Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada

Ilustraciones y fotografías

Autores:: Pinzón Cupitra, Andrés Felipe

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
dc.title.translated.eng.fl_str_mv	Establishment of a protocol for total body irradiation with the intensity-modulated volumetric arc therapy technique.
title	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
spellingShingle	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada 610 - Medicina y salud Radioterapia de intensidad modulada Irradiación corporal total Rayos X Intensity-modulated radiotherapy Whole-body irradiation X-rays TBI TBI/VMAT Simulador anatómico ICT Anatomical simulator
title_short	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
title_full	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
title_fullStr	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
title_full_unstemmed	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
title_sort	Establecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad modulada
dc.creator.fl_str_mv	Pinzón Cupitra, Andrés Felipe
dc.contributor.advisor.none.fl_str_mv	Veloza Salcedo, Luz Stella Simbaqueba Ariza, Axel Danny
dc.contributor.author.none.fl_str_mv	Pinzón Cupitra, Andrés Felipe
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud
topic	610 - Medicina y salud Radioterapia de intensidad modulada Irradiación corporal total Rayos X Intensity-modulated radiotherapy Whole-body irradiation X-rays TBI TBI/VMAT Simulador anatómico ICT Anatomical simulator
dc.subject.other.spa.fl_str_mv	Radioterapia de intensidad modulada Irradiación corporal total Rayos X
dc.subject.other.eng.fl_str_mv	Intensity-modulated radiotherapy Whole-body irradiation X-rays
dc.subject.proposal.eng.fl_str_mv	TBI TBI/VMAT
dc.subject.proposal.spa.fl_str_mv	Simulador anatómico ICT Anatomical simulator
description	Ilustraciones y fotografías
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-09-09T15:04:25Z
dc.date.available.none.fl_str_mv	2021-09-09T15:04:25Z
dc.date.issued.none.fl_str_mv	2021-08
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80143
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80143 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	[1] MINSALUD Ministerio de Salud Nacional. Observatorio nacional de c ́ancer- gu ́ıametol ́ogica, 2018.[2] Raymond Miralbell; Michel Rouzaud; Eugene Grob; Philippe Nouet; Sabine Bieri;Sabine B. Majno; Patrick Botteron; Manuel Montero; Jean C. Precoma. Can atotal body irradiation technique be fast and reproducible?International Journal ofRadiation OncologyBiologyPhysics, 29:1167–1173, 1994.M; Hamill G; Stanhope R; Leiper A D Papadimitriou, A; Urena. Growth hormonetreatment of growth failure secondary to total body irradiation and bone marrowtransplantation.Archives of Disease in Childhood, 66, 06 1991.[4] Quast U. Whole body radiotherapy: A tbi-guideline.Journal of medical physics,31:5–12, 2006.[5] Chuang KS Lin JF Lee JC Lin JC Chen HH, Wu J. Total body irradiation withstep translation and dynamic field matching.Biomed Res Int, 1:5–12, 2013.[6] Santam Chakraborty, Suja Cheruliyil, Resmi K. Bharathan, and Geetha Muttath.Total body irradiation using vmat (rapidarc): A planning study of a novel treatmentdelivery method.International Journal of Cancer Therapy and Oncology, 3:03028,2015.[7] Fowler J Hui SK, Kapatoes J. Feasibility study of helical tomotherapy for totalbody or total marrow irradiation.International Journal of Cancer Therapy andOncology, 32:3214–3224, 2005.[8] Karl Otto. Volumetric modulated arc therapy: Imrt in a single gantry arc.Medicalphysics, 35:310–7, 02 2008.[9] Andreas Springer, Josef Hammer, Erwin Winkler, Christine Track, Roswitha Hup-pert, Alexandra B ̈ohm, Hedwig Kasparu, Ansgar Weltermann, Gregor Aschauer,Andreas Petzer, E. Putz, Alexander Altenburger, Rainer Gruber, Karin Moser, Ka-rin Wiesauer, and Hans Geinitz. Total body irradiation with volumetric modulated Bibliograf ́ıa105arc therapy: Dosimetric data and first clinical experience.Radiation Oncology, 11,12 2016.[10] Roeske JC Aydogan B, Mundt AJ. Linac-based intensity modulated total marrowirradiation (im-tmi).Technol Cancer Res Treat, 5:513–519, 2006.[11] C.R. Richmond. Icrp publication 23.International Journal of Radiation Onco-logyBiologyPhysics, 12, 1986.[12] B. Jung. Book review: Phantoms and computational models in therapy, diagnosisand protection. icru report 48.Acta Radiologica, 35, 03 1994.[13] Computerized Imaging Reference Systems CIRS Inc.ATOM®Dosimetry Phan-toms, 2013.[14] Piera; Castagna Luca; Reggiori Giacomo; Sarina Barbara; Tomatis Stefano; AlongiFilippo; Nicolini Giorgia; Fogliata Antonella; Cozzi Luca; Scorsetti Marta Mancosu,Pietro; Navarria. Interplay effects between dose distribution quality and positio-ning accuracy in total marrow irradiation with volumetric modulated arc therapy.Medical Physics, 40, 10 2013.[15] Michael; Zhang You; Hrycushko Brian; Lamphier Richard; Lee Pam; ChambersEric; Ramirez Ezequiel; Reynolds Robert; Yan Yulong; Jiang Steve B.; TimmermanRobert; Desai Neil; Abdulrahman Ramzi; Gu Xuejun Ouyang, Luo; Folkerts. Volu-metric modulated arc therapy based total body irradiation: Workflow and clinicalexperience with an indexed rotational immobilization system.Physics and Imagingin Radiation Oncology, 4, 10 2017.[16] Roel; Kießling Robert; Freislederer Philipp; Li Minglun; Walter Franziska; NiyaziMaximilian; Reiner Michael; Belka Claus; Corradini Stefanie Losert, Christoph; Sh-pani. Novel rotatable tabletop for total-body irradiation using a linac-based vmattechnique.Radiation Oncology, 14, 12 2019.[17] Jeffrey Y. C. Wong.Total Marrow Irradiation: A Comprehensive Review. SpringerNature, 2020.[18] FACR FACMP Stewart Carlyle Bushong, ScD.Manual de Radiolog ́ıa para tecnicos.ELSEVIER, 9 edition, 2010.[19] Pedro Ruiz Manzano (ed.) Antonio Brosed Serreta (ed.).Fundamentos de F ́ısicaM ́edica, Volumen 2: Radiodiagn ́ostico: bases f ́ısicas, equipos y control de calidad.SEFM, 2012. 106Bibliograf ́ıa[20] Luis N ́u ̃nez Mart ́ın.Elementos de radiof ́ısica para t ́ecnicos superiores en radioterapiay dosimetr ́ıa. 2016.[21] Josef; Winkler Erwin; Track Christine; Huppert Roswitha; B ̈ohm Alexandra; Kas-paru Hedwig; Weltermann Ansgar; Aschauer Gregor; Petzer Andreas L.; Putz Ernst;Altenburger Alexander; Gruber Rainer; Moser Karin; Wiesauer Karin; Geinitz HansSpringer, Andreas; Hammer. Total body irradiation with volumetric modulated arctherapy: Dosimetric data and first clinical experience.Radiation Oncology, 11, 122016.[22] Mete; Kavak Gulbin O.; Fan John; Radosevich James A.; Aydogan Bulent Suru-cu, Murat; Yeginer. Verification of dose distribution for volumetric modulated arctherapy total marrow irradiation in a humanlike phantom.Medical Physics, 39, 122011.[23] Bulent Aydogan; Mete Yeginer; Gulbin O. Kavak; John Fan; James A. Radose-vich; Kim Gwe-Ya. Total marrow irradiation with rapidarc volumetric arc therapy.International Journal of Radiation OncologyBiologyPhysics, 81, 2011.[24] Esther Mill ́an Cebri ́an (ed.) Antonio Brosed Serreta (ed.).Fundamentos de F ́ısi-ca M ́edica, Volumen 4: Radioterapia externa II: Dosimetr ́ıa cl ́ınica, algoritmos dec ́alculo, sistemas de planificaci ́on y control de calidad, volume 4. SEFM, 2013.[25] D Greene.Linear accelerators for radiation therapy. Institute of Physics Pub,Bristol, UK Philadelphia, 1997.[26] Peter Metcalfe.The physics of radiotherapy x-rays and electrons. Medical PhysicsPub, Madison, Wis, 2007.[27] John P. Gibbons PhD Faiz M. Khan PhD.Khan’s the physics of radiation therapy.Lippincott Williams Wilkins/Wolters Kluwer, fifth edition edition, 2014.[28] Report 83.Journal of the International Commission on Radiation Units and Mea-surements, 10(1):NP–NP, 06 2016.[29] C.Clifton Ling; John Humm; Steven Larson; Howard Amols; Zvi Fuks; Steven Lei-bel; Jason A Koutcher. Towards multidimensional radiotherapy (md-crt): biologi-cal imaging and biological conformality.International Journal of Radiation Onco-logyBiologyPhysics, 47, 2000. Bibliograf ́ıa107[30] Esther Mill ́an Cebri ́an (ed.) Antonio Brosed Serreta (ed.).Fundamentos de F ́ısi-ca M ́edica, Volumen 4: Radioterapia externa II: Dosimetr ́ıa cl ́ınica, algoritmos dec ́alculo, sistemas de planificaci ́on y control de calidad. SEFM, 2013.[31] C X Yu. Intensity-modulated arc therapy with dynamic multileaf collimation: analternative to tomotherapy.Physics in Medicine and Biology, 40, 1995.[32] Cedric Yu and Grace Tang. Intensity-modulated arc therapy: Principles, technolo-gies and clinical implementation.Physics in medicine and biology, 56:R31–54, 032011.[33] Benjamin; Pearman Keith; Shang Qingyang; Hayes Lane; Maurer Jacqueline; Van-derstraeten Caroline; Wiant David Liu, Han; Sintay. Comparison of the progressiveresolution optimizer and photon optimizer in vmat optimization for stereotactictreatments.Journal of Applied Clinical Medical Physics, 05 2018.[34] C. Clifton Ling; Pengpeng Zhang; Yves Archambault; Jiri Bocanek; GraceTang; Thomas LoSasso. Commissioning and quality assurance of rapidarc radiothe-rapy delivery system.International Journal of Radiation OncologyBiologyPhysics,72, 2008.[35] Inc. Varian Medical Systems.Eclipse Photon and Electron Algorithms ReferenceGuide. Varian Medical Systems, Inc., 2015.[36] Beth; Turner Emma Peters, Mitchell; Taylor. An evidence-based review of totalbody irradiation.Journal of Medical Imaging and Radiation Sciences, 46, 12 2015.[37] I. F.; Okumus A.; Uzel O. E. Tas, B.; Durmus. Aip conference proceedings [author(s)turkish physical society 32nd international physics congress (tps32) - bodrum, tur-key (6–9 september 2016)] - linac-based total body irradiation (tbi) with volumetricmodulated arc therapy (vmat). volume 1815, 2017.[38] Piera; Castagna Luca; Reggiori Giacomo; Stravato Antonella; Gaudino Anna; Sa-rina Barbara; Tomatis Stefano; Scorsetti Marta Mancosu, Pietro; Navarria. Planrobustness in field junction region from arcs with different patient orientation intotal marrow irradiation with vmat.Physica Medica, 6 2015.[39] Ronald J. Watts. Evaluation of a diode detector array for use as a linear acceleratorqc device.Medical Physics, 25, 1998. 108Bibliograf ́ıa[40] A.; Bourhaleb F.; Cirio R.; Donetti M.; Fidanzio A.; Garelli E.; Giordanengo S.;Madon E.; Marchetto F.; Nastasi U.; Peroni C.; Piermattei A.; Sanz Freire C. J.;Sardo A.; Trevisiol E. Amerio, S.; Boriano. Dosimetric characterization of a largearea pixel-segmented ionization chamber.Medical Physics, 31, 2004.[41] S; Cirio R; Boriano A; Bourhaleb F; Cornelius I; Donetti M; Garelli E; Gomola I;Marchetto F; Porzio M; Freire C J Sanz; Sardo A; Peroni C Stasi, M; Giordanengo.D-imrt verification with a 2d pixel ionization chamber: dosimetric and clinical resultsin head and neck cancer.Physics in Medicine and Biology, 50, 10 2005.[42] Daniel L ́etourneau; Misbah Gulam; Di Yan; Mark Oldham; John W. Wong. Eva-luation of a 2d diode array for imrt quality assurance.Radiotherapy and Oncology,70, 2004.[43] A L; Romani F; Ferri A Spezi, E; Angelini. Characterization of a 2d ion cham-ber array for the verification of radiotherapy treatments.Physics in Medicine andBiology, 50, 07 2005.[44] Arne; Djouguela Armand; Kollhoff Ralf; Rubach Antje; Willborn Kay C.; Har-der Dietrich Poppe, Bjoern; Blechschmidt. Two-dimensional ionization chamberarrays for imrt plan verification.Medical Physics, 33, 2006.[45] Arne; Djouguela Armand; Kollhoff Ralf; Rubach Antje; Willborn Kay C.; Har-der Dietrich Poppe, Bjoern; Blechschmidt.Gu ́ıa del usuario de ArcCHECK®Lamejor soluci ́on de control de calidad, 2006.[46] Sun Nuclear Corporation.SNC PatientT MSoftware Reference Guide. Sun NuclearCorporation, Melbourne- Florida, USA, 2020.[47] William B.; Mutic Sasa; Purdy James A. Low, Daniel A.; Harms. A technique forthe quantitative evaluation of dose distributions.Medical Physics, 25, 1998.[48] Colm Morrison, Kirsty Symons, Simon Woodings, and Michael House. Verificationof junction dose between vmat arcs of total body irradiation using a sun nucleararccheck phantom.Journal of Applied Clinical Medical Physics, 18, 10 2017.[49] G. P. Glasgow E. B. Podgorsak J. Van Dyk, J. M. Galvin. Aapm task group 29 reportno 17: The physical aspects of total and half body photon irratiation.AmericanAssociation of Physicists in Medicine, 1986.
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dc.format.extent.spa.fl_str_mv	xii, 108 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Maestría en Física Médica
dc.publisher.department.spa.fl_str_mv	Departamento de Física
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Veloza Salcedo, Luz Stella3a36897fe109b54ccfd23245f32934d4Simbaqueba Ariza, Axel Danny1f90fadbb0a96002c88a7d86ee1e3f74Pinzón Cupitra, Andrés Felipee9e833511c29bb335a0e0ae61d0d90b52021-09-09T15:04:25Z2021-09-09T15:04:25Z2021-08https://repositorio.unal.edu.co/handle/unal/80143Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Ilustraciones y fotografíasEn este trabajo se estableció un protocolo TBI/VMAT que requirió la previa construcción de un simulador anatómico para caracterizar algunas de las etapas del tratamiento, tales como: 1) la inmovilización del paciente en una camilla construida para TBI/VMAT con la habilidad de girar libremente alrededor de su eje central, 2) la obtención de imágenes diagnósticas de cuerpo completo del paciente mediante fusión de imágenes parciales, 3) la planeación de los haces de radiación utilizando múltiples isocentros para el cálculo de la dosis absorbida por los órganos y tejidos del paciente y, 4) la verificación del tratamiento antes y durante su aplicación, usando arreglos de detectores. En el protocolo de TBI/VMAT desarrollado en este trabajo se establecen los elementos requeridos, tales como una camilla especial y accesorios de inmovilización, para implementar el tratamiento en cualquier centro de radioterapia que disponga de acelerador lineal clínico con producción de fotones de 6 MV. Se determinó que aunque el equipo de tomografía computarizada puede hacer una adquisición de hasta 140 cm sin pausa, cuando la altura de un paciente supera el rango máximo de irradiación permitido sin tener que modificar su posición en el acelerador, en nuestro caso 110 cm, se debe considerar la adquisición de imágenes parciales. Para facilitar la planeación VMAT el paciente debe inmovilizarse con las piernas juntas y los brazos unidos al cuerpo y para las imágenes parciales se recomienda una ubicación inicial cráneo-caudal con una posterior rotación a la posición caudo-craneal. La planeación del tratamiento se hace con 5 isocentros ubicados a lo largo del cuerpo, con un esquema de tratamiento de 1200 cGy en seis sesiones. La dosis se optimizó en las intersecciones de los arcos de radiación y en la intersección que se genera adicionalmente en la pelvis cuando se rota al paciente para dar el tratamiento. Como resultado de las planeaciones se logró una distribución homogénea de la dosis en el volumen objetivo y una reducción de los puntos calientes en las zonas de intersección en la pelvis. La dosis en pulmón no logró reducirse hasta la dosis objetivo, pero posiblemente esto se logre en un paciente cuando los brazos estén unidos a su cuerpo. A diferencia de la TBI convencional, en la TBI/VMAT se puede conocer la distribución dosis entregada al paciente y a los OARs permitiendo una evaluación del tratamiento. Se hizo la verificación en de la ejecución del tratamiento planeado con el tratamiento entregado usando mediciones en arreglos de detectores semiconductores. Al establecer como criterio una diferencia máxima del 3\% en la dosis y de 3 mm en la posición, se obtuvo que solo un 2\% de los valores están por fuera de este rango. En conclusión, este trabajo permitió obtener por medio de un simulador anatómico un protocolo para la implementación por primera vez en Colombia de TBI/VMAT, el cual servirá de base para la implementación futura de esta técnica en pacientes. (Texto tomado de la fuente). (Texto tomado de la fuente)Total body irradiation (TBI) is a therapy intended for administration, with high-energy X-rays emanating from a clinical linear accelerator, of a uniform radiation dose in the patient’s whole body, minimizing radiation dose in organs at risk. This technique has proven its effectiveness in conditioning patients with diseases such as leukemia, multiple myeloma or some types of lymphoma, prior to the stem cell transplant. TBI is given for two purposes: 1) to destroy cancer cells that have not been killed by surgery, chemotherapy or local radiotherapy, and 2) to decrease the response of patient’s immune system, preventing it from attacking the newly transplanted stem cells. The most common method of delivering TBI is with the patient at several meters from the source, requiring the standard settings to be changed in the treatment room. Additionally, to reduce dose in organs at risk, it is necessary to fabricate customized blocks made of toxic materials such as lead or cerrobend (a lead, zinc and bismuth alloy). One option to solve these problems is to implement TBI with intensity-modulated volumetric arc therapy (VMAT), thus avoiding the need for personalized shields and allowing the therapy to be performed at the standard radiotherapy distances. In this work, a protocol for TBI/VMAT was established, which required the prior construction of a phantom to characterize some of the treatment stages, such as: 1) immobilization of the patient on a treatment table with the ability to freely rotate about the central axis, 2) obtaining diagnostic images of the entire body of the patient by fusion of partial images, 3) planning of the radiation beams using multi-isocenters for calculation of the absorbed dose in organs and tissues of the patient and 4) treatment verification before and during its application, using detector arrays. The TBI/VMAT protocol developed in this work establishes the required elements, such as a special table and immobilization accessories, to implement the treatment in any radiotherapy center that has a clinical linear accelerator with photon production at voltages of 6 MV. It was determined that although the computer tomography system can make an acquisition of 140 cm without pause, partial images should be considered if patient’s height is higher than the maximum range of irradiation (110 cm) without having to modify the position of the patient in the accelerator. To facilitate VMAT planning, the patient should be immobilized with the legs close to each other and with the arms close to the body and for the partial images it is recommended an initial cranio-caudal position of the patient with a subsequent rotation in the caudo-cranial position. The treatment planning has 5 isocenters along the body, giving 1200 cGy over 6 sessions with a maximum dose of 800 cGy in lungs. Dose was optimized at the intersections of the irradiation arcs and at the intersection of the beams generated when the patient is rotated during the treatment. A comparison was made in the anatomical simulator between the planned treatment and the delivered treatment using measurements with arrays of semiconductor detectors. With the criterion of a maximum difference of 3 % in the dose and 3 mm in the position, it was obtained that only 2 % of the values are outside this range. In conclusion, this work made it possible to establish, by using an anatomical simulator, a protocol for the first implementation in Colombia of TBI/VMAT, which will serve as the basis for the future implementation of this technique in patients.Primera etapa de protocolo de tratamiento de irradiación corporal total empleando arcoterapia de intensidad modulada utilizando camilla giratoria. Con un simulador anatómico se evidencia identifican pautas para las etapas de: inmovilizacion, simulación, planeación,control de calidad y entrega de tratamiento.MaestríaMagíster en Física MédicaRadioterapiaxii, 108 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Física MédicaDepartamento de FísicaFacultad de CienciasBogotá, ColombiaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludRadioterapia de intensidad moduladaIrradiación corporal totalRayos XIntensity-modulated radiotherapyWhole-body irradiationX-raysTBITBI/VMATSimulador anatómicoICTAnatomical simulatorEstablecimiento de un protocolo para irradiación corporal total con la técnica de arcoterapia volumétrica de intensidad moduladaEstablishment of a protocol for total body irradiation with the intensity-modulated volumetric arc therapy technique.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TM[1] MINSALUD Ministerio de Salud Nacional. Observatorio nacional de c ́ancer- gu ́ıametol ́ogica, 2018.[2] Raymond Miralbell; Michel Rouzaud; Eugene Grob; Philippe Nouet; Sabine Bieri;Sabine B. Majno; Patrick Botteron; Manuel Montero; Jean C. Precoma. Can atotal body irradiation technique be fast and reproducible?International Journal ofRadiation OncologyBiologyPhysics, 29:1167–1173, 1994.M; Hamill G; Stanhope R; Leiper A D Papadimitriou, A; Urena. Growth hormonetreatment of growth failure secondary to total body irradiation and bone marrowtransplantation.Archives of Disease in Childhood, 66, 06 1991.[4] Quast U. Whole body radiotherapy: A tbi-guideline.Journal of medical physics,31:5–12, 2006.[5] Chuang KS Lin JF Lee JC Lin JC Chen HH, Wu J. Total body irradiation withstep translation and dynamic field matching.Biomed Res Int, 1:5–12, 2013.[6] Santam Chakraborty, Suja Cheruliyil, Resmi K. Bharathan, and Geetha Muttath.Total body irradiation using vmat (rapidarc): A planning study of a novel treatmentdelivery method.International Journal of Cancer Therapy and Oncology, 3:03028,2015.[7] Fowler J Hui SK, Kapatoes J. Feasibility study of helical tomotherapy for totalbody or total marrow irradiation.International Journal of Cancer Therapy andOncology, 32:3214–3224, 2005.[8] Karl Otto. Volumetric modulated arc therapy: Imrt in a single gantry arc.Medicalphysics, 35:310–7, 02 2008.[9] Andreas Springer, Josef Hammer, Erwin Winkler, Christine Track, Roswitha Hup-pert, Alexandra B ̈ohm, Hedwig Kasparu, Ansgar Weltermann, Gregor Aschauer,Andreas Petzer, E. Putz, Alexander Altenburger, Rainer Gruber, Karin Moser, Ka-rin Wiesauer, and Hans Geinitz. Total body irradiation with volumetric modulated Bibliograf ́ıa105arc therapy: Dosimetric data and first clinical experience.Radiation Oncology, 11,12 2016.[10] Roeske JC Aydogan B, Mundt AJ. Linac-based intensity modulated total marrowirradiation (im-tmi).Technol Cancer Res Treat, 5:513–519, 2006.[11] C.R. Richmond. Icrp publication 23.International Journal of Radiation Onco-logyBiologyPhysics, 12, 1986.[12] B. Jung. Book review: Phantoms and computational models in therapy, diagnosisand protection. icru report 48.Acta Radiologica, 35, 03 1994.[13] Computerized Imaging Reference Systems CIRS Inc.ATOM®Dosimetry Phan-toms, 2013.[14] Piera; Castagna Luca; Reggiori Giacomo; Sarina Barbara; Tomatis Stefano; AlongiFilippo; Nicolini Giorgia; Fogliata Antonella; Cozzi Luca; Scorsetti Marta Mancosu,Pietro; Navarria. 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Aapm task group 29 reportno 17: The physical aspects of total and half body photon irratiation.AmericanAssociation of Physicists in Medicine, 1986.GeneralORIGINAL10123897502021.pdf10123897502021.pdfTesis de Maestría en Física Médicaapplication/pdf51882651https://repositorio.unal.edu.co/bitstream/unal/80143/3/10123897502021.pdf184fe0d8129257257354e57ed27ebea5MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80143/4/license.txtcccfe52f796b7c63423298c2d3365fc6MD54THUMBNAIL10123897502021.pdf.jpg10123897502021.pdf.jpgGenerated Thumbnailimage/jpeg4820https://repositorio.unal.edu.co/bitstream/unal/80143/5/10123897502021.pdf.jpg3aa6163ba493a13d9251315debad241dMD55unal/80143oai:repositorio.unal.edu.co:unal/801432024-07-28 01:13:05.971Repositorio Institucional Universidad Nacional de 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