“Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”

Ilustraciones a color

Autores:
Lozano Camelo, Olga Cristina
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/79413
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/79413
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Leucemia
Médula Ósea
Bone Marrow
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
Leucemia linfoblástica aguda
FFPE
ID3
IGJ
PreAmp
Genes
Acute lymphoblastic leukemia
FFPE
ID1
ID3
IGJ
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_424cd49a9eda6f257686c57893af59ca
oai_identifier_str oai:repositorio.unal.edu.co:unal/79413
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
dc.title.translated.eng.fl_str_mv "Pilot study for the determination of the expression of ID1, ID3 and IGJ in Acute Lymphoblastic Leukemia B from bone marrow samples"
title “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
spellingShingle “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
610 - Medicina y salud::616 - Enfermedades
Leucemia
Médula Ósea
Bone Marrow
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
Leucemia linfoblástica aguda
FFPE
ID3
IGJ
PreAmp
Genes
Acute lymphoblastic leukemia
FFPE
ID1
ID3
IGJ
title_short “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
title_full “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
title_fullStr “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
title_full_unstemmed “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
title_sort “Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”
dc.creator.fl_str_mv Lozano Camelo, Olga Cristina
dc.contributor.advisor.none.fl_str_mv Combita Rojas, Alba Lucía
dc.contributor.author.none.fl_str_mv Lozano Camelo, Olga Cristina
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en biología del cáncer
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Leucemia
Médula Ósea
Bone Marrow
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
Leucemia linfoblástica aguda
FFPE
ID3
IGJ
PreAmp
Genes
Acute lymphoblastic leukemia
FFPE
ID1
ID3
IGJ
dc.subject.decs.none.fl_str_mv Leucemia
Médula Ósea
Bone Marrow
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
dc.subject.proposal.spa.fl_str_mv Leucemia linfoblástica aguda
FFPE
ID3
IGJ
PreAmp
Genes
dc.subject.proposal.eng.fl_str_mv Acute lymphoblastic leukemia
FFPE
ID1
ID3
IGJ
description Ilustraciones a color
publishDate 2020
dc.date.issued.none.fl_str_mv 2020-11-15
dc.date.accessioned.none.fl_str_mv 2021-04-26T19:45:34Z
dc.date.available.none.fl_str_mv 2021-04-26T19:45:34Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/79413
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/79413
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.rights.license.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.format.extent.spa.fl_str_mv 1 recurso en línea (112 páginas)
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Medicina - Maestría en Genética Humana
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Combita Rojas, Alba Lucía6314d25773a6df920534c402dcbbd1b1Lozano Camelo, Olga Cristina83ca3d2a1331ae3e540b660a8fba70c0Grupo de Investigación en biología del cáncer2021-04-26T19:45:34Z2021-04-26T19:45:34Z2020-11-15https://repositorio.unal.edu.co/handle/unal/79413Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Ilustraciones a colorLa Leucemia Linfoblástica Aguda B (LLA-B), es una malignidad que se desarrolla en la médula ósea, comprometiendo los precursores hematopoyéticos de linaje B. La población adulta en Colombia presenta una tasa inferior de sobrevida con relación a la que se reporta en otros países. En este trabajo exploratorio descriptivo se observa el comportamiento de la expresión de los genes ID1, ID3 e IGJ, en líneas celulares, tejido de MO (médula ósea) fresco y Fijado en formalina embebido en parafina (FFPE). Metodología Se realizó aislamiento de ARN, conversión a ADNc, seguidamente, se observó asociaciones en amplificación y expresión de ID1, ID3 e IGJ en líneas celulares AGS, MCF7, REH y THP-1 y tejidos de pacientes diagnosticados con LLA-B frescos y en FFPE a través de qPCR (PCR cuantitativa en tiempo real) y análisis por el método de 2- ΔΔCq. Para mejorar el rendimiento en la amplificación de los genes de interés en biopsia de M.O en tejido FFPE, se probaron variables de laboratorio y la preamplificación de ADNc. Resultados Se caracterizaron las líneas celulares REH, AGS, MCF7 y THP-1, seguidamente se observó sus patrones de expresión para los genes objetivo. En el tejido FFPE se apreció una mejora con el empleo de la preamplificación. Finalmente, se comparó la expresión en cinco aspirados de M.O en pacientes con LLA-B, donde la expresión para ID1 e ID3 fue diferencial. Conclusión La observación comparativa de genes entre tejidos permite la realización de asociaciones acerca de la amplificación en diferentes tejidos y pacientes. Realizar modificaciones a los protocolos de extracción y la aplicación de preAmp puede permitir el mejoramiento de la detección de expresión de genes en tejido de M.O en FFPE, haciendo parte de las alternativas para aprovechar estos tejidos de valor que se tienen almacenados.Acute Lymphoblastic Leukemia B (B-ALL) is a malignancy that develops in the bone marrow, compromising the hematopoietic precursors of lineage B. The adult population in Colombia has a lower survival rate compared to that reported in other countries. In this descriptive exploratory work, the expression behavior of the ID1, D3 and IGJ genes is observed in cell lines, fresh BM (bone Marrow) tissue and Formalin-fixed, paraffinembedded (FFPE). Methodology: RNA Isolation and conversión to cDNA were performed, then associations in amplification and expression of ID1, ID3 and IGJ were observed in AGS and MCF7, REH and THP-1 cell lines and tissues of patients diagnosed with fresh B- ALL and in FFPE throug qPCR (quantitative real-time PCR) and analysis by the 2 - ΔΔCq method. To improve performance in the the amplification of the genes of interest in biopsy of BM in FFPE tissue, laboratory variables and preamplification of cDNA were tested. Results: The REH, AGS, MCF7 and THP-1 cell lines were caracterizad, followed by their expression patterns for the target genes. Improvement in the FFPE fabric was seen with the use of preamplification. Finally the expression in fuve aspirates of BM in patients with B-ALL was compared, where the expression for ID1 and ID3 was differential. Conclusion: The comparative observation of genes between tissues allowas the realization of association in different tissues and patients. Making modifications to the extraction protocols and the application of preAmp can allow the improvement of the detection of gene expression in BM tissue in FFPE, making part of the alternatives to take advantage of theses valuable tissues that are stored.MaestríaBiología celular e inmunobiología de leucemias y linfomas1 recurso en línea (112 páginas)application/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Genética HumanaFacultad de MedicinaBogotáUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesLeucemiaMédula ÓseaBone MarrowLeucemia-Linfoma Linfoblástico de Células PrecursorasPrecursor Cell Lymphoblastic Leukemia-LymphomaGenesLeucemia linfoblástica agudaFFPEID3IGJPreAmpGenesAcute lymphoblastic leukemiaFFPEID1ID3IGJ“Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”"Pilot study for the determination of the expression of ID1, ID3 and IGJ in Acute Lymphoblastic Leukemia B from bone marrow samples"Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAdvani, A. 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Molecular Oncology, 13(11), 2305–2328. https://doi.org/10.1002/1878-0261.12570“Estudio piloto para la determinación de la expresión de ID1, ID3 e IGJ en Leucemia Linfoblástica Aguda B a partir de muestras de médula ósea”Instituto Nacional de Cancerología E.S.EORIGINAL1018417049.2020.pdf1018417049.2020.pdfTesis de Maestría en Genética Humanaapplication/pdf3934923https://repositorio.unal.edu.co/bitstream/unal/79413/1/1018417049.2020.pdfcdf36e46a3b3de8a838da624373340c9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/79413/2/license.txtcccfe52f796b7c63423298c2d3365fc6MD52THUMBNAIL1018417049.2020.pdf.jpg1018417049.2020.pdf.jpgGenerated Thumbnailimage/jpeg5515https://repositorio.unal.edu.co/bitstream/unal/79413/3/1018417049.2020.pdf.jpg71e15239c8c1dac6ab5ead15f6af2c25MD53unal/79413oai:repositorio.unal.edu.co:unal/794132023-07-12 23:03:30.06Repositorio Institucional Universidad Nacional de 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

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