Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)

ilustraciones, diagramas

Autores:: Ahumada Ossa, Laura Marcela

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

id	UNACIONAL2_4099985e5a1419fec1fd248420e74876
oai_identifier_str	oai:repositorio.unal.edu.co:unal/85385
network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
dc.title.translated.eng.fl_str_mv	Serotonin, vitamin D, eating habits and physical activity in functional bowel disorders in a group of adults: case-control study (Bogotá-2022-2023)
title	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
spellingShingle	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023) 610 - Medicina y salud::612 - Fisiología humana Enfermedades Intestinales Estilo de Vida Saludable Intestinal Diseases Healthy Lifestyle Trastornos funcionales intestinales Vitamina D Serotonina Eje intestino-cerebro Estilos de vida saludable Functional bowel disorders Vitamin D Serotonin Gut-brain axis Healthy lifestyles
title_short	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
title_full	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
title_fullStr	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
title_full_unstemmed	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
title_sort	Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
dc.creator.fl_str_mv	Ahumada Ossa, Laura Marcela
dc.contributor.advisor.none.fl_str_mv	Poveda Espinosa, Elpidia Agudelo Cañas, Samantha
dc.contributor.author.none.fl_str_mv	Ahumada Ossa, Laura Marcela
dc.contributor.researchgroup.spa.fl_str_mv	Alimentación y Nutrición Humana
dc.contributor.orcid.spa.fl_str_mv	Ahumada Ossa, Laura Marcela [0000-0002-6028-0468]
dc.contributor.cvlac.spa.fl_str_mv	Ahumada Ossa, Laura Marcela [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001786244#red_identificadores]
dc.contributor.researchgate.spa.fl_str_mv	Ahumada Ossa, Laura Marcela [https://www.researchgate.net/profile/Laura-M-Ahumada-Ossa]
dc.contributor.googlescholar.spa.fl_str_mv	Ahumada Ossa, Laura Marcela [https://scholar.google.com/citations?user=HzLUahsAAAAJ&hl=es]
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::612 - Fisiología humana
topic	610 - Medicina y salud::612 - Fisiología humana Enfermedades Intestinales Estilo de Vida Saludable Intestinal Diseases Healthy Lifestyle Trastornos funcionales intestinales Vitamina D Serotonina Eje intestino-cerebro Estilos de vida saludable Functional bowel disorders Vitamin D Serotonin Gut-brain axis Healthy lifestyles
dc.subject.decs.spa.fl_str_mv	Enfermedades Intestinales Estilo de Vida Saludable
dc.subject.decs.eng.fl_str_mv	Intestinal Diseases Healthy Lifestyle
dc.subject.proposal.spa.fl_str_mv	Trastornos funcionales intestinales Vitamina D Serotonina Eje intestino-cerebro Estilos de vida saludable
dc.subject.proposal.eng.fl_str_mv	Functional bowel disorders Vitamin D Serotonin Gut-brain axis Healthy lifestyles
description	ilustraciones, diagramas
publishDate	2023
dc.date.issued.none.fl_str_mv	2023-12-01
dc.date.accessioned.none.fl_str_mv	2024-01-22T14:08:19Z
dc.date.available.none.fl_str_mv	2024-01-22T14:08:19Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/85385
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/85385 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Margolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain Axis: From Motility to Mood [Internet]. 2021. Available from: https://www.sciencedirect.com/science/article/pii/S0016508521002687 Black CJ, Drossman DA, Talley NJ, Ruddy J, Ford AC. Functional gastrointestinal disorders: advances in understanding and management. The Lancet [Internet]. 2020;396(10263):1664–74. Available from: http://dx.doi.org/10.1016/S0140-6736(20)32115-2 Hustoft TN, Hausken T, Ystad SO, Valeur J, Brokstad K, Hatlebakk JG, et al. Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology and Motility. 2017;29(4):1–9. Barbalho SM, Goulart R de A, Araújo AC, Guiguer ÉL, Bechara MD. Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D. Expert Rev Gastroenterol Hepatol. 2019 Apr 3;13(4):345–59. Linsalata M, Riezzo G, Orlando A, D’attoma B, Prospero L, Tutino V, et al. The relationship between low serum vitamin d levels and altered intestinal barrier function in patients with ibs diarrhoea undergoing a long-term low-fodmap diet: Novel observations from a clinical trial. Nutrients. 2021 Mar 1;13(3):1–18. Bruta K, Vanshika, Bhasin K, Bhawana. The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review. Transl Med Commun. 2021 Dec;6(1). Fikree A, Byrne P. Management of functional gastrointestinal disorders. Clinical Medicine, Journal of the Royal College of Physicians of London. 2021 Jan 1;21(1):44–52. Dale HF, Jensen C, Hausken T, Hatlebakk JG, Brønstad I, Valeur J, et al. Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome. Nutrients. 2019;11:1–13. Harris LA, Cash BD, Moftah K, Franklin H. An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients with Functional Gastrointestinal Symptoms. J Clin Gastroenterol. 2022 May 1;56(5):444–51. Mukhtar K, Nawaz H, Abid S. Functional gastrointestinal disorders and gut-brain axis: What does the future hold? Vol. 25, World Journal of Gastroenterology. Baishideng Publishing Group Co; 2019. p. 552–66. Wang R, Sun J, Li G, Zhang M, Niu T, Kang X, et al. Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota. Benef Microbes. 2021;12(1):31–42. Mearin F, Ciriza C, Mínguez M, Rey E, Mascort JJ, Peña E, et al. Clinical practice guidelines: Irritable bowel syndrome with constipation and functional constipation in adults: Concept, diagnosis, and healthcare continuity. (Part 1 of 2). Aten Primaria. 2017 Jan 1;49(1):42–55. Wilson B, Rossi M, Dimidi E, Whelan K. Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: A systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. 2019 Apr 1;109(4):1098–111. Ibrahim F, Stribling P. A 5ad dietary protocol for functional bowel disorders. Nutrients. 2019 Aug 1;11(8). Li XR, Liu CJ, Tang XD, Zhang HM, Luo YY, Zhang L, et al. Gut Microbiota Alterations from Three-Strain Yogurt Formulation Treatments in Slow-Transit Constipation. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020;2020. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018 May 4;9(3):236–51. Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Vol. 14, Expert Review of Gastroenterology and Hepatology. Taylor and Francis Ltd; 2020. p. 39–46. Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, Shanahan F, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: A double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10(6):617–27. Barbara G, Cremon C, Bellini M, Corsetti M, Di Nardo G, Falangone F, et al. Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP). Digestive and Liver Disease. 2023 Feb 1;55(2):187–207. Ford AC, Sperber AD, Corsetti M, Camilleri M. Functional Gastrointestinal Disorders 2: Irritable bowel syndrome. The Lancet. 2020 Nov 21;396(10263):1675–88. Camilleri M. Diagnosis and Treatment of Irritable Bowel Syndrome: A Review. Vol. 325, JAMA - Journal of the American Medical Association. American Medical Association; 2021. p. 865–77. Mitselou A, Grammeniatis V, Varouktsi A, Papadatos SS, Katsanos K, Galani V. Proinflammatory cytokines in irritable bowel syndrome: A comparison with inflammatory bowel disease. Intest Res. 2020;18(1):115–20. Paduano D, Cingolani A, Tanda E, Usai P. Effect of Three Diets (Low-FODMAP, Gluten-free and Balanced) on Irritable Bowel Syndrome Symptoms and Health-Related Quality of Life. Nutrients. 2019;11(1566). Abboud M, Rizk R, AlAnouti F, Papandreou D, Haidar S, Mahboub N. The Health Effects of Vitamin D and Probiotic Co-Supplementation: A Systematic Review of Randomized Controlled Trials. Nutrients. 2020 Dec 30;13(1). Zhang C, Zhang Y, Ma K, Wang G, Tang M, Wang R, et al. Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model. Ann Transl Med. 2022 Mar;10(6):316–316. Martoni CJ, Evans M, Chow CET, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019 Sep 1;20(9):435–46. Williams CE, Williams EA, Corfe BM. Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know? Vol. 72, European Journal of Clinical Nutrition. Nature Publishing Group; 2018. p. 1358–63. Larson-Meyer DE, Douglas CS, Thomas JJ, Johnson EC, Barcal JN, Heller JE, et al. Validation of a vitamin D specific questionnaire to determine vitamin D status in athletes. Nutrients. 2019 Nov 1;11(11). Bouillon R. Comparative analysis of nutritional guidelines for vitamin D. Vol. 13, Nature Reviews Endocrinology. Nature Publishing Group; 2017. p. 466–79. Niño DA, Mora-Plazas M, Poveda E. Vitamina D, sus posibles efectos en la función inmune y la respuesta ante la COVID-19: una revisión sistemática exploratoria. Revista de Nutrición Clínica y Metabolismo. 2021 Jul 15;4(3):73–97. Vásquez-Awad D, Alberto Cano-Gutiérrez C, Gómez-Ortiz A, Ángel González M, Guzmán-Moreno R, Ignacio Martínez-Reyes J, et al. Vitamina D. Consenso colombiano de expertos. Med. 2017;39(2):140–57. Yamamoto EA, Jørgensen TN. Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity. Vol. 10, Frontiers in Immunology. Frontiers Media S.A.; 2020. Yomayusa González N, Herrera Méndez EM, Low Padilla E, Oliveros Velásquez JD, Mendivelso Duarte F, Gómez Gómez OV, et al. Recomendaciones para el uso racional de la prueba 25-hidroxivitamina D Resumen de política. Revista Colombiana de Nefrología. 2019 Nov 22;6(2):179–92. Palacios Ariza MA, Pinto Pinzón DA, Albarracín Acosta OJ, Alvis Botello JH, Céspedes Gaitán SX, Dorado Fuentes OD, et al. Consenso colombiano para el diagnóstico, tratamiento y prevención del déficit de vitamina D en población general y patologías específicas: Guía de práctica clínica [Internet]. Revista Médica Sanitas; 2023. Available from: https://doi.org/10.26852/01234250.638 Ministerio de Salud y Protección Social, Instituto colombiano de Bienestar familiar, Universidad Nacional de Colombia, Instituto Nacional de Salud. Encuesta Nacional de la situación Nutricional- ENSIN- 2015. 2015. Welford RWD, Vercauteren M, Trébaul A, Cattaneo C, Eckert D, Garzotti M, et al. Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Sci Rep. 2016 Jul 21;6. Cao H, Liu X, An Y, Zhou G, Liu Y, Xu M, et al. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Sci Rep. 2017 Dec 1;7(1). S Athar. Serotonin and Tryptophan. In: Encyclopedia of Movement Disorders. Medical University of South Carolina, Charleston, SC, USA: Elsevier; 2010. Hanel V, Schalla MA, Stengel A. Irritable bowel syndrome and functional dyspepsia in patients with eating disorders - a systematic review. Vol. 29, European Eating Disorders Review. John Wiley and Sons Ltd; 2021. p. 692–719. Israelyan N, Margolis KG. Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Vol. 132, Pharmacological Research. Academic Press; 2018. p. 1–6. Moroianu LA, Cecilia C, Ardeleanu V, Pantea Stoian A, Cristescu V, Barbu RE, et al. Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes. Medicina (B Aires). 2022 May 11;58(5):652. Janus T, Korbal U, Żukowski M, Lewosiuk A, Koper K, Żukowska A, et al. Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders. Stem Cell Rev Rep. 2023 Apr 1;19(3):807–16. Mearin F, Ciriza C, Mínguez M, Rey E, Mascort JJ, Peña E, et al. Irritable bowel syndrome with constipation and functional constipation in adults: Treatment (Part 2 of 2). Aten Primaria. 2017 Mar 1;49(3):177–94. Huo J, Wu L, Lv J, Cao H, Gao Q. Effect of fruit intake on functional constipation: A systematic review and meta-analysis of randomized and crossover studies. Front Nutr [Internet]. 2022 Oct 6;9. Available from: https://www.frontiersin.org/articles/10.3389/fnut.2022.1018502/full Cozma-Petrut A, Loghin F, Miere D, Dumitrascu DL. Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771–83. National Institute for Health and Care Excellence (NICE). Irritable bowel syndrome in adults: diagnosis and management. Clinical guideline [CG61]. 2018;1–22. Available from: https://www.nice.org.uk/guidance/cg61/resources/irritable-bowel-syndrome-in-adults-diagnosis-and-management-pdf-975562917829%0Ahttps://www.nice.org.uk/guidance/cg61 McKenzie YA, Bowyer RK, Leach H, Gulia P, Horobin J, O’Sullivan NA, et al. British Dietetic Association systematic review and evidence-based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). J Hum Nutr Diet. 2016;29(5). Rincón RA, Grillo CF, Rodriguez A, Concha A, Costa V, Gómez ÁA, et al. Guía de práctica clínica para el diagnóstico y tratamiento del estreñimiento crónico funcional en población adulta. Rev Col Gastroenterol. 2015;30:57–66. Del Toro-Barbosa M, Hurtado-Romero A, Garcia-Amezquita LE, García-Cayuela T. Psychobiotics: Mechanisms of action, evaluation methods and effectiveness in applications with food products. Vol. 12, Nutrients. MDPI AG; 2020. p. 1–31. Aslam H, Mohebbi M, Ruusunen A, Dawson SL, Williams LJ, Berk M, et al. Associations between dairy consumption and constipation in adults: A cross-sectional study. Nutr Health. 2022 Mar 1;28(1):31–9. Organización Mundial de la Salud. Directrices de la OMS sobre actividad física y hábitos sedentarios. 2020. 1–24 p. (WHO) World Health Organization. Recomendaciones mundiales sobre actividad física para la salud. 2010. 1–58 p. Guzel T, Mirowska-Guzel D. The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy. Vol. 27, Molecules. MDPI; 2022. van Oudenhove L, Levy RL, Crowell MD, Drossman DA, Halpert AD, Keefer L, et al. Biopsychosocial aspects of functional gastrointestinal disorders: How central and environmental processes contribute to the development and expression of functional gastrointestinal disorders. Gastroenterology. 2016 May 1;150(6):1355-1367.e2. Alvarado J, R WO, Andrés M, Santos J, B PAR, L GAP, et al. Guía de práctica clínica para el diagnóstico y tratamiento del síndrome de intestino irritable en población adulta. Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología. 2015;Guías de p. Alammar N, Stein E. Irritable Bowel Syndrome: What Treatments Really Work. Medical Clinics of North America [Internet]. 2019;103(1):137–52. Available from: https://doi.org/10.1016/j.mcna.2018.08.006 Adriani A, Ribaldone DG, Astegiano M, Durazzo M, Saracco GM, Pellicano R. Irritable bowel syndrome : the clinical approach. Panminerva Med. 2018;60(4):213–22. Fakhoury HMA, Kvietys PR, AlKattan W, Anouti F Al, Elahi MA, Karras SN, et al. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. Vol. 200, Journal of Steroid Biochemistry and Molecular Biology. Elsevier Ltd; 2020. Sociedad de Agricultores de Colombia (SAC). Así es la hortofruticultura nacional. Revista Nacional de Agricultura [Internet]. 2021;Edición 1018(Septiembre):1–8. Available from: https://sac.org.co/asi-es-la-hortofruticultura-nacional/ Austin PC, Steyerberg EW. Events per variable (EPV) and the relative performance of different strategies for estimating the out-of-sample validity of logistic regression models. Stat Methods Med Res. 2017 Apr 1;26(2):796–808. Radovanovic-dinic B, Tesic-rajkovic S, Grgov S, Petrovic G, Zivkovic V. Irritable bowel syndrome – from etiopathogenesis to therapy. 2018;162(1):1–9. Farmer AD. Irritable bowel syndrome Key points. Medicine [Internet]. 2019;(Figure 1):3–6. Available from: https://doi.org/10.1016/j.mpmed.2019.03.009 Defrees DN, Bailey J. Irritable Bowel Syndrome: Epidemiology, Pathophysiology, Diagnosis, and Treatment. Primary Care Clinics in Office Practice [Internet]. 2017;44(4):655–71. Available from: https://doi.org/10.1016/j.pop.2017.07.009 Sebastián Domingo JJ. Los nuevos criterios de Roma (IV) de los trastornos funcionales digestivos en la práctica clínica. Med Clin (Barc) [Internet]. 2017;148(10):464–8. Available from: http://dx.doi.org/10.1016/j.medcli.2016.12.020 Capili B, Anastasi JK, Chang M. Addressing the Role of Food in Irritable Bowel Syndrome Symptom Management. TJNP: The Journal for Nurse Practitioners [Internet]. 2016;12(5):324–9. Available from: http://dx.doi.org/10.1016/j.nurpra.2015.12.007 Bonfrate L, Portincasa P, Ballou S, de Bari O, Lembo A. Irritable bowel syndrome and diet. Gastroenterol Rep (Oxf). 2017;5(1):11–9. Sara Lucía Pareja Sierra, Elena Roura Carvajal RMV y AAC. Nutrición Hospitalaria. Nutr Hosp. 2018;35:121–9. Escobar JS, Klotz B, Valdes BE, Agudelo GM. The gut microbiota of Colombians differs from that of Americans, Europeans and Asians. BMC Microbiol. 2015;14(1):1–14. Gajdos P, Román N, Tóth-Király I, Rigó A. Functional gastrointestinal symptoms and increased risk for orthorexia nervosa. Eating and Weight Disorders. 2022 Apr 1;27(3):1113–21. Roman Francisca, Santibañez Patricia. Uso de las Escalas de Depresión Ansiedad Estrés (DASS-21) como Instrumento de Tamizaje en Jóvenes con Problemas Clínicos. ACTA DE INVESTIGACIÓN PSICOLÓGICA . 2016;6(1):2325–36. Carrera Y. Cuestionario Internacional de actividad física (IPAQ). Revista Enfermería del Trabajo. 2017;7(11):49–54. Rijnaarts I, de Roos N, Zoetendal EG, de Wit N, Witteman BJM. Development and validation of the FiberScreen: A short questionnaire to screen fibre intake in adults. Journal of Human Nutrition and Dietetics. 2021 Dec 1;34(6):969–80. Rollet M, Bohn T, Vahid F. Association between Dietary Factors and Constipation in Adults Living in Luxembourg and Taking Part in the ORISCAV-LUX 2 Survey. Nutrients. 2022 Jan 1;14(1). Prada Gómez GE, Herrán Falla ÓF, Oróstegui Prada SA. Atlas fotográfico de porciones para cuantificar el consumo de alimentos y nutrientes en Santander, Colombia. Primera edición 2011. Universidad Industrial de Santander (UIS), editor. Vol. I. Bucaramanga, Colombia: Universidad Industrial de Santander; 2011. 1–143 p. Parhizgar N, Azadyekta M, Parhizgar P. Validity and Reliability Assessments of a 16-item Food Frequency Questionnaire as a Probiotic and Prebiotic Consumption Scale in People Aged 20 to 40 Years in Tehran. Nutrition and Food Sciences Research [Internet]. 2021 Mar 1;8(2):35–42. Available from: http://nfsr.sbmu.ac.ir/article-1-446-en.html Palsson OS, Whitehead WE, Van Tilburg MAL, Chang L, Chey W, Crowell MD, et al. Development and validation of the Rome IV diagnostic questionnaire for adults. Gastroenterology. 2016 May 1;150(6):1481–91. Ministerio de Salud y Protección Social. Resolución 2465 de 2016. República de Colombia Colombia; Jun 14, 2016 p. 1–47. Instituto Colombiano de Bienestar Familiar ICBF, Organización de las Naciones Unidas para la Alimentación y Agricultura F. Guías Alimentarias Basadas en Alimentos para la población Colombiana mayor de 2 años [Internet]. Vol. 49, Documento ténico. 2015. 314 p. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/SNA/guias-alimentarias-basadas-en-alimentos.pdf Ministerio de Salud y Protección Social. Resolución 3803 de 2016. República de Colombia 2016 p. 1–26. Ruiz F, Garcia M. DASS-21. ClinikLab Laboratorio de psicología clínica. (2):1–2. Puga JL, García García J. Eventos por Variable en Regresión Logística y Redes Bayesianas para Predecir Actitudes Emprendedoras. Vol. 16, Revista Electrónica de Metodología Aplicada. 2011. Sabbagh LC, William Otero Regino. Guía de práctica clínica para el diagnóstico y tratamiento del síndrome de intestino irritable en población adulta. Rev Col Gastroenterol. 2016;1–32. Kim YS, Kim N. Sex-gender differences in irritable bowel syndrome. J Neurogastroenterol Motil. 2018 Oct 1;24(4):544–58. Narayanan SP, Anderson B, Bharucha AE. Sex- and Gender-Related Differences in Common Functional Gastroenterologic Disorders. Vol. 96, Mayo Clinic Proceedings. Elsevier Ltd; 2021. p. 1071–89. Emerenziani S, Guarino MPL, Asensio LMT, Altomare A, Ribolsi M, Balestrieri P, et al. Role of overweight and obesity in gastrointestinal disease. Vol. 12, Nutrients. MDPI AG; 2020. Mc Gettigan N, Hanley M, Skelly F, Dowling J, Dunne R, Morrin MM, et al. Impact of a physician-led exercise programme on quality of life, muscle mass and clinical response in inflammatory bowel disease patients during induction with disease-modifying therapy: a study protocol. BMJ Open Gastro [Internet]. 2022 [cited 2023 Nov 12];9:959. Available from: http://bmjopengastro.bmj.com/ Martínez-Torres J, Lizarazo MAB, Malpica PAC, Escobar-Velásquez KD, Suárez LSC, Moreno-Bayona JA, et al. Prevalence of vitamin D deficiency and insufficiency and associated factors in Colombian women in 2015. Nutr Hosp. 2022 Jul 1;39(4):843–51. Vargas H, Mera A, Pinzón Fernández M, Agredo V. Vitamin D nutritional status in the adult population in Colombia – An analytical cross-sectional study. Heliyon. 2020 Feb 1;6(2). Raymond-Lezman JR, Riskin SI. Benefits and Risks of Sun Exposure to Maintain Adequate Vitamin D Levels. Cureus [Internet]. 2023 May 5 [cited 2023 Nov 28];15(5). Available from: /pmc/articles/PMC10239563/ Zhang J, Cao ZB. Exercise: A Possibly Effective Way to Improve Vitamin D Nutritional Status. Vol. 14, Nutrients. MDPI; 2022. Barandouzi ZA, Lee J, del Carmen Rosas M, Chen J, Henderson WA, Starkweather AR, et al. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Sci Rep. 2022 Dec 1;12(1). Linsalata M, Prospero L, Riezzo G, Orlando A, D’Attoma B, Ignazzi A, et al. Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome. Neurogastroenterology and Motility. 2023 Mar 1;35(3). Obermanns J, Krawczyk E, Juckel G, Emons B. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression. European Journal of Neuroscience. 2021 May 1;53(10):3476–89. Ogłodek EA. Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress. Int J Environ Res Public Health. 2022 Dec 1;19(24). Vahora IS, Tsouklidis N, Kumar R, Soni R, Khan S. How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome. Cureus. 2020 Aug 19; Illesca-Matus R, Ardiles NM, Munoz F, Moya PR. Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System. Int J Mol Sci [Internet]. 2023 Jul 12;24(14):11372. Available from: https://www.mdpi.com/1422-0067/24/14/11372 Kaur H, Bose C, Mande SS. Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis. Front Neurosci. 2019 Dec 18;13. Gajdos P, Román N, Tóth-Király I, Rigó A. Functional gastrointestinal symptoms and increased risk for orthorexia nervosa. Eating and Weight Disorders. 2022 Apr 1;27(3):1113–21. Grozić A, Coker K, Dussik CM, Sabir MS, Sabir Z, Bradley A, et al. Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D. PLoS One. 2022 Oct 1;17(10 October). Manterola C, Otzen T. Bias in Clinical Research. International Journal of Morphology. 2015;33(3):1156–64.
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.spa.fl_str_mv	132 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.coverage.temporal.spa.fl_str_mv	2022 - 2023
dc.coverage.city.spa.fl_str_mv	Bogotá
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina - Maestría en Fisiología
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
dc.publisher.place.spa.fl_str_mv	Bogotá,Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
bitstream.url.fl_str_mv	https://repositorio.unal.edu.co/bitstream/unal/85385/1/license.txt https://repositorio.unal.edu.co/bitstream/unal/85385/4/Tesis%20MScLauraAhumada_CC_FBD_ser_VD_organized.pdf https://repositorio.unal.edu.co/bitstream/unal/85385/3/1020824904.2023.pdf.jpg https://repositorio.unal.edu.co/bitstream/unal/85385/5/Tesis%20MScLauraAhumada_CC_FBD_ser_VD_organized.pdf.jpg
bitstream.checksum.fl_str_mv	eb34b1cf90b7e1103fc9dfd26be24b4a 2760efed3474ce927342b714029d3925 2d4c70877e0e0720ff9b0910f897239b 6230a9ebd9e54eae579b3b53576697d0
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
repository.mail.fl_str_mv	repositorio_nal@unal.edu.co
_version_	1806886656751435776
spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Poveda Espinosa, Elpidiaacffd715e5e824459b7fc289eeafcc3fAgudelo Cañas, Samantha43564a288802c79ccf17fe47483892cdAhumada Ossa, Laura Marcela130d7f3dc99c5baa0294fbfd365bf9b0600Alimentación y Nutrición HumanaAhumada Ossa, Laura Marcela [0000-0002-6028-0468]Ahumada Ossa, Laura Marcela [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001786244#red_identificadores]Ahumada Ossa, Laura Marcela [https://www.researchgate.net/profile/Laura-M-Ahumada-Ossa]Ahumada Ossa, Laura Marcela [https://scholar.google.com/citations?user=HzLUahsAAAAJ&hl=es]2022 - 2023Bogotá2024-01-22T14:08:19Z2024-01-22T14:08:19Z2023-12-01https://repositorio.unal.edu.co/handle/unal/85385Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasIntroducción: Algunas investigaciones han relacionado niveles de vitamina D más bajos y desregulación serotoninérgica en los trastornos funcionales intestinales (cuyas siglas en inglés son FBD) que surgen de interacciones desordenadas en el eje-intestino-cerebro. Otros factores que pueden asociarse a los FBD son la son la alimentación, la actividad física y las condiciones psicoemocionales. Objetivo: determinar si las concentraciones séricas alteradas de serotonina, vitamina D, los hábitos alimentarios inadecuados relacionados con salud intestinal y el sedentarismo son factores de asociación para el desarrollo de trastornos funcionales intestinales en un grupo de adultos de 18 a 60 años de Bogotá. Metodología: estudio de 87 controles y 79 casos, que correspondieron a personas con diagnóstico de FBD por criterios ROMA IV. Se evaluaron concentraciones de serotonina y 25(OH)D, proteína C reactiva, consumo de fibra, agua, prebióticos y probióticos; actividad física (IPAQ) y estrés, ansiedad y depresión (DASS-21). Resultados: las concentraciones séricas alteradas de serotonina, vitamina D, los hábitos alimentarios inadecuados y el sedentarismo son factores que no se asocian con el desarrollo de FBD en la población de estudio, pero se encontró que el sexo masculino (OR 0,17; IC95% 0,74-0,42, p=0,000), puntaje global de DASS-21 (OR 1,10; IC95% 1,05-1,15, p=0,000) y el puntaje del consumo de prebióticos y probióticos (OR 0,94; IC95% 0,89-0,98, p=0,006) son factores que se asocian con la presencia de FBD. Conclusiones: se identificó una asociación significativa entre la existencia de ansiedad, estrés y depresión con la presencia de FBD. Igualmente, se considera necesario continuar investigando la relación entre el consumo de prebióticos y probióticos y el desarrollo de FBD. (Texto tomado de la fuente)Introduction: Some research has linked lower vitamin D levels and serotonergic dysregulation in functional bowel disorders (FBD) that arise from disordered interactions in the gut-brain axis. Other factors that may be associated with FBD are diet, physical activity, and psycho-emotional conditions. Objective: to determine whether altered serum concentrations of serotonin, vitamin D, inadequate dietary habits related to intestinal health and a sedentary lifestyle are association factors for the development of functional intestinal disorders in a group of adults aged 18 to 60 years from Bogotá. Methods: study of 87 controls and 79 cases, which corresponded to people diagnosed with FBD according to ROME IV criteria. Serotonin and 25(OH)D concentrations, C-reactive protein, fiber consumption, water, prebiotics, and probiotics were evaluated; physical activity (IPAQ) and stress, anxiety and depression (DASS-21). Results: altered serum concentrations of serotonin, vitamin D, inadequate eating habits and a sedentary lifestyle are factors that are not associated with the development of FBD in the study population, but it was found that male sex (OR 0.17; CI95 % 0.74-0.42, p=0.000), DASS-21 global score (OR 1.10; 95% CI 1.05-1.15, p=0.000) and the prebiotic and probiotics consumption score (OR 0.94; 95% CI 0.89-0.98, p=0.006) are factors that are associated with the presence of FBD. Conclusions: a significant association was identified between the existence of anxiety, stress, and depression with the presence of FBD. Likewise, it is considered necessary to continue investigating the relationship between the consumption of prebiotics and probiotics and the development of FBD.MaestríaMagíster en FisiologíaEstudio de 87 controles y 79 casos, que correspondieron a personas con diagnóstico de FBD por criterios ROMA IV. Se evaluaron concentraciones de serotonina y 25(OH)D, proteína C reactiva, consumo de fibra, agua, prebióticos y probióticos; actividad física (IPAQ) y estrés, ansiedad y depresión (DASS-21).Prevención y tratamiento de las enfermedades crónicas132 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en FisiologíaFacultad de MedicinaBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::612 - Fisiología humanaEnfermedades IntestinalesEstilo de Vida SaludableIntestinal DiseasesHealthy LifestyleTrastornos funcionales intestinalesVitamina DSerotoninaEje intestino-cerebroEstilos de vida saludableFunctional bowel disordersVitamin DSerotoninGut-brain axisHealthy lifestylesSerotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)Serotonin, vitamin D, eating habits and physical activity in functional bowel disorders in a group of adults: case-control study (Bogotá-2022-2023)Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMMargolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain Axis: From Motility to Mood [Internet]. 2021. Available from: https://www.sciencedirect.com/science/article/pii/S0016508521002687Black CJ, Drossman DA, Talley NJ, Ruddy J, Ford AC. Functional gastrointestinal disorders: advances in understanding and management. The Lancet [Internet]. 2020;396(10263):1664–74. Available from: http://dx.doi.org/10.1016/S0140-6736(20)32115-2Hustoft TN, Hausken T, Ystad SO, Valeur J, Brokstad K, Hatlebakk JG, et al. Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology and Motility. 2017;29(4):1–9.Barbalho SM, Goulart R de A, Araújo AC, Guiguer ÉL, Bechara MD. Irritable bowel syndrome: a review of the general aspects and the potential role of vitamin D. Expert Rev Gastroenterol Hepatol. 2019 Apr 3;13(4):345–59.Linsalata M, Riezzo G, Orlando A, D’attoma B, Prospero L, Tutino V, et al. The relationship between low serum vitamin d levels and altered intestinal barrier function in patients with ibs diarrhoea undergoing a long-term low-fodmap diet: Novel observations from a clinical trial. Nutrients. 2021 Mar 1;13(3):1–18.Bruta K, Vanshika, Bhasin K, Bhawana. The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review. Transl Med Commun. 2021 Dec;6(1).Fikree A, Byrne P. Management of functional gastrointestinal disorders. Clinical Medicine, Journal of the Royal College of Physicians of London. 2021 Jan 1;21(1):44–52.Dale HF, Jensen C, Hausken T, Hatlebakk JG, Brønstad I, Valeur J, et al. Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome. Nutrients. 2019;11:1–13.Harris LA, Cash BD, Moftah K, Franklin H. An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients with Functional Gastrointestinal Symptoms. J Clin Gastroenterol. 2022 May 1;56(5):444–51.Mukhtar K, Nawaz H, Abid S. Functional gastrointestinal disorders and gut-brain axis: What does the future hold? Vol. 25, World Journal of Gastroenterology. Baishideng Publishing Group Co; 2019. p. 552–66.Wang R, Sun J, Li G, Zhang M, Niu T, Kang X, et al. Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota. Benef Microbes. 2021;12(1):31–42.Mearin F, Ciriza C, Mínguez M, Rey E, Mascort JJ, Peña E, et al. Clinical practice guidelines: Irritable bowel syndrome with constipation and functional constipation in adults: Concept, diagnosis, and healthcare continuity. (Part 1 of 2). Aten Primaria. 2017 Jan 1;49(1):42–55.Wilson B, Rossi M, Dimidi E, Whelan K. Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: A systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. 2019 Apr 1;109(4):1098–111.Ibrahim F, Stribling P. A 5ad dietary protocol for functional bowel disorders. Nutrients. 2019 Aug 1;11(8).Li XR, Liu CJ, Tang XD, Zhang HM, Luo YY, Zhang L, et al. Gut Microbiota Alterations from Three-Strain Yogurt Formulation Treatments in Slow-Transit Constipation. Canadian Journal of Infectious Diseases and Medical Microbiology. 2020;2020.Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018 May 4;9(3):236–51.Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Vol. 14, Expert Review of Gastroenterology and Hepatology. Taylor and Francis Ltd; 2020. p. 39–46.Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, Shanahan F, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: A double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10(6):617–27.Barbara G, Cremon C, Bellini M, Corsetti M, Di Nardo G, Falangone F, et al. Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP). Digestive and Liver Disease. 2023 Feb 1;55(2):187–207.Ford AC, Sperber AD, Corsetti M, Camilleri M. Functional Gastrointestinal Disorders 2: Irritable bowel syndrome. The Lancet. 2020 Nov 21;396(10263):1675–88.Camilleri M. Diagnosis and Treatment of Irritable Bowel Syndrome: A Review. Vol. 325, JAMA - Journal of the American Medical Association. American Medical Association; 2021. p. 865–77.Mitselou A, Grammeniatis V, Varouktsi A, Papadatos SS, Katsanos K, Galani V. Proinflammatory cytokines in irritable bowel syndrome: A comparison with inflammatory bowel disease. Intest Res. 2020;18(1):115–20.Paduano D, Cingolani A, Tanda E, Usai P. Effect of Three Diets (Low-FODMAP, Gluten-free and Balanced) on Irritable Bowel Syndrome Symptoms and Health-Related Quality of Life. Nutrients. 2019;11(1566).Abboud M, Rizk R, AlAnouti F, Papandreou D, Haidar S, Mahboub N. The Health Effects of Vitamin D and Probiotic Co-Supplementation: A Systematic Review of Randomized Controlled Trials. Nutrients. 2020 Dec 30;13(1).Zhang C, Zhang Y, Ma K, Wang G, Tang M, Wang R, et al. Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model. Ann Transl Med. 2022 Mar;10(6):316–316.Martoni CJ, Evans M, Chow CET, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019 Sep 1;20(9):435–46.Williams CE, Williams EA, Corfe BM. Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know? Vol. 72, European Journal of Clinical Nutrition. Nature Publishing Group; 2018. p. 1358–63.Larson-Meyer DE, Douglas CS, Thomas JJ, Johnson EC, Barcal JN, Heller JE, et al. Validation of a vitamin D specific questionnaire to determine vitamin D status in athletes. Nutrients. 2019 Nov 1;11(11).Bouillon R. Comparative analysis of nutritional guidelines for vitamin D. Vol. 13, Nature Reviews Endocrinology. Nature Publishing Group; 2017. p. 466–79.Niño DA, Mora-Plazas M, Poveda E. Vitamina D, sus posibles efectos en la función inmune y la respuesta ante la COVID-19: una revisión sistemática exploratoria. Revista de Nutrición Clínica y Metabolismo. 2021 Jul 15;4(3):73–97.Vásquez-Awad D, Alberto Cano-Gutiérrez C, Gómez-Ortiz A, Ángel González M, Guzmán-Moreno R, Ignacio Martínez-Reyes J, et al. Vitamina D. Consenso colombiano de expertos. Med. 2017;39(2):140–57.Yamamoto EA, Jørgensen TN. Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity. Vol. 10, Frontiers in Immunology. Frontiers Media S.A.; 2020.Yomayusa González N, Herrera Méndez EM, Low Padilla E, Oliveros Velásquez JD, Mendivelso Duarte F, Gómez Gómez OV, et al. Recomendaciones para el uso racional de la prueba 25-hidroxivitamina D Resumen de política. Revista Colombiana de Nefrología. 2019 Nov 22;6(2):179–92.Palacios Ariza MA, Pinto Pinzón DA, Albarracín Acosta OJ, Alvis Botello JH, Céspedes Gaitán SX, Dorado Fuentes OD, et al. Consenso colombiano para el diagnóstico, tratamiento y prevención del déficit de vitamina D en población general y patologías específicas: Guía de práctica clínica [Internet]. Revista Médica Sanitas; 2023. Available from: https://doi.org/10.26852/01234250.638Ministerio de Salud y Protección Social, Instituto colombiano de Bienestar familiar, Universidad Nacional de Colombia, Instituto Nacional de Salud. Encuesta Nacional de la situación Nutricional- ENSIN- 2015. 2015.Welford RWD, Vercauteren M, Trébaul A, Cattaneo C, Eckert D, Garzotti M, et al. Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Sci Rep. 2016 Jul 21;6.Cao H, Liu X, An Y, Zhou G, Liu Y, Xu M, et al. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Sci Rep. 2017 Dec 1;7(1).S Athar. Serotonin and Tryptophan. In: Encyclopedia of Movement Disorders. Medical University of South Carolina, Charleston, SC, USA: Elsevier; 2010.Hanel V, Schalla MA, Stengel A. Irritable bowel syndrome and functional dyspepsia in patients with eating disorders - a systematic review. Vol. 29, European Eating Disorders Review. John Wiley and Sons Ltd; 2021. p. 692–719.Israelyan N, Margolis KG. Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Vol. 132, Pharmacological Research. Academic Press; 2018. p. 1–6.Moroianu LA, Cecilia C, Ardeleanu V, Pantea Stoian A, Cristescu V, Barbu RE, et al. Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes. Medicina (B Aires). 2022 May 11;58(5):652.Janus T, Korbal U, Żukowski M, Lewosiuk A, Koper K, Żukowska A, et al. Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders. Stem Cell Rev Rep. 2023 Apr 1;19(3):807–16.Mearin F, Ciriza C, Mínguez M, Rey E, Mascort JJ, Peña E, et al. Irritable bowel syndrome with constipation and functional constipation in adults: Treatment (Part 2 of 2). Aten Primaria. 2017 Mar 1;49(3):177–94.Huo J, Wu L, Lv J, Cao H, Gao Q. Effect of fruit intake on functional constipation: A systematic review and meta-analysis of randomized and crossover studies. Front Nutr [Internet]. 2022 Oct 6;9. Available from: https://www.frontiersin.org/articles/10.3389/fnut.2022.1018502/fullCozma-Petrut A, Loghin F, Miere D, Dumitrascu DL. Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771–83.National Institute for Health and Care Excellence (NICE). Irritable bowel syndrome in adults: diagnosis and management. Clinical guideline [CG61]. 2018;1–22. Available from: https://www.nice.org.uk/guidance/cg61/resources/irritable-bowel-syndrome-in-adults-diagnosis-and-management-pdf-975562917829%0Ahttps://www.nice.org.uk/guidance/cg61McKenzie YA, Bowyer RK, Leach H, Gulia P, Horobin J, O’Sullivan NA, et al. British Dietetic Association systematic review and evidence-based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). J Hum Nutr Diet. 2016;29(5).Rincón RA, Grillo CF, Rodriguez A, Concha A, Costa V, Gómez ÁA, et al. Guía de práctica clínica para el diagnóstico y tratamiento del estreñimiento crónico funcional en población adulta. Rev Col Gastroenterol. 2015;30:57–66.Del Toro-Barbosa M, Hurtado-Romero A, Garcia-Amezquita LE, García-Cayuela T. Psychobiotics: Mechanisms of action, evaluation methods and effectiveness in applications with food products. Vol. 12, Nutrients. MDPI AG; 2020. p. 1–31.Aslam H, Mohebbi M, Ruusunen A, Dawson SL, Williams LJ, Berk M, et al. Associations between dairy consumption and constipation in adults: A cross-sectional study. Nutr Health. 2022 Mar 1;28(1):31–9.Organización Mundial de la Salud. Directrices de la OMS sobre actividad física y hábitos sedentarios. 2020. 1–24 p.(WHO) World Health Organization. Recomendaciones mundiales sobre actividad física para la salud. 2010. 1–58 p.Guzel T, Mirowska-Guzel D. The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy. Vol. 27, Molecules. MDPI; 2022.van Oudenhove L, Levy RL, Crowell MD, Drossman DA, Halpert AD, Keefer L, et al. Biopsychosocial aspects of functional gastrointestinal disorders: How central and environmental processes contribute to the development and expression of functional gastrointestinal disorders. Gastroenterology. 2016 May 1;150(6):1355-1367.e2.Alvarado J, R WO, Andrés M, Santos J, B PAR, L GAP, et al. Guía de práctica clínica para el diagnóstico y tratamiento del síndrome de intestino irritable en población adulta. Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología. 2015;Guías de p.Alammar N, Stein E. Irritable Bowel Syndrome: What Treatments Really Work. Medical Clinics of North America [Internet]. 2019;103(1):137–52. Available from: https://doi.org/10.1016/j.mcna.2018.08.006Adriani A, Ribaldone DG, Astegiano M, Durazzo M, Saracco GM, Pellicano R. Irritable bowel syndrome : the clinical approach. Panminerva Med. 2018;60(4):213–22.Fakhoury HMA, Kvietys PR, AlKattan W, Anouti F Al, Elahi MA, Karras SN, et al. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. Vol. 200, Journal of Steroid Biochemistry and Molecular Biology. Elsevier Ltd; 2020.Sociedad de Agricultores de Colombia (SAC). Así es la hortofruticultura nacional. Revista Nacional de Agricultura [Internet]. 2021;Edición 1018(Septiembre):1–8. Available from: https://sac.org.co/asi-es-la-hortofruticultura-nacional/Austin PC, Steyerberg EW. Events per variable (EPV) and the relative performance of different strategies for estimating the out-of-sample validity of logistic regression models. Stat Methods Med Res. 2017 Apr 1;26(2):796–808.Radovanovic-dinic B, Tesic-rajkovic S, Grgov S, Petrovic G, Zivkovic V. Irritable bowel syndrome – from etiopathogenesis to therapy. 2018;162(1):1–9.Farmer AD. Irritable bowel syndrome Key points. Medicine [Internet]. 2019;(Figure 1):3–6. Available from: https://doi.org/10.1016/j.mpmed.2019.03.009Defrees DN, Bailey J. Irritable Bowel Syndrome: Epidemiology, Pathophysiology, Diagnosis, and Treatment. Primary Care Clinics in Office Practice [Internet]. 2017;44(4):655–71. Available from: https://doi.org/10.1016/j.pop.2017.07.009Sebastián Domingo JJ. Los nuevos criterios de Roma (IV) de los trastornos funcionales digestivos en la práctica clínica. Med Clin (Barc) [Internet]. 2017;148(10):464–8. Available from: http://dx.doi.org/10.1016/j.medcli.2016.12.020Capili B, Anastasi JK, Chang M. Addressing the Role of Food in Irritable Bowel Syndrome Symptom Management. TJNP: The Journal for Nurse Practitioners [Internet]. 2016;12(5):324–9. Available from: http://dx.doi.org/10.1016/j.nurpra.2015.12.007Bonfrate L, Portincasa P, Ballou S, de Bari O, Lembo A. Irritable bowel syndrome and diet. Gastroenterol Rep (Oxf). 2017;5(1):11–9.Sara Lucía Pareja Sierra, Elena Roura Carvajal RMV y AAC. Nutrición Hospitalaria. Nutr Hosp. 2018;35:121–9.Escobar JS, Klotz B, Valdes BE, Agudelo GM. The gut microbiota of Colombians differs from that of Americans, Europeans and Asians. BMC Microbiol. 2015;14(1):1–14.Gajdos P, Román N, Tóth-Király I, Rigó A. Functional gastrointestinal symptoms and increased risk for orthorexia nervosa. Eating and Weight Disorders. 2022 Apr 1;27(3):1113–21.Roman Francisca, Santibañez Patricia. Uso de las Escalas de Depresión Ansiedad Estrés (DASS-21) como Instrumento de Tamizaje en Jóvenes con Problemas Clínicos. ACTA DE INVESTIGACIÓN PSICOLÓGICA . 2016;6(1):2325–36.Carrera Y. Cuestionario Internacional de actividad física (IPAQ). Revista Enfermería del Trabajo. 2017;7(11):49–54.Rijnaarts I, de Roos N, Zoetendal EG, de Wit N, Witteman BJM. Development and validation of the FiberScreen: A short questionnaire to screen fibre intake in adults. Journal of Human Nutrition and Dietetics. 2021 Dec 1;34(6):969–80.Rollet M, Bohn T, Vahid F. Association between Dietary Factors and Constipation in Adults Living in Luxembourg and Taking Part in the ORISCAV-LUX 2 Survey. Nutrients. 2022 Jan 1;14(1).Prada Gómez GE, Herrán Falla ÓF, Oróstegui Prada SA. Atlas fotográfico de porciones para cuantificar el consumo de alimentos y nutrientes en Santander, Colombia. Primera edición 2011. Universidad Industrial de Santander (UIS), editor. Vol. I. Bucaramanga, Colombia: Universidad Industrial de Santander; 2011. 1–143 p.Parhizgar N, Azadyekta M, Parhizgar P. Validity and Reliability Assessments of a 16-item Food Frequency Questionnaire as a Probiotic and Prebiotic Consumption Scale in People Aged 20 to 40 Years in Tehran. Nutrition and Food Sciences Research [Internet]. 2021 Mar 1;8(2):35–42. Available from: http://nfsr.sbmu.ac.ir/article-1-446-en.htmlPalsson OS, Whitehead WE, Van Tilburg MAL, Chang L, Chey W, Crowell MD, et al. Development and validation of the Rome IV diagnostic questionnaire for adults. Gastroenterology. 2016 May 1;150(6):1481–91.Ministerio de Salud y Protección Social. Resolución 2465 de 2016. República de Colombia Colombia; Jun 14, 2016 p. 1–47.Instituto Colombiano de Bienestar Familiar ICBF, Organización de las Naciones Unidas para la Alimentación y Agricultura F. Guías Alimentarias Basadas en Alimentos para la población Colombiana mayor de 2 años [Internet]. Vol. 49, Documento ténico. 2015. 314 p. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/SNA/guias-alimentarias-basadas-en-alimentos.pdfMinisterio de Salud y Protección Social. Resolución 3803 de 2016. República de Colombia 2016 p. 1–26.Ruiz F, Garcia M. DASS-21. ClinikLab Laboratorio de psicología clínica. (2):1–2.Puga JL, García García J. Eventos por Variable en Regresión Logística y Redes Bayesianas para Predecir Actitudes Emprendedoras. Vol. 16, Revista Electrónica de Metodología Aplicada. 2011.Sabbagh LC, William Otero Regino. Guía de práctica clínica para el diagnóstico y tratamiento del síndrome de intestino irritable en población adulta. Rev Col Gastroenterol. 2016;1–32.Kim YS, Kim N. Sex-gender differences in irritable bowel syndrome. J Neurogastroenterol Motil. 2018 Oct 1;24(4):544–58.Narayanan SP, Anderson B, Bharucha AE. Sex- and Gender-Related Differences in Common Functional Gastroenterologic Disorders. Vol. 96, Mayo Clinic Proceedings. Elsevier Ltd; 2021. p. 1071–89.Emerenziani S, Guarino MPL, Asensio LMT, Altomare A, Ribolsi M, Balestrieri P, et al. Role of overweight and obesity in gastrointestinal disease. Vol. 12, Nutrients. MDPI AG; 2020.Mc Gettigan N, Hanley M, Skelly F, Dowling J, Dunne R, Morrin MM, et al. Impact of a physician-led exercise programme on quality of life, muscle mass and clinical response in inflammatory bowel disease patients during induction with disease-modifying therapy: a study protocol. BMJ Open Gastro [Internet]. 2022 [cited 2023 Nov 12];9:959. Available from: http://bmjopengastro.bmj.com/Martínez-Torres J, Lizarazo MAB, Malpica PAC, Escobar-Velásquez KD, Suárez LSC, Moreno-Bayona JA, et al. Prevalence of vitamin D deficiency and insufficiency and associated factors in Colombian women in 2015. Nutr Hosp. 2022 Jul 1;39(4):843–51.Vargas H, Mera A, Pinzón Fernández M, Agredo V. Vitamin D nutritional status in the adult population in Colombia – An analytical cross-sectional study. Heliyon. 2020 Feb 1;6(2).Raymond-Lezman JR, Riskin SI. Benefits and Risks of Sun Exposure to Maintain Adequate Vitamin D Levels. Cureus [Internet]. 2023 May 5 [cited 2023 Nov 28];15(5). Available from: /pmc/articles/PMC10239563/Zhang J, Cao ZB. Exercise: A Possibly Effective Way to Improve Vitamin D Nutritional Status. Vol. 14, Nutrients. MDPI; 2022.Barandouzi ZA, Lee J, del Carmen Rosas M, Chen J, Henderson WA, Starkweather AR, et al. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Sci Rep. 2022 Dec 1;12(1).Linsalata M, Prospero L, Riezzo G, Orlando A, D’Attoma B, Ignazzi A, et al. Somatization is associated with altered serum levels of vitamin D, serotonin, and brain-derived neurotrophic factor in patients with predominant diarrhea irritable bowel syndrome. Neurogastroenterology and Motility. 2023 Mar 1;35(3).Obermanns J, Krawczyk E, Juckel G, Emons B. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression. European Journal of Neuroscience. 2021 May 1;53(10):3476–89.Ogłodek EA. Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress. Int J Environ Res Public Health. 2022 Dec 1;19(24).Vahora IS, Tsouklidis N, Kumar R, Soni R, Khan S. How Serotonin Level Fluctuation Affects the Effectiveness of Treatment in Irritable Bowel Syndrome. Cureus. 2020 Aug 19;Illesca-Matus R, Ardiles NM, Munoz F, Moya PR. Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System. Int J Mol Sci [Internet]. 2023 Jul 12;24(14):11372. Available from: https://www.mdpi.com/1422-0067/24/14/11372Kaur H, Bose C, Mande SS. Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis. Front Neurosci. 2019 Dec 18;13.Gajdos P, Román N, Tóth-Király I, Rigó A. Functional gastrointestinal symptoms and increased risk for orthorexia nervosa. Eating and Weight Disorders. 2022 Apr 1;27(3):1113–21.Grozić A, Coker K, Dussik CM, Sabir MS, Sabir Z, Bradley A, et al. Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D. PLoS One. 2022 Oct 1;17(10 October).Manterola C, Otzen T. Bias in Clinical Research. International Journal of Morphology. 2015;33(3):1156–64.EstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85385/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINALTesis MScLauraAhumada_CC_FBD_ser_VD_organized.pdfTesis MScLauraAhumada_CC_FBD_ser_VD_organized.pdfTesis de Maestría en Fisiologíaapplication/pdf1217336https://repositorio.unal.edu.co/bitstream/unal/85385/4/Tesis%20MScLauraAhumada_CC_FBD_ser_VD_organized.pdf2760efed3474ce927342b714029d3925MD54THUMBNAIL1020824904.2023.pdf.jpg1020824904.2023.pdf.jpgGenerated Thumbnailimage/jpeg5159https://repositorio.unal.edu.co/bitstream/unal/85385/3/1020824904.2023.pdf.jpg2d4c70877e0e0720ff9b0910f897239bMD53Tesis MScLauraAhumada_CC_FBD_ser_VD_organized.pdf.jpgTesis MScLauraAhumada_CC_FBD_ser_VD_organized.pdf.jpgGenerated Thumbnailimage/jpeg5089https://repositorio.unal.edu.co/bitstream/unal/85385/5/Tesis%20MScLauraAhumada_CC_FBD_ser_VD_organized.pdf.jpg6230a9ebd9e54eae579b3b53576697d0MD55unal/85385oai:repositorio.unal.edu.co:unal/853852024-02-06 23:03:44.149Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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

Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)

Publicaciones similares