Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022
ilustraciones, gráficas, tablas
- Autores:
-
Moreno González, Carlos Alfonso
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/83363
- Palabra clave:
- 610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
Trastornos del Olfato/diagnóstico
Anosmia
Técnicas y Procedimientos Diagnósticos
Olfaction Disorders/diagnosis
Anosmia
Diagnostic Techniques and Procedures
Trastornos olfatorios
Prueba diagnóstica
Identificación olfatoria
Versión colombiana
CC-SIT
Olfactory disorders
Diagnostic test
Olfactory identification
Colombian version
CC-SIT
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| dc.title.translated.eng.fl_str_mv |
Development of a new smell identification psychophysical olfactory test for Bogotá D.C. population at National University Hospital of Colombia between 2020 and 2022 |
| title |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| spellingShingle |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología Trastornos del Olfato/diagnóstico Anosmia Técnicas y Procedimientos Diagnósticos Olfaction Disorders/diagnosis Anosmia Diagnostic Techniques and Procedures Trastornos olfatorios Prueba diagnóstica Identificación olfatoria Versión colombiana CC-SIT Olfactory disorders Diagnostic test Olfactory identification Colombian version CC-SIT |
| title_short |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| title_full |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| title_fullStr |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| title_full_unstemmed |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| title_sort |
Construcción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022 |
| dc.creator.fl_str_mv |
Moreno González, Carlos Alfonso |
| dc.contributor.advisor.spa.fl_str_mv |
Osorio Bernal, Luz Ángela Fuentes Francia, Andrés Leonardo |
| dc.contributor.author.spa.fl_str_mv |
Moreno González, Carlos Alfonso |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología |
| topic |
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología Trastornos del Olfato/diagnóstico Anosmia Técnicas y Procedimientos Diagnósticos Olfaction Disorders/diagnosis Anosmia Diagnostic Techniques and Procedures Trastornos olfatorios Prueba diagnóstica Identificación olfatoria Versión colombiana CC-SIT Olfactory disorders Diagnostic test Olfactory identification Colombian version CC-SIT |
| dc.subject.decs.spa.fl_str_mv |
Trastornos del Olfato/diagnóstico Anosmia Técnicas y Procedimientos Diagnósticos |
| dc.subject.decs.eng.fl_str_mv |
Olfaction Disorders/diagnosis Anosmia Diagnostic Techniques and Procedures |
| dc.subject.proposal.spa.fl_str_mv |
Trastornos olfatorios Prueba diagnóstica Identificación olfatoria Versión colombiana CC-SIT |
| dc.subject.proposal.eng.fl_str_mv |
Olfactory disorders Diagnostic test Olfactory identification Colombian version CC-SIT |
| description |
ilustraciones, gráficas, tablas |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-02-07T19:01:56Z |
| dc.date.available.none.fl_str_mv |
2023-02-07T19:01:56Z |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Especialidad Médica |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/83363 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/83363 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
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Bireme |
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Cho SH. Clinical Diagnosis and Treatment of Olfactory Dysfunction. Hanyang Med Rev. 2014;34(3):107. Laska M. Human and A. In: A B, editor. Springer Handbook of Odor. 1st ed. Freising, Germany: Springer; 2017. p. 675–89. Ribeiro JC, Simões J, Silva F, Silva ED, Hummel C, Hummel T, et al. Cultural adaptation of the Portuguese version of the “Sniffin’’ Sticks" smell test: Reliability, validity, and normative data.” PLoS One. 2016;11(2):1–12. Yang J, Pinto JM. The Epidemiology of Olfactory Disorders. Curr Otorhinolaryngol Rep. 2016;4(2):130– 41. Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Schöpf V, Mainland JD, et al. Anosmia-A Clinical Review. Chem Senses. 2017;42(7):513–23. Sorokowska A, Sorokowski P, Hummel T. Cross-Cultural Administration of an Odor Discrimination Test. Chemosens Percept. 2014;7(2):85–90. Antsov E, Silveira-Moriyama L, Kilk S, Kadastik-Eerme L, Toomsoo T, Lees A, et al. Adapting the Sniffin’ Sticks olfactory test to diagnose Parkinson’s disease in Estonia. Park Relat Disord [Internet]. 2014;20(8):830–3. Available from: http://dx.doi.org/10.1016/j.parkreldis.2014.04.012 Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(January):1–7. Brämerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of Olfactory Dysfunction: The Skövde Population-Based Study. Laryngoscope. 2004;114(4):733–7. Schubert CR, Cruickshanks KJ, Murphy C, Huang GH, Klein BEK, Klein R, et al. Olfactory impairment in adults: The beaver dam experience. Ann N Y Acad Sci. 2009;1170:531–6. Schöpf V, Kollndorfer K. Clinical Assessment of Olfactory Performance - Why Patient Interviews Are Not Enough : A Report on Lessons Learned in Planning Studies With Anosmic Patients. HNO. 2015;63(7):511–5. Croy I, Nordin S, Hummel T. Olfactory Disorders and Quality of Life-An Updated Review. Chem Senses. 2014;39(3):185–94. Nordin S, Brämerson A. Complaints of Olfactory Disorders: Epidemiology, Assessment and Clinical Implications. Curr Opin Allergy Clin Immunol. 2008;8(1):10–5. Seiberling KA, Conley DB. Aging and Olfactory and Taste Function. Otolaryngol Clin North Am. 2004;37(6 SPEC.ISS.):1209–28. Lennington JB, Yang Z, Conover JC. Neural Stem Cells and the Regulation of Adult Neurogenesis. Reprod Biol Endocrinol. 2003; 1:1–7. Smith WM, Davidson TM, Murphy C. Toxin-Induced Chemosensory Dysfunction: A Case Series and Review. Am J Rhinol Allergy. 2009;23(6):578–81. Ajmani GS, Suh HH, Wroblewski KE, Pinto JM. Smoking and Olfactory Dysfunction: A Systematic Literature Review and Meta-analysis. Laryngoscope. 2017;127(8):1753–61. Schiffman SS. Influence of Medications on Taste and Smell. World J Otorhinolaryngol - Head Neck Surg [Internet]. 2018;4(1):84–91. Available from: https://doi.org/10.1016/j.wjorl.2018.02.005 . Lee DY, Lee WH, Wee JH, Kim JW. Prognosis of Postviral Olfactory Loss: Follow-up Study for Longer Than One Year. Am J Rhinol Allergy. 2014;28(5):419–22. Gudis DA, Soler ZM. Chronic Rhinosinusitis-Related Smell Loss: Medical and Surgical Treatment Efficacy. Curr Otorhinolaryngol Rep. 2016;4(2):142–7. Howell J, Costanzo RM, Reiter ER. Head Trauma and Olfactory Function. World J Otorhinolaryngol - Head Neck Surg [Internet]. 2018;4(1):39–45. Available from: https://doi.org/10.1016/j.wjorl.2018.02.001 Neuland C, Bitter T, Marschner H, Gudziol H, Guntinas-Lichius O. Health-related and specific olfaction- related quality of life in patients with chronic functional anosmia or severe hyposmia. Laryngoscope. 2011;121(4):867–72. Havermans RC, Hermanns J, Jansen A. Eating Without a Nose: Olfactory Dysfunction and Sensory- Specific Satiety. Chem Senses. 2010;35(8):735–41. 24. Philpott CM, Boak D. The Impact of Olfactory Disorders in the United Kingdom. Chem Senses. 2014;39(8):711–8. Philpott CM, Boak D. The Impact of Olfactory Disorders in the United Kingdom. Chem Senses. 2014;39(8):711–8. Manesse C, Ferdenzi C, Sabri M, Bessy M, Rouby C, Faure F, et al. Dysosmia-Associated Changes in Eating Behavior. Chemosens Percept. 2017;10(4):104–13. Aschenbrenner K, Hummel C, Teszmer K, Krone F, Ishimaru T, Seo HS, et al. The Influence of Olfactory Loss on Dietary Behaviors. Laryngoscope. 2008;118(1):135–44. Hoffman HJ, Rawal S, Li CM, Duffy VB. New Chemosensory Component In The U.S. National Health and Nutrition Examination Survey (NHANES): First-Year Results For Measured Olfactory Dysfunction. Rev Endocr Metab Disord [Internet]. 2016;17(2):221–40. Available from: http://dx.doi.org/10.1007/s11154-016-9364-1 Keller A, Malaspina D. Hidden Consequences of Olfactory Dysfunction: A Patient Report Series. BMC Ear, Nose Throat Disord. 2013;13(1). Pence TS, Reiter ER, DiNardo LJ, Costanzo RM. Risk Factors For Hazardous Events In Olfactory- Impaired Patients. JAMA Otolaryngol - Head Neck Surg. 2014;140(10):951–5. Pinto JM, Wroblewski KE, Kern DW, Schumm LP, McClintock MK. Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults. PLoS One. 2014;9(10):1–9. Nordin S, Hedén Blomqvist E, Olsson P, Stjårne P, Ehnhage A. Effects of Smell Loss on Daily Life and Adopted Coping Strategies in Patients With Nasal Polyposis with Asthma. Acta Otolaryngol. 2011;131(8):826–32. Croy I, Bojanowski V, Hummel T. Men Without a Sense of Smell Exhibit a Strongly Reduced Number of Sexual Relationships, Women Exhibit Reduced Partnership Security - A Reanalysis of Previously Published Data. Biol Psychol [Internet]. 2013;92(2):292–4. Available from: http://dx.doi.org/10.1016/j.biopsycho.2012.11.008 Haxel BR, Nisius A, Fruth K, Mann WJ, Muttray A. Deficits in Medical Counseling in Olfactory Dysfunction. HNO. 2012;60(5):432–8. Jung YG, Lee JS, Park GC. Does Post-Infectious Olfactory Loss Affect Mood More Severely Than Chronic Sinusitis With Olfactory Loss? Laryngoscope. 2014;124(11):2456–60. Kollndorfer K, Reichert JL, Brückler B, Hinterleitner V, Schöpf V. Self-Esteem as an Important Factor in Quality of Life and Depressive Symptoms in Anosmia: A Pilot Study. Clin Otolaryngol. 2017;42(6):1229–34. Kohli P, Soler ZM, Nguyen SA, Muus JS, Schlosser RJ. The Association Between Olfaction and Depression: A Systematic Review. Chem Senses. 2016;41(6):479–86. Werner S, Nies E. Olfactory Dysfunction Revisited: A Reappraisal of Work-Related Olfactory Dysfunction Caused by Chemicals. J Occup Med Toxicol. 2018;13(1). Rawal S, Hoffman HJ, Chapo AK, Duffy VB. Sensitivity and Specificity of Self-Reported Olfactory Function in a Home-Based Study of Independent-Living, Healthy Older Women. Chemosens Percept. 2014;7(3–4):108–16. Doty RL. Office Procedures For Quantitative Assessment of Olfactory Function. Am J Rhinol. 2007;21(4):460–73. Doty RL. Olfactory Dysfunction and Its Measurement in the Clinic. World J Otorhinolaryngol Neck Surg [Internet]. 2015;1(1):28–33. Available from: http://dx.doi.org/10.1016/j.wjorl.2015.09.007 Campabadal A, Segura B, Junque C, Serradell M, Abos A, Uribe C, et al. Comparing The Accuracy And Neuroanatomical Correlates Of The UPSIT-40 And The Sniffin’ Sticks Test In REM Sleep Behavior Disorder. Park Relat Disord [Internet]. 2019;65(May):197–202. Available from: https://doi.org/10.1016/j.parkreldis.2019.06.013 Hugh SC, Siu J, Hummel T, Forte V, Campisi P, Papsin BC, et al. Olfactory Testing in Children Using Objective Tools: Comparison of Sniffin’ Sticks and University of Pennsylvania Smell Identification Test (UPSIT). J Otolaryngol - Head Neck Surg. 2015;44(March):1–5. Smell Identification Test UPSIT - MediSense | Smelltest.eu [Internet]. [cited 2020 Jun 27]. Available from: https://smelltest.eu/en/product/smell-identification-test-2/ Yu CY, Wu RM. Application Of The University Of Pennsylvania Smell Identification Test (Traditional Chinese Version) for Detecting Olfactory Deficits In Early Parkinson’s Disease In a Taiwanese Cohort. J Parkinsons Dis. 2014;4(2):175–80. Doty RL, Marcus A, Lee WW. Development of the 12-Item Cross-Cultural Smell Identification Test (CC- SIT). Laryngoscope. 1996;106(March):353–6. El Rassi E, Mace JC, Steele TO, Alt JA, Soler ZM, Fu R, et al. Sensitivity Analysis And Diagnostic Accuracy Of The Brief Smell Identification Test In Patients With Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(3):287–92. . Wolfensberger M, Schnieper I, Welge-Lüssen A. Sniffin’Sticks®: A New Olfactory Test Battery. Acta Otolaryngol. 2000;120(2):303–6. Hinz A, Luck T, Riedel-Heller SG, Herzberg PY, Rolffs C, Wirkner K, et al. Olfactory Dysfunction: Properties of the Sniffin’ Sticks Screening 12 Test and Associations With Quality of Life. Eur Arch Oto- Rhino-Laryngology [Internet]. 2019;276(2):389–95. Available from: http://dx.doi.org/10.1007/s00405- 018-5210-2 Sniffin’ Sticks Identification Test 16, blue - MediSense | Smelltest.eu [Internet]. [cited 2020 Jun 27]. Available from: https://smelltest.eu/en/product/burghart-sniffin-sticks-identification-test-16-blue/ Oleszkiewicz A, Taut M, Sorokowska A, Radwan A, Kamel R, Hummel T. Development of the Arabic Version Of The “Sniffin’ Sticks” Odor Identification Test. Eur Arch Oto-Rhino-Laryngology. 2016;273(5):1179–84. Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T. Cognitive Factors in Odor Detection, Odor Discrimination, and Odor Identification Tasks. J Clin Exp Neuropsychol. 2010;32(10):1062–7. Feng, Guo; Zhuang, Yuan; Yao; Fangshu; Ye, Yuting; Wan QWZ. Development of the Chinese Smell Identification Test. Chem Senses. 2019;44(3):185–95. Eibenstein A, Fioretti AB, Lena C, Rosati N, Ottaviano I, Fusetti M. Olfactory Screening Test: Experience In 102 Italian Subjects. Acta Otorhinolaryngol Ital. 2005;25(1):18–22. Konstantinidis I, Printza A, Genetzaki S, Mamali K, Kekes G, Constantinidis J. Cultural Adaptation Of An Olfactory Identification Test: The Greek Version Of Sniffin’ Sticks. Rhinology. 2008;46(4):292–6. Niklassen AS, Ovesen T, Fernandes H, Fjaeldstad AW. Danish Validation of Sniffin’ Sticks Olfactory Test for Threshold, Discrimination, and Identification. Laryngoscope. 2018;128(8):1759–66. Pinkhardt EH, Liu H, Ma D, Chen J, Pachollek A, Kunz MS, et al. Olfactory Screening of Parkinson’s Disease Patients and Healthy Subjects in China and Germany: A Study of Cross-Cultural Adaptation of the Sniffin’ Sticks 12-Identification Test. PLoS One [Internet]. 2019;14(11):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0224331 Altundag A, Tekeli H, Salihoglu M, Cayonu M, Yasar H, Kendirli MT, et al. Cross-Culturally Modified University Of Pennsylvania Smell Identification Test For A Turkish Population. Am J Rhinol Allergy. 2015;29(5):138–41. Su, B., Wu, D. and Wei, Y. (2021) “Development of Chinese odor identification test,” Annals of Translational Medicine, 9(6), pp. 499–499. Available at: https://doi.org/10.21037/atm-21-913. Saito S, Ayabe-Kanamura S, Takashima Y, Gotow N, Naito N, Nozawa T, et al. Development Of A Smell Identification Test Using A Novel Stick-Type Odor Presentation Kit. Chem Senses. 2006;31(4):379–91. Gupta N, Singh PP, Goyal A, Bhatia D. Assessment of Olfaction Using the “I-Smell” Test in an Indian Population: A Pilot Study. Indian J Otolaryngol Head Neck Surg. 2013;65(1):6–11. |
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Atribución-NoComercial 4.0 Internacional |
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42 páginas sin enumerar |
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2020-2022 |
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Bogotá |
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Colombia |
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Cundinamarca |
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http://vocab.getty.edu/page/tgn/1000838 |
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Universidad Nacional de Colombia |
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Bogotá - Medicina - Especialidad en Otorrinolaringología |
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Facultad de Medicina |
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Bogotá, Colombia |
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Universidad Nacional de Colombia - Sede Bogotá |
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Universidad Nacional de Colombia |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Osorio Bernal, Luz Ángela5afb35072b6db05fb591756892f19ef9Fuentes Francia, Andrés Leonardo2846fec026b6b1460c96b42eff594f13Moreno González, Carlos Alfonso6f47e886441e1d34b144719f551a39062020-2022BogotáColombiaCundinamarcahttp://vocab.getty.edu/page/tgn/10008382023-02-07T19:01:56Z2023-02-07T19:01:56Z2023https://repositorio.unal.edu.co/handle/unal/83363Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasLos trastornos olfatorios afectan un 25% de la población, su prevalencia aumenta con la edad. A pesar de ser comunes, tienden a ser pasados por alto en la consulta médica. Las pruebas psicofísicas disponibles son producidas, principalmente, por Estados Unidos y Europa, y su aplicación queda limitada a países que comparten su trasfondo cultural. Objetivo: desarrollar una prueba psicofísica de identificación olfatoria validada, rápida, costo-efectiva y confiable para la población colombiana entre 18 y 80 años. Materiales y métodos: Se diseñó una prueba olfatoria (POC) con 12 olores reconocibles por la población general, a partir de una encuesta con escala tipo Likert. Se aplicó en un hospital de cuarto nivel a personas con y sin alteración olfatoria para obtener valores de normalidad y cuantificar tiempo de realización. Se repitió la prueba entre 30 y 120 días a una proporción de participantes para evaluar su fiabilidad, y contra el Cross Cultural Smell Identification Test (CC-SIT) para validarlo con el estándar internacional. Resultados: Los 12 olores tuvieron una tasa de reconocimiento mayor 75% y el tiempo de aplicación promedio fue de 392.82 segundos. Un valor inferior a 8 fue el corte para identificar disfunción olfatoria. La fiabilidad y correlación con el CC-SIT fueron aceptables, con un alfa de Cronbach de 0.824 e índice Kappa de Cohen de 0.85. Su sensibilidad y especificidad fueron de 87.5% y 97.5%, respectivamente. Conclusión: La POC es una herramienta útil para el diagnóstico de trastornos olfatorios en la población colombiana, comparable con el estándar internacional. (Texto tomado de la fuente).Olfactory disorders affect 25% of the population, and their prevalence increases with age. Despite being common, they tend to be overlooked in medical consult. The available psychophysical tests are mainly produced in the United States and Europe, and their application is limited to countries that share their cultural background. Objective: to develop a validated, rapid, cost-effective and reliable psychophysical olfactory identification for the colombian population between 18 and 80 years of age. Materials and methods: an olfactory test (POC) was designed with 12 odors recognizable by the general population, based on a Likert-type scale survey. It was applied in a fourth level hospital to subjects with and without olfactory alterations to obtain normal values and quantify completion time. It was repeated between 30 to 120 days with a proportion of participants to assess reliability, and against the Cross Cultural Smell Identification Test (CC-SIT) to validate with the international standard. Results: the 12 odors had a recognition rate greater than75% and the average application time was 392.82 seconds. A value lower to 8 was the cutoff to identify olfactory dysfunction. Reliability and correlation with CC-SIT were acceptable, with a Cronbach’s alpha of 0.824 and Cohen´s kappa coefficient of 0.85. Its sensibility and specificity were 87.5% and 97.5%, respectively. Conclusion: The POC is a useful tool for the diagnosis of olfactory disorders in colombian population, comparable to the international standard.Especialidades MédicasEspecialista en Otorrinolaringología42 páginas sin enumerarapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en OtorrinolaringologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiologíaTrastornos del Olfato/diagnósticoAnosmiaTécnicas y Procedimientos DiagnósticosOlfaction Disorders/diagnosisAnosmiaDiagnostic Techniques and ProceduresTrastornos olfatoriosPrueba diagnósticaIdentificación olfatoriaVersión colombianaCC-SITOlfactory disordersDiagnostic testOlfactory identificationColombian versionCC-SITConstrucción de una nueva prueba psicofísica olfatoria de identificación para la población de Bogotá D.C. del Hospital Universitario Nacional de Colombia, entre 2020 y 2022Development of a new smell identification psychophysical olfactory test for Bogotá D.C. population at National University Hospital of Colombia between 2020 and 2022Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeCho SH. Clinical Diagnosis and Treatment of Olfactory Dysfunction. Hanyang Med Rev. 2014;34(3):107.Laska M. Human and A. In: A B, editor. Springer Handbook of Odor. 1st ed. Freising, Germany: Springer; 2017. p. 675–89.Ribeiro JC, Simões J, Silva F, Silva ED, Hummel C, Hummel T, et al. Cultural adaptation of the Portuguese version of the “Sniffin’’ Sticks" smell test: Reliability, validity, and normative data.” PLoS One. 2016;11(2):1–12.Yang J, Pinto JM. The Epidemiology of Olfactory Disorders. Curr Otorhinolaryngol Rep. 2016;4(2):130– 41.Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Schöpf V, Mainland JD, et al. Anosmia-A Clinical Review. Chem Senses. 2017;42(7):513–23.Sorokowska A, Sorokowski P, Hummel T. Cross-Cultural Administration of an Odor Discrimination Test. Chemosens Percept. 2014;7(2):85–90.Antsov E, Silveira-Moriyama L, Kilk S, Kadastik-Eerme L, Toomsoo T, Lees A, et al. Adapting the Sniffin’ Sticks olfactory test to diagnose Parkinson’s disease in Estonia. Park Relat Disord [Internet]. 2014;20(8):830–3. Available from: http://dx.doi.org/10.1016/j.parkreldis.2014.04.012Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(January):1–7.Brämerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of Olfactory Dysfunction: The Skövde Population-Based Study. Laryngoscope. 2004;114(4):733–7.Schubert CR, Cruickshanks KJ, Murphy C, Huang GH, Klein BEK, Klein R, et al. Olfactory impairment in adults: The beaver dam experience. Ann N Y Acad Sci. 2009;1170:531–6.Schöpf V, Kollndorfer K. Clinical Assessment of Olfactory Performance - Why Patient Interviews Are Not Enough : A Report on Lessons Learned in Planning Studies With Anosmic Patients. HNO. 2015;63(7):511–5.Croy I, Nordin S, Hummel T. Olfactory Disorders and Quality of Life-An Updated Review. Chem Senses. 2014;39(3):185–94.Nordin S, Brämerson A. Complaints of Olfactory Disorders: Epidemiology, Assessment and Clinical Implications. Curr Opin Allergy Clin Immunol. 2008;8(1):10–5.Seiberling KA, Conley DB. Aging and Olfactory and Taste Function. Otolaryngol Clin North Am. 2004;37(6 SPEC.ISS.):1209–28.Lennington JB, Yang Z, Conover JC. Neural Stem Cells and the Regulation of Adult Neurogenesis. Reprod Biol Endocrinol. 2003; 1:1–7.Smith WM, Davidson TM, Murphy C. Toxin-Induced Chemosensory Dysfunction: A Case Series and Review. Am J Rhinol Allergy. 2009;23(6):578–81.Ajmani GS, Suh HH, Wroblewski KE, Pinto JM. Smoking and Olfactory Dysfunction: A Systematic Literature Review and Meta-analysis. Laryngoscope. 2017;127(8):1753–61.Schiffman SS. Influence of Medications on Taste and Smell. World J Otorhinolaryngol - Head Neck Surg [Internet]. 2018;4(1):84–91. Available from: https://doi.org/10.1016/j.wjorl.2018.02.005. Lee DY, Lee WH, Wee JH, Kim JW. Prognosis of Postviral Olfactory Loss: Follow-up Study for Longer Than One Year. Am J Rhinol Allergy. 2014;28(5):419–22.Gudis DA, Soler ZM. Chronic Rhinosinusitis-Related Smell Loss: Medical and Surgical Treatment Efficacy. Curr Otorhinolaryngol Rep. 2016;4(2):142–7.Howell J, Costanzo RM, Reiter ER. Head Trauma and Olfactory Function. World J Otorhinolaryngol - Head Neck Surg [Internet]. 2018;4(1):39–45. Available from: https://doi.org/10.1016/j.wjorl.2018.02.001Neuland C, Bitter T, Marschner H, Gudziol H, Guntinas-Lichius O. Health-related and specific olfaction- related quality of life in patients with chronic functional anosmia or severe hyposmia. Laryngoscope. 2011;121(4):867–72.Havermans RC, Hermanns J, Jansen A. Eating Without a Nose: Olfactory Dysfunction and Sensory- Specific Satiety. Chem Senses. 2010;35(8):735–41. 24. Philpott CM, Boak D. The Impact of Olfactory Disorders in the United Kingdom. Chem Senses. 2014;39(8):711–8.Philpott CM, Boak D. The Impact of Olfactory Disorders in the United Kingdom. Chem Senses. 2014;39(8):711–8.Manesse C, Ferdenzi C, Sabri M, Bessy M, Rouby C, Faure F, et al. Dysosmia-Associated Changes in Eating Behavior. Chemosens Percept. 2017;10(4):104–13.Aschenbrenner K, Hummel C, Teszmer K, Krone F, Ishimaru T, Seo HS, et al. The Influence of Olfactory Loss on Dietary Behaviors. Laryngoscope. 2008;118(1):135–44.Hoffman HJ, Rawal S, Li CM, Duffy VB. New Chemosensory Component In The U.S. National Health and Nutrition Examination Survey (NHANES): First-Year Results For Measured Olfactory Dysfunction. Rev Endocr Metab Disord [Internet]. 2016;17(2):221–40. Available from: http://dx.doi.org/10.1007/s11154-016-9364-1Keller A, Malaspina D. Hidden Consequences of Olfactory Dysfunction: A Patient Report Series. BMC Ear, Nose Throat Disord. 2013;13(1).Pence TS, Reiter ER, DiNardo LJ, Costanzo RM. Risk Factors For Hazardous Events In Olfactory- Impaired Patients. JAMA Otolaryngol - Head Neck Surg. 2014;140(10):951–5.Pinto JM, Wroblewski KE, Kern DW, Schumm LP, McClintock MK. Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults. PLoS One. 2014;9(10):1–9.Nordin S, Hedén Blomqvist E, Olsson P, Stjårne P, Ehnhage A. Effects of Smell Loss on Daily Life and Adopted Coping Strategies in Patients With Nasal Polyposis with Asthma. Acta Otolaryngol. 2011;131(8):826–32.Croy I, Bojanowski V, Hummel T. Men Without a Sense of Smell Exhibit a Strongly Reduced Number of Sexual Relationships, Women Exhibit Reduced Partnership Security - A Reanalysis of Previously Published Data. Biol Psychol [Internet]. 2013;92(2):292–4. Available from: http://dx.doi.org/10.1016/j.biopsycho.2012.11.008Haxel BR, Nisius A, Fruth K, Mann WJ, Muttray A. Deficits in Medical Counseling in Olfactory Dysfunction. HNO. 2012;60(5):432–8.Jung YG, Lee JS, Park GC. Does Post-Infectious Olfactory Loss Affect Mood More Severely Than Chronic Sinusitis With Olfactory Loss? Laryngoscope. 2014;124(11):2456–60.Kollndorfer K, Reichert JL, Brückler B, Hinterleitner V, Schöpf V. Self-Esteem as an Important Factor in Quality of Life and Depressive Symptoms in Anosmia: A Pilot Study. Clin Otolaryngol. 2017;42(6):1229–34.Kohli P, Soler ZM, Nguyen SA, Muus JS, Schlosser RJ. The Association Between Olfaction and Depression: A Systematic Review. Chem Senses. 2016;41(6):479–86.Werner S, Nies E. Olfactory Dysfunction Revisited: A Reappraisal of Work-Related Olfactory Dysfunction Caused by Chemicals. J Occup Med Toxicol. 2018;13(1).Rawal S, Hoffman HJ, Chapo AK, Duffy VB. Sensitivity and Specificity of Self-Reported Olfactory Function in a Home-Based Study of Independent-Living, Healthy Older Women. Chemosens Percept. 2014;7(3–4):108–16.Doty RL. Office Procedures For Quantitative Assessment of Olfactory Function. Am J Rhinol. 2007;21(4):460–73.Doty RL. Olfactory Dysfunction and Its Measurement in the Clinic. World J Otorhinolaryngol Neck Surg [Internet]. 2015;1(1):28–33. Available from: http://dx.doi.org/10.1016/j.wjorl.2015.09.007Campabadal A, Segura B, Junque C, Serradell M, Abos A, Uribe C, et al. Comparing The Accuracy And Neuroanatomical Correlates Of The UPSIT-40 And The Sniffin’ Sticks Test In REM Sleep Behavior Disorder. Park Relat Disord [Internet]. 2019;65(May):197–202. Available from: https://doi.org/10.1016/j.parkreldis.2019.06.013Hugh SC, Siu J, Hummel T, Forte V, Campisi P, Papsin BC, et al. Olfactory Testing in Children Using Objective Tools: Comparison of Sniffin’ Sticks and University of Pennsylvania Smell Identification Test (UPSIT). J Otolaryngol - Head Neck Surg. 2015;44(March):1–5.Smell Identification Test UPSIT - MediSense | Smelltest.eu [Internet]. [cited 2020 Jun 27]. Available from: https://smelltest.eu/en/product/smell-identification-test-2/Yu CY, Wu RM. Application Of The University Of Pennsylvania Smell Identification Test (Traditional Chinese Version) for Detecting Olfactory Deficits In Early Parkinson’s Disease In a Taiwanese Cohort. J Parkinsons Dis. 2014;4(2):175–80.Doty RL, Marcus A, Lee WW. Development of the 12-Item Cross-Cultural Smell Identification Test (CC- SIT). Laryngoscope. 1996;106(March):353–6.El Rassi E, Mace JC, Steele TO, Alt JA, Soler ZM, Fu R, et al. Sensitivity Analysis And Diagnostic Accuracy Of The Brief Smell Identification Test In Patients With Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(3):287–92.. Wolfensberger M, Schnieper I, Welge-Lüssen A. Sniffin’Sticks®: A New Olfactory Test Battery. Acta Otolaryngol. 2000;120(2):303–6.Hinz A, Luck T, Riedel-Heller SG, Herzberg PY, Rolffs C, Wirkner K, et al. Olfactory Dysfunction: Properties of the Sniffin’ Sticks Screening 12 Test and Associations With Quality of Life. Eur Arch Oto- Rhino-Laryngology [Internet]. 2019;276(2):389–95. Available from: http://dx.doi.org/10.1007/s00405- 018-5210-2Sniffin’ Sticks Identification Test 16, blue - MediSense | Smelltest.eu [Internet]. [cited 2020 Jun 27]. Available from: https://smelltest.eu/en/product/burghart-sniffin-sticks-identification-test-16-blue/Oleszkiewicz A, Taut M, Sorokowska A, Radwan A, Kamel R, Hummel T. Development of the Arabic Version Of The “Sniffin’ Sticks” Odor Identification Test. Eur Arch Oto-Rhino-Laryngology. 2016;273(5):1179–84.Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T. Cognitive Factors in Odor Detection, Odor Discrimination, and Odor Identification Tasks. J Clin Exp Neuropsychol. 2010;32(10):1062–7.Feng, Guo; Zhuang, Yuan; Yao; Fangshu; Ye, Yuting; Wan QWZ. Development of the Chinese Smell Identification Test. Chem Senses. 2019;44(3):185–95.Eibenstein A, Fioretti AB, Lena C, Rosati N, Ottaviano I, Fusetti M. Olfactory Screening Test: Experience In 102 Italian Subjects. Acta Otorhinolaryngol Ital. 2005;25(1):18–22.Konstantinidis I, Printza A, Genetzaki S, Mamali K, Kekes G, Constantinidis J. Cultural Adaptation Of An Olfactory Identification Test: The Greek Version Of Sniffin’ Sticks. Rhinology. 2008;46(4):292–6.Niklassen AS, Ovesen T, Fernandes H, Fjaeldstad AW. Danish Validation of Sniffin’ Sticks Olfactory Test for Threshold, Discrimination, and Identification. Laryngoscope. 2018;128(8):1759–66.Pinkhardt EH, Liu H, Ma D, Chen J, Pachollek A, Kunz MS, et al. Olfactory Screening of Parkinson’s Disease Patients and Healthy Subjects in China and Germany: A Study of Cross-Cultural Adaptation of the Sniffin’ Sticks 12-Identification Test. PLoS One [Internet]. 2019;14(11):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0224331Altundag A, Tekeli H, Salihoglu M, Cayonu M, Yasar H, Kendirli MT, et al. Cross-Culturally Modified University Of Pennsylvania Smell Identification Test For A Turkish Population. Am J Rhinol Allergy. 2015;29(5):138–41.Su, B., Wu, D. and Wei, Y. (2021) “Development of Chinese odor identification test,” Annals of Translational Medicine, 9(6), pp. 499–499. Available at: https://doi.org/10.21037/atm-21-913.Saito S, Ayabe-Kanamura S, Takashima Y, Gotow N, Naito N, Nozawa T, et al. Development Of A Smell Identification Test Using A Novel Stick-Type Odor Presentation Kit. Chem Senses. 2006;31(4):379–91.Gupta N, Singh PP, Goyal A, Bhatia D. Assessment of Olfaction Using the “I-Smell” Test in an Indian Population: A Pilot Study. Indian J Otolaryngol Head Neck Surg. 2013;65(1):6–11.EstudiantesMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83363/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1098776117.2022.pdf1098776117.2022.pdfTesis de Especialidad en Otorrinolaringologíaapplication/pdf535872https://repositorio.unal.edu.co/bitstream/unal/83363/2/1098776117.2022.pdfbe525f12ead0e95a2f4e017d4d770812MD52THUMBNAIL1098776117.2022.pdf.jpg1098776117.2022.pdf.jpgGenerated Thumbnailimage/jpeg4253https://repositorio.unal.edu.co/bitstream/unal/83363/3/1098776117.2022.pdf.jpgfc27a567ee62c9101a40d227c4bf181aMD53unal/83363oai:repositorio.unal.edu.co:unal/833632023-08-15 23:04:31.722Repositorio Institucional Universidad Nacional de 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