguridad establecidos por la legislación europea. Lo que los convierte en alternativas para la fotoprotección y puede favorecer la bioprospección de los HL del neotrópico. (Texto tomado de la fuente).Paramos are sui generis high mountain biomes located in neotropics, whose organisms are constantly exposed to low temperatures and high sun irradiation. Sun rays, especially ultraviolet (UV) and near-infrarred (NIR) radiation, have been identified as an aetiological factor of skin problems including photo-aging and some types of skin cancer (SC). Natural products from Paramos’ flora, particularly lichenized fungi (LF), have been scarcely explored; however, lichen substances not only absorb UV radiation, but also have antioxidant activity. Hence, LF can be proposed as an original source for compounds with photoprotective activity. \par Several paramo's LF extracts have been evaluated for antioxidant and photoprotective activities. Lobariella sipmanii was one of the most active extracts and has the highest variety of compounds. From this LF three compounds were obtained for the first time. Pseudocypherallin A (1), 2,4-dihydroxy-3,5,6-trimethyl methylbenzoate (2) and methyl orsellinate (3). Monoaromatic compounds (2 and 3) presented UV-B and near infrared radiation absorption (SPF = 21.86 +/- 0.09 & 38.41 +/- 0.26 at 200 ug/mL) and low spectral amplitude (Critical wavelength = 333.9 nm & 319.5 nm). Moreover, their NIR spectra were similar to commercially available sunscreens; thus, also offered protection in this region. Whereas compound 1 had SPF value of 9.82 +/- 0.58 at 200 ug/mL and higher spectral amplitude (Critical wavelength = 365.8 nm), similar to modern wide-spectrum sunscreens like bemotrizinol (Critical wavelength = 374.2 nm). \par Compounds 1 and 2 had scavenging activity (EC50 = 217,1 uM & 342,3 uM respectively) and exhibit lipid peroxidation ihnibition percentages in 24 hours similar to BHT (p > 0,05), while compound 3 had not presented any antioxidant activity. Oxidative stress is one factor that accelerate SC and cutaneous problems development; therefore, radical scavenging, ferric reducing power and lipid peroxidation inhibition from compounds 1 and 2 constitute benefits regarding current commercially available sunscreens. Furthermore, isolated compounds obtained lower allergenicity potential, lower predicted in silico toxicity and bioaccumulation factors, and complied with safety EU requirements for chemical substances. It converts them into better alternatives for photoprotection and could favour neotropical LF bioprospection.Paramos sind sui generis Hochgebirgsbiome im Neotropikum, deren Organismen ständig niedrigen Temperaturen und hoher Sonnenbestrahlung ausgesetzt sind. Sonnenstrahlen, insbesondere Ultraviolett- (UV) und Nahinfrarotstrahlung (NIR), wurde als ätiologischer Faktor von Hautproblemen wie Fotodermatosen und verschiedenen Arten von Hautkrebs identifiziert. Naturalstoffen isolierten von der Flora der Paramos, insbesondere lizenzierte Pilzen (LP), sind wenig studiert worden. Nicht nur absorbieren Flecthenstoffen UV-Strahlung sondern auch haben antioxidativen Aktivität, deswegen könnten LP als ursprüngliche Quelle für neuen Sonnenschutzmitteln vorschlagen werden. Antioxidativen and lichtschutzenden Aktivitäten von einigen LP-Extrakten wurden hierin untersucht. Lobariella sipmanii war eine von aktivesten Extrakte und hatte die höchste Vielfalt an Flechtenstoffen. Aus dieser Flechte wurden zum ersten Mal drei Flechtenstoffen erhalten: Pseudocypherallin A (1), 2,4-dihydroxy-3,5,6-trimethylmethylbenzoat (2) und Methylorsellinat (3). Die monoaromatischen Flechtenstoffen 2 und 3 zeigten eine Absorption von UV-B- und Nahinfrarotstrahlung (SPF = 21,86 +/- 0,09 und 38,41 +/- 0,26 zum 200 ug/mL) und eine geringe spektrale Amplitude (Kritische Wellenlänge = 333,9 nm und 319,5 nm). Darüber hinaus waren ihre Nahinfrarotspektren ähnlich wie kommerzielle erhältliche Sonnenschutzmitteln und boten daher auch im diesen Bereich Schutz. Während Flechtenstoffe 1 einen SPF-Wert von 9,82 +/- 0,58 zum 200 ug/mL und eine höhere spektrale Amplitude (Kritische Wellenlänge = 365,8 nm) aufwies, ähnlich wie breitspektrales Sonnenschutzmittel wie Bemotrizinol (Kritische Wellenlänge = 374,2 nm). Flechtenstoffen 1 und 2 hatten Scavenger-Aktivität (WK50= 217,1 uM und 342,3 uM jeweils) and zeigten Lipidperoxidationhemmungsätzen in 24 Stunden ähnlich wie BHT (p > 0,05), während Stoffe 3 keine antioxidative Aktivität aufwies. Oxidativer Stress ist ein Faktor, der die Entwicklung von Hautkrebs beschleunigt. Darum sind Radikalfängeraktivität, Eisenreduktionsaktivität und Lipidperoxidationhemmung vorteilhaft im Hinblick auf die derzeit kommerzielle erhältliche Sonnenschutzmittel. Die isolierten Flechtenstoffen erhielten sowohl niedrigeres Allergenespotenzial, und wenige in silico-Giftigkeit- und Bioakkumulationsfaktoren als auch EU-Sicherheitsanforderungen für Chemikalien. Dies macht sie zu besseren Alternativen für den Sonnenschutz und könnte die Bioprospektion von Neotropikum LP begünstigen.Código HERMES: 35978MaestríaMagíster en Ciencias - QuímicaSustancias bioactivas de líquenes colombianosxix, 159 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afines::547 - Química orgánicaBioprospecciónLíquenesPropiedades antioxidantesbioprospectinglichensantioxidant propertiesBioprospecciónFotoprotecciónLobariella sipmaniiHongos liquenizadosPáramoPhotoprotectionBioprospectionLobariella sipmaniiLichenized fungiParamoBioprospektionFotoprotektionLobariella sipmaniiLizenzierte PilzeParamophotoprotectionBioprospección de hongos liquenizados del páramo de Sumapaz como fuente prometedora de fármacos duales con actividad antioxidante y fotoprotectoraBioprospection of lichenized fungi from páramo de Sumapaz (Bogotá - Colombia) as promising sources of antioxidant and photoprotective dual drugsBioprospektion von lichenisierten Pilzen aus dem Sumapaz-Páramo (Bogotá - Kolumbien) als vielversprechende Quelle für duale Arzneimittel mit antioxidativer und lichtschützender WirkungTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotáColombiaCundinamarcahttp://vocab.getty.edu/page/tgn/1000838Abbas, A.; Lichtman, A. & Pillai, S.: , 2017; Cellular and Molecular Immunology; Elsevier; 9a edición; ISBN 9780323479783; URL https://www.elsevier.com/books/cellular-and-molecular-immunology/abbas/978-0-323-47978-3.Abla, M. 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S. & Kim, H.: , 2017; The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis; Scientific Reports; 7 (1): 1--13; doi:10.1038/s41598-017-08225-1; URL http://dx.doi.org/10.1038/s41598-017-08225-1Bioprospección de líquenes del páramo de Sumapaz, Colombia como fuente original de sustancias duales con actividad antioxidante y fotoprotectora para la prevención de problemas dérmicos asociados a la radiación solarDirección de Investigación - Universidad Nacional de ColombiaBibliotecariosEstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86142/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1013589412-2024.pdf1013589412-2024.pdfTesis de Maestría en Ciencias - Químicaapplication/pdf14757404https://repositorio.unal.edu.co/bitstream/unal/86142/2/1013589412-2024.pdf0c2b367c397336de56cda34870b1090bMD52THUMBNAIL1013589412-2024.pdf.jpg1013589412-2024.pdf.jpgGenerated 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