Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis
ilustraciones, diagramas
- Autores:
-
Martínez Solarte, Miguel Angel
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/84277
- Palabra clave:
- 610 - Medicina y salud::612 - Fisiología humana
610 - Medicina y salud::613 - Salud y seguridad personal
Presión arterial
Monitoreos de presión sanguínea
Enfermedades cardiovasculares
Arterial Pressure
Blood Pressure Monitors
Cardiovascular Diseases
hipertensión arterial
Riesgo cardiovascular
Ejercicio aeróbico
Ejercicio isométrico
Essential hypertension
Aerobic exercise
Isometric exercise
Cardiovascular risk
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
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Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| dc.title.translated.eng.fl_str_mv |
Effects of the dynamic aerobic exercise and the isometric exercise training on the Essential Hypertension treatment: systematic review and meta- analysis |
| title |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| spellingShingle |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis 610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::613 - Salud y seguridad personal Presión arterial Monitoreos de presión sanguínea Enfermedades cardiovasculares Arterial Pressure Blood Pressure Monitors Cardiovascular Diseases hipertensión arterial Riesgo cardiovascular Ejercicio aeróbico Ejercicio isométrico Essential hypertension Aerobic exercise Isometric exercise Cardiovascular risk |
| title_short |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| title_full |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| title_fullStr |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| title_full_unstemmed |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| title_sort |
Efectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisis |
| dc.creator.fl_str_mv |
Martínez Solarte, Miguel Angel |
| dc.contributor.advisor.none.fl_str_mv |
Garcia, Oscar Armando |
| dc.contributor.author.none.fl_str_mv |
Martínez Solarte, Miguel Angel |
| dc.contributor.referee.none.fl_str_mv |
Hamed Riveros, Nicolas Farid Garcia Corredor, Lady Juliet |
| dc.contributor.googlescholar.spa.fl_str_mv |
Martinez Solarte, Miguel Angel |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::613 - Salud y seguridad personal |
| topic |
610 - Medicina y salud::612 - Fisiología humana 610 - Medicina y salud::613 - Salud y seguridad personal Presión arterial Monitoreos de presión sanguínea Enfermedades cardiovasculares Arterial Pressure Blood Pressure Monitors Cardiovascular Diseases hipertensión arterial Riesgo cardiovascular Ejercicio aeróbico Ejercicio isométrico Essential hypertension Aerobic exercise Isometric exercise Cardiovascular risk |
| dc.subject.decs.spa.fl_str_mv |
Presión arterial Monitoreos de presión sanguínea Enfermedades cardiovasculares |
| dc.subject.decs.eng.fl_str_mv |
Arterial Pressure Blood Pressure Monitors Cardiovascular Diseases |
| dc.subject.proposal.spa.fl_str_mv |
hipertensión arterial Riesgo cardiovascular Ejercicio aeróbico Ejercicio isométrico |
| dc.subject.proposal.eng.fl_str_mv |
Essential hypertension Aerobic exercise Isometric exercise Cardiovascular risk |
| description |
ilustraciones, diagramas |
| publishDate |
2023 |
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2023-07-26T14:43:05Z |
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2023-07-26T14:43:05Z |
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2023 |
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Trabajo de grado - Maestría |
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info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
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Text |
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http://purl.org/redcol/resource_type/TM |
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acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/84277 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/84277 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. J Am Coll Cardiol. mayo de 2018;71(19):e127-248 Millar PJ, McGowan CL, Cornelissen VA, Araujo CG, Swaine IL. Evidence for the Role of Isometric Exercise Training in Reducing Blood Pressure: Potential Mechanisms and Future Directions. Sports Med. marzo de 2014;44(3):345-56. Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. The Lancet. mayo de 2014;383(9932):1899-911. Cornelissen VA, Smart NA. Exercise Training for Blood Pressure: A Systematic Review and Meta‐analysis. J Am Heart Assoc. 23 de enero de 2013;2(1):e004473. López-Valenciano A, Ruiz-Pérez I, Ayala F, Sánchez-Meca J, Vera-Garcia FJ. Updated systematic review and meta-analysis on the role of isometric resistance training for resting blood pressure management in adults. J Hypertens. julio de 2019;37(7):1320-33. Inder JD, Carlson DJ, Dieberg G, McFarlane JR, Hess NC, Smart NA. Isometric exercise training for blood pressure management: a systematic review and meta analysis to optimize benefit. Hypertens Res. febrero de 2016;39(2):8 Smart NA, Way D, Carlson D, Millar P, McGowan C, Swaine I, et al. Effects of isometric resistance training on resting blood pressure: individual participant data meta-analysis. J Hypertens. octubre de 2019;37(10):1927-38. Sardeli AV. Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials. Exp Gerontol. 2020;4. PRISMA-P Group, Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. diciembre de 2015;4(1):1. Kulkarni S, Rao R, Goodman JDH, Connolly K, O’Shaughnessy KM. Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study. Medicine (Baltimore). 9 de abril de 2021;100(14):e24654. Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine (Baltimore). enero de 2017;96(4):e5641. Piedrahíta MCC, Olarte LMC, Rivas DC. ADHESIÓN AL TRATAMIENTO DE LA HIPERTENSIÓN ARTERIAL EN DOS MUNICIPIOS DE COLOMBIA. 2010-2011. Hacia Promoc Salud. 2013;17. Souza ACC de, Borges JWP, Moreira TMM. Quality of life and treatment adherence in hypertensive patients: systematic review with meta-analysis. Rev Saúde Pública [Internet]. 2016 [citado 7 de noviembre de 2022];50(0). Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034- 89102016000100505&lng=en&tlng=en Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. diciembre de 2021;18(1):24. Grässler B, Thielmann B, Böckelmann I, Hökelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. diciembre de 2021;18(1):24. 6. Pedralli ML, Eibel B, Waclawovsky G, Schaun MI, Nisa-Castro-Neto W, Umpierre D, et al. Effects of exercise training on endothelial function in individuals with hypertension: a systematic review with meta-analysis. J Am Soc Hypertens. diciembre de 2018;12(12):e65-75. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. Exercise and Hypertension: Med Sci Sports Exerc. marzo de 2004;36(3):533-53 de Barcelos GT, Heberle I, Coneglian JC, Vieira BA, Delevatti RS, Gerage AM. Effects of Aerobic Training Progression on Blood Pressure in Individuals With Hypertension: A Systematic Review With Meta-Analysis and Meta-Regression. Front Sports Act Living. 17 de febrero de 2022;4:719063. Taylor AC, Mccartney N, Kamath MV, Wiley RL. Isometric Training Lowers Resting Blood Pressure and Modulates Autonomic Control: Med Sci Sports Exerc. febrero de 2003;35(2):251-6. Gorostidi M, Gijón-Conde T, de la Sierra A, Rodilla E, Rubio E, Vinyoles E, et al. Guía práctica sobre el diagnóstico y tratamiento de la hipertensión arterial en España, 2022. Sociedad Española de Hipertensión - Liga Española para la Lucha contra la Hipertensión Arterial (SEH-LELHA). Hipertens Riesgo Vasc. octubre de 2022;39(4):174-94. Pescatello LS, MacDonald HV, Lamberti L, Johnson BT. Exercise for Hypertension: A Prescription Update Integrating Existing Recommendations with Emerging Research. Curr Hypertens Rep. noviembre de 2015;17(11):87. Moraes-Silva IC, Mostarda CT, Silva-Filho AC, Irigoyen MC. Hypertension and Exercise Training: Evidence from Clinical Studies. En: Xiao J, editor. Exercise for Cardiovascular Disease Prevention and Treatment [Internet]. Singapore: Springer Singapore; 2017 [citado 23 de enero de 2023]. p. 65-84. (Advances in Experimental Medicine and Biology; vol. 1000). Disponible en: http://link.springer.com/10.1007/978- 981-10-4304-8_5 Santos CM da C, Pimenta CA de M, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. junio de 2007;15(3):508-11. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan- a web and mobile app for systematic reviews. World Health Organization. Waist circumference and waist-hip ratio : report of a WHO expert consultation, Geneva, 8-11 December 2008. 2011 [citado 18 de marzo de 2023]; Disponible en: https://apps.who.int/iris/handle/10665/44583 Executive Summary. Obes Res. septiembre de 1998;6(S2):51S-179S. Moseley AM, Herbert RD, Sherrington C, Maher CG. Evidence for physiotherapy practice: A survey of the Physiotherapy Evidence Database (PEDro). Aust J Physiother. 2002;48(1):43-9. Maher c, sherrington C, Herbert R, Moseley A, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical therapy [Internet]. Physical Therapy; 2003. Disponible en: https://pubmed.ncbi.nlm.nih.gov/12882612 de Morton NA. The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother. 2009;55(2):129-33. Higgins J, Savović J, Page M, Elbers R, Sterne J. Chapter 8: Assessing risk of bias in a randomized trial [Internet]. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022).; 2022. Disponible en: www.training.cochrane.org/handbook. Review Manager (RevMan). The cochrane collaboration; 2020 Sterne J, Savović J, Page M, Elbers R, Blencowe N, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ; 2019. McKenzie J, Brennan S, Ryan S, Thomson H, Jhonston R. Chapter 9: Summarizing study characteristics and preparing for synthesis [Internet]. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022); 2022. Disponible en: www.training.cochrane.org/handbook. Molmen-Hansen HE, Stolen T, Tjonna AE, Aamot IL, Ekeberg IS, Tyldum GA, et al. Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients. Eur J Prev Cardiol. abril de 2012;19(2):151-60. Tsai JC, Chang WY, Kao CC, Lu MS, Chen YJ, Chan P. BENEFICIAL EFFECT ON BLOOD PRESSURE AND LIPID PROFILE BY PROGRAMMED EXERCISE TRAINING IN TAIWANESE PATIENTS WITH MILD HYPERTENSION. Clin Exp Hypertens. enero de 2002;24(4):315-24. Tsai J, Yang H, Wang W, Hsieh M, Chen P, Kao C, et al. The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension. Clin Exp Hypertens. enero de 2004;26(3):255-65. Tanabe Y, Urata H, Kiyonaga A, Ikeda M, Tanaka H, Shindo M, et al. Changes in Serum Concentrations of Taurine and Other Amino Acids in Clinical Antihypertensive Exercise Therapy. Clin Exp Hypertens A. enero de 1989;11(1):149-65. Lamina S. Comparative Effect of Interval and Continuous Training Programs on Serum Uric Acid in Management of Hypertension: A Randomized Controlled Trial. J Strength Cond Res. marzo de 2011;25(3):719-26. Duncan JJ, Farr JE, Hagan RD, Blair SN. The Effects of Aerobic Exercise on Plasma Catecholamines and Blood Pressure in Patients With Mild Essential Hypertension. Wong A, Kwak YS, Scott SD, Pekas EJ, Son WM, Kim JS, et al. The effects of swimming training on arterial function, muscular strength, and cardiorespiratory capacity in postmenopausal women with stage 2 hypertension. Menopause. junio de 2019;26(6):653-8. Faulkner MA. Effects of Isometric Handgrip Training on Resting Arterial Blood Pressure and Arterial Compliance in Medicated Hypertensive Individuals. Badrov MB, Horton S, Millar PJ, McGowan CL. Cardiovascular stress reactivity tasks successfully predict the hypotensive response of isometric handgrip training in hypertensives: Isometric exercise and cardiovascular reactivity. Psychophysiology. abril de 2013;50(4):407-14. Okamoto T, Hashimoto Y, Kobayashi R. Isometric handgrip training reduces blood pressure and wave reflections in East Asian, non-medicated, middle-aged and older adults: a randomized control trial. Aging Clin Exp Res. agosto de 2020;32(8):1485-91. Jin YZ, Yan S, Yuan WX. Effect of isometric handgrip training on resting blood pressure in adults: a meta-analysis of randomized controlled trials. J Sports Med Phys Fitness [Internet]. enero de 2017 [citado 5 de abril de 2023];57(1-2). Disponible en: https://www.minervamedica.it/index2.php?show=R40Y2017N01A0154 Almeida JPA de S, Bessa M, Lopes LTP, Gonçalves A, Roever L, Zanetti HR. Isometric handgrip exercise training reduces resting systolic blood pressure but does not interfere with diastolic blood pressure and heart rate variability in hypertensive subjects: a systematic review and meta-analysis of randomized clinical trials. Hypertens Res. septiembre de 2021;44(9):1205-12. Hanssen H, Boardman H, Deiseroth A, Moholdt T, Simonenko M, Kränkel N, et al. Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Eur J Prev Cardiol. 19 de febrero de 2022;29(1):205-15. McGowan CL, Visocchi A, Faulkner M, Verduyn R, Rakobowchuk M, Levy AS, et al. Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives. Eur J Appl Physiol. 25 de enero de 2007;99(3):227-34. Arenas G, Huerta A, Molina E, Gonzalez J, Espinoza A. Efecto del entrenamiento de fuerza prensil de intensidad ascendente sobre la presión arterial y la cinética de oxigenación muscular en personas mayores hipertensas tipo l. Salud UIS [Internet]. 21 de octubre de 2020 [citado 5 de abril de 2023];52(4). Disponible en: https://www.redalyc.org/articulo.oa?id=343868237004 Fecchio RY, de Sousa JCS, Oliveira-Silva L, da Silva Junior ND, Pio-Abreu A, da Silva GV, et al. Effects of dynamic, isometric and combined resistance training on blood pressure and its mechanisms in hypertensive men. Hypertens Res. abril de 2023;46(4):1031-43. Cornelissen VA, Buys R, Smart NA. Endurance exercise beneficially affects ambulatory blood pressure: a systematic review and meta-analysis. J Hypertens. abril de 2013;31(4):639-48. Blacher J, Staessen JA, Girerd X, Gasowski J, Thijs L, Liu L, et al. Pulse Pressure Not Mean Pressure Determines Cardiovascular Risk in Older Hypertensive Patients. ARCH INTERN MED. 2000;160. Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study. Circulation. 6 de marzo de 2001;103(9):1245-9. Leal JM, Galliano LM, Del Vecchio FB. Effectiveness of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Hypertensive Patients: a Systematic Review and Meta-Analysis. Curr Hypertens Rep. marzo de 2020;22(3):26. Cahu Rodrigues SL, Farah BQ, Silva G, Correia M, Pedrosa R, Vianna L, et al. Vascular effects of isometric handgrip training in hypertensives. Clin Exp Hypertens. 2 de enero de 2020;42(1):24-30. |
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Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garcia, Oscar Armando74f75663d36159218b014b044f97c2fcMartínez Solarte, Miguel Angel8dfd705350f402a7e354283af607f9cfHamed Riveros, Nicolas FaridGarcia Corredor, Lady JulietMartinez Solarte, Miguel Angel2023-07-26T14:43:05Z2023-07-26T14:43:05Z2023https://repositorio.unal.edu.co/handle/unal/84277Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasLa hipertensión arterial primaria o esencial es uno de los tipos de la enfermedad crónica de presión arterial elevada, referenciada como de origen heterogéneo y poligénico; sobre la cual ejercen efecto diversos factores adquiridos y ambientales. Siguiendo el desarrollo metodológico Cochrane y los requerimientos de la declaración PRISMA, se realizó una revisión sistemática y metaanálisis cuantificando los efectos del ejercicio dinámico aeróbico y el ejercicio isométrico sobre la presión arterial en los adultos diagnosticados con hipertensión arterial primaria. Se incluyeron ensayos clínicos aleatorizados que investigaron el efecto de la intervención con ejercicio isométrico mayor a 3 semanas y dinámico aeróbico mayor a 6 semanas. 9 estudios fueron finalmente agrupados y sintetizados mediante el método estadístico inverso de varianza, con efecto de medida de diferencia media y un modelo de análisis para efectos aleatorios con intervalo de confianza del 95%. 8 semanas de exposición demostraron la reducción significativa de la presión arterial sistólica (PAS) con las dos exposiciones, a diferencia de la presión arterial diastólica (PAD) y la frecuencia cardiaca (FC) donde el efecto del ejercicio isométrico parece no ser sustancial. La relación del tiempo de exposición con el efecto, reveló que la PAS tiende a disminuir con intervenciones prolongadas de entrenamiento aeróbico, mientras la PAD actúa de manera contraria. Reducciones en la presión arterial media (PAM) y presión de pulso (PP) fueron identificadas luego de 10 semanas de entrenamiento isométrico, pero no pudieron ser contrastadas con el aeróbico debido a la baja disponibilidad de datos para agruparlos. Se concluye que las dos intervenciones evidenciaron significancia estadística en la reducción de la presión arterial y que se esperan variaciones mayores inducidas por el ejercicio aeróbico, sin embargo, las características iniciales de los individuos juegan un papel importante en los resultados obtenidos y por ende en la relevancia clínica de las reducciones. (Texto tomado de la fuente)Primary or essential hypertension is one of the types of chronic high blood pressure, referred to as having a heterogeneous and polygenic origin, on which various factors have an effect. Following the Cochrane methodological development and the requirements of the PRISMA statement, a systematic review and meta-analysis was conducted to quantify the effects of dynamic aerobic exercise and isometric exercise on blood pressure in adults diagnosed with primary hypertension. Randomized clinical trials investigating the effects of the intervention with isometric exercise lasting more than 3 weeks and aerobic exercise lasting more than 6 weeks were included. Nine studies were finally grouped and synthesized using the inverse variance statistical method, with a random effects analysis model. Eight weeks of exposure demonstrated a significant reduction in systolic blood pressure (SBP) with both types of exercise, unlike diastolic blood pressure (DBP) and heart rate (HR) where the effect of isometric exercise appears to be unsubstantial. The relationship between exposure time and effect revealed that SBP tends to decrease with prolonged aerobic training interventions, while DBP acts in the opposite way. Reductions in mean arterial pressure (MAP) and pulse pressure (PP) were identified after 10 weeks of isometric training but could not be compared with aerobic exercise due to limited data availability for pooling. It is concluded that both interventions showed statistical significance in reducing blood pressure, and greater variations are expected to be induced by aerobic exercise. However, the initial characteristics of the individuals play an important role in the obtained results and therefore in the clinical relevance of the reductions.MaestríaMagíster en FisiologíaRevision sistemática con metaanálisisFisiología del Ejercicioxiv, 64 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en FisiologíaFacultad de MedicinaBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::612 - Fisiología humana610 - Medicina y salud::613 - Salud y seguridad personalPresión arterialMonitoreos de presión sanguíneaEnfermedades cardiovascularesArterial PressureBlood Pressure MonitorsCardiovascular Diseaseshipertensión arterialRiesgo cardiovascularEjercicio aeróbicoEjercicio isométricoEssential hypertensionAerobic exerciseIsometric exerciseCardiovascular riskEfectos del ejercicio dinámico aeróbico e isométrico en el tratamiento de la Hipertensión arterial primaria: Revisión sistemática y metaanálisisEffects of the dynamic aerobic exercise and the isometric exercise training on the Essential Hypertension treatment: systematic review and meta- analysisTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMWhelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. 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Clin Exp Hypertens. 2 de enero de 2020;42(1):24-30.EstudiantesInvestigadoresMaestrosPúblico generalORIGINALTRabajo de Grado Miguel Angel Martínez.pdfTRabajo de Grado Miguel Angel Martínez.pdfTesis de grado de Maestría en Fisiologíaapplication/pdf991086https://repositorio.unal.edu.co/bitstream/unal/84277/2/TRabajo%20de%20Grado%20Miguel%20Angel%20Mart%c3%adnez.pdf32e0dccfa8529610fcf612203b424520MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84277/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51THUMBNAILTRabajo de Grado Miguel Angel Martínez.pdf.jpgTRabajo de Grado Miguel Angel Martínez.pdf.jpgGenerated Thumbnailimage/jpeg5537https://repositorio.unal.edu.co/bitstream/unal/84277/3/TRabajo%20de%20Grado%20Miguel%20Angel%20Mart%c3%adnez.pdf.jpgcceba24775245c8ac44acb58a9193e30MD53unal/84277oai:repositorio.unal.edu.co:unal/842772024-08-15 23:15:00.48Repositorio Institucional Universidad Nacional de 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