Solubility of acetaminophen in poliol-alcohol-water system

Acetaminophen solubility was determined to 20.0 ± 0.5°C in solvent mixtures: Purified Water – Alcohol USP – Propylene glycol USP, as well as in the solvent mixture Purified Water – Alcohol USP – Polyethylene glycol 200 NF, establishing the lines of isosolubility that go to define the composi...

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Autores:
Coronado, Yanneth Patricia
Fonseca, Juan Camilo
Luengas, Pilar Ester
Barbosa, Helber
Martínez, Fleming
Tipo de recurso:
Article of journal
Fecha de publicación:
1999
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/23778
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/23778
http://bdigital.unal.edu.co/14815/
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openAccess
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Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Coronado, Yanneth Patricia0abae063-b4e3-467f-a169-9293ede57be5300Fonseca, Juan Camilof57683ae-00cf-410d-b931-c7454bc5bea4300Luengas, Pilar Ester289b1dfa-855f-4845-95bf-22f443b19a5f300Barbosa, Helberaa823656-1d2a-4887-a972-4331d8762572300Martínez, Flemingbe007cbd-0d6f-4f71-bc0c-9a77ef95fca23002019-06-25T21:18:36Z2019-06-25T21:18:36Z1999https://repositorio.unal.edu.co/handle/unal/23778http://bdigital.unal.edu.co/14815/Acetaminophen solubility was determined to 20.0 ± 0.5°C in solvent mixtures: Purified Water – Alcohol USP – Propylene glycol USP, as well as in the solvent mixture Purified Water – Alcohol USP – Polyethylene glycol 200 NF, establishing the lines of isosolubility that go to define the composition regions of the solvent mixtures in study more probable for the design in a homogenity liquid form of Acetaminophen in each one of the studied systems. It was found that the addition of the Polyethylene glycol 200 to hydroalcoholic mix does not affect of meaningful way the solubility of the Acetaminophen, if the binary relations are appropiate, depending the quantity of polyol added; while upon adding Propylene glycol USP, the solubilities obtained for the hidroalcoholic mixtures are seen reduced.Se determinó la solubilidad del Acetaminofén USP a 20.0 ± 0.5ºC en mezclas solventes representativas de los sistemas Agua Purificada – Alcohol USP – Propilenoglicol USP y Agua Purificada – Alcohol USP – Polietilenoglicol 200 NF, estableciendo las líneas de isosolubilidad en coordenadas triangulares, que definen las regiones de composición de las mezclas solventes en estudio más útiles para el diseño de formas líquidas homogéneas de este fármaco en cada uno de los sistemas estudiados. Se encontró que la adición del Polietilenoglicol 200 a la mezcla hidroalcohólica no afecta de manera significativa la solubilidad del Acetaminofén siempre y cuando la relación de la mezcla binaria Agua – Alcohol se encuentre en las proporciones adecuadas, según la cantidad de poliol adicionado; mientras que al adicionar Propilenoglicol USP, las solubilidades obtenidas para las mezclas hidroalcohólicas se ven disminuidas.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/9172Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356Coronado, Yanneth Patricia and Fonseca, Juan Camilo and Luengas, Pilar Ester and Barbosa, Helber and Martínez, Fleming (1999) Solubility of acetaminophen in poliol-alcohol-water system. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .Solubility of acetaminophen in poliol-alcohol-water systemArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL9172-15371-1-PB.pdfapplication/pdf196821https://repositorio.unal.edu.co/bitstream/unal/23778/1/9172-15371-1-PB.pdf1769c408f7357d8c74d7d25eb6221314MD51THUMBNAIL9172-15371-1-PB.pdf.jpg9172-15371-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg2336https://repositorio.unal.edu.co/bitstream/unal/23778/2/9172-15371-1-PB.pdf.jpgb6c4fd3b4600c32607c56d702c1f2680MD52unal/23778oai:repositorio.unal.edu.co:unal/237782023-10-13 23:06:16.056Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Solubility of acetaminophen in poliol-alcohol-water system
title Solubility of acetaminophen in poliol-alcohol-water system
spellingShingle Solubility of acetaminophen in poliol-alcohol-water system
title_short Solubility of acetaminophen in poliol-alcohol-water system
title_full Solubility of acetaminophen in poliol-alcohol-water system
title_fullStr Solubility of acetaminophen in poliol-alcohol-water system
title_full_unstemmed Solubility of acetaminophen in poliol-alcohol-water system
title_sort Solubility of acetaminophen in poliol-alcohol-water system
dc.creator.fl_str_mv Coronado, Yanneth Patricia
Fonseca, Juan Camilo
Luengas, Pilar Ester
Barbosa, Helber
Martínez, Fleming
dc.contributor.author.spa.fl_str_mv Coronado, Yanneth Patricia
Fonseca, Juan Camilo
Luengas, Pilar Ester
Barbosa, Helber
Martínez, Fleming
description Acetaminophen solubility was determined to 20.0 ± 0.5°C in solvent mixtures: Purified Water – Alcohol USP – Propylene glycol USP, as well as in the solvent mixture Purified Water – Alcohol USP – Polyethylene glycol 200 NF, establishing the lines of isosolubility that go to define the composition regions of the solvent mixtures in study more probable for the design in a homogenity liquid form of Acetaminophen in each one of the studied systems. It was found that the addition of the Polyethylene glycol 200 to hydroalcoholic mix does not affect of meaningful way the solubility of the Acetaminophen, if the binary relations are appropiate, depending the quantity of polyol added; while upon adding Propylene glycol USP, the solubilities obtained for the hidroalcoholic mixtures are seen reduced.
publishDate 1999
dc.date.issued.spa.fl_str_mv 1999
dc.date.accessioned.spa.fl_str_mv 2019-06-25T21:18:36Z
dc.date.available.spa.fl_str_mv 2019-06-25T21:18:36Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/14815/
url https://repositorio.unal.edu.co/handle/unal/23778
http://bdigital.unal.edu.co/14815/
dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv http://revistas.unal.edu.co/index.php/rccquifa/article/view/9172
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas
Revista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.ispartofseries.none.fl_str_mv Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356
dc.relation.references.spa.fl_str_mv Coronado, Yanneth Patricia and Fonseca, Juan Camilo and Luengas, Pilar Ester and Barbosa, Helber and Martínez, Fleming (1999) Solubility of acetaminophen in poliol-alcohol-water system. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
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dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
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institution Universidad Nacional de Colombia
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