Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo
ilustraciones, fotografías, graficas
- Autores:
-
Ocampo Páramo, Adolfo Mario
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/82052
- Palabra clave:
- 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Huesos
TEJIDO OSEO
Osteoporosis
Andamio
Extrusión
Impresión
Electrohidrodinámico
Osteoporosis
Scaffolding
Extrusion
Printing
Electrohydrodynamic
3D
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| dc.title.translated.eng.fl_str_mv |
Design of an electrohydrodynamic 3D printing system to improve the resolution of printed scaffolds for bone tissue |
| title |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| spellingShingle |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería Huesos TEJIDO OSEO Osteoporosis Andamio Extrusión Impresión Electrohidrodinámico Osteoporosis Scaffolding Extrusion Printing Electrohydrodynamic 3D |
| title_short |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| title_full |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| title_fullStr |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| title_full_unstemmed |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| title_sort |
Diseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseo |
| dc.creator.fl_str_mv |
Ocampo Páramo, Adolfo Mario |
| dc.contributor.advisor.none.fl_str_mv |
Clavijo Grimaldo, Dianney |
| dc.contributor.author.none.fl_str_mv |
Ocampo Páramo, Adolfo Mario |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Biomecánica / Universidad Nacional de Colombia Gibm-Uncb |
| dc.subject.ddc.spa.fl_str_mv |
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería |
| topic |
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería Huesos TEJIDO OSEO Osteoporosis Andamio Extrusión Impresión Electrohidrodinámico Osteoporosis Scaffolding Extrusion Printing Electrohydrodynamic 3D |
| dc.subject.other.eng.fl_str_mv |
Huesos |
| dc.subject.lemb.spa.fl_str_mv |
TEJIDO OSEO |
| dc.subject.proposal.spa.fl_str_mv |
Osteoporosis Andamio Extrusión Impresión Electrohidrodinámico |
| dc.subject.proposal.eng.fl_str_mv |
Osteoporosis Scaffolding Extrusion Printing Electrohydrodynamic |
| dc.subject.proposal.none.fl_str_mv |
3D |
| description |
ilustraciones, fotografías, graficas |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-08-24T13:13:13Z |
| dc.date.available.none.fl_str_mv |
2022-08-24T13:13:13Z |
| dc.date.issued.none.fl_str_mv |
2022 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/TM |
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acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/82052 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/82052 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
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RedCol LaReferencia |
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Aurel ARION, TG Dobrescu, and Nicoleta-Elisabeta PASCU. 3d surface modelling aspects for 3d printing. Proceedings in Manufacturing Systems, 9(4):199–204, 2014. Jingwei Xie, Jiang Jiang, Pooya Davoodi, Madapusi P Srinivasan, and Chi-Hwa Wang. Electrohydrodynamic atomization: A two-decade effort to produce and process micro- /nanoparticulate materials. Chemical engineering science, 125:32–57, 2015. Cem Balda Dayan, Ferdows Afghah, Burcu Saner Okan, Mehmet Yıldız, Yusuf Mence- loglu, Mustafa Culha, and Bahattin Koc. Modeling 3d melt electrospinning writing by response surface methodology. Materials & Design, 148:87–95, 2018. Yuan Jin, Qing Gao, Chaoqi Xie, Guangyong Li, Jianke Du, Jianzhong Fu, and Yong He. Fabrication of heterogeneous scaffolds using melt electrospinning writing: Design and optimization. Materials & Design, 185:108274, 2020. Kai Li, Dazhi Wang, Kuipeng Zhao, Kedong Song, and Junsheng Liang. Electrohy- drodynamic jet 3d printing of pcl/pvp composite scaffold for cell culture. Talanta, 211:120750, 2020. Trinath Biswal, Sushant Kumar BadJena, and Debabrata Pradhan. Sustainable bioma- terials and their applications: A short review. Materials Today: Proceedings, 2020. Patitapabana Parida, Ajit Behera, and S Chandra Mishra. Classification of biomaterials used in medicine. 2012. Toktam Ghassemi, Azadeh Shahroodi, Mohammad H Ebrahimzadeh, Alireza Mousa- vian, Jebraeel Movaffagh, and Ali Moradi. Current concepts in scaffolding for bone tissue engineering. Archives of Bone and Joint Surgery, 6(2):90, 2018. Masami Okamoto and Baiju John. Synthetic biopolymer nanocomposites for tissue engineering scaffolds. Progress in Polymer Science, 38(10-11):1487–1503, 2013. Alexandros Repanas, Sofia Andriopoulou, and Birgit Glasmacher. The significance of electrospinning as a method to create fibrous scaffolds for biomedical engineering and drug delivery applications. Journal of Drug Delivery Science and Technology, 31:137– 146, 2016. Gloria I Ruiz-Henao, Henry Mauricio Arenas-Quintero, Jorge M. Estrada-a ́lvarez, and Yuledy Villegas-Mun ̃oz. Trastornos de la densidad mineral ́osea en personas con vih en tratamiento antirretroviral pereira- risaralda-colombia, 2017. Luis Alonso González, Gloria María Vásquez, and José Fernando Molina. Epidemiology of osteoporosis, 2009. Jonatan Miguel-Carrera, Carlos García-Porrua, Francisco Javier de Toro Santos, and Jose Antonio Picallo-Sánchez. Prevalencia de osteoporosis, estimación de la probabilidad de fractura y estudio del metabolismo óseo en pacientes con reciente diagnóstico de cáncer de próstata en el área sanitaria de lugo. Atención Primaria, 50(3):176–183, 2018. Manuel Muñoz Torres, M Varsavsky, and MD Avilés Pérez. Osteoporosis. definición. epidemiología - revista de osteoporosis y metabolismo mineral - publicación oficial seiomm, 2010. Flores-Figueroa, E., Montesinos, J. J., & Mayani, H. (2006). Células troncales mesenquimales: historia, biología y aplicación clínica. Revista de investigación clínica, 58(5), 498-511. Elena Fernández Burguera. Ingeniería de tejidos. Vijayavenkataraman, S., Yan, W. C., Lu, W. F., Wang, C. H., & Fuh, J. Y. H. (2018). 3D bioprinting of tissues and organs for regenerative medicine. Advanced drug delivery reviews, 132, 296-332. Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isa- bella Bartolotti, and Brunella Grigolo. Scaffolds for bone tissue engineering: State of the art and new perspectives. Materials Science and Engineering: C, 78:1246–1262, 2017. Ibrahim T. Ozbolat and Monika Hospodiuk. Current advances and future perspectives in extrusion-based bioprinting. Biomaterials, 76:321–343, 2016. Barrero, A., Márquez, M., & Loscertales, I. G. (2005). Microchorros y nanochorros. Investigación y ciencia, (351), 44-51. Jingwei Xie, Jiang Jiang, Pooya Davoodi, Madapusi P Srinivasan, and Chi-Hwa Wang. 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Dianney Clavijo-Grimaldo, Nubia Ponce-Zapata, and Ciro Casadiego-Torrado. Control of bacterial proliferation and formation of biofilm in membranes for food packaging manufactured by electrospinning. Chemical Engineering Transactions, 75:241–246, 2019. L Ghasemi-Mobarakeh, D Semnani, and M Morshed. A novel method for porosity measurement of various surface layers of nanofibers mat using image analysis for tissue engineering applications. Journal of applied polymer science, 106(4):2536–2542, 2007. Ralph E Holmes, Robert W Wardrop, and Larry M Wolford. Hydroxylapatite as a bone graft substitute in orthognathic surgery: histologic and histometric findings. Journal of oral and maxillofacial surgery, 46(8):661–671, 1988. Hideki Yoshikawa, Noriyuki Tamai, Tsuyoshi Murase, and Akira Myoui. Interconnected porous hydroxyapatite ceramics for bone tissue engineering. Journal of the Royal Society Interface, 6(suppl 3):S341–S348, 2009. 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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Clavijo Grimaldo, Dianney4b13611d3332df5d0ea7077fa160b1faOcampo Páramo, Adolfo Mariofa64a0a4f59f310e58161f8560e5edccGrupo de Investigación en Biomecánica / Universidad Nacional de Colombia Gibm-Uncb2022-08-24T13:13:13Z2022-08-24T13:13:13Z2022https://repositorio.unal.edu.co/handle/unal/82052Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, graficasLa osteoporosis es una patología esquelética caracterizada por la perdida de masa ósea que, dependiendo el riesgo del paciente, requiere desde tratamientos farmacéuticos hasta intervenciones quirúrgicas. Los fármacos se encargan de compensar dicha perdida ósea, mas no previenen la ocurrencia de una fractura. Ante la eventualidad de una fractura se recurre a la cirugía donde utilizando diferentes tipos de biomateriales se fabrican andamios óseos para reemplazar el tejido perdido y/o afectado. Una de las técnicas comunes de fabricación de estos andamios es la impresión por extrusión, debido a su facilidad de implementación. Sin embargo, esta técnica cuenta con importantes limitaciones, en cuanto a resolución se trata, refiriéndose así al diámetro de las fibras y porosidad. Estas características son fundamentales para imitar las propiedad de un tejido óseo sano, lo que se desea para que el proceso curativo del paciente se de de la forma deseada. Con el fin de lograr andamios que biomimeticen el ambiente celular óseo, desde hace unos años se han estudiado diferentes técnicas de impresión de andamios, una de ellas es la impresión Electrohidrodinámica(EHDA). Con este método de impresión se pretende mejorar la resolución de los andamios que se han venido realizando por extrusión. En el presente proyecto se inicio modificando el equipo de impresión EHDA, agregando un mecanismo de movimiento en los ejes XY para movilizar la base colectora y así habilitar la impresión 3D, dé tal forma que los resultados a obtener entre los dos sistemas de impresión EHDA vs Extrusión sean comparables. Se fabricaron andamios tanto por extrusión como por Electrospinning. Por medio del microscopio electrónico de barrido se obtuvieron imágenes detalladas de cada uno. Con dichas imágenes se procedió a realizar las respectivas medidas de porosidad y diámetro de fibras para cada andamio impreso, tanto por extrusión como por EHDA, utilizando el método de análisis de imagen por medio del software ``Image J" (National Institutes of Health). Al comparar los datos se obtiene que con la técnica de Electrospinning se pueden fabricar andamios a partir de nano y micro fibras, mientras que con la técnica de Extrusión las fibras se encuentran en el orden de los micrómetros y milímetros. Los poros para los andamios se encuentran en el mismo orden del tamaño de sus fibras, esto quiere decir que los andamios fabricados por Electrospinning cuentan con un tamaño de poros considerablemente menor a los fabricados por Extrusión, que a su vez indica que para la fabricación de andamios óseos la técnica EHDA es una mejor opción, puesto que es capaz de emular con mayor fidelidad el ambiente celular óseo propicio para la proliferación y supervivencia de este tipo celular. (Texto tomado de la fuente)Osteoporosis is a skeletal pathology characterized by the loss of bone mass that, depending on the patient's risk, requires from pharmaceutical treatments to surgical interventions. The drugs are responsible for compensating for this bone loss, but they do not prevent the occurrence of a fracture. In the event of a fracture, surgery is used where, using different types of biomaterials, bone scaffolds are manufactured to replace the lost and/or affected tissue. One of the common manufacturing techniques for these scaffolds is extrusion printing, due to its ease of implementation. However, this technique has important limitations, in terms of resolution, referring to the diameter of the fibers and porosity. These characteristics are essential to imitate the properties of healthy bone tissue, which is desired so that the patient's healing process occurs as desired. In order to achieve scaffolds that biomimetic the bone cell environment, different scaffold printing techniques have been studied for a few years, one of them is Electrohydrodynamic printing (EHDA). With this printing method it is intended to improve the resolution of the scaffolds that have been made by extrusion. In this project, we began by modifying the EHDA printing equipment, adding a movement mechanism in the XY axes to mobilize the collector base and thus enable 3D printing, in such a way that the results to be obtained between the two EHDA printing systems vs. Extrusion are comparable. Scaffolds were manufactured both by extrusion and Electrospinning. Detailed images of each were obtained by means of the scanning electron microscope. With these images, the respective measurements of porosity and fiber diameter were made for each printed scaffold, both by extrusion and by EHDA, using the image analysis method using the ``Image J" software (National Institutes of Health). When comparing the data, it is obtained that with the Electrospinning technique, scaffolds can be manufactured from nano and micro fibers, while with the Extrusion technique, the fibers are in the order of micrometers and millimeters. The pore size in the scaffolds are in the same order of size of their fibers, this means that the scaffolds manufactured by Electrospinning have a considerably smaller pore size than those manufactured by Extrusion, which in turn indicates that for the manufacture of bone scaffolds the EHDA technique it is a better option, since it is able to more faithfully emulate the bone cell environment propitious to the proliferation and survival of this cell type.Ministerio de Ciencia, tecnología e innovación de Colombia, la Fundación Universidad Sanitas y la Universidad Nacional de Colombia financiaron gran parte de esta investigación a través del proyecto Código 1101744555730 (Contrato 630-2017).MaestríaMagíster en Ingeniería BiomédicaBiomaterialesxvi, 92 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Ingeniería BiomédicaDepartamento de MorfologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaHuesosTEJIDO OSEOOsteoporosisAndamioExtrusiónImpresiónElectrohidrodinámicoOsteoporosisScaffoldingExtrusionPrintingElectrohydrodynamic3DDiseño de un sistema de impresión electrohidrodinámico 3D para mejorar la resolución de andamios impresos para el tejido óseoDesign of an electrohydrodynamic 3D printing system to improve the resolution of printed scaffolds for bone tissueTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMRedColLaReferenciaAurel ARION, TG Dobrescu, and Nicoleta-Elisabeta PASCU. 3d surface modelling aspects for 3d printing. 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Journal of the Mechanical Behavior of Biomedical Materials, 117:104378, 2021.Código 1101744555730 (Contrato 630-2017)Ministerio de Ciencia, tecnología e innovación de ColombiaFundación Universidad SanitasUniversidad Nacional de ColombiaEstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/82052/2/license.txt8153f7789df02f0a4c9e079953658ab2MD52ORIGINAL1018484140.2022.pdf1018484140.2022.pdfTesis de Maestría en Ingeniería Biomédicaapplication/pdf102651608https://repositorio.unal.edu.co/bitstream/unal/82052/3/1018484140.2022.pdfab3d53f0c525b86d038b64736de54f75MD53THUMBNAIL1018484140.2022.pdf.jpg1018484140.2022.pdf.jpgGenerated Thumbnailimage/jpeg4925https://repositorio.unal.edu.co/bitstream/unal/82052/4/1018484140.2022.pdf.jpg7998ecf224da33d80aa1ec1b2ffc8473MD54unal/82052oai:repositorio.unal.edu.co:unal/820522024-08-08 23:11:59.662Repositorio Institucional Universidad Nacional de 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