Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)

ilustraciones

Autores:: Paredes Cañón, Astrid Lucila

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
dc.title.translated.eng.fl_str_mv	Evaluation of fetal viability in Colombian criollo mares through the serum measurement of Dehydroepiandrosterone (DHEA)
title	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
spellingShingle	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA) 570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales Fertilidad Trastornos de la reproducción fertility reproductive disorders Deshidroepiandrosterona/análisis Dehydroepiandrosterone/analysis Dehidroepiandrosterona Esteroide Desarrollo fetal Gestacion Ultrasonografia Viabilidad fetal Aborto Dehydroepiandrosterone Steroid Fetal development Pregnancy Ultrasonography Abortion Fetal viability
title_short	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
title_full	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
title_fullStr	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
title_full_unstemmed	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
title_sort	Evaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)
dc.creator.fl_str_mv	Paredes Cañón, Astrid Lucila
dc.contributor.advisor.spa.fl_str_mv	Lozano Márquez, Harvey
dc.contributor.author.spa.fl_str_mv	Paredes Cañón, Astrid Lucila
dc.contributor.researchgroup.spa.fl_str_mv	Reproducción Animal y Salud de Hato
dc.subject.ddc.spa.fl_str_mv	570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales
topic	570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animales Fertilidad Trastornos de la reproducción fertility reproductive disorders Deshidroepiandrosterona/análisis Dehydroepiandrosterone/analysis Dehidroepiandrosterona Esteroide Desarrollo fetal Gestacion Ultrasonografia Viabilidad fetal Aborto Dehydroepiandrosterone Steroid Fetal development Pregnancy Ultrasonography Abortion Fetal viability
dc.subject.agrovoc.spa.fl_str_mv	Fertilidad Trastornos de la reproducción
dc.subject.agrovoc.eng.fl_str_mv	fertility reproductive disorders
dc.subject.decs.spa.fl_str_mv	Deshidroepiandrosterona/análisis
dc.subject.decs.eng.fl_str_mv	Dehydroepiandrosterone/analysis
dc.subject.proposal.spa.fl_str_mv	Dehidroepiandrosterona Esteroide Desarrollo fetal Gestacion Ultrasonografia Viabilidad fetal Aborto
dc.subject.proposal.eng.fl_str_mv	Dehydroepiandrosterone Steroid Fetal development Pregnancy Ultrasonography Abortion Fetal viability
description	ilustraciones
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-06-13T20:17:40Z
dc.date.available.none.fl_str_mv	2023-06-13T20:17:40Z
dc.date.issued.none.fl_str_mv	2023-06
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84013
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84013 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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The Saga of the Ring B Unsaturated Equine Estrogens* (Vol. 9, Issue 4). Boeta, M., & Zarco, L. (2012). Luteogenic and luteotropic effects of eCG during pregnancy in the mare. Animal Reproduction Science, 130(1–2), 57–62. https://doi.org/10.1016/j.anireprosci.2012.01.001 Bucca, S. (2005). Equine fetal gender determination from mid- to advanced-gestation by ultrasound. Theriogenology, 64(3), 568–571. https://doi.org/10.1016/j.theriogenology.2005.05.013 Bucca, S., Fogarty, U., Collins, A., & Small, V. (2005). Assessment of feto-placental well-being in the mare from mid-gestation to term: Transrectal and transabdominal ultrasonographic features. Theriogenology, 64(3), 542–557. https://doi.org/10.1016/j.theriogenology.2005.05.011 Canisso, I. F., Ball, B. A., Esteller-Vico, A., Williams, N. M., Squires, E. L., & Troedsson, M. H. (2015). Changes in maternal androgens and oestrogens in mares with experimentally-induced ascending placentitis. Equine Veterinary Journal, 49(2), 244–249. https://doi.org/10.1111/evj.12556 Chavatte-Palmer, P., Derisoud, E., & Robles, M. (2022). Pregnancy and placental development in horses: an update. In Domestic Animal Endocrinology (Vol. 79). Elsevier Inc. https://doi.org/10.1016/j.domaniend.2021.106692 Conley, A. J. (2016). Review of the reproductive endocrinology of the pregnant and parturient mare. Theriogenology, 86(1), 355–365. https://doi.org/10.1016/j.theriogenology.2016.04.049 Crisci, A., Rota, A., Panzani, D., Sgorbini, M., Ousey, J. C., & Camillo, F. (2014). Clinical, ultrasonographic, and endocrinological studies on donkey pregnancy. Theriogenology, 81(2), 275–283. https://doi.org/10.1016/j.theriogenology.2013.09.026 de Mestre, A. M., Miller, D., Roberson, M. S., Liford, J., Chizmar, L. C., McLaughlin, K. E., & Antczak, D. F. (2009). Glial cells missing homologue 1 is induced in differentiating equine chorionic girdle trophoblast cells. 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CHARACTERIZATION OF INTRAUTERINE MOBILITY OF THE EARLY EQUINE CONCEPTUS. Lohse, J., Cabello, R., Ponce, R., Alliende, F., & Alvear, C. (2016). Evaluación ultrasonográfica del espesor conjunto útero placentario en yeguas de raza de tiro Ardenés, Región de Valparaíso, Chile. Sustainability, Agri, Food and Environmental Research, 4(1), 33–40. https://doi.org/10.7770/safer-v4n1-art1001 Macleay, C. M., Carrick, J., Shearer, P., Begg, A., Stewart, M., Heller, J., Chicken, C., & Brookes, V. J. (2022). A Scoping Review of the Global Distribution of Causes and Syndromes Associated with Mid-to Late-Term Pregnancy Loss in Horses between 1960 and 2020. In Veterinary Sciences (Vol. 9, Issue 4). MDPI. https://doi.org/10.3390/vetsci9040186 Meirelles, M. G., Alonso, M. A., Affonso, F. J., Oliveira Favaron, P., Miglino, M. A., & Fernandes, C. B. (n.d.). Disponível em. In Rev. Bras. Reprod. Anim (Issue 1). www.cbra.org.br Morfin, R., & Courchay, G. (1994). Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. Journal of Steroid Biochemistry and Molecular Biology, 50(1–2), 91–100. https://doi.org/10.1016/0960-0760(94)90176-7 Moslemi, S., Silberzahn, P., & Gaillard, J. L. (1995). The synthesis of 19-norandrostenedione from dehydroepiandrosterone in equine placenta is inhibited by aromatase inhibitors 4-hydroxyandrostenedione and fadrozole. Comparative Biochemistry and Physiology -- Part B: Biochemistry And, 112(4), 613–618. https://doi.org/10.1016/0305-0491(95)00117-4 Nagel, C., Aurich, J., & Aurich, C. (2011). Heart rate and heart rate variability in the pregnant mare and its foetus. Reproduction in Domestic Animals, 46(6), 990–993. https://doi.org/10.1111/j.1439-0531.2011.01772.x Nef, S., & Parada, L. F. (2000). Hormones in male sexual development. In Genes and Development (Vol. 14, Issue 24, pp. 3075–3086). https://doi.org/10.1101/gad.843800 Noronha, L. E., Huggler, K. E., de Mestre, A. M., Miller, D. C., & Antczak, D. F. (2012). Molecular evidence for natural killer-like cells in equine endometrial cups. Placenta, 33(5), 379–386. https://doi.org/10.1016/j.placenta.2012.01.018 Ousey, J. C. (2004). Peripartal endocrinology in the mare and foetus. Reproduction in Domestic Animals, 39(4), 222–231. https://doi.org/10.1111/j.1439-0531.2004.00507.x Ousey, J. C. (2006). Hormone Profiles and Treatments in the Late Pregnant Mare. Veterinary Clinics of North America - Equine Practice, 22(3), 727–747. https://doi.org/10.1016/j.cveq.2006.08.004 Ousey, J. C., Forhead, A. J., Rossdale, P. D., Grainger, L., Houghton, E., & Fowden, A. L. (2003). Ontogeny of uteroplacental progestagen production in pregnant mares during the second half of gestation. Biology of Reproduction, 69(2), 540–548. https://doi.org/10.1095/biolreprod.102.013292 Ousey, J. C., Houghton, E., Grainger, L., Rossdale, P. D., & Fowden, A. L. (2005). Progestagen profiles during the last trimester of gestation in Thoroughbred mares with normal or compromised pregnancies. Theriogenology, 63(7), 1844–1856. https://doi.org/10.1016/j.theriogenology.2004.08.010 Pashen, R. L. (1984). Maternal and foetal endocrinology during late pregnancy and parturition in the mare. Equine Veterinary Journal, 16(4), 233–238. https://doi.org/10.1111/j.2042-3306.1984.tb01918.x Prough, R. A., Clark, B. J., & Klinge, C. M. (2016). Novel mechanisms for DHEA action. In Journal of Molecular Endocrinology (Vol. 56, Issue 3, pp. R139–R155). BioScientifica Ltd. https://doi.org/10.1530/JME-16-0013 Raeside, J. I. (1976). Dehydroepiandrosterone in the fetal gonads of the horse. Journal of Reproduction and Fertility, 46(2), 423–425. https://doi.org/10.1530/jrf.0.0460423 Raeside, J. I., Christie, H. L., & Betteridge, K. J. (2015). 5Alpha-reduced steroids are major metabolites in the early equine embryo proper and its membranes. Biology of Reproduction, 93(3), 1–8. https://doi.org/10.1095/biolreprod.115.131680 Rance, T. A., & Park, B. K. (1978). The measurement of oestrone, equilin and dehydroepiandrosterone in the peripheral plasma of pregnant pony mares by radioimmunoassay. Journal of Steroid Biochemistry, 9(11), 1065–1069. https://doi.org/10.1016/0022-4731(78)90033-X Reef, V. B., Vaala, W. E., Worth, L. T., Spencer, P. A., & Hammett, B. (1995). Ultrasonographic Evaluation of the Fetus and Intrauterine Environment in Healthy Mares During Late Gestation. Veterinary Radiology & Ultrasound, 36(6), 533–541. https://doi.org/10.1111/j.1740-8261.1995.tb00308.x Rege, J., Nakamura, Y., Wang, T., Merchen, T. D., Sasano, H., & Rainey, W. E. (2014). Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis. Journal of Clinical Endocrinology and Metabolism, 99(3). https://doi.org/10.1210/jc.2013-3198 Renaudin, C. D., Troedsson, M. H. 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dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
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dc.format.extent.spa.fl_str_mv	xix, 51 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.coverage.country.spa.fl_str_mv	Colombia
dc.coverage.tgn.none.fl_str_mv	http://vocab.getty.edu/page/tgn/1000050
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animal
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina Veterinaria y de Zootecnia
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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repository.name.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lozano Márquez, Harveyda2561b42defd9b27db09535e7e6af5a600Paredes Cañón, Astrid Lucilab1f5912efe63938e21732a52589e6626Reproducción Animal y Salud de Hato2023-06-13T20:17:40Z2023-06-13T20:17:40Z2023-06https://repositorio.unal.edu.co/handle/unal/84013Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustracionesLa determinación de parámetros de viabilidad fetal por medio de la evaluación sérica de la dehidroepiandrosterona (DHEA) y la ultrasonografía transrectal, son de gran importancia para el diagnóstico y monitoreo de la gestación equina. El objetivo de este estudio fue determinar la concentración sérica de DHEA en yeguas de grupo racial criollo colombiano y la asociación de los cambios ultrasonográficos de la placenta a partir del día 90 hasta el 320 de la gestación. Se realizó un estudio prospectivo, con una población escogida a conveniencia de 23 yeguas gestantes, a las cuales se les realizó examen clínico, ultrasonográfico y toma de muestras sanguíneas, estas, se tomaron a partir del día 90 de gestación con intervalos de 30 días. La concentración sérica de DHEA fue medida por un ensayo de ELISA y se implementó un modelo de medidas repetidas en el tiempo para analizar los datos obtenidos. La concentración de DHEA arrojó valores de 2,79 ± 0,328 a 2,10 ± 0,328 ng/ml, teniendo en cuenta que el rango de detección va de 2 a 10 ng/ml, se evidenció una asociación entre el aumento del grosor útero-placentario y la concentración sérica, relacionado con el desarrollo fetal. No se presentaron diferencias estadísticamente significativas indicando que los valores obtenidos pueden ser determinantes de viabilidad fetal; dentro del estudio se presentaron cuatro abortos, con valores de DHEA de 1,31 ± 0,09; 1,21 ± 0,41; 1,31 ± 0,42; 1,87 ± 0,60 ng/ml, infiriendo que estos valores por debajo del rango normal pueden ser indicativo de aborto. (Texto tomado de la fuente).The determination of fetal viability parameters through the serum evaluation of dehydroepiandrosterone (DHEA) and transrectal ultrasonography are of great importance for the diagnosis and monitoring of equine pregnancy. The objective of this study was to determine the serum concentration of DHEA in mares of the Colombian Creole breed group and the association of ultrasonographic changes of the placenta from day 90 to 320 of gestation. A prospective study was carried out, with a population chosen at convenience of 23 pregnant mares, which underwent clinical, ultrasonographic examination and blood sampling, these were taken from day 90 of gestation with intervals of 30 days. Serum DHEA concentration was measured by an ELISA assay and a repeated measures model was implemented over time to analyze the data obtained. The DHEA concentration yielded values of 2.79 ± 0.328 to 2.10 ± 0.328 ng/ml, considering that the detection range goes from 2 to 10 ng/ml, an association was evidenced between the increase in uterine thickness- placental and serum concentration, related to fetal development. There were no statistically significant differences, indicating that the values obtained may be determinants of fetal viability; Within the study, four abortions occurred, with DHEA values of 1.31 ± 0.09; 1.21 ± 0.41; 1.31 ± 0.42; 1.87 ± 0.60 ng/ml, inferring that these values below the normal range may be indicative of abortion.MaestríaMagíster en Salud Animal o Magíster en Producción AnimalTeriogenologiaxix, 51 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción AnimalFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animalesFertilidadTrastornos de la reproducciónfertilityreproductive disordersDeshidroepiandrosterona/análisisDehydroepiandrosterone/analysisDehidroepiandrosteronaEsteroideDesarrollo fetalGestacionUltrasonografiaViabilidad fetalAbortoDehydroepiandrosteroneSteroidFetal developmentPregnancyUltrasonographyAbortionFetal viabilityEvaluación de la viabilidad fetal en yeguas criollas colombianas a través de la medición sérica de Dehidroepiandrosterona (DHEA)Evaluation of fetal viability in Colombian criollo mares through the serum measurement of Dehydroepiandrosterone (DHEA)Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMColombiahttp://vocab.getty.edu/page/tgn/1000050Allen, W. 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A comparison of progesterone assays for determination of peripheral pregnane concentrations in the late pregnant mare. Theriogenology, 106, 127–133. https://doi.org/10.1016/j.theriogenology.2017.10.002EstudiantesGrupos comunitariosInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84013/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53ORIGINAL1076652012 2023.pdf1076652012 2023.pdfTesis de Maestria en Salud Animalapplication/pdf737390https://repositorio.unal.edu.co/bitstream/unal/84013/4/1076652012%202023.pdf8f9fe382ff799d03357ac6fef7c59be3MD54THUMBNAIL1076652012 2023.pdf.jpg1076652012 2023.pdf.jpgGenerated Thumbnailimage/jpeg5532https://repositorio.unal.edu.co/bitstream/unal/84013/5/1076652012%202023.pdf.jpg7ab67d796717ad2253d20fa7f360c99aMD55unal/84013oai:repositorio.unal.edu.co:unal/840132023-08-09 23:04:14.389Repositorio Institucional Universidad Nacional de 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