Solubility of acetaminophen in poliol-alcohol-water system
Acetaminophen solubility was determined to 20.0 ± 0.5°C in solvent mixtures: Purified Water – Alcohol USP – Propylene glycol USP, as well as in the solvent mixture Purified Water – Alcohol USP – Polyethylene glycol 200 NF, establishing the lines of isosolubility that go to define the composi...
- Autores:
-
Coronado, Yanneth Patricia
Fonseca, Juan Camilo
Luengas, Pilar Ester
Barbosa, Helber
Martínez, Fleming
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 1999
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/23778
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/23778
http://bdigital.unal.edu.co/14815/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
| Summary: | Acetaminophen solubility was determined to 20.0 ± 0.5°C in solvent mixtures: Purified Water – Alcohol USP – Propylene glycol USP, as well as in the solvent mixture Purified Water – Alcohol USP – Polyethylene glycol 200 NF, establishing the lines of isosolubility that go to define the composition regions of the solvent mixtures in study more probable for the design in a homogenity liquid form of Acetaminophen in each one of the studied systems. It was found that the addition of the Polyethylene glycol 200 to hydroalcoholic mix does not affect of meaningful way the solubility of the Acetaminophen, if the binary relations are appropiate, depending the quantity of polyol added; while upon adding Propylene glycol USP, the solubilities obtained for the hidroalcoholic mixtures are seen reduced. |
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