Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance

ilustraciones, diagramas,

Autores:
Muñoz Sanjuan, Carolina Maria
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/84802
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/84802
https://repositorio.unal.edu.co/
Palabra clave:
Terapia con cupuntura
Terapias complementarias
Acupuncture Therapy
Complementary Therapies
Acupuntura
Anorexia
Caquexia
Cancer
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_3dc98ccc9088ec6292b3a37f1647076a
oai_identifier_str oai:repositorio.unal.edu.co:unal/84802
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
dc.title.translated.spa.fl_str_mv Acupuncture for the management of patients with anorexia- cachexia associated with cancer: scope review
title Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
spellingShingle Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
Terapia con cupuntura
Terapias complementarias
Acupuncture Therapy
Complementary Therapies
Acupuntura
Anorexia
Caquexia
Cancer
title_short Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
title_full Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
title_fullStr Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
title_full_unstemmed Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
title_sort Acupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcance
dc.creator.fl_str_mv Muñoz Sanjuan, Carolina Maria
dc.contributor.advisor.none.fl_str_mv Mercado Pedroza, Manuel Esteban
dc.contributor.author.none.fl_str_mv Muñoz Sanjuan, Carolina Maria
dc.contributor.researchgroup.spa.fl_str_mv Medicina Tradicional China y Acupuntura
dc.subject.decs.spa.fl_str_mv Terapia con cupuntura
Terapias complementarias
topic Terapia con cupuntura
Terapias complementarias
Acupuncture Therapy
Complementary Therapies
Acupuntura
Anorexia
Caquexia
Cancer
dc.subject.decs.eng.fl_str_mv Acupuncture Therapy
Complementary Therapies
dc.subject.proposal.spa.fl_str_mv Acupuntura
Anorexia
Caquexia
Cancer
description ilustraciones, diagramas,
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-10-17T14:00:47Z
dc.date.available.none.fl_str_mv 2023-10-17T14:00:47Z
dc.date.issued.none.fl_str_mv 2023-10-02
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/84802
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/84802
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv 1. Dhanapal R, Saraswathi TR, Govind R. Cancer cachexia. J Oral Maxillofac Pathol. 2011;15(3):257-260. doi: 10.4103/0973-029X.86670.
2. Ramos E, Suzuki S, Marks D, Inui A, Asakawa A, Meguid M. Cancer anorexia- cachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care. 2004;7(4):427-34 doi: 10.1097/01.mco.0000134363.53782.cb.
3. Tuca A, Jimenez-Fonseca P, Gascón P. Clinical evaluation and optimal management of cancer cachexia. Clinical Reviews in Oncology/Hematology. 2013;88(3):625-36.
4. Sarhill N, Mahmoud F, Walsh D, Nelson KA, Komurcu S, Davis M, et al. Evaluation of nutritional status in advanced metastatic cancer. Supportive Care in Cancer. 2003;11(10):652-9.
5. Kanzaki M, Soda K, Gin PT, Kai T, Konishi F, Kawakami M. Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine. Cytokine. 2005;32:234-9. doi: 10.1016/j.cyto.2005.10.002.
6. Cardona D. Tratamiento farmacológico de la anorexia-caquexia cancerosa. Nutrición Hospitalaria. 2006;21(3):17-26.
7. Diffee GM, Kalfas K, Al-Majid S, McCarthy DO. Altered expression of skeletal muscle myosin isoforms in cancer cachexia. Am J Physiol Cell Physiol. 2002;283:C1376-C1382. doi.org/10.1152/ajpcell.00154.2002.
8. Vargas-Arce Y, Abarca-Gómez L. Prevalence of cachexia related to cancer in patients at a primary level: a palliative approach. Acta Médica Costarricence. 2016;58(4):171-7.
9. Dufau L. Prevalencia de la desnutrición en el paciente oncológico. Rev DIAETA. 2010;28:31-6.
10. Soza S, Sánchez K, Motola D, Green D. Síndrome de anorexia- caquexia en el paciente oncológico. Gac Médica México. 2008;144:435-40.
11. García L, Parejo CS, Pereira C. Causas e impacto clínico de la desnutrición y caquexia en el paciente oncológico. Nutr Hosp. 2006;3:10-6.
12. Hofbauer KG, Anker SD, Inui A, Nicholson JR. Pharmacotherapy of caquexia. United States of America: Taylor & Francis Group, LLC; 2006.
13. Vaughan VC, Martin P, Lewandowski PA. Cancer cachexia: impact, mechanisms and emerging treatments. J Caquexia Sarcopenia Muscle. 2013;4(2):95-109 doi: 10.1007/s13539-012-0087-1.
14. Suzuki H, Asakawa A, Amitani H, Nakamura N, Inui A. Cancer cachexia-- pathophysiology and management. J Gastroenterol. 2013;48(5):574-94. doi: 10.1007/s00535-013-0787-0.
15. Mantovani G, Madeddu C. Cancer cachexia: medical management. Support Care Cancer. 2010;18:1-9.
16. Pisters P, Brennan MF. Protein and Amino Acid Metabolism in Cancer Cachexia. Berlin (Germany): Springer; 2013. 275 p.
17. Argilés JM, Busquets S, Toledo M, López-Soriano J. The role of cytokines in cancer cachexia. Curr Opin Support Palliat Care. 2009;3(4):263-8. doi: 10.1097/SPC.0b013e3283311d09.
18. Argilés JM, Busquets S, García-Martínez C, López-Soriano FJ. Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future. Nutrition. 2005;21(9):977-85. doi: 10.1016/j.nut.2005.02.003.
19. Del Fabbro E, Inui A, Strasser F. Cancer Cachexia. London (England): Springer; 2014. 83 p.
20. Hopkinson JB. Psychosocial impact of cancer cachexia. J Caquexia Sarcopenia Muscle. 2014;5(2).
21. Lövgren M, Tishelman C, Sprangers M, Koyi H, Hamberg K. Symptoms and problems with functioning among women and men with inoperable lung cancer - a longitudinal study. Lung Cancer. 2008;60:113-124. doi: 10.1016/j.lungcan.2007.09.015.
22. Tarricone R, Ricca G, Nyanzi-Wakholi B, Medina-Lara A. Impact of cancer anorexia-cachexia syndrome on health-related quality of life and resource utilisation: A systematic review. Crit Rev Oncol Hematol. 2016;99:49-62 doi: 10.1016/j.critrevonc.2015.12.008.
23. Hopkinson J, Wright D, Corner J. Exploring the experience of weight loss in people with advanced cancer. J Adv Nurs. 2006;54:304-12. doi: 10.1111/j.1365- 2648.2006.03818.x.
24. Lu Z, Fang Y, Liu C, Zhang X, Xin X, He Y, et al. Early Interdisciplinary Supportive Care in Patients With Previously Untreated Metastatic Esophagogastric Cancer: A Phase III Randomized Controlled Trial. J Clin Oncol. 2021;39(7):748-756 doi: 10.1200/JCO.20.01254.
25. Reid J, McKenna H, Fitzsimons D, McCance TV. The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members. Int J Nurs Stud. 2009;46:606-16 doi: 10.1016/j.ijnurstu.2008.10.012.
26. Reid J, McKenna H, Fitzsimons D, McCance TV. The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members. Int J Nurs Stud. 2009;46:606-16 doi: 10.1016/j.ijnurstu.2008.10.012.
27. Sun H, Sudip T, Fu X, Wen S, Liu H, Yu S. Cachexia is associated with depression, anxiety and quality of life in cancer patients. BMJ Support Palliat Care. 2020;doi: 10.1136/bmjspcare-2019-002176.
28. Locher JL, Robinson CO, Bailey FA,. Disruptions in the organisation of meal preparation and their family caregivers. Psychooncology. 2010;19(9):967-74. doi: 10.1002/pon.1656.
29. Garcia VR, López-Briz E, Carbonell R, Gonzalvez JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013;3:doi: 10.1002/14651858.CD004310.pub3.
30. Penna F, Bonetto A, Aversa Z, Giacomo V, Rossi F, Costelli P, et al. Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting. J Cachexia Sarcopenia Muscle. 2016;7(3):345-54 doi: 10.1002/jcsm.12050.
31. Gordon JN, Trebble TM, Duncan HD, Johns T, Goggin PM. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut. 2005;54(4):540-545. doi: 10.1136/gut.2004.047563.
32. Solheim TS, Fearon K, Blum D, Kaasa S. Non-steroidal anti-inflammatory treatment in cancer cachexia: a systematic literature review. Acta Oncol. 2013;52(1):6-17 doi: 10.3109/0284186X.2012.724536.
33. Santos J, Costa A, Dias T, Satari S, Costa MP, Gil R. Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates. Pharmaceuticals (Basel). 2021;14(11):1084.
34. Kirubakaran R, Gaidhane A, Gaidhane S, Simkhada P, Quazi Z. Ghrelin for the management of cachexia associated with cancer. Cochrane Database Syst Rev. 2018;2:doi: 10.1002/14651858.CD012229.pub2.
35. Jatoi A, Dakhil S, Nguyen Pl, Sloan JA, Kugler JW, Rowland KM, et al. A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group. Cancer. 2007;110(6):1396-403. doi: 10.1002/cncr.22944.
36. Penna F, Busquets S, Toledo M, Pin F, Massa D, López-Soriano FJ, Costelli P, Argilés JM. Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models. J Lipid Res. 2013;54:3045-51.
37. Van Hal M, Dydyk AM, Green MS. Acupunture. StatPearls [Internet]. 2023;
38. Lu W, Dean-Clower E, Doherty-Gilman A, Osenthal DS. The Value of Acupuncture in Cancer Care. Hematol Oncol Clin North Am. 2008;22(4):631-viii doi: 10.1016/j.hoc.2008.04.005.
39. Cho W. Acupuncture and moxibustion as an evidence-based therapy for cancer. Netherlands: Springer; 2012. 356 p.
40. Cancer Research UK. Worldwide cancer statistics [Internet]. Worldwide cancer statistics. 2020 [citado 12 de agosto de 2023]. Disponible en: https://www.cancerresearchuk.org/health-professional/cancer- statistics/worldwide- cancer#:~:text=Incidence%20worldwide,of%20all%20cancers%20diagnosed% 20worldwide.
41. Amano K, Hopkinson JB, Baracos V, Mori N. Holistic multimodal care for patients with cancer cachexia and their family caregivers. Asia-Pacific Journal of Oncology Nursing. 2023;https://doi.org/10.1016/j.apjon.2023.100290.
42. Stewart GD, Skipworth RF, Fearon K. Cancer cachexia and fatigue. CME Palliative Care. 2006;6(2):140-3.
43. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Faisinger RL. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7.
44. Tijerina AJ. The biochemical basis of metabolism in cancer cachexia. Dimens Crit Care Nurs. 2004;23(6):237-43 doi: 10.1097/00003465-200411000-00001.
45. Ni J, Zhang L. Cancer Cachexia: Definition, Staging, and Emerging Treatments. Cancer Manag Res. 2020;12:5597-5605 doi: 10.2147/CMAR.S261585.
46. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491-497. doi: 10.1016/S0149-2918(05)80001-3.
47. Wang Y, An Z, Lin D, Jun E. Targeting cancer cachexia: Molecular mechanisms and clinical study. Med Comm. 2022;3:e164. DOI: 10.1002/mco2.164.
48. Jiménez R, Cabanas R, Fernández R, Chagues O, González M, Peón L, et al. Caracterización nutricional del síndrome anorexia-caquexia en el paciente oncológico pediátrico. Rev Cubana Pediatr. 2011;83(4):337-45.
49. Zhong X, Zimmers TA. Sex differences in cancer cachexia. Current Osteoporosis Reports. 2020;18(6):646-54.
50. Vanhoutte G, van de Wiel M, Wouters K, Sels M, Bartolomeeussen L, De Keersmaecker S, et al. Cachexia in cancer: what is in the definition? BMJ Open Gastroenterol. 2016;3(1):e000097 doi: 10.1136/bmjgast-2016-000097.
51. Pin F, Barreto R, Couch ME, Bonetto A, O`Connell TM. Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism. J Cachexia Sarcopenia Muscle. 2019;10(1):140-54.
52. Le Bricon T, Gugins S, Cynober L, Baracos VE. Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor‐bearing rats. Metabolism: clinical and experimental. 1995;44(1340-1348).
53. Le Bricon T, Gugins S, Cynober L, Baracos VE. Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor‐bearing rats. Metabolism: clinical and experimental. 1995;44:1340-8.
54. Barreto R, Waning DL, Gao H, Liu Y, Zimmers TA, Bonetto A. Chemotherapy‐related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. 2016;7:43442-60.
55. Damrauer J, Stadler M, Acharyya S, Baldwin A, Couch ME, Guttridge DC. Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia. Eur J Transl Myol. 2018;28(2):7590. doi: 10.4081/ejtm.2018.7590.
56. Porta J, Gómez B, Tuca A. Manual de Control de síntomas en pacientes con cáncer avanzado y terminal. 2 a Edición. Madrid (España): Arán Ediciones; 2008. 373 p.
57. Walsh D, Caraceni A, Faisinger R, Glare P, Goh C, Foley K, et al. Medicina Paliativa. Barcelona (España): Elsevier España; 2010.
58. Matsuo H, Sakuma K. Pathophysiology of cachexia and characteristics of dysphagia in chronic diseases. Asia Pac J Oncol Nurs. 2022;9(10):100120.
59. Conno F, Ventafridda V, Saita L. Skin problems in advanced and terminal cancer patients. Journal of Pain and Sumptom Management. 1991;6(4):247-56.
60. Malla J, Zahra A, Venugopal S, Yadhav T, Shoukrie S, Selvaraj R, et al. What Role Do Inflammatory Cytokines Play in Cancer Cachexia? Cureus. 2022;14(7):e26798 doi: 10.7759/cureus.26798.
61. AlSudais H, Rajgara R, Saleh A, Wiper-Bergeron NJ. C/EBPβ promotes the expression of atrophy-inducing factors by tumours and is a central regulator of cancer cachexia. Cachexia Sarcopenia Muscle. 2022;13:743-57.
62. Mattox TW. Cancer Cachexia: Cause, Diagnosis, and Treatment. Nutr Clin Pract. 2017;32(5):599-606. doi: 10.1177/0884533617722986.
63. VanderVeen BN, Fix DK, Carson JA. Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation. Oxid Med Cell Longev. 2017;3292087 doi: 10.1155/2017/3292087.
64. Lelbach A, Muzes G, Feher J. Current perspectives of catabolic mediators of cancer cachexia. J Med Sci Monit. 2007;13:0-173.
65. González M, Ordóñez A, Feliu J, Zamora P, Espinosa E. Tratado de Medicina Paliativa y tratamiento soporte del paciente con cáncer. Segunda Edición. 2° Edición. Madrid (España): Editorial Médica Panamericana; 2007. 486 p.
66. Bermúdez M, Becerra R, Galvis JC. Sarcopenia versus caquexia. Repert Med Circ. 2015;24(1):7-15.
67. Tavares P, Moreira D, Lara L, Ferreira R. Revisiting the clinical usefulness of C- reactive protein in the set of cancer cachexia. Porto Biomed J. 2021;6(1):e123. doi: 10.1097/j.pbj.0000000000000123.
68. Jain S, Gautam V, Naseem S. Acute-phase proteins: as diagnostic tool. J Pharm Bioallied Sci. 2011;3:118-27.
69. Sproston NR, Ashworth J. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754.
70. Wu Y, Potempa LA, El KD, Filep JG. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015;396:1181-97.
71. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-12.
72. Ferri F. Consultor Clínico. Diagnóstico y tratamiento. Barcelona (España): Elsevier España; 2023. 1628 p.
73. Argilés JM, López-Soriano FJ, Toledo M, Betancourt A, Serpe R, Busquets S. The cachexia score (CASCO): a new tool for staging cachectic cancer patients. J Cachexia Sarcopenia Muscle. 2011;2(2):87-93. doi: 10.1007/s13539-011- 0027-5.
74. Kiew W. El gran libro de la medicina china. Barcelona (España): Urano; 2003. 332 p.
75. Micunovic I. Origin of Chinese Medicine, Acupuncture & Moxibustion. J Altern Complement Integr Med. 2018;4(054):1-8. DOI: 10.24966/ACIM-7562/100054.
76. Coba JL. Acupuntura, vórtices y energías. Su significado oculto y profundo. Quito (Ecuador): Universidad Andina Simón Bolívar; 2018. 980 p.
77. Ramey D, Buell PD. A true history of acupuncture. Focus on Alternative and Complementary Therapies. 2010;9(4):269-273. doi.org/10.1211/fact.2004.00244.
78. Maurer N, Nissel H, Egerbacher M, Gornik E, Schuller P, Traxler H. Anatomical Evidence of Acupuncture Meridians in the Human Extracellular Matrix: Results from a Macroscopic and Microscopic Interdisciplinary Multicentre Study on Human Corpses. Evid Based Complement Alternat Med. 2019;6976892. doi: 10.1155/2019/6976892.
79. Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-8.
80. Hermann-Carl H. Atlas de acupuntura. México D.F: Editorial Paidotribo; 2019. 304 p.
81. Ching N. The fundamentals of acupuncture. Philadelphia (USA): Singing Dragon; 2017. 750 p.
82. Battaloğlu B. A New Theory on the Evaluation of Traditional Chinese Acupuncture Mechanisms from the Latest Medical Scientific Point of View. Acupunct Electrother Res. 2015;40(3):189-204. doi: 10.3727/036012915x14473562232987.
83. Stone JA, Johnstone PA. Mechanisms of action for acupuncture in the oncology setting. Curr Treat Options Oncol. 2010;11(3-4):118-27. doi: 10.1007/s11864- 010-0128-y.
84. Mori H, Kuge H, Hideaki T, Taniwaki E, Hanyu K, Morisawa T. Effects of acupuncture treatment on natural killer cell activity, pulse rate, and pain reduction for older adults: an uncontrolled, observational study. Journal of Integrative Medicine. 2013;11(2):101-5.
85. Liu R, Zhang Y, Li K, Xu H, Cheng Z, Pang F, et al. Effect of acupuncture on regulating IL-17, TNF-ɑ and AQPs in Sjögren’s syndrome. Oral Disease. 2023;doi.org/10.1111/odi.14680.
86. Serin L, Seung-Nam K. The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis. Front Immunol. 2022;13:doi.org/10.3389/fimmu.2022.878463.
87. Zhu J, Arsovska B, Kozovska K. Acupuncture Treatment for Fertility. Open Access Maced J of Med Sci. 2018;1-3.
88. Yun L, Liqun W, Shuqi Y, Chunxiao W, Liming L, Wei Y. Acupuncture for infertile women without undergoing assisted reproductive techniques (ART). Medicine (Baltimore). 2019;98(29):e16463 doi: 10.1097/MD.0000000000016463.
89. Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, et al. The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review. Front Endocrinol. 2022;13:doi.org/10.3389/fendo.2022.1009537.
90. Molsberger A. The role of acupuncture in the treatment of migraine. CMAJ. 2012;184(4):391-2.
91. Chen P, Li J, Han X, Grech D, Xiong M, Bekker A, et al. Acupuncture for alcohol use disorder. Int J Physiol Pathophysiol Pharmacol. 2018;10(1):60-9.
92. Wen H, Chen R, Zhang P, Wei X, Dong Y, Ge S, et al. Acupuncture for Opioid Dependence Patients Receiving Methadone Maintenance Treatment: A Network Meta-Analysis. Front Psychiatry. 2021;12:doi.org/10.3389/fpsyt.2021.767613.
93. Esmaeli F, Ibrahim F, Abd R, Seghatoleslam T. Acupuncture therapy for drug addiction. Chin Med. 2016;11(16):2-10. DOI 10.1186/s13020-016-0088-7.
94. Armour M, Smith CA, Wang L, Naidoo D, Yang G, MacPherson H, et al. Acupuncture for Depression: A Systematic Review and Meta-Analysis. J Clin Med. 2019;8(8):1140. doi: 10.3390/jcm8081140.
95. Rosario M, Shumiiko C, Eiji J, Tesseroli JT. Effects of acupuncture in adults with temporomandibular disorders. Rev Dor Sao Paolo. 2014;15(2):87-90.
96. Chen J, Liu A, Zhou Q, Yu W, Guo T, Jia Y, et al. Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews. Int J Gen Med. 2021;14:8481-8494. doi: 10.2147/IJGM.S342435.
97. Chen W, Yang G, Liu B, Manheimer E, Liu J. Manual Acupuncture for Treatment of Diabetic Peripheral Neuropathy: A Systematic Review of Randomized Controlled Trials. PLoS ONE. 2013;8(9):e73764. doi:10.1371/journal.pone.0073764.
98. Alp H. Application of acupuncture in the treatment of venous insufficiency and varicose veins. Cardiovasc Surg Int. 2019;7(2):31-33. DOI: 10.5606/e- cvsi.2019.702.
99. Lam Ching W, Li HJ, Guo J, Yao L, Chau J, Lo S, et al. Acupuncture for post- stroke depression: a systematic review and network meta-analysis. BMC Psychiatry. 2023;314:doi.org/10.1186/s12888-023-04749-1.
100. Lee J, Lee J, Kim S. Use of Acupuncture for the Treatment of Sports- Related Injuries in Athletes: A Systematic Review of Case Reports. Int J Environ Res Public Health. 2020;17(21):8226. doi: 10.3390/ijerph17218226.
101. Gentil L. Treatment of sport injuries with acupunture: a literature review. Rev Bras Med Esporte. 2018;24(4):316-21.
102. Jang S, Ko Y, Sasaki Y, Park S, Jo J, Kang NH, et al. Acupuncture as an adjuvant therapy for management of treatment-related symptoms in breast cancer patients. Medicine (Baltimore). 2020;99(50):e21820. doi: 10.1097/MD.0000000000021820.
103. Valença R, Costa R, Fernandes S, Yamamura ML. Use of acupuncture in women surviving breast cancer: an integrative review. Mastology. 2022;32:e20220032.
104. Kong F, Wang Z, Wang N, Xhao L, Mei Q, Yu Y, et al. The Clinical Observation of Acupuncture Combined With Antiemetic Drugs in the Prevention and Treatment of CINV in Breast Cancer Patients. Front Oncol. 2022;12:doi.org/10.3389/fonc.2022.888651.
105. Zhang J, Qin Z, So T, Chan TY, Yang S, Chen H, et al. Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor- participant blinded, randomized, sham-controlled trial. Breast Cancer Research. 2023;25(49):doi.org/10.1186/s13058-023-01645-0.
106. Choi T, Soo M, Kim T, Zaslaski C, Ernst E. Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Support Care Cancer. 2012;20(6):1147-58. doi: 10.1007/s00520-012-1432-9.
107. Lu W, Hu D, Dean-Clower E, Doherty-Gilman A, Legedza A, Lee H, et al. Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials. J Soc Integr Oncol. 2007;5(1):1-10 doi: 10.2310/7200.2006.035.
108. Deng G, Hou BL, Holodny AI, Cassileth BR. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study. BMC Complement Altern Med. 2008;8:37 doi: 10.1186/1472-6882-8-37.
109. Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast. 2013;22:320-3.
110. Ge AX, Ryan ME, Giaccone G, Hughes M, Pavletic SZ. Acupuncture treatment for persistent hiccups in patients with cancer. J Altern Complement Med. 2010;16(7):811-6 doi: 10.1089/acm.2009.0456.
111. Vijaykanth S, Mangaiarkarasi N, Prabu P. Efficacy of acupuncture for the treatment of sciatica: A case report. Indian J Case Reports. 2020;1-2.
112. Oliveira L, Hollanda D, Alves D, Stefanello J, Cortes C. Effectiveness of auricular acupuncture in the treatment of cancer pain: randomized clinical trial. Rev Esc Enferm USP. 2018;52:e03402.
113. Trager RJ, Brewka EC, Kaiser CM, Patterson AJ, Dusek JA. Acupuncture in multidisciplinary treatment of postCOVID-19 Syndrome: A Case Report. Med Acupunct. 2022;34(3):177-183. doi: 10.1089/acu.2021.0086.
114. Munn Z, Pollock D, Khalil H, Alexander L, Mclnerney P, Godfrey CM, et al. What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis. JBI Evid Synth. 2022;20(4):950-952 doi: 10.11124/JBIES-21-00483.
115. Joanna Briggs Institute. Appendix 11.1 JBI template source of evidence details, characteristics and results extraction instrument [Internet]. JBI Manual for Evidence Synthesis. 2022 [citado 2 de septiembre de 2023]. Disponible en: https://jbi-global-wiki.refined.site/space/MANUAL/4687579
116. Asociación Médica Mundial. Declaración de Helsinki de la AMM [Internet]. 2013 [citado 11 de septiembre de 2023]. Disponible en: https://minciencias.gov.co/sites/default/files/ckeditor_files/6.pdf
117. Ministerio de Salud. Resolución Número 8430 de 1993 [Internet]. Minsalud; 1993 [citado 11 de septiembre de 2023]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESO LUCION-8430-DE-1993.PDF
118. Rolling B, Paice J. Oxford Textbook of Palliative Nursing. United States of America: Oxford University Press; 2019. 1000 p.
119. Abd-Elsayed A. Pain. A review guide. Switzerland: Springer; 2019. 1334 p.
120. Wheelwright S, Darlington A, Hopkinson JB, Fitssimmons D, Johnson C. A systematic review and thematic synthesis of quality of life in the informal carers of cancer patients with cachexia. Palliat Med. 2016;30(2):149-60 doi: 10.1177/0269216315588743.
121. Bonomi PD, Walsh D, Currow DC, Ballinari G, Skipworth R. Cancer cachexia impact on chemotherapy dose reduction, treatment discontinuation, and survival: A qualitative systematic review. Journal of Clinical Oncology. 2022;40(6):e24103-e24103.
122. Tian G, Zhao C, Zhang X, Mu E, Jiang Y, Wei W, et al. Evidence-based traditional Chinese medicine research two decades of development, its impact, and breakthrough. Journal of Evidence-Based Medicine. 2021;14:65-74.
123. Callaghan AB. Healing with needles. An introductory guide to acupuncture. New Zealand: Xspurts; 2005. 320 p.
124. Deng S, Zhao X, Du R, He S, Wen Y, Huang L, et al. Is acupuncture no more than a placebo? Extensive discussion required about possible bias (Review). Experimental and Therapeutic Medicine. 2015;10(4):1247-1252 https://doi.org/10.3892/etm.2015.2653.
125. Strittmatter B. Ear Acupuncture: A Precise Pocket Atlas, Based on the Works of Nogier/Bahr. 2 nd Edition. Thieme; 2011. 448 p.
126. Fernández-Jané C, Vilaró J, Fei Y, Wang C, Liu J, Huang N, et al. Filiform needle acupuncture for copd: A systematic review and meta-analysis. Complementary Therapies in Medicine. 2019;47:102182 https://doi.org/10.1016/j.ctim.2019.08.016.
127. Yan Z, MuRong Z, Huo B, Zhon H, Yi C, Liu M, et al. Acupuncture as a Complementary Therapy for Cancer-Induced Bone Pain: A Systematic Review and Meta-Analysis. Front Pain Res. 2022;3:https://doi.org/10.3389/fpain.2022.925013.
128. National Cancer Institute. NCI Dictionary of Cancer Terms [Internet]. NCI Dictionary of Cancer Terms. 2023 [citado 8 de septiembre de 2023]. Disponible en: https://www.cancer.gov/
129. Kaptchuk TJ, Goldman P, Stone DA, Stason WB. Do medical devices have enhanced placebo effects? J Clin Epidemiol. 2000;53(8):786-92 doi: 10.1016/s0895-4356(00)00206-7.
130. Guerra JA. Problemas de investigación en acupuntura. En: Ensayos clínicos en intervenciones no farmacológicas. España: Fundación Dr Antonio Esteve; 2001. p. 95.
131. Aranjo S. Does the Choice of Placebo Determine the Results of Clinical Studies on Acupuncture? Forsh Komplementarmed. 1998;5(Suppl S1):8-11 doi: 10.1159/000057100.
132. Kaptchuk TJ, Stason WB, Davis RB, Legedza A, Schnyer RN, Kerr CE, et al. Sham device v inert pill: Randomised controlled trial of two placebo treatments. BMJ. 2006;332(7538):391-7.
133. Lee YS, Kim SY, Kim M, Kim M, Won J, Lee H, et al. Reporting quality of sham needles used as controls in acupuncture trials: a methodological evaluation. Chin Med. 2022;17(1):64 doi: 10.1186/s13020-022-00608-5.
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mercado Pedroza, Manuel Estebanfe9f281ce4b15b63a9c640a327f390f4Muñoz Sanjuan, Carolina Mariaffb49c9a04565a6938a2f1743fac3a59Medicina Tradicional China y Acupuntura2023-10-17T14:00:47Z2023-10-17T14:00:47Z2023-10-02https://repositorio.unal.edu.co/handle/unal/84802Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas,Introducción: el síndrome anorexia-caquexia asociado a cáncer se caracteriza por pérdida de peso, inapetencia, astenia, y náusea, entre otros síntomas. Su prevalencia es alta, especialmente en cáncer gastrointestinal, y las terapias convencionales a menudo presentan efectos secundarios, motivo por el cual, la acupuntura se ha considerado como alternativa terapéutica. El objetivo de esta revisión de alcance fue explorar la evidencia sobre los efectos de la acupuntura en este tema. Materiales y métodos: este estudio correspondió a una revisión de alcance. Se realizaron búsquedas electrónicas en Pubmed, EMBASE, LILACS, Science Direct, Cochrane Library, BVS MTCI Américas, Korean Medical Article Database, y China National Knowledge Infrastructure, entre otras. Se revisó la lista de resultados en varias fases, se seleccionaron los artículos y se realizó extracción de datos. Resultados: se obtuvieron 498 artículos, de los cuales seis cumplieron criterios de elegibilidad: uno correspondió a un estudio de factibilidad, uno a un ensayo controlado aleatorizado y cuatro a estudios piloto. El uso de acupuntura es factible y seguro, aunque la evidencia es limitada con múltiples falencias metodológicas. Solo un estudio reportó como evento adverso dolor en pabellón auricular. Conclusiones: la presente revisión señala la factibilidad y seguridad de la acupuntura en el síndrome anorexia-caquexia asociado a cáncer; sin embargo, la evidencia es escasa, preliminar y heterogénea. Se requieren estudios con mayor rigor metodológico, estandarización en procesos y mayor tamaño de muestra para confirmar los efectos. Se sugiere el uso de la acupuntura en el contexto de la práctica basada en evidencia. Palabras clave: acupuntura, anorexia, caquexia, cáncer (Texto tomado de la fuente)anorexia-cachexia syndrome associated with cancer is characterized by weight loss, loss of appetite, asthenia, and nausea, among other symptoms. Its prevalence is high, especially in gastrointestinal cancer, and conventional therapies often have side effects, which is why acupuncture has been considered as a therapeutic alternative. The aim of this scoping review was to explore the evidence on the effects of acupuncture on this topic. Materials and methods: this study corresponded to a scoping review. Electronic searches were performed in Pubmed, EMBASE, LILACS, Science Direct, Cochrane Library, BVS MTCI Americas, Korean Medical Article Database, and China National Knowledge Infrastructure, among others. The list of results was reviewed in several phases, articles were selected and data extraction was performed. Results: 498 articles were obtained, of which six met eligibility criteria: one corresponded to a feasibility study, one to a randomized controlled trial and four to pilot studies. The use of acupuncture is feasible and safe, although the evidence is limited with multiple methodological flaws. Only one study reported ear pain as an adverse event. Conclusions: the present review points out the feasibility and safety of acupuncture in anorexia-cachexia syndrome associated with cancer; However, the evidence is scarce, preliminary and heterogeneous. Studies with greater methodological rigor, standardization in processes and a larger sample size are required to confirm the effects. The use of acupuncture in the context of evidence-based practice is suggested.MaestríaMagister en medicina alternativa con enfasis en medicina tradicional china acupunturaMedicina Alternativa67 páginasapplication/pdfspaAcupuntura para el manejo de los pacientes con anorexia-caquexia asociada a cancer: revisión de alcanceAcupuncture for the management of patients with anorexia- cachexia associated with cancer: scope reviewTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - Medicina - Maestría en Medicina AlternativaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá1. Dhanapal R, Saraswathi TR, Govind R. Cancer cachexia. J Oral Maxillofac Pathol. 2011;15(3):257-260. doi: 10.4103/0973-029X.86670.2. Ramos E, Suzuki S, Marks D, Inui A, Asakawa A, Meguid M. Cancer anorexia- cachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care. 2004;7(4):427-34 doi: 10.1097/01.mco.0000134363.53782.cb.3. Tuca A, Jimenez-Fonseca P, Gascón P. Clinical evaluation and optimal management of cancer cachexia. Clinical Reviews in Oncology/Hematology. 2013;88(3):625-36.4. Sarhill N, Mahmoud F, Walsh D, Nelson KA, Komurcu S, Davis M, et al. Evaluation of nutritional status in advanced metastatic cancer. Supportive Care in Cancer. 2003;11(10):652-9.5. Kanzaki M, Soda K, Gin PT, Kai T, Konishi F, Kawakami M. Erythropoietin attenuates cachectic events and decreases production of interleukin-6, a cachexia-inducing cytokine. Cytokine. 2005;32:234-9. doi: 10.1016/j.cyto.2005.10.002.6. Cardona D. Tratamiento farmacológico de la anorexia-caquexia cancerosa. Nutrición Hospitalaria. 2006;21(3):17-26.7. Diffee GM, Kalfas K, Al-Majid S, McCarthy DO. Altered expression of skeletal muscle myosin isoforms in cancer cachexia. Am J Physiol Cell Physiol. 2002;283:C1376-C1382. doi.org/10.1152/ajpcell.00154.2002.8. Vargas-Arce Y, Abarca-Gómez L. Prevalence of cachexia related to cancer in patients at a primary level: a palliative approach. Acta Médica Costarricence. 2016;58(4):171-7.9. Dufau L. Prevalencia de la desnutrición en el paciente oncológico. Rev DIAETA. 2010;28:31-6.10. Soza S, Sánchez K, Motola D, Green D. Síndrome de anorexia- caquexia en el paciente oncológico. Gac Médica México. 2008;144:435-40.11. García L, Parejo CS, Pereira C. Causas e impacto clínico de la desnutrición y caquexia en el paciente oncológico. Nutr Hosp. 2006;3:10-6.12. Hofbauer KG, Anker SD, Inui A, Nicholson JR. Pharmacotherapy of caquexia. United States of America: Taylor & Francis Group, LLC; 2006.13. Vaughan VC, Martin P, Lewandowski PA. Cancer cachexia: impact, mechanisms and emerging treatments. J Caquexia Sarcopenia Muscle. 2013;4(2):95-109 doi: 10.1007/s13539-012-0087-1.14. Suzuki H, Asakawa A, Amitani H, Nakamura N, Inui A. Cancer cachexia-- pathophysiology and management. J Gastroenterol. 2013;48(5):574-94. doi: 10.1007/s00535-013-0787-0.15. Mantovani G, Madeddu C. Cancer cachexia: medical management. Support Care Cancer. 2010;18:1-9.16. Pisters P, Brennan MF. Protein and Amino Acid Metabolism in Cancer Cachexia. Berlin (Germany): Springer; 2013. 275 p.17. Argilés JM, Busquets S, Toledo M, López-Soriano J. The role of cytokines in cancer cachexia. Curr Opin Support Palliat Care. 2009;3(4):263-8. doi: 10.1097/SPC.0b013e3283311d09.18. Argilés JM, Busquets S, García-Martínez C, López-Soriano FJ. Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future. Nutrition. 2005;21(9):977-85. doi: 10.1016/j.nut.2005.02.003.19. Del Fabbro E, Inui A, Strasser F. Cancer Cachexia. London (England): Springer; 2014. 83 p.20. Hopkinson JB. Psychosocial impact of cancer cachexia. J Caquexia Sarcopenia Muscle. 2014;5(2).21. Lövgren M, Tishelman C, Sprangers M, Koyi H, Hamberg K. Symptoms and problems with functioning among women and men with inoperable lung cancer - a longitudinal study. Lung Cancer. 2008;60:113-124. doi: 10.1016/j.lungcan.2007.09.015.22. Tarricone R, Ricca G, Nyanzi-Wakholi B, Medina-Lara A. Impact of cancer anorexia-cachexia syndrome on health-related quality of life and resource utilisation: A systematic review. Crit Rev Oncol Hematol. 2016;99:49-62 doi: 10.1016/j.critrevonc.2015.12.008.23. Hopkinson J, Wright D, Corner J. Exploring the experience of weight loss in people with advanced cancer. J Adv Nurs. 2006;54:304-12. doi: 10.1111/j.1365- 2648.2006.03818.x.24. Lu Z, Fang Y, Liu C, Zhang X, Xin X, He Y, et al. Early Interdisciplinary Supportive Care in Patients With Previously Untreated Metastatic Esophagogastric Cancer: A Phase III Randomized Controlled Trial. J Clin Oncol. 2021;39(7):748-756 doi: 10.1200/JCO.20.01254.25. Reid J, McKenna H, Fitzsimons D, McCance TV. The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members. Int J Nurs Stud. 2009;46:606-16 doi: 10.1016/j.ijnurstu.2008.10.012.26. Reid J, McKenna H, Fitzsimons D, McCance TV. The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members. Int J Nurs Stud. 2009;46:606-16 doi: 10.1016/j.ijnurstu.2008.10.012.27. Sun H, Sudip T, Fu X, Wen S, Liu H, Yu S. Cachexia is associated with depression, anxiety and quality of life in cancer patients. BMJ Support Palliat Care. 2020;doi: 10.1136/bmjspcare-2019-002176.28. Locher JL, Robinson CO, Bailey FA,. Disruptions in the organisation of meal preparation and their family caregivers. Psychooncology. 2010;19(9):967-74. doi: 10.1002/pon.1656.29. Garcia VR, López-Briz E, Carbonell R, Gonzalvez JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013;3:doi: 10.1002/14651858.CD004310.pub3.30. Penna F, Bonetto A, Aversa Z, Giacomo V, Rossi F, Costelli P, et al. Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting. J Cachexia Sarcopenia Muscle. 2016;7(3):345-54 doi: 10.1002/jcsm.12050.31. Gordon JN, Trebble TM, Duncan HD, Johns T, Goggin PM. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut. 2005;54(4):540-545. doi: 10.1136/gut.2004.047563.32. Solheim TS, Fearon K, Blum D, Kaasa S. Non-steroidal anti-inflammatory treatment in cancer cachexia: a systematic literature review. Acta Oncol. 2013;52(1):6-17 doi: 10.3109/0284186X.2012.724536.33. Santos J, Costa A, Dias T, Satari S, Costa MP, Gil R. Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates. Pharmaceuticals (Basel). 2021;14(11):1084.34. Kirubakaran R, Gaidhane A, Gaidhane S, Simkhada P, Quazi Z. Ghrelin for the management of cachexia associated with cancer. Cochrane Database Syst Rev. 2018;2:doi: 10.1002/14651858.CD012229.pub2.35. Jatoi A, Dakhil S, Nguyen Pl, Sloan JA, Kugler JW, Rowland KM, et al. A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group. Cancer. 2007;110(6):1396-403. doi: 10.1002/cncr.22944.36. Penna F, Busquets S, Toledo M, Pin F, Massa D, López-Soriano FJ, Costelli P, Argilés JM. Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models. J Lipid Res. 2013;54:3045-51.37. Van Hal M, Dydyk AM, Green MS. Acupunture. StatPearls [Internet]. 2023;38. Lu W, Dean-Clower E, Doherty-Gilman A, Osenthal DS. The Value of Acupuncture in Cancer Care. Hematol Oncol Clin North Am. 2008;22(4):631-viii doi: 10.1016/j.hoc.2008.04.005.39. Cho W. Acupuncture and moxibustion as an evidence-based therapy for cancer. Netherlands: Springer; 2012. 356 p.40. Cancer Research UK. Worldwide cancer statistics [Internet]. Worldwide cancer statistics. 2020 [citado 12 de agosto de 2023]. Disponible en: https://www.cancerresearchuk.org/health-professional/cancer- statistics/worldwide- cancer#:~:text=Incidence%20worldwide,of%20all%20cancers%20diagnosed% 20worldwide.41. Amano K, Hopkinson JB, Baracos V, Mori N. Holistic multimodal care for patients with cancer cachexia and their family caregivers. Asia-Pacific Journal of Oncology Nursing. 2023;https://doi.org/10.1016/j.apjon.2023.100290.42. Stewart GD, Skipworth RF, Fearon K. Cancer cachexia and fatigue. CME Palliative Care. 2006;6(2):140-3.43. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Faisinger RL. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7.44. Tijerina AJ. The biochemical basis of metabolism in cancer cachexia. Dimens Crit Care Nurs. 2004;23(6):237-43 doi: 10.1097/00003465-200411000-00001.45. Ni J, Zhang L. Cancer Cachexia: Definition, Staging, and Emerging Treatments. Cancer Manag Res. 2020;12:5597-5605 doi: 10.2147/CMAR.S261585.46. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491-497. doi: 10.1016/S0149-2918(05)80001-3.47. Wang Y, An Z, Lin D, Jun E. Targeting cancer cachexia: Molecular mechanisms and clinical study. Med Comm. 2022;3:e164. DOI: 10.1002/mco2.164.48. Jiménez R, Cabanas R, Fernández R, Chagues O, González M, Peón L, et al. Caracterización nutricional del síndrome anorexia-caquexia en el paciente oncológico pediátrico. Rev Cubana Pediatr. 2011;83(4):337-45.49. Zhong X, Zimmers TA. Sex differences in cancer cachexia. Current Osteoporosis Reports. 2020;18(6):646-54.50. Vanhoutte G, van de Wiel M, Wouters K, Sels M, Bartolomeeussen L, De Keersmaecker S, et al. Cachexia in cancer: what is in the definition? BMJ Open Gastroenterol. 2016;3(1):e000097 doi: 10.1136/bmjgast-2016-000097.51. Pin F, Barreto R, Couch ME, Bonetto A, O`Connell TM. Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism. J Cachexia Sarcopenia Muscle. 2019;10(1):140-54.52. Le Bricon T, Gugins S, Cynober L, Baracos VE. Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor‐bearing rats. Metabolism: clinical and experimental. 1995;44(1340-1348).53. Le Bricon T, Gugins S, Cynober L, Baracos VE. Negative impact of cancer chemotherapy on protein metabolism in healthy and tumor‐bearing rats. Metabolism: clinical and experimental. 1995;44:1340-8.54. Barreto R, Waning DL, Gao H, Liu Y, Zimmers TA, Bonetto A. Chemotherapy‐related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. 2016;7:43442-60.55. Damrauer J, Stadler M, Acharyya S, Baldwin A, Couch ME, Guttridge DC. Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia. Eur J Transl Myol. 2018;28(2):7590. doi: 10.4081/ejtm.2018.7590.56. Porta J, Gómez B, Tuca A. Manual de Control de síntomas en pacientes con cáncer avanzado y terminal. 2 a Edición. Madrid (España): Arán Ediciones; 2008. 373 p.57. Walsh D, Caraceni A, Faisinger R, Glare P, Goh C, Foley K, et al. Medicina Paliativa. Barcelona (España): Elsevier España; 2010.58. Matsuo H, Sakuma K. Pathophysiology of cachexia and characteristics of dysphagia in chronic diseases. Asia Pac J Oncol Nurs. 2022;9(10):100120.59. Conno F, Ventafridda V, Saita L. Skin problems in advanced and terminal cancer patients. Journal of Pain and Sumptom Management. 1991;6(4):247-56.60. Malla J, Zahra A, Venugopal S, Yadhav T, Shoukrie S, Selvaraj R, et al. What Role Do Inflammatory Cytokines Play in Cancer Cachexia? Cureus. 2022;14(7):e26798 doi: 10.7759/cureus.26798.61. AlSudais H, Rajgara R, Saleh A, Wiper-Bergeron NJ. C/EBPβ promotes the expression of atrophy-inducing factors by tumours and is a central regulator of cancer cachexia. Cachexia Sarcopenia Muscle. 2022;13:743-57.62. Mattox TW. Cancer Cachexia: Cause, Diagnosis, and Treatment. Nutr Clin Pract. 2017;32(5):599-606. doi: 10.1177/0884533617722986.63. VanderVeen BN, Fix DK, Carson JA. Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation. Oxid Med Cell Longev. 2017;3292087 doi: 10.1155/2017/3292087.64. Lelbach A, Muzes G, Feher J. Current perspectives of catabolic mediators of cancer cachexia. J Med Sci Monit. 2007;13:0-173.65. González M, Ordóñez A, Feliu J, Zamora P, Espinosa E. Tratado de Medicina Paliativa y tratamiento soporte del paciente con cáncer. Segunda Edición. 2° Edición. Madrid (España): Editorial Médica Panamericana; 2007. 486 p.66. Bermúdez M, Becerra R, Galvis JC. Sarcopenia versus caquexia. Repert Med Circ. 2015;24(1):7-15.67. Tavares P, Moreira D, Lara L, Ferreira R. Revisiting the clinical usefulness of C- reactive protein in the set of cancer cachexia. Porto Biomed J. 2021;6(1):e123. doi: 10.1097/j.pbj.0000000000000123.68. Jain S, Gautam V, Naseem S. Acute-phase proteins: as diagnostic tool. J Pharm Bioallied Sci. 2011;3:118-27.69. Sproston NR, Ashworth J. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754.70. Wu Y, Potempa LA, El KD, Filep JG. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015;396:1181-97.71. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-12.72. Ferri F. Consultor Clínico. Diagnóstico y tratamiento. Barcelona (España): Elsevier España; 2023. 1628 p.73. Argilés JM, López-Soriano FJ, Toledo M, Betancourt A, Serpe R, Busquets S. The cachexia score (CASCO): a new tool for staging cachectic cancer patients. J Cachexia Sarcopenia Muscle. 2011;2(2):87-93. doi: 10.1007/s13539-011- 0027-5.74. Kiew W. El gran libro de la medicina china. Barcelona (España): Urano; 2003. 332 p.75. Micunovic I. Origin of Chinese Medicine, Acupuncture & Moxibustion. J Altern Complement Integr Med. 2018;4(054):1-8. DOI: 10.24966/ACIM-7562/100054.76. Coba JL. Acupuntura, vórtices y energías. Su significado oculto y profundo. Quito (Ecuador): Universidad Andina Simón Bolívar; 2018. 980 p.77. Ramey D, Buell PD. A true history of acupuncture. Focus on Alternative and Complementary Therapies. 2010;9(4):269-273. doi.org/10.1211/fact.2004.00244.78. Maurer N, Nissel H, Egerbacher M, Gornik E, Schuller P, Traxler H. Anatomical Evidence of Acupuncture Meridians in the Human Extracellular Matrix: Results from a Macroscopic and Microscopic Interdisciplinary Multicentre Study on Human Corpses. Evid Based Complement Alternat Med. 2019;6976892. doi: 10.1155/2019/6976892.79. Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-8.80. Hermann-Carl H. Atlas de acupuntura. México D.F: Editorial Paidotribo; 2019. 304 p.81. Ching N. The fundamentals of acupuncture. Philadelphia (USA): Singing Dragon; 2017. 750 p.82. Battaloğlu B. A New Theory on the Evaluation of Traditional Chinese Acupuncture Mechanisms from the Latest Medical Scientific Point of View. Acupunct Electrother Res. 2015;40(3):189-204. doi: 10.3727/036012915x14473562232987.83. Stone JA, Johnstone PA. Mechanisms of action for acupuncture in the oncology setting. Curr Treat Options Oncol. 2010;11(3-4):118-27. doi: 10.1007/s11864- 010-0128-y.84. Mori H, Kuge H, Hideaki T, Taniwaki E, Hanyu K, Morisawa T. Effects of acupuncture treatment on natural killer cell activity, pulse rate, and pain reduction for older adults: an uncontrolled, observational study. Journal of Integrative Medicine. 2013;11(2):101-5.85. Liu R, Zhang Y, Li K, Xu H, Cheng Z, Pang F, et al. Effect of acupuncture on regulating IL-17, TNF-ɑ and AQPs in Sjögren’s syndrome. Oral Disease. 2023;doi.org/10.1111/odi.14680.86. Serin L, Seung-Nam K. The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis. Front Immunol. 2022;13:doi.org/10.3389/fimmu.2022.878463.87. Zhu J, Arsovska B, Kozovska K. Acupuncture Treatment for Fertility. Open Access Maced J of Med Sci. 2018;1-3.88. Yun L, Liqun W, Shuqi Y, Chunxiao W, Liming L, Wei Y. Acupuncture for infertile women without undergoing assisted reproductive techniques (ART). Medicine (Baltimore). 2019;98(29):e16463 doi: 10.1097/MD.0000000000016463.89. Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T, et al. The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review. Front Endocrinol. 2022;13:doi.org/10.3389/fendo.2022.1009537.90. Molsberger A. The role of acupuncture in the treatment of migraine. CMAJ. 2012;184(4):391-2.91. Chen P, Li J, Han X, Grech D, Xiong M, Bekker A, et al. Acupuncture for alcohol use disorder. Int J Physiol Pathophysiol Pharmacol. 2018;10(1):60-9.92. Wen H, Chen R, Zhang P, Wei X, Dong Y, Ge S, et al. Acupuncture for Opioid Dependence Patients Receiving Methadone Maintenance Treatment: A Network Meta-Analysis. Front Psychiatry. 2021;12:doi.org/10.3389/fpsyt.2021.767613.93. Esmaeli F, Ibrahim F, Abd R, Seghatoleslam T. Acupuncture therapy for drug addiction. Chin Med. 2016;11(16):2-10. DOI 10.1186/s13020-016-0088-7.94. Armour M, Smith CA, Wang L, Naidoo D, Yang G, MacPherson H, et al. Acupuncture for Depression: A Systematic Review and Meta-Analysis. J Clin Med. 2019;8(8):1140. doi: 10.3390/jcm8081140.95. Rosario M, Shumiiko C, Eiji J, Tesseroli JT. Effects of acupuncture in adults with temporomandibular disorders. Rev Dor Sao Paolo. 2014;15(2):87-90.96. Chen J, Liu A, Zhou Q, Yu W, Guo T, Jia Y, et al. Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews. Int J Gen Med. 2021;14:8481-8494. doi: 10.2147/IJGM.S342435.97. Chen W, Yang G, Liu B, Manheimer E, Liu J. Manual Acupuncture for Treatment of Diabetic Peripheral Neuropathy: A Systematic Review of Randomized Controlled Trials. PLoS ONE. 2013;8(9):e73764. doi:10.1371/journal.pone.0073764.98. Alp H. Application of acupuncture in the treatment of venous insufficiency and varicose veins. Cardiovasc Surg Int. 2019;7(2):31-33. DOI: 10.5606/e- cvsi.2019.702.99. Lam Ching W, Li HJ, Guo J, Yao L, Chau J, Lo S, et al. Acupuncture for post- stroke depression: a systematic review and network meta-analysis. BMC Psychiatry. 2023;314:doi.org/10.1186/s12888-023-04749-1.100. Lee J, Lee J, Kim S. Use of Acupuncture for the Treatment of Sports- Related Injuries in Athletes: A Systematic Review of Case Reports. Int J Environ Res Public Health. 2020;17(21):8226. doi: 10.3390/ijerph17218226.101. Gentil L. Treatment of sport injuries with acupunture: a literature review. Rev Bras Med Esporte. 2018;24(4):316-21.102. Jang S, Ko Y, Sasaki Y, Park S, Jo J, Kang NH, et al. Acupuncture as an adjuvant therapy for management of treatment-related symptoms in breast cancer patients. Medicine (Baltimore). 2020;99(50):e21820. doi: 10.1097/MD.0000000000021820.103. Valença R, Costa R, Fernandes S, Yamamura ML. Use of acupuncture in women surviving breast cancer: an integrative review. Mastology. 2022;32:e20220032.104. Kong F, Wang Z, Wang N, Xhao L, Mei Q, Yu Y, et al. The Clinical Observation of Acupuncture Combined With Antiemetic Drugs in the Prevention and Treatment of CINV in Breast Cancer Patients. Front Oncol. 2022;12:doi.org/10.3389/fonc.2022.888651.105. Zhang J, Qin Z, So T, Chan TY, Yang S, Chen H, et al. Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor- participant blinded, randomized, sham-controlled trial. Breast Cancer Research. 2023;25(49):doi.org/10.1186/s13058-023-01645-0.106. Choi T, Soo M, Kim T, Zaslaski C, Ernst E. Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Support Care Cancer. 2012;20(6):1147-58. doi: 10.1007/s00520-012-1432-9.107. Lu W, Hu D, Dean-Clower E, Doherty-Gilman A, Legedza A, Lee H, et al. Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials. J Soc Integr Oncol. 2007;5(1):1-10 doi: 10.2310/7200.2006.035.108. Deng G, Hou BL, Holodny AI, Cassileth BR. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study. BMC Complement Altern Med. 2008;8:37 doi: 10.1186/1472-6882-8-37.109. Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast. 2013;22:320-3.110. Ge AX, Ryan ME, Giaccone G, Hughes M, Pavletic SZ. Acupuncture treatment for persistent hiccups in patients with cancer. J Altern Complement Med. 2010;16(7):811-6 doi: 10.1089/acm.2009.0456.111. Vijaykanth S, Mangaiarkarasi N, Prabu P. Efficacy of acupuncture for the treatment of sciatica: A case report. Indian J Case Reports. 2020;1-2.112. Oliveira L, Hollanda D, Alves D, Stefanello J, Cortes C. Effectiveness of auricular acupuncture in the treatment of cancer pain: randomized clinical trial. Rev Esc Enferm USP. 2018;52:e03402.113. Trager RJ, Brewka EC, Kaiser CM, Patterson AJ, Dusek JA. Acupuncture in multidisciplinary treatment of postCOVID-19 Syndrome: A Case Report. Med Acupunct. 2022;34(3):177-183. doi: 10.1089/acu.2021.0086.114. Munn Z, Pollock D, Khalil H, Alexander L, Mclnerney P, Godfrey CM, et al. What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis. JBI Evid Synth. 2022;20(4):950-952 doi: 10.11124/JBIES-21-00483.115. Joanna Briggs Institute. Appendix 11.1 JBI template source of evidence details, characteristics and results extraction instrument [Internet]. JBI Manual for Evidence Synthesis. 2022 [citado 2 de septiembre de 2023]. Disponible en: https://jbi-global-wiki.refined.site/space/MANUAL/4687579116. Asociación Médica Mundial. Declaración de Helsinki de la AMM [Internet]. 2013 [citado 11 de septiembre de 2023]. Disponible en: https://minciencias.gov.co/sites/default/files/ckeditor_files/6.pdf117. Ministerio de Salud. Resolución Número 8430 de 1993 [Internet]. Minsalud; 1993 [citado 11 de septiembre de 2023]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESO LUCION-8430-DE-1993.PDF118. Rolling B, Paice J. Oxford Textbook of Palliative Nursing. United States of America: Oxford University Press; 2019. 1000 p.119. Abd-Elsayed A. Pain. A review guide. Switzerland: Springer; 2019. 1334 p.120. Wheelwright S, Darlington A, Hopkinson JB, Fitssimmons D, Johnson C. A systematic review and thematic synthesis of quality of life in the informal carers of cancer patients with cachexia. Palliat Med. 2016;30(2):149-60 doi: 10.1177/0269216315588743.121. Bonomi PD, Walsh D, Currow DC, Ballinari G, Skipworth R. Cancer cachexia impact on chemotherapy dose reduction, treatment discontinuation, and survival: A qualitative systematic review. Journal of Clinical Oncology. 2022;40(6):e24103-e24103.122. Tian G, Zhao C, Zhang X, Mu E, Jiang Y, Wei W, et al. Evidence-based traditional Chinese medicine research two decades of development, its impact, and breakthrough. Journal of Evidence-Based Medicine. 2021;14:65-74.123. Callaghan AB. Healing with needles. An introductory guide to acupuncture. New Zealand: Xspurts; 2005. 320 p.124. Deng S, Zhao X, Du R, He S, Wen Y, Huang L, et al. Is acupuncture no more than a placebo? Extensive discussion required about possible bias (Review). Experimental and Therapeutic Medicine. 2015;10(4):1247-1252 https://doi.org/10.3892/etm.2015.2653.125. Strittmatter B. Ear Acupuncture: A Precise Pocket Atlas, Based on the Works of Nogier/Bahr. 2 nd Edition. Thieme; 2011. 448 p.126. Fernández-Jané C, Vilaró J, Fei Y, Wang C, Liu J, Huang N, et al. Filiform needle acupuncture for copd: A systematic review and meta-analysis. Complementary Therapies in Medicine. 2019;47:102182 https://doi.org/10.1016/j.ctim.2019.08.016.127. Yan Z, MuRong Z, Huo B, Zhon H, Yi C, Liu M, et al. Acupuncture as a Complementary Therapy for Cancer-Induced Bone Pain: A Systematic Review and Meta-Analysis. Front Pain Res. 2022;3:https://doi.org/10.3389/fpain.2022.925013.128. National Cancer Institute. NCI Dictionary of Cancer Terms [Internet]. NCI Dictionary of Cancer Terms. 2023 [citado 8 de septiembre de 2023]. Disponible en: https://www.cancer.gov/129. Kaptchuk TJ, Goldman P, Stone DA, Stason WB. Do medical devices have enhanced placebo effects? J Clin Epidemiol. 2000;53(8):786-92 doi: 10.1016/s0895-4356(00)00206-7.130. Guerra JA. Problemas de investigación en acupuntura. En: Ensayos clínicos en intervenciones no farmacológicas. España: Fundación Dr Antonio Esteve; 2001. p. 95.131. Aranjo S. Does the Choice of Placebo Determine the Results of Clinical Studies on Acupuncture? Forsh Komplementarmed. 1998;5(Suppl S1):8-11 doi: 10.1159/000057100.132. Kaptchuk TJ, Stason WB, Davis RB, Legedza A, Schnyer RN, Kerr CE, et al. Sham device v inert pill: Randomised controlled trial of two placebo treatments. BMJ. 2006;332(7538):391-7.133. Lee YS, Kim SY, Kim M, Kim M, Won J, Lee H, et al. Reporting quality of sham needles used as controls in acupuncture trials: a methodological evaluation. Chin Med. 2022;17(1):64 doi: 10.1186/s13020-022-00608-5.Terapia con cupunturaTerapias complementariasAcupuncture TherapyComplementary TherapiesAcupunturaAnorexiaCaquexiaCancerORIGINAL528496582023.pdf528496582023.pdfTesis de Tesis de Maestría en Medicina Alternativaapplication/pdf1752222https://repositorio.unal.edu.co/bitstream/unal/84802/6/528496582023.pdf5155d03334faa68c1e0d4f63022e0d0dMD56LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84802/5/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD55THUMBNAIL528496582023.pdf.jpg528496582023.pdf.jpgGenerated Thumbnailimage/jpeg4574https://repositorio.unal.edu.co/bitstream/unal/84802/7/528496582023.pdf.jpg1dc6d4b8b9d77f4617cecfd0f499c042MD57unal/84802oai:repositorio.unal.edu.co:unal/848022024-08-18 23:13:32.544Repositorio Institucional Universidad Nacional de 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