Mathematical model for the analysis of vaccination and vector control on malaria incidence

Objectives: A model describing malaria behavior through a system of ordinary differential equations. Methods: In order to construct the model, the interaction between man and the malaria vector was taken into account in different infectivity and immunity states. We also considered the vaccination e...

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Autores:: Vásquez Pinzón, Juan U.
Méndez-Sánchez, Stella C.
Duque Luna, Jonny E.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2003

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

Description
Summary:	Objectives: A model describing malaria behavior through a system of ordinary differential equations. Methods: In order to construct the model, the interaction between man and the malaria vector was taken into account in different infectivity and immunity states. We also considered the vaccination effect by means of an infection blocking vaccine and parameters representing larval and adult vector control. Results: The model developed enables simulation of malaria disease behavior in various settings: in a natural manner without intervention, with either vector control or vaccination, and considering vector control and vaccination together. Conclusions: We obtained numerical conditions for the existence of a non-trivial equilibrium state, conditioned to the existence of a single real positive root of a fourth degree polynomial. This is a problem that remains unsolved.

Mathematical model for the analysis of vaccination and vector control on malaria incidence

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