Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables
ilustraciones, fotografías, gráficas, tablas
- Autores:
-
Toro Bernal, Fernando
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/82966
- Palabra clave:
- 610 - Medicina y salud::615 - Farmacología y terapéutica
Embalaje de Medicamentos
Etiquetado de Medicamentos
Redes de Comunicación de Computadores
Drug Packaging
Drug Labeling
Computer Communication Networks
Farmacovigilancia
Errores de medicación
Medicamentos LASARA
Web 2.0
No-code
Pharmacovigilance
Medication errors
Look-alike drug
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
| id |
UNACIONAL2_341b6d27243440d29a14715b44c138e7 |
|---|---|
| oai_identifier_str |
oai:repositorio.unal.edu.co:unal/82966 |
| network_acronym_str |
UNACIONAL2 |
| network_name_str |
Universidad Nacional de Colombia |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| dc.title.translated.eng.fl_str_mv |
Design and validation of an instrument for the identification of look-alike drug in the primary packaging of injectables products |
| title |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| spellingShingle |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables 610 - Medicina y salud::615 - Farmacología y terapéutica Embalaje de Medicamentos Etiquetado de Medicamentos Redes de Comunicación de Computadores Drug Packaging Drug Labeling Computer Communication Networks Farmacovigilancia Errores de medicación Medicamentos LASARA Web 2.0 No-code Pharmacovigilance Medication errors Look-alike drug |
| title_short |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| title_full |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| title_fullStr |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| title_full_unstemmed |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| title_sort |
Diseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectables |
| dc.creator.fl_str_mv |
Toro Bernal, Fernando |
| dc.contributor.advisor.spa.fl_str_mv |
López Gutiérrez, José Julián |
| dc.contributor.author.spa.fl_str_mv |
Toro Bernal, Fernando |
| dc.contributor.researchgroup.spa.fl_str_mv |
Red para el uso Adecuado de Medicamentos (RAM) |
| dc.contributor.webdeveloper.spa.fl_str_mv |
Telaraña Farmacéutica |
| dc.contributor.orcid.spa.fl_str_mv |
https://orcid.org/0000-0003-3222-743X |
| dc.contributor.researchgate.spa.fl_str_mv |
https://www.researchgate.net/profile/Fernando-Toro-Bernal |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::615 - Farmacología y terapéutica |
| topic |
610 - Medicina y salud::615 - Farmacología y terapéutica Embalaje de Medicamentos Etiquetado de Medicamentos Redes de Comunicación de Computadores Drug Packaging Drug Labeling Computer Communication Networks Farmacovigilancia Errores de medicación Medicamentos LASARA Web 2.0 No-code Pharmacovigilance Medication errors Look-alike drug |
| dc.subject.decs.spa.fl_str_mv |
Embalaje de Medicamentos Etiquetado de Medicamentos Redes de Comunicación de Computadores |
| dc.subject.decs.eng.fl_str_mv |
Drug Packaging Drug Labeling Computer Communication Networks |
| dc.subject.proposal.spa.fl_str_mv |
Farmacovigilancia Errores de medicación Medicamentos LASARA Web 2.0 |
| dc.subject.proposal.eng.fl_str_mv |
No-code Pharmacovigilance Medication errors Look-alike drug |
| description |
ilustraciones, fotografías, gráficas, tablas |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022-07-07 |
| dc.date.accessioned.none.fl_str_mv |
2023-01-17T02:02:52Z |
| dc.date.available.none.fl_str_mv |
2023-01-17T02:02:52Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/82966 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/82966 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.indexed.spa.fl_str_mv |
Bireme |
| dc.relation.references.spa.fl_str_mv |
Organización Mundial de la Salud. La OMS lanza una iniciativa mundial para reducir a la mitad los errores relacionados con la medicación en cinco años [Internet]. Organización Mundial de la Salud. 2017 [cited 2020 Aug 31]. p. 1. Available from: https://www.who.int/es/news-room/detail/29-03-2017-who-launches-global-effort-to-halve-medication-related-errors-in-5-years World Health Organization. Global campaign: Medication Without Harm [Internet]. World Health Organization. [cited 2020 Aug 31]. p. 1. Available from: https://www.who.int/initiatives/medication-without-harm Palacio Lapuente F, Hernández Rodríguez M a. Isoapariencia. Una necesidad imperiosa en la prescripción por denominación oficial española. Atención Primaria [Internet]. 2011 Dec;43(12):625–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0212656711005014 Organización Mundial de la Salud. Sistemas de notificación y aprendizaje sobre errores de medicación: el papel de los centros de farmacovigilancia [Internet]. Ginebra; 2018 [cited 2020 Aug 31]. Available from: https://apps.who.int/iris/bitstream/handle/10665/276898/9789243507941-spa.pdf?sequence=1&isAllowed=y Jiménez F, Valcárcel R, Vaca C, Orozco J, López J AN. Suplemento No. 1 Conceptos Básicos en Farmacovigilancia. Boletín Farmacovigil [Internet]. 2006 [cited 2020 Aug 31];12(1):1–7. Available from: https://xdoc.mx/preview/suplemento-del-boletin-12-2006-5c1aa59a9312e World Health Organization. The third WHO Global Patient Safety Challenge: Medication Without Harm [Internet]. World Health Organization. [cited 2020 Sep 1]. p. 1. Available from: https://www.who.int/publications/i/item/BLT.17.198002 World Health Organization. Medication Without Harm - WHO Global Patient Safety Challenge [Internet]. 2017 [cited 2020 Sep 1]. p. 1–16. Available from: http://apps.who.int/iris/bitstream/10665/255263/1/WHO-HIS-SDS-2017.6-eng.pdf?ua=1&ua=1 World Health Organization. Medication Without Harm: Real-life stories [Internet]. Patient stories of harm. 2017 [cited 2020 Sep 7]. p. 1. Available from: https://www.who.int/news-room/photo-story/photo-story-detail/medication-without-harm-real-life-stories Montero Delgado J a., Plata Paniagua S, Arenas Villafranca J j. El problema de la isoapariencia de medicamentos en España: es hora de actuar. J Healthc Qual Res [Internet]. 2020 Mar;35(2):126–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2603647920300191 ISanidad. Condenados por homicidio imprudente dos enfermeros del Hospital Infanta Cristina [Internet]. ASP. 2016 [cited 2020 Sep 14]. p. 1. Available from: http://isanidad.com/75208/condenados-por-homicidio-imprudente-dos-enfermeros-del-hospital-infanta-cristina/%0A Delegación Española del Institute for Safe Medication Practices. Sistema de Notificación y Aprendizaje de Errores de Medicación - Etiquetado/envasado proclive a error [Internet]. Instituto Para El Uso Seguro De Los Medicamentos Delegación Española. 2020 [cited 2020 Sep 14]. p. 1. Available from: http://www.ismp-espana.org/envasado_proclive_error/index Montero Delgado JA. Stop Errores de Medicación [Internet]. Stop Errores de Medicación. 2020 [cited 2020 Sep 14]. p. 1. Available from: https://www.stoperroresdemedicacion.org/ Ministerio de Salud de Colombia. Mejorar La Seguridad En La Utilización De Medicamentos [Internet]. Bogotá; 2015 [cited 2020 Sep 14]. p. 1–133. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/CA/seguridad-en-la-utilizacion-de-medicamentos.pdf Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Guía para los usuarios sobre lineamientos en visitas de seguimiento a los programas de farmacovigilancia para establecimientos pertenecientes a la red nacional de farmacovigilancia [Internet]. 2016 [cited 2020 Sep 14]. p. 1–18. Available from: https://es.scribd.com/document/407612761/IVC-VIG-GU009-Version-3-Farmacovigilancia Instituto Nacional de Vigilancia de Medicamentos y Alimentos. ABC Seguridad en el uso de medicamentos [Internet]. Imprenta Nacional de Colombia; 2014 [cited 2020 Sep 14]. p. 1–54. Available from: http://www.observamed.org/Farmacovigilancia_FMC/INVIMA_Cartilla2_SeguridadEnUsoMedicamentos_2014.pdf Food And Drug Administration. FDA Adverse Events Reporting System (FAERS) Public Dashboard [Internet]. Qlik Sense. 2020 [cited 2020 Sep 11]. p. 1. Available from: https://fis.fda.gov/sense/app/95239e26-e0be-42d9-a960-9a5f7f1c25ee/sheet/7a47a261-d58b-4203-a8aa-6d3021737452/state/analysis Ministerio de Sanidad Servicios Sociales e Igualdad. Evolución de la implantación de prácticas seguras de utilización de medicamentos en los hospitales españoles (2007-2011) [Internet]. Madrid; 2012 [cited 2020 Sep 15]. p. 1–142. Available from: https://www.seguridaddelpaciente.es/resources/documentos/evolucion_practicas_seguras_medicamentos.pdf National Coordinating Council for Medication Error Reporting and Prevention. About Medication Errors [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/about-medication-errors National Coordinating Council for Medication Error Reporting and Prevention. Types of Medication Errors [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/types-medication-errors National Coordinating Council for Medication Error Reporting and Prevention. Taxonomy of Medication Errors Now Available [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/taxonomy-medication-errors-now-available World Health Organization. Annex 9 Guidelines on packaging for pharmaceutical. WHO Tech Rep Ser [Internet]. 2002;(902):120–53. Available from: https://cdn.who.int/media/docs/default-source/medicines/norms-and-standards/guidelines/regulatory-standards/trs902-annex9.pdf?sfvrsn=82b4c57d_2 EUROPEAN PHARMACOPOEIA. 3.2.1. Glass Containers for pharmaceutical use [Internet]. 2005. 363–367 p. Available from: https://www.biomed.co.th/downloads/EP7-3.2.1-Glass containers-for-pharmaceutical-use.pdf Nasa P. A Review on Pharmaceutical Packaging Material. World J Pharm Res [Internet]. 2014;3(5):344–68. Available from: https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1405426296.pdf Mallik Jony., Alam Md. Feroz., Hossain Syed Mainul, Rahaman Mahfujur, Begum Ferdousi DJ. Pharmaceutical Packaging-An art of protection, preservation and presentation- An exhaustive review. Int J Mordern Pharm Res [Internet]. 2018;7(1):29–37. Available from: https://ijmpronline.com/download/article/14/1518858432.pdf Álvarez MR, Torrado-Fonseca M. El método Delphi. REIRE Rev d’Innovación i Recer en Educ [Internet]. 2016 [cited 2020 Oct 19];9(9 (1)):87–102. Available from: https://revistes.ub.edu/index.php/REIRE/article/view/reire2016.9.1916 Sánchez R, Echeverry J. Validación de escalas de medición en salud. Rev Salud Pública [Internet]. 2004 [cited 2020 Oct 7];6:302–18. Available from: https://scielosp.org/article/rsap/2004.v6n3/302-318/ Parra ABS. La estadística en la validación de escalas, una visión práctica para su construcción o su adaptación. I3+ [Internet]. 2015 Aug 31 [cited 2020 Oct 7];2(2):46–61. Available from: http://revistasdigitales.uniboyaca.edu.co/index.php/reiv3/article/view/111 Ventura-León J. Escalas, inventarios y cuestionarios: ¿son lo mismo? Educ Médica [Internet]. 2020 May;21(3):218–20. Available from: https://linkinghub.elsevier.com/retrieve/pii/S157518131930097X Romera C, Casado A. Validación de escalas de medición en salud [Internet]. Dynamic; 2015 [cited 2020 Oct 7]. Available from: https://www.dynasolutions.com/publicaciones/pdf/30.pdf Lagunes-Córdoba R. Recomendaciones sobre los procedimientos de construcción y validación de instrumentos y escalas de medición en la psicología de la salud. Psicol y Salud. 2017;27:5. Choudhury N. World Wide Web and Its Journey from Web 1 .0 to Web 4.0. Int J Comput Sci Inf Technol [Internet]. 2014;5(6):8096–100. Available from: https://ijcsit.com/docs/Volume 5/vol5issue06/ijcsit20140506265.pdf Solanki MR, Dongaonkar A. A Journey of Human Comfort: Web 1.0 to Web 4.0. Int J Res Sci Innov [Internet]. 2016;III(Ix):75–8. Available from: https://www.rsisinternational.org/IJRSI/Issue31/75-78.pdf Parvathi M, Mariselvi R. A Bird’s Eye on the Evolution – Web 1.0 to Web 5.0. Int J Adv Res Trends Eng Technol [Internet]. 2017;4(4):167–76. Available from: https://bit.ly/2HQTVDL Kendall K. The Rise of the No-Code Movement [Internet]. Sitepoint. 2020 [cited 2020 Nov 15]. p. 1. Available from: https://www.sitepoint.com/the-rise-of-the-no-code-movement/ Lossada F. El color y sus armonías. Colección. Mérida: Universidad De Los Andes; 2012. 1–70 p. Villagrán Arroyal I. Gestión Del Color. In: Retoque digital de imágenes [Internet]. Primera. Málaga: IC Editorial; 2014. p. 1–60. Available from: http://reader.digitalbooks.pro/book/preview/38703/c1.html?1611870730150#sigil_toc_id_1 National Council of Educational Research and Training. COLOUR. In: Towards a New Age Graphic Design Textbook in Graphic Design for Class XII [Internet]. Primera. Delhi; 2011. p. 44–59. Available from: https://ncert.nic.in/textbook/pdf/legd104.pdf Google. Selector de color [Internet]. Buscar con Google. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://www.google.com/search?q=selector+de+color&rlz=1C1ALOY_esCO951CO951&oq=selector+de+color&aqs=chrome..69i57j0i512l9.544j0j7&sourceid=chrome&ie=UTF-8 Yu L, Zhang L, van de Weijer J, Khan FS, Cheng Y, Parraga CA. Beyond Eleven Color Names for Image Understanding. Mach Vis Appl [Internet]. 2018 Feb 26;29(2):361–73. Available from: http://link.springer.com/10.1007/s00138-017-0902-y W3C. CSS Color Module Level 3 [Internet]. Color Units. 2021 [cited 2022 Jan 26]. p. 1. Available from: https://www.w3.org/TR/css-color-3/#profiles Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Consulta y aprovecha los datos abiertos de Invima [Internet]. Preventino Recomienda a Consumidores. 2021 [cited 2021 Oct 22]. Available from: https://www.invima.gov.co/en/consulta-y-aprovecha-los-datos-abiertos-de-invima Ministerio de Tecnologías de la Información y Comunicaciones. El Invima demuestra cómo sacarle provecho a los Datos Abiertos [Internet]. Sala de prensa. 2020 [cited 2021 Oct 22]. Available from: https://mintic.gov.co/portal/inicio/Sala-de-prensa/Noticias/135738:El-Invima-demuestra-como-sacarle-provecho-a-los-Datos-Abiertos Ministerio de Tecnologías de la Información y Comunicaciones. Datos Abiertos [Internet]. Buscar. 2021 [cited 2021 Oct 22]. Available from: https://www.datos.gov.co/browse?Información-de-la-Entidad_Nombre-de-la-Entidad=Instituto+Nacional+de+Vigilancia+de+Medicamentos+y+Alimentos&limitTo=datasets&provenance=official&sortBy=newest Converting Colors. Source Values (one color value per line) [Internet]. Mass Conversion. 2021 [cited 2021 Feb 8]. p. 1. Available from: https://convertingcolors.com/mass-conversion.html Stackoom. How to highlight a cell using the hex color value within the cell? [Internet]. Question. 2015 [cited 2021 Feb 8]. p. 1. Available from: https://stackoom.com/en/question/hruw De las Salas R. Criterios para la deprescripción de medicamentos en pacientes adultos mayores con diabetes mellitus tipo 2 [Internet]. Universidad Nacional De Colombia; 2020. Available from: https://repositorio.unal.edu.co/handle/unal/79184?show=full Escobar-Pérez J, Cuervo-Martínez Á. Validez De Contenido Y Juicio De Expertos: Una Aproximación a Su Utilización. Av en Medición. 2008;6(September):27–36. Gobierno y Gestión de Servicios de TI Unal. Guía de condiciones del servicio de correo electrónico [Internet]. Bogota; 2020. p. 1–7. Available from: https://dntic.unal.edu.co/images/documentos/COND_USO_CORREO_ELECTRONICO.pdf StarUML. Download [Internet]. StarUML. 2022 [cited 2022 Jan 19]. p. 1. Available from: https://staruml.io/ Talarian. Form Publisher [Internet]. Google WorkSpace Marketplace. 2022 [cited 2022 Apr 14]. p. 1. Available from: https://workspace.google.com/marketplace/app/form_publisher/827172627657 Form Publisher. Getting Started [Internet]. Documentation - Form Publisher Support. 2022 [cited 2022 Apr 14]. p. 1. Available from: https://support.form-publisher.com/hc/en-us/categories/201581669-Getting-Started Boateng GO, Neilands TB, Frongillo EA, Melgar-Quiñonez HR, Young SL. Best Practices for Developing and Validating Scales for Health, Social, and Behavioral Research: A Primer. Front Public Heal. 2018;6(June):1–18. Galicia Alarcón LA, Balderrama Trápaga JA, Edel Navarro R. Content validity by experts judgment: Proposal for a virtual tool. Apertura. 2017;9(2):42–53. Peralta-Linares YA, González-Consuegra R V. Validity and reliability of the Spanish version of the Arrhythmia-specific questionnaire in tachycardia and arrhythmia (ASTA). Rev Colomb Cardiol [Internet]. 2018 Sep;25(5):305–13. Available from: https://rccardiologia.com/previos/RCC 2018 Vol. 25/RCC_2018_25_5_SEP-OCT/RCC_2018_25_5_305-313.pdf Soriano Rodríguez AM. Diseño y validación de instrumentos de medición. Diá-logos. 2015;(14):19–40. Galeano S. Validez y confiabilidad el instrumento Jefferson scale of attitudes toward physician-nurse collaboration en el contexto Colombiano [Internet]. 2018. Available from: http://bdigital.unal.edu.co/64703/1/1529930438619_validez y confiabilidad del JSNPCS. Sandra Juliana Galeano.pdf Magdalena L, Sierra P, Enselmina M, Vargas M. Área de investigación: Administración de la tecnología. XX Congr Int Contaduría, Adm e Informática [Internet]. 2015; Available from: http://congreso.investiga.fca.unam.mx/docs/xx/docs/2.02.pdf Manterola C, Otzen T. Assessment of summaries presented in congresses. Study of validation. Rev Chil Cir [Internet]. 2016;68(4):302–9. Available from: http://dx.doi.org/10.1016/j.rchic.2015.11.002 Andújar C. Introducción a la teoría y construcción de instrumentos de medición. 2001. 101 p. Mayhua LG. Propiedades psicométricas de los instrumentos de medición en las tesis de la facultad de enfermería de la universidad nacional del altiplano, puno - 2016 [Internet]. Universidad Nacional del Altiplano; 2017. Available from: http://repositorio.unap.edu.pe/handle/UNAP/3636 García de Yébenes Prous MJ, Rodríguez Salvanés F, Carmona Ortells L. Validation of questionnaires. Vol. 5, Reumatologia Clinica. 2009. p. 171–7. Abad F, Garrido J, Olea J, Ponsoda V. Introducción a la Psicometría: Teoría Clásica de los Tests y Teoría de la Respuesta al Ítem [Internet]. 1st ed. Madrid: Universidad Autónoma de Madrid; 2006. 1–101 p. Available from: https://www.papelesdelpsicologo.es/pdf/1796.pdf Luján-Tangarife JA, Cardona-Arias JA. Construcción y validación de escalas de medición en salud: Revisión de propiedades psicométricas. Arch Med. 2015;11(3):1–10. Streiner D, Norman G, Cairney J. Health Measurement Scales: A Practical Guide to Their Development and Use. Oxford: Oxford University Press; 2015. 1–415 p. Supo J. Cómo validar un instrumento: Aprende a crear y validar instrumentos como un experto [Internet]. Copyright. 2016. 53 p. Available from: http://www.cua.uam.mx/pdfs/coplavi/s_p/doc_ng/validacion-de-instrumentos-de-medicion.pdf MonkeyLearn. WordCloud Generator [Internet]. Source text. 2022 [cited 2022 Jul 16]. p. 1. Available from: https://monkeylearn.com/word-cloud Tristán-López a. Modificación al modelo de Lawshe para el dictamen cuantitativo de la validez de contenido de un instrumento objetivo. Av en medición. 2008;6:37–48. Bernal-García MI, Salamanca Jiménez DR, Perez Gutiérrez N, Quemba Mesa MP. Validez de contenido por juicio de expertos de un instrumento para medir percepciones físico-emocionales en la práctica de disección anatómica. Educ Médica [Internet]. 2020 Nov;21(6):349–56. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1575181318302584 Montoya A, Ortiz J, Paul E, Galindo J, Ochoa D. Segmentación A una Base de Datos [Internet]. RPubs by RStudio. 2018 [cited 2022 Jul 16]. p. 1. Available from: https://rpubs.com/andrestoya/391125 Rods A. Método Elbow, para elegir el número ideal de clusters [Internet]. Curso de Introducción al Álgebra Lineal: Vectores. 2021 [cited 2022 Jul 16]. p. 1. Available from: https://platzi.com/tutoriales/2127-intro-algebra/11447-metodo-elbow-para-elegir-el-numero-ideal-de-clusters/#:~:text=El método Elbow o **,elemento con su centroide correspondiente. Ortega M. El coeficiente de correlacion de los rangos de spearman caracterización. Rev Habanera Ciencias Médicas [Internet]. 2009;8(2):20. Available from: https://www.redalyc.org/pdf/1804/180414044017.pdf Khamis H. Measures of association: How to choose? Vol. 24, Journal of Diagnostic Medical Sonography. 2008. p. 155–62. Balsamiq®️. Balsamiq Cloud: Fast, Approachable, Collaborative Wireframing [Internet]. Log In to Balsamiq Cloud. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://balsamiq.cloud/#login Google. Sitios web recientes [Internet]. Sites. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://sites.google.com/?hl=es Google. Google Drive: acceso sencillo y seguro a todo tu contenido [Internet]. Google WorkSpace. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://www.google.com/intl/es_es/drive/ Pixabay. Increíbles Imágenes Gratis Para Descargar [Internet]. Pixabay. 2022 [cited 2022 Jan 18]. p. 1. Available from: https://pixabay.com/es/ Sabah A, Ahmed I, Arsalan A, Arif A, Tanwir S, Abbas A. Features , Functions and Selection of Pharmaceutical Packaging materials. Indian J Pharm Sci Res [Internet]. 2014;1(1):1–12. Available from: https://www.researchgate.net/publication/261143936_Features_Functions_and_selection_of_Pharmaceutical_Packing_Materials Akers MJ. Sterile Drug Products - Formulation, Packaging, Manufacturing, and Quality [Internet]. 1st ed. Swarbrick J, editor. CRC Press; 2010. 1–516 p. Available from: https://www.routledge.com/Sterile-Drug-Products-Formulation-Packaging-Manufacturing-and-Quality/Akers/p/book/9780849339936# Sierra Martínez N. Envases de vidrio de uso farmacéutico : guía para el control de calidad [Internet]. Baquero C, editor. Bogotá: Universidad Nacional de Colombia; 2012. 1–73 p. Available from: https://repositorio.unal.edu.co/handle/unal/79933 Pareek V, Khunteta A. Pharmaceutical packaging: Current trends and future. Int J Pharm Pharm Sci. 2014;6(6):480–5. Borja Orantes J. Recopilación Bibliografica de Materiales de Envase Primario, Secundario y Terciario, para las Formas Farmacéuticas Liquidas, sólidas y semisólidas. Univ El Salvador Fac Química y Frmacia [Internet]. 2016;3(2):331. Available from: http://ri.ues.edu.sv/4988/1/16100316.pdf Schaut RA, Weeks WP. Historical review of glasses used for parenteral packaging. PDA J Pharm Sci Technol. 2017;71(4):279–96. Sacha GA, Saffell-Clemmer W, Abram K, Akers MJ. Practical fundamentals of glass, rubber, and plastic sterile packaging systems. Pharm Dev Technol. 2010;15(1):6–34. Beltrán Rico M, Marcilla Gomis A. TEMA 2. TIPOS DE PLASTICOS, ADITIVACIÓN Y MEZCLADO. In: Tecnología de Polímeros - Procesado y propiedades [Internet]. 1st ed. Alicante: Publicaciones de la Universidad de Alicante; 2012. p. 252– 285. Available from: https://publicaciones.ua.es/es/catalogo/tecnologia-de-polimeros/978-84-9717-232-5 Kremer Pigmente. Pigmentos [Internet]. Shop. 2021 [cited 2021 Dec 30]. Available from: https://www.kremer-pigmente.com/es/shop/pigmentos/ Calderón Martínez AC. Procedimiento para el manejo adecuado de los desechos de vidrio provenientes de ampollas, generados en el Área de Producción de Líquidos Estériles Inyectables de un Laboratorio Farmacéutico de Guatemala [Internet]. Universidad De San Carlos De Guatemala; 2016. Available from: https://biblioteca-farmacia.usac.edu.gt/Tesis/MAIES201.pdf Gad SC. Pharmaceutical Manufacturing Handbook: Production and Processes. Pharmaceutical Manufacturing Handbook: Production and Processes. 2007. 1–1370 p. Schott AG. Viales [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 4]. p. 1. Available from: https://www.schott.com/es-es/products/vials Schott AG. Jeringas [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.schott.com/es-es/products/syringes Stevanato Group. Cartuchos de vidrio de gran Volumen [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/cartuchos/cartuchos-de-vidrio-de-gran-volumen/ Fresenius Kabi. The art of innovation freeflex. Technical Manual [Internet]. Vol. 1. Bad Homburg: Fresenius Kabi Deutschland GmbH Technical; 2016. p. 1–20. Available from: https://gruposdetrabajo.sefh.es/gps/images/stories/MANUAL_TECNICO_Freeflex_Fresenius_Kabi.pdf Grifols. Fleboflex® Luer [Internet]. Fleboflex®. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.fleboflex.com/es/fleboflex-luer Schott AG. Ampoule [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.schott.com/es-es/products/ampoules Gerresheimer. Ampoules made of glass [Internet]. Pharmaceutical Primary Packaging. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.gerresheimer.com/catalogue/products/pharmaceutical-primary-packaging/ampoules-made-of-glass.html?limit=all Adelphi Healthcare Packaging. VialVet PET Crimp Neck Vials [Internet]. Plastic Bottles. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/pet-crimp-neck-vials SGD Pharma. INFUSION BOTTLES [Internet]. Products & Innovation. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.sgd-pharma.com/infusion-bottles Stevanato Group. SG Nexa® 3X EZ-fill® [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/cartuchos/ Medi Pharma Plan. Multi Chamber Bag Product [Internet]. Non PVC IV Solution. 2021. p. 1. Available from: http://www.medipharmaplan.com/new/eng/product/non_3.html# Schott AG. Ampollas [Internet]. Mainz; 2021. p. 1–12. Available from: https://www.catalogodelempaque.com/documenta/contenido/120314/Brochure_Ampoules_Spanish_ROW.pdf Coleman WP, Flynn TC, Delanzac K, Coleman WP, Coleman KM. Inaccurate labeling of intravenous fluid bags: Implications for anesthesiologists [2]. J Clin Anesth. 2003;15(3):242–3. Hernández F, Navascués I. Notas galénicas: ampollas. Panacea [Internet]. 2000;1(1):11–2. Available from: https://www.tremedica.org/wp-content/uploads/n1_NotasGalenicas.pdf Schott Kaisha. SCHOTT KAISHA Ampoules [Internet]. Products. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.schott-kaisha.com/ampoules.html Carraretto AR, Freitas Curi E, de Almeida CED, Monteiro Abatti RE. Ampollas de Vidrio: Riesgos y Beneficios. Rev Bras Anestesiol. 2011;61(4):280–4. Stevanato Group. Ampoules [Internet]. Drug Containment Solution. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/ampoules/ Making.com. Types of ampoules: shapes that fit the standards [Internet]. Let’s make ampoules. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://making.com/ampoules/ Suzuki S, Gilbar P, Yu B, Matsuyama C, Yamaguchi M. Current status of drug vial optimization use to prevent waste associated with injectable anticancer agents. J Oncol Pharm Pract. 2019;25(1):244–6. West Pharmaceutical Services. Daikyo® Crystal Zenith® Vials [Internet]. Vials. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.westpharma.com/products/vial-containment-solutions/vials/daikyo-crystal-zenith-vials Adelphi Healthcare Packaging. FluroTec® Stoppers [Internet]. Rubber Stoppers. 2021 [cited 2021 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/flurotec-stoppers Adelphi Healthcare Packaging. Crimp Seals with Plastic Discs [Internet]. Aluminium Crimp Seals. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/crimp-seals-with-plastic-discs Stevanato Group. Viales SG EZ-fill®: Excelencia operacional en sus procesos de llenado [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/viales Soto C, Stiner J, Noji DO, Rusheen JM, Huang YM. Creating a Simulated Pharmacy. Simul Healthc. 2016;11(3):218–22. Stevanato Group. EZLINKTM - Vial Adapter [Internet]. Drug Containment Solution. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/vial-systems/ezlink/ Becton Dickinson. SmartSiteTM vented vial access device [Internet]. Needle Free Systems And Connectors. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.bd.com/en-uk/products/infusion/iv-therapy/needle-free-systems-and-connectors/smartsite-vented-vial-access-device Schott Kaisha. Specialty Products [Internet]. Specialty Products. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://schott-kaisha.com/specialty-products.html FACET Pharm/Med Manufacturing. Complex Container/Closure [Internet]. Tube Filling. 2021 [cited 2021 Jan 5]. p. 1. Available from: https://www.facetllc.com/tube-filling/ Stoelzle Pharma. Injection vials & infusion bottles [Internet]. Products. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stoelzle.com/pharma/products/injection-vial/ Fresenius Kabi. Bottles, plastic (50 - 1000 ml) [Internet]. Sterile Pharmaceuticals. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://cmo.fresenius-kabi.com/bottles-plastic BBraun. ECOFLAC® PLUS [Internet]. Infusion Therapy. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.bbraun.co.uk/en/products-and-therapies/infusion-therapy/ecoflac--plus.html Eester C van. Webinar Parenteral Packaging for Cartridges in Drug Delivery Devices [Internet]. Looking to the Future of Parenteral Packaging. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://datwyler.com/media/news/parenteral-packaging-for-cartridges-in-drug-delivery-devices#webinar-1-video Schott AG. Cartuchos [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.schott.com/es-es/products/cartridges Langley C, Robert W, Adams L. Cartucho de medicamento que tiene medios de identificación [Internet]. Reino Unido; ES2429901T3, 2008. p. 1. Available from: http://www.oepm.es/pdf/ES/0000/000/02/42/99/ES-2429901_T3.pdf ICU Medical. EVA Infusion Bags [Internet]. Compounding Accesories. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.icumed.com/products/specialty/compounding-accessories/eva-infusion-bags Techno Flex. Dual-Mix® [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/dual-mix/ ICU Medical. 2-Chamber Bags [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/2-chamber-bags/ ICU Medical. Bolsas de 3 cámaras [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/3-chamber-bags/ American Society for Parenteral and Enteral Nutrition. Part III: Preparing,Labeling, and Dispensing [Internet]. Multi-Chamber Bag Parenteral Nutrition (MCB-PN) Video Series. 2018 [cited 2022 Jan 9]. p. 1. Available from: https://www.nutritioncare.org/MCBPN/ BBraun. Cephalosporins in the DUPLEX® Container [Internet]. Ready to Use Drug Delivery System. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/cephalosporins-intheduplexcontainer.html BBraun. Carbapenems in the DUPLEX® Container [Internet]. Ready to Use Drug Delivery System. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/carbapenems-in-theduplexcontainer.html Fresenius Kabi. Multi-chamber bags [Internet]. Sterile Pharmaceuticals. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://cmo.fresenius-kabi.com/multi-chamber-bags Colomb V, Marlowe ML, Bonnot D, Rigo J. Practical use of a new three-chamber bag for parenteral nutrition in pediatric patients. ESPEN J [Internet]. 2012;7(2):e93–9. Available from: http://dx.doi.org/10.1016/j.clnme.2012.01.002 BBraun. Bolsas Tricompartimendas [Internet]. Nutrición Parenteral. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraun.es/es/productos-y-terapias/catalogo-de-productos/nutricion-clinica/nutricion-parenteral/bolsas-tricompartimentadas.html Fresenius Kabi. Locking Protective Cap [Internet]. Accessories. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://freeflexivbags.com/ffx-accessories/ Samson Medical Technologies. SmartPak Products [Internet]. SmartPak Products. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://samsonmt.com/smartpak-products/ BBraun. Lidocaine Hydrochloride and 5% Dextrose Injection USP [Internet]. Premixed Drugs. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/lidocaine-hydrochlorideand5dextroseinjectionusp.html Fresenius Kabi. Premix Products [Internet]. Freeflex® bags. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://freeflexivbags.com/premix-products/ Doyle GR, McCutcheon JA. Clinical Procedures for Safer Patient Care [Internet]. British Columbia Institute of Technology. 2015. 479–487 p. Available from: https://opentextbc.ca/clinicalskills/ Becton Dickinson. BD plunger stoppers [Internet]. Add ons and components. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/plunger-stoppers Becton Dickinson. BD plunger rods [Internet]. Add ons and components. 2021 [cited 2021 Jan 6]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/plunger-rods Song M. An Introduction To Prefilled Syringe Selection — Needle-Free And Dual-Chamber Devices [Internet]. Pharmaceutical Online. 2019 [cited 2022 Jan 6]. p. 1. Available from: https://www.pharmaceuticalonline.com/doc/an-introduction-to-prefilled-syringe-selection-needle-free-and-dual-chamber-devices-0001 Jadhav SP, Shaikshanik S, Patil C, Sonawane DD, Jadhav KR, Salunkhe KS. Review on Prefilled Syringe as A Modern Technique for Packaging and Delivery of Parenteral. Int J Recent Sci Res [Internet]. 2020;11(04):38301–6. Available from: http://recentscientific.com/review-prefilled-syringe-modern-technique-packaging-and-delivery-parenteral Fisterra. Administración parenteral de medicamentos: conceptos generales [Internet]. Técnicas Atención Primaria. 2011 [cited 2022 Jan 5]. p. 1. Available from: https://www.fisterra.com/ayuda-en-consulta/tecnicas-atencion-primaria/administracion-parenteral-medicamentos-conceptos-generales/ Soikes R. Moving from Vial to Prefilled Syringe [Internet]. Pharmaceutical Technology. 2009 [cited 2021 Jan 6]. p. 1. Available from: https://www.pharmtech.com/view/moving-vial-prefilled-syringe Gonzales M. Migrating a Drug Product Presentation from Vial to Prefilled Syringe [Internet]. ONdrugDelivery Online. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.ondrugdelivery.com/migrating-a-drug-product-presentation-from-vial-to-prefilled-syringe/ Basu B, Dharamsi A, Makwana S, Makasana Y. Prefilled syringes: An innovation in parenteral packaging. Int J Pharm Investig. 2011;1(4):200. Song M. An Introduction To Prefilled Syringe Selection — Prefilled Syringes With Staked-In Needles [Internet]. Pharmaceutical Online. 2019 [cited 2022 Jan 6]. p. 1. Available from: https://www.pharmaceuticalonline.com/doc/an-introduction-to-prefilled-syringe-selection-prefilled-syringes-with-staked-in-needles-0001 Credence Medsystems. The Companion Dual Chamber Reconstitution Syringe [Internet]. Safety Syringe System. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.credencemed.com/dual-chamber/ Becton Dickinson. BD backstops [Internet]. Add ons and components. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/backstops Becton Dickinson. BD EclipseTM needle [Internet]. Safety needles. 2021 [cited 2021 Jan 10]. p. 1. Available from: https://www.bd.com/en-us/offerings/capabilities/syringes-and-needles/safety-syringes-and-needles/safety-needles/bd-eclipse-needle Becton Dickinson. BD UltraSafe PassiveTM needle guard [Internet]. Safety and shielding systems. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/safety-and-shielding-systems/ultrasafe-passive-needle-guard Becton Dickinson. BD PreventisTM needle shielding system [Internet]. Safety and shielding systems. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/safety-and-shielding-systems/preventis-needle-shielding-system Credence Medsystems. The Companion Staked Needle Syringe [Internet]. Safety Syringe System. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://www.credencemed.com/staked/ Owen Mumford. UniSafe® 1mL [Internet]. Prefilled Syringes. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://www.owenmumford.com/en/drug-delivery/prefilled-syringes/unisafer-1ml Stevanato Group. SG ISS - Integrated Safety System [Internet]. Syringe Systems. 2021 [cited 2021 Jan 10]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/syringe-systems/sg-iss/ Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Guía etiquetas medicamentos [Internet]. Bogotá; 2017. p. 24. Available from: https://www.invima.gov.co/documents/20143/367911/Guía+de+etiquetas+de+medicamentos.pdf/abec2216-9182-a440-66f0-4fb17242cebc?t=1565042313222&download=true World Health Organization. Parenteral preparations [Internet]. The International Pharmacopoeia - Tenth Edition. 2020 [cited 2022 Jan 10]. p. 1. Available from: https://digicollections.net/phint/2020/index.html#d/b.6.2.1.5 Health Canada. Guidance Document: Labelling of Pharmaceutical Drugs for Human Use [Internet]. 2015. p. 90. Available from: https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/dhp-mps/alt_formats/pdf/prodpharma/applic-demande/guide-ld/label_guide_ld-eng.pdf New Zealand Medicines And Medical Devices Safety Autorithy. Guideline on the Regulation of Therapeutics Products in New Zeland - Part 5: Labelling of medicines and related products [Internet]. New Zealand; 2018. p. 1–18. Available from: https://www.medsafe.govt.nz/regulatory/Guideline/GRTPNZ/Part5.pdf National Patient Safety Agency. Design for patient safety: A guide to labelling and packaging of injectable medicines [Internet]. 1st ed. United Kingdom; 2008. p. 96. Available from: https://www.rca.ac.uk/research-innovation/research-centres/helen-hamlyn-centre/research-projects/2007-projects/safer-design/ Estock JL, Murray AW, Mizah MT, Mangione MP, Goode JS, Eibling DE. Label Design Affects Medication Safety in an Operating Room Crisis. J Patient Saf [Internet]. 2018;14(2):101–6. Available from: http://insights.ovid.com/crossref?an=01209203-201806000-00006 International Medication Safety Network. Position Statement: Making Medicines Naming, Labeling and Packaging Safer [Internet]. 2013. p. 11. Available from: http://www.ismp-espana.org/ficheros/IMSN. Making Medicines Naming%2C Labeling and Packaging Safer.pdf PHARMAC. Labelling preferences for prescription pharmaceuticals [Internet]. New Zeland; 2016. p. 1–8. Available from: https://pharmac.govt.nz/medicine-funding-and-supply/medicine-supply-management/pharmac-labelling-preferences-for-prescription-pharmaceuticals/ Therapeutic Goods Administration. Medicine labels: Guidance on TGO 91 and TGO 92 [Internet]. 2021. p. 1–79. Available from: https://www.tga.gov.au/sites/default/files/medicine-labels-guidance-tgo-91-and-tgo-92_0.pdf Medicines and Healthcare products Regulatory Agency. Best practice guidance on labelling and packaging of medicines [Internet]. 2014. p. 1–16. Available from: https://www.gov.uk/government/publications/best-practice-in-the-labelling-and-packaging-of-medicines#full-publication-update-history European Commission. Guideline on the readability of the labelling and package leaflet of medicinal products for human use [Internet]. Bruselas; 2009. p. 1–27. Available from: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-2/c/2009_01_12_readability_guideline_final_en.pdf European Commission. Guideline on the Packaging Information Packaging Information of Medicinal Products for Human Use Authorised by the Union [Internet]. Bruselas; 2016. p. 1–44. Available from: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-2/2016_12_packaging_guidelines_revision_14_4.pdf Health Products Regulatory Authority. Guide to labels and leaflets for human medicines [Internet]. Irlanda; 2021. p. 30. Available from: https://www.hpra.ie/docs/default-source/publications-forms/guidance-documents/aut-g0034-guide-to-labels-and-leaflets-of-human-medicines-v21.pdf?sfvrsn=60 Australian Commission on Safety and Quality in Health Care. Report on the National Round Table on Safer Naming, Labelling and Packaging of Medicines [Internet]. Sidney; 2011. p. 1–51. Available from: https://www.safetyandquality.gov.au/sites/default/files/migrated/National-Round-Table-on-Safer-Naming-Labelling-and-Packaging-Report.pdf Government of Canada. Packaging and labelling guide for cannabis products: Requirements under the Cannabis Act and the Cannabis Regulations [Internet]. 2019. 1–40 p. Available from: https://www.canada.ca/content/dam/hc-sc/documents/services/cannabis-regulations-licensed-producers/packaging-labelling-guide-cannabis-products/Packaging_and_labelling_guide_for_cannabis_products_rev.pdf US Department of Health and Human Services, Center for Drug Evaluation and Research, Food And Drug Administration. Safety Considerations for Container Labels and Carton Labeling Design to Minimize Medication Errors [Internet]. 2013. p. 1–26. Available from: https://www.regulations.gov/docket/FDA-2013-D-0401/document Food And Drug Administration C for DE and R. Safety Considerations for Product Design to Minimize Medication Errors [Internet]. Guidance for Industry. 2016. p. 480. Available from: https://www.fda.gov/files/drugs/published/Safety-Considerations-for-Product-Design-to-Minimize-Medication-Errors-Guidance-for-Industry.pdf Meeting IA. 17th ISoP Annual Meeting “Pharmacovigilance in the 21st Century” Liverpool, UK 15–18 October, 2017. Drug Saf. 2017;40(10):937–1045. da Silva Pons E, Moraes CG, Falavigna M, Sirtori LR, da Cruz F, Webster G, et al. Users’ preferences and perceptions of the comprehensibility and readability of medication labels. PLoS One. 2019;14(2):1–15. United States Pharmacopeial. Labeling <7> [Internet]. 2019. p. 1–9. Available from: https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/gc-7-labeling-rb-notice-20190830.pdf Patient Dafety Advisory. Drug Labeling and Packaging — Looking Beyond What Meets the Eye. Pennsylvania Patient Saf Report Syst. 2007;4(3):1–6. Institute for Safe Medication Practices. Improving Medication Safety in Community Pharmacy : Assessing Risk and Opportunities For Change [Internet]. 1st ed. 2009. 1–123 p. Available from: https://www.ismp.org/sites/default/files/attachments/2018-02/ISMP_AROC_whole_document.pdf Institute for Safe Medication Practices Canada. Labelling and Packaging: An Aggregate Analysis of Medication Incident Reports [Internet]. Toronto; 2013. p. 1–22. Available from: www.ismp-canada.org Momtahan K, Burns CM, Jeon J, Hyland S, Gabriele S. Using human factors methods to evaluate the labelling of injectable drugs. Healthc Q. 2008;11(3 Spec No.):122–8. Mackay E, Jennings J, Webber S. Medicines safety in anaesthetic practice. BJA Educ [Internet]. 2019;19(5):151–7. Available from: https://doi.org/10.1016/j.bjae.2019.01.001 Simas da Rocha B, Garcia Moraes C, Miyake Okumura L, da Cruz F, Sirtori L, da Silva Pons E. Interventions to Reduce Problems Related to the Readability and Comprehensibility of Drug Packages and Labels: A Systematic Review. J Patient Saf. 2021;17(8):e1494–506. Norwegian Medicines Agency. Norwegian guideline for packaging of human and veterinary medicinal products with marketing authorisation / registration [Internet]. 2020. p. 1–23. Available from: https://legemiddelverket.no/Documents/English/Regulatory affairs/Guideline_final_pub_coll_19.2.20.pdf Google. Google Drive Direct Link Generator [Internet]. How to Get Your Sharing URL. 2021 [cited 2021 Dec 21]. p. 1. Available from: https://sites.google.com/site/gdocs2direct/ Instituto Nacional de Vigilancia de Medicamentos y Alimentos. CONSULTA DATOS DE PRODUCTOS [Internet]. Consulta Registro Sanitario. 2022 [cited 2022 Jan 5]. p. 1. Available from: https://consultaregistro.invima.gov.co/Consultas/consultas/consreg_encabcum.jsp García ME, Lena F. Aplicación del metodo delphi en el diseño de una investigación cuantitativa sobre el fenómeno FABLAB. Empiria Rev Metodol Ciencias Soc [Internet]. 2018;(40):129–66. Available from: https://doi.org/10.5944/empiria.40.2018.22014 Google. Dibujos de Google [Internet]. Chrome web store. 2015 [cited 2022 Jan 18]. p. 1. Available from: https://chrome.google.com/webstore/detail/google-drawings/mkaakpdehdafacodkgkpghoibnmamcme?hl=es Creately. La Guía Fácil de los Diagramas de Clases UML | Tutorial de Diagramas de Clases [Internet]. Diagramas. 2021 [cited 2022 Jan 19]. p. 1. Available from: https://creately.com/blog/es/diagramas/tutorial-de-diagrama-de-clases/ Van Wetter C, Boulfalfal H, Anckaert F, Tassin O. PS-045 Look-alike injectable drugs: Detection and first assessment: Abstract PS-045 Table 1. Eur J Hosp Pharm. 2016;23(Suppl 1):A233.2-A233. Montero Delgado JA, Plata Paniagua S, Arenas Villafranca JJ. The problem of different brands of the same drug in Spain: It is time to act. J Healthc Qual Res. 2020;35(2):126–8. Irizarry R. Agrupación. In: Introducción a la ciencia de datos [Internet]. 1st ed. Bookdown; 2021. p. 60. Available from: https://rafalab.github.io/dslibro/clustering.html Amat R. Clustering y heatmaps: aprendizaje no supervisado [Internet]. Ciencia De Datos. 2017 [cited 2022 Jul 16]. p. 1. Available from: https://www.cienciadedatos.net/documentos/37_clustering_y_heatmaps#Heatmaps Twitter. What would you like to embed? [Internet]. Twitter Publish. 2022 [cited 2022 May 2]. p. 1. Available from: https://publish.twitter.com/?hideConversation=on&query=https%3A%2F%2Ftwitter.com%2FMartaMullera%2Fstatus%2F1501623547759898629&theme=dark&widget=Tweet Creative Commons. Atribución 4.0 Internacional (CC BY 4.0) [Internet]. Licenses. 2022 [cited 2022 Apr 24]. p. 1. Available from: https://creativecommons.org/licenses/by/4.0/deed.es Canva. ¿Qué vas a diseñar? [Internet]. Inicio. 2022 [cited 2022 Apr 24]. p. 1. Available from: https://www.canva.com/ Google. Google Maps [Internet]. Google Maps. 2022 [cited 2022 Apr 3]. p. 1. Available from: https://www.google.com/maps/ Google. Google My Maps [Internet]. Google Maps. 2022 [cited 2022 Apr 20]. p. 1. Available from: https://mymaps.google.com/ International Medication Safety Network. Reporting Form [Internet]. Reporting Portal. 2022. p. 1. Available from: https://www.intmedsafe.net/the-international-medication-error-reporting-portal/report-form/ Delegación Española del Institute for Safe Medication Practices. PROGRAMA DE NOTIFICACIÓN DE ERRORES DE MEDICACIÓN [Internet]. Salamanca; 2022. p. 1. Available from: http://www.ismp-espana.org/ficheros/formulario.pdf Institute for Safe Medication Practices. Healthcare Practitioner’s Medication Error Reporting Form [Internet]. Error Reporting. 2022 [cited 2022 May 2]. p. 1. Available from: https://www.ismp.org/form/merp-form Agencia Española de Medicamentos y Productos Sanitarios. Comunicación de aspectos del etiquetado susceptibles de provocar errores de medicación [Internet]. Ficha técnica, prospecto y etiquetado. 2021 [cited 2022 May 2]. p. 1. Available from: https://www.aemps.gob.es/industria-farmaceutica/etiquetado-y-prospectos/comunicacion-de-aspectos-del-etiquetado-susceptibles-de-provocar-errores-de-medicacion/ Vargas-neri JL, Pérez-vázquez P, Em DDL. Panorama de los errores de medicación en Latinoamérica: oportunidades para la ergonomía. 2021;3(2):94–109. Ministerio de Salud de Colombia. Por la cual se define el estándar de datos de medicamentos de uso humano en Colombia y se dictan otras disposiciones [Internet]. Resolución 3311 Colombia; 2018 p. 1–28. Available from: https://www.minsalud.gov.co/Normatividad_Nuevo/3311 Define Estandar de datos de medicamentos de uso Humano en Colombia.pdf Agencia Española de Medicamentos y Productos Sanitarios. Centro de Información de Medicamentos - CIMA [Internet]. Rituximab. 2017 [cited 2022 Feb 28]. p. 1. Available from: https://cima.aemps.es/cima/publico/lista.html Raza Owaisi H. 3D covid-19 vaccine vails model [Internet]. TurboSquid. 2019 [cited 2022 Feb 28]. p. 1. Available from: https://www.turbosquid.com/3d-models/3d-vaccine-covid-vails-model-1706186 Kovacs V. Online 3D Viewer [Internet]. Online 3D Viewer. 2021 [cited 2022 Feb 28]. p. 1. Available from: https://3dviewer.net/ International Medication Safety Network. Targeting International best practice for safe labelling and packaging of prescription medicines [Internet]. The IMSN continues its work on labelling and packaging safety and deepens its relationship with pharmacovigilance. 2018 [cited 2022 Mar 14]. p. 1. Available from: https://www.intmedsafe.net/the-imsn-continues-its-work-on-labelling-and-packaging-safety-and-deepens-its-relationship-with-pharmacovigilance/ Varela-Ruiz M, Díaz-Bravo L, García-Durán R. Descripción y usos del método Delphi en investigación del área de la salud. Investig en Eduación Médica [Internet]. 2012;1(2):90–5. Available from: http://riem.facmed.unam.mx/sites/all/archivos/V1Num02/07_MI_DESCRIPCION_Y_USOS.PDF López-Gómez E. El método delphi en la investigación actual en educación: Una revisión teórica y metodológica. Educ XX1. 2018;21(1):17–40. Hellier E, Edworthy J, Derbyshire N, Costello A. Considering the impact of medicine label design characteristics on patient safety. Ergonomics. 2006;49(5–6):617–30. Garnica S, Aristizabal A. Making safer medicines: Improving labeling and packaging to prevent medication errors. Drug Saf [Internet]. 2017;40(10):1018. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L618778421%0Ahttp://dx.doi.org/10.1007/s40264-017-0580-8 Ostini R, Roughead EE, Kirkpatrick CMJ, Monteith GR, Tett SE. Quality Use of Medicines - Medication safety issues in naming; Look-alike, sound-alike medicine names. Int J Pharm Pract. 2012;20(6):349–57. Machado-Duque ME, Machado-Alba JE, Gaviria-Mendoza A, Valladales-Restrepo LF, Parrado-Fajardo IY, Ospina-Castellanos M, et al. Identificación de errores de medicación mediante un programa de seguimiento y minimización en pacientes ambulatorios de Colombia, 2018-2019. Biomedica. 2020;41(1):1–22. Rando K, Rey G. Errores de medicamentos LASA en anestesiología en Uruguay. Rev Médica del Uruguay. 2017;33(2):53–103. Patel S, Robertson B, McConachie I. Catastrophic drug errors involving tranexamic acid administered during spinal anaesthesia. Anaesthesia. 2019;74(7):904–14. Hellebek A, Schytte-Hansen S, Fischer H, Clemmensen MH, Kart T. Patient safety in drug label design: Analysis of reported adverse events before and after introducing a new label design. Eur J Hosp Pharm. 2013;20(4):212–7. Valverde MP, Martín R. Prevención de errores de medicación. Farm Hosp. 2002;25(6):376–9. International Pharmaceutical Federation. Patient Safety: Pharmacists’ Role in “Medication without harm.” International Pharmaceutical Federation. 2020. p. 105. Bryan R, Aronson JK, Williams A, Jordan S. The problem of look-alike, sound-alike name errors: Drivers and solutions. Br J Clin Pharmacol. 2021;87(2):386–94. Instituto para el Uso Seguro de de los Medicamentos. Boletín de Recomendaciones para la Prevención de Errores de Medicación Los 10 errores de medicación de mayor riesgo. Gob España Minist Sanid [Internet]. 2022;06(51):1–5. Available from: http://www.ismp-espana.org/ficheros/Boletin 50 %28Febrero 2021%29.pdf Pérez Ingidua carla, rivas paterna AB, Portolés Pérez antonio, laredo velasco leonor, Vargas Castrillón emilio. La isoapariencia farmacéutica un factor de riesgo de errores de medicación. Metas de Enfermería. 2020;23(7):7–15. Palacio J, Astier P, Hernández MÁ. Drugs: When appearances mislead. Aten Primaria. 2017;49(7):375–7. Nocode.Tech. ¿No sabe codificar? No hay problema. [Internet]. 2022 [cited 2022 Jun 24]. p. 1. Available from: https://es.nocode.tech/ Gonzalo F. ¿Qué es Nocode? Desarrollar webs y apps sin código [Internet]. Blog. 2021 [cited 2022 Jun 24]. p. 1. Available from: https://www.nocoders.academy/blog/que-es-nocode NocodeHackers. Construye tus proyectos sin saber programar [Internet]. 2022 [cited 2022 Jun 24]. p. 1. Available from: https://www.nocodehackers.es/ National Patient Safety Agency. Design patient safety: A guide to the graphic design of medication packaging [Internet]. 2nd ed. United Kingdom; 2007. 80 p. Available from: https://webarchive.nationalarchives.gov.uk/ukgwa/20080727044055mp_/http://www.npsa.nhs.uk/EasySiteWeb/GatewayLink.aspx?alId=5599 Institute for Safe Medication Practices Canada. Good Label and Package Practices Guide for Prescription Drugs [Internet]. 1st ed. 2019. 1–79 p. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/reports-publications/medeffect-canada/good-label-package-practices-guide-prescription-drugs-profile/guidance-document.html International Medication Safety Network. Position Statement: Safer design of vaccines packaging and labelling [Internet]. 2015. p. 5. Available from: http://www.ismp-espana.org/ficheros/IMSN-Position-Statement-Vaccines-packaginglabelling-201512.pdf Larmené-Beld KHM, Alting EK, Taxis K. A systematic literature review on strategies to avoid look-alike errors of labels. Eur J Clin Pharmacol. 2018;74(8):985–93. Grifols. Fleboflex®- Nuestro envase por excelencia [Internet]. Fleboflex®. 2021 [cited 2021 Jan 18]. p. 1. Available from: https://www.fleboflex.com/documents/438093/438234/HGFTP11170002%282%29-Fleboflex-F-Luer.pdf/22975b0e-a33e-7c36-023a-663a3a57bc31?t=1572421243000 Losada H. Clasificación De Las Tipografías [Internet]. Blog con H de diseño. 2020 [cited 2022 Jan 18]. p. 1. Available from: https://helenalosada.es/clasificacion-de-las-tipografias/ Trudeau M, Green E, Cosby R, Charbonneau F, Easty T, Ko Y, et al. Key components of intravenous chemotherapy labeling: A systematic review and practice guideline. J Oncol Pharm Pract. 2011;17(4):409–24. Otero López MJ, Martín Muñoz R, Sánchez Barba M, Abad Sazatornil R, Andreu Crespo A, Arteta Jiménez M, et al. Elaboración de una relación de nombres de medicamentos similares en los que se recomienda utilizar letras mayúsculas resaltadas. Farm Hosp. 2011;35(5):225–35. Health Quality & Safety Commission New Zealand. Tall Man Lettering List: Report December 2013 [Internet]. New Zealand; 2013. 1–40 p. Available from: https://www.hqsc.govt.nz/assets/Medication-Safety/Tall-Man-lettering/Tall-Man-report-Dec-2013.PDF World Health Organization. ATC/DDD Index 2022 [Internet]. WHO Collaborating Centre for Drug Statistics Methodology. 2022 [cited 2022 Jan 10]. p. 1. Available from: https://www.whocc.no/atc_ddd_index/ Borradale H, Andersen P, Wallis M, Oprescu F. Misreading Injectable Medications—Causes and Solutions: An Integrative Literature Review. Jt Comm J Qual Patient Saf [Internet]. 2020;46(5):291–8. Available from: https://doi.org/10.1016/j.jcjq.2020.01.007 Gabriele S. The role of typography in differentiating look-alike/sound-alike drug names. Healthc Q. 2006;9 Spec No:88–95. Rachel M Kruer, Andrew S Jarrell AL. Reducing medication errors in critical care : A multimodal approach. Clin Pharmacol Adv Appl [Internet]. 2014;(6):117–26. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155993/ Food And Drug Administration. Strength Conversion in Drug Listing [Internet]. Electronic Drug Registration and Listing System (eDRLS). 2021 [cited 2022 Jan 18]. p. 1. Available from: https://www.fda.gov/drugs/electronic-drug-registration-and-listing-system-edrls/strength-conversion-drug-listing Garnerin P, Perneger T, Chopard P, Arès M, Baalbaki R, Bonnabry P, et al. Drug selection errors in relation to medication labels: A simulation study. Anaesthesia. 2007;62(11):1090–4. Prakash S, Mullick P, Kumar A, Pawar M. Safe Labeling Practices to Minimize Medication Errors in Anesthesia: 5 Case Reports and Review of the Literature. A&A Pract. 2018;10(10):261–4. Berger F. La apariencia distintiva (trade dress): un signo marcario en expansión [Internet]. Universidad De Plermo; 2008. Available from: https://dspace.palermo.edu/dspace/bitstream/handle/10226/855/BERGER TESIS.pdf?sequence=1&isAllowed=y Ministerio de Salud de Colombia. Lista de vías de administración definidas por el Ministerio de Salud en el marco del estándar de datos de medicamentos [Internet]. Bogotá; 2018. p. 1–3. Available from: http://www.medicamentosaunclic.gov.co/contenidos/tabla.pdf Ministerio de Salud de Colombia. Definiciones establecidas por el Ministerio de Salud para las formas farmacéuticas en sus diferentes tipos [Internet]. Bogotá; 2018. p. 4–13. Available from: http://www.medicamentosaunclic.gov.co/contenidos/tabla.pdf León L, Orlando Y, Pravia P, Caridad M, Delgado M. Procedimiento para la selección de la Comunidad de Expertos con técnicas multicriterio. Ciencias Holguín. 2016;22(1):34–49. Hurtado S. CRITERIO DE EXPERTOS. SU PROCESAMIENTO A TRAVÉS DEL MÉTODO DELPHY [Internet]. METODOLOGÍA Y EPISTEMOLOGÍA. 2012 [cited 2022 Feb 2]. p. 1. Available from: http://www.ub.edu/histodidactica/index.php?option=com_content&view=article&id=21:criterio-de-expertos-su-procesamiento-a-traves-del-metodo-delphy&catid=11:metodologia-y-epistemologia&Itemid=103 Randolph J. Online Kappa Calculator [Internet]. Information. 2016 [cited 2022 May 5]. p. 1. Available from: http://justusrandolph.net/kappa/ Adelphi Healthcare Packaging. Ampoules [Internet]. Product range. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://adelphi-hp.com/product-range/ampoules APG Pharma Packing. Infusion vial [Internet]. Vials. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.apg-pharma.com/vials/infusion-vial MFS. Make Fortnite Skins [Internet]. Make Fortnite Skins. 2020 [cited 2022 Mar 23]. p. 1. Available from: https://make-fortnite-skins.com/ |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.license.spa.fl_str_mv |
Reconocimiento 4.0 Internacional |
| dc.rights.uri.spa.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Reconocimiento 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
xxiv, 242 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.publisher.program.spa.fl_str_mv |
Bogotá - Ciencias - Maestría en Ciencias - Farmacología |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias |
| dc.publisher.place.spa.fl_str_mv |
Bogotá, Colombia |
| dc.publisher.branch.spa.fl_str_mv |
Universidad Nacional de Colombia - Sede Bogotá |
| institution |
Universidad Nacional de Colombia |
| bitstream.url.fl_str_mv |
https://repositorio.unal.edu.co/bitstream/unal/82966/1/license.txt https://repositorio.unal.edu.co/bitstream/unal/82966/2/1019102077.2022.pdf |
| bitstream.checksum.fl_str_mv |
eb34b1cf90b7e1103fc9dfd26be24b4a 24e9c0be3ab3b1a39c552636bd01332b |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| repository.mail.fl_str_mv |
repositorio_nal@unal.edu.co |
| _version_ |
1806886392209342464 |
| spelling |
Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2López Gutiérrez, José Julián3a58a87f8b78db130791f61c010929e4Toro Bernal, Fernando46f514c608170ad8618424b7d662d470600Red para el uso Adecuado de Medicamentos (RAM)Telaraña Farmacéuticahttps://orcid.org/0000-0003-3222-743Xhttps://www.researchgate.net/profile/Fernando-Toro-Bernal2023-01-17T02:02:52Z2023-01-17T02:02:52Z2022-07-07https://repositorio.unal.edu.co/handle/unal/82966Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, gráficas, tablasLa isoapariencia es la semejanza en el empaque o etiquetado de los medicamentos que aumenta la probabilidad de cometer errores durante la atención en salud. A nivel mundial, cada país es libre de gestionar estos riesgos mediante la implementación de barreras de seguridad para que no se desencadenen errores de medicación en un paciente. El objetivo de esta investigación consistió en diseñar y validar un instrumento mediante la caracterización de los atributos mínimos en el empaque primario de los medicamentos inyectables que permita identificar su isoapariencia. Los materiales y métodos para el desarrollo de esta tesis de maestría consistieron en seis etapas. En la primera se realizó una revisión bibliográfica exhaustiva y exploración del portal Datos Abiertos. Para la segunda se conformó un grupo Delphi con expertos a nivel nacional e internacional. En la tercera se diseñó un instrumento para la recolección y análisis de la información. La cuarta consistió en pilotar el instrumento en una institución de baja complejidad. En la quinta se validó estadísticamente el instrumento. La sexta se orientó a construir una herramienta digital. Como resultados se identificaron 36 atributos que permiten evaluar la isoapariencia en el empaque primario de los medicamentos inyectables, los cuales fueron validados por 17 expertos. Además, se construyó la primera plataforma web 2.0 no-code pública denominada ISOFARINY©. En conclusión, la isoapariencia en Colombia sí existe y el instrumento desarrollado en esta investigación permitirá identificar de manera objetiva las parejas de medicamentos inyectables que son fallas activas en el conjunto de productos farmacéuticos comercializados a nivel local, nacional o mundial para diseñar estrategias que minimicen el riesgo por parte de los diferentes actores involucrados en la cadena logística del medicamento. (Texto tomado de la fuente).The look-alike drug is the similarity in the packaging or labeling of medicines that increases the probability of making errors during health care. Worldwide, each country is free to manage these risks by implementing security barriers so that medication errors are not triggered in a patient. The objective of this research was to design and validate an instrument by characterizing the minimum attributes in the primary packaging of injectable products that allows identifying their look-alike drug. The materials and methods for the development of this master's thesis consisted of six stages. In the first, an exhaustive bibliographic review and exploration of the portal “Datos Abiertos” was carried out. For the second, a Delphi group was formed with national and international experts. In the third, an instrument was designed for the collection and analysis of information. The fourth consisted of piloting the instrument in a low-complexity institution. In the fifth, the instrument was statistically validated. The sixth was aimed at building a digital tool. As results, 36 attributes were identified that allow evaluating the look-alike drug in the primary packaging of injectable products, which were validated by 17 experts. In addition, the first public web 2.0 no-code platform called ISOFARINY© was built. In conclusion, the look-alike drug in Colombia does exist and the instrument developed in this research will make it possible to objectively identify the pairs of injectable drugs that are active failures in the set of pharmaceutical products marketed locally, nationally or globally to design strategies that minimize the risk by the different actors involved in the drug logistics chain.“En tiempos de cambio, quienes estén abiertos al aprendizaje se adueñarán del futuro, mientras que aquellos que creen saberlo todo estarán bien equipados para un mundo que ya no existe” - Eric HofferMaestríaMagíster en Ciencias - FarmacologíaPara el desarrollo de esta tesis de maestría consistieron en seis etapas. En la primera se realizó una revisión bibliográfica exhaustiva y exploración del portal Datos Abiertos. Para la segunda se conformó un grupo Delphi con expertos a nivel nacional e internacional. En la tercera se diseñó un instrumento para la recolección y análisis de la información. La cuarta consistió en pilotar el instrumento en una institución de baja complejidad. En la quinta se validó estadísticamente el instrumento. La sexta se orientó a construir una herramienta digital.FarmacovigilanciaISOFARINY©️ es la primera plataforma web 2.0 colombiana que aborda la situación de alto riesgo de isoapariencia farmacéutica en medicamentos inyectables bajo un entorno digital amigable y atractivo visualmente para sus usuarios finales --> https://www.isofariny.org/xxiv, 242 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - FarmacologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::615 - Farmacología y terapéuticaEmbalaje de MedicamentosEtiquetado de MedicamentosRedes de Comunicación de ComputadoresDrug PackagingDrug LabelingComputer Communication NetworksFarmacovigilanciaErrores de medicaciónMedicamentos LASARAWeb 2.0No-codePharmacovigilanceMedication errorsLook-alike drugDiseño y validación de un instrumento para la identificación de isoapariencia en el empaque primario de medicamentos inyectablesDesign and validation of an instrument for the identification of look-alike drug in the primary packaging of injectables productsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeOrganización Mundial de la Salud. La OMS lanza una iniciativa mundial para reducir a la mitad los errores relacionados con la medicación en cinco años [Internet]. Organización Mundial de la Salud. 2017 [cited 2020 Aug 31]. p. 1. Available from: https://www.who.int/es/news-room/detail/29-03-2017-who-launches-global-effort-to-halve-medication-related-errors-in-5-yearsWorld Health Organization. Global campaign: Medication Without Harm [Internet]. World Health Organization. [cited 2020 Aug 31]. p. 1. Available from: https://www.who.int/initiatives/medication-without-harmPalacio Lapuente F, Hernández Rodríguez M a. Isoapariencia. Una necesidad imperiosa en la prescripción por denominación oficial española. Atención Primaria [Internet]. 2011 Dec;43(12):625–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0212656711005014Organización Mundial de la Salud. Sistemas de notificación y aprendizaje sobre errores de medicación: el papel de los centros de farmacovigilancia [Internet]. Ginebra; 2018 [cited 2020 Aug 31]. Available from: https://apps.who.int/iris/bitstream/handle/10665/276898/9789243507941-spa.pdf?sequence=1&isAllowed=yJiménez F, Valcárcel R, Vaca C, Orozco J, López J AN. Suplemento No. 1 Conceptos Básicos en Farmacovigilancia. Boletín Farmacovigil [Internet]. 2006 [cited 2020 Aug 31];12(1):1–7. Available from: https://xdoc.mx/preview/suplemento-del-boletin-12-2006-5c1aa59a9312eWorld Health Organization. The third WHO Global Patient Safety Challenge: Medication Without Harm [Internet]. World Health Organization. [cited 2020 Sep 1]. p. 1. Available from: https://www.who.int/publications/i/item/BLT.17.198002World Health Organization. Medication Without Harm - WHO Global Patient Safety Challenge [Internet]. 2017 [cited 2020 Sep 1]. p. 1–16. Available from: http://apps.who.int/iris/bitstream/10665/255263/1/WHO-HIS-SDS-2017.6-eng.pdf?ua=1&ua=1World Health Organization. Medication Without Harm: Real-life stories [Internet]. Patient stories of harm. 2017 [cited 2020 Sep 7]. p. 1. Available from: https://www.who.int/news-room/photo-story/photo-story-detail/medication-without-harm-real-life-storiesMontero Delgado J a., Plata Paniagua S, Arenas Villafranca J j. El problema de la isoapariencia de medicamentos en España: es hora de actuar. J Healthc Qual Res [Internet]. 2020 Mar;35(2):126–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2603647920300191ISanidad. Condenados por homicidio imprudente dos enfermeros del Hospital Infanta Cristina [Internet]. ASP. 2016 [cited 2020 Sep 14]. p. 1. Available from: http://isanidad.com/75208/condenados-por-homicidio-imprudente-dos-enfermeros-del-hospital-infanta-cristina/%0ADelegación Española del Institute for Safe Medication Practices. Sistema de Notificación y Aprendizaje de Errores de Medicación - Etiquetado/envasado proclive a error [Internet]. Instituto Para El Uso Seguro De Los Medicamentos Delegación Española. 2020 [cited 2020 Sep 14]. p. 1. Available from: http://www.ismp-espana.org/envasado_proclive_error/indexMontero Delgado JA. Stop Errores de Medicación [Internet]. Stop Errores de Medicación. 2020 [cited 2020 Sep 14]. p. 1. Available from: https://www.stoperroresdemedicacion.org/Ministerio de Salud de Colombia. Mejorar La Seguridad En La Utilización De Medicamentos [Internet]. Bogotá; 2015 [cited 2020 Sep 14]. p. 1–133. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/CA/seguridad-en-la-utilizacion-de-medicamentos.pdfInstituto Nacional de Vigilancia de Medicamentos y Alimentos. Guía para los usuarios sobre lineamientos en visitas de seguimiento a los programas de farmacovigilancia para establecimientos pertenecientes a la red nacional de farmacovigilancia [Internet]. 2016 [cited 2020 Sep 14]. p. 1–18. Available from: https://es.scribd.com/document/407612761/IVC-VIG-GU009-Version-3-FarmacovigilanciaInstituto Nacional de Vigilancia de Medicamentos y Alimentos. ABC Seguridad en el uso de medicamentos [Internet]. Imprenta Nacional de Colombia; 2014 [cited 2020 Sep 14]. p. 1–54. Available from: http://www.observamed.org/Farmacovigilancia_FMC/INVIMA_Cartilla2_SeguridadEnUsoMedicamentos_2014.pdfFood And Drug Administration. FDA Adverse Events Reporting System (FAERS) Public Dashboard [Internet]. Qlik Sense. 2020 [cited 2020 Sep 11]. p. 1. Available from: https://fis.fda.gov/sense/app/95239e26-e0be-42d9-a960-9a5f7f1c25ee/sheet/7a47a261-d58b-4203-a8aa-6d3021737452/state/analysisMinisterio de Sanidad Servicios Sociales e Igualdad. Evolución de la implantación de prácticas seguras de utilización de medicamentos en los hospitales españoles (2007-2011) [Internet]. Madrid; 2012 [cited 2020 Sep 15]. p. 1–142. Available from: https://www.seguridaddelpaciente.es/resources/documentos/evolucion_practicas_seguras_medicamentos.pdfNational Coordinating Council for Medication Error Reporting and Prevention. About Medication Errors [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/about-medication-errorsNational Coordinating Council for Medication Error Reporting and Prevention. Types of Medication Errors [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/types-medication-errorsNational Coordinating Council for Medication Error Reporting and Prevention. Taxonomy of Medication Errors Now Available [Internet]. NCCMERP. 2014 [cited 2020 Sep 15]. p. 1. Available from: https://www.nccmerp.org/taxonomy-medication-errors-now-availableWorld Health Organization. Annex 9 Guidelines on packaging for pharmaceutical. WHO Tech Rep Ser [Internet]. 2002;(902):120–53. Available from: https://cdn.who.int/media/docs/default-source/medicines/norms-and-standards/guidelines/regulatory-standards/trs902-annex9.pdf?sfvrsn=82b4c57d_2EUROPEAN PHARMACOPOEIA. 3.2.1. Glass Containers for pharmaceutical use [Internet]. 2005. 363–367 p. Available from: https://www.biomed.co.th/downloads/EP7-3.2.1-Glass containers-for-pharmaceutical-use.pdfNasa P. A Review on Pharmaceutical Packaging Material. World J Pharm Res [Internet]. 2014;3(5):344–68. Available from: https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1405426296.pdfMallik Jony., Alam Md. Feroz., Hossain Syed Mainul, Rahaman Mahfujur, Begum Ferdousi DJ. Pharmaceutical Packaging-An art of protection, preservation and presentation- An exhaustive review. Int J Mordern Pharm Res [Internet]. 2018;7(1):29–37. Available from: https://ijmpronline.com/download/article/14/1518858432.pdfÁlvarez MR, Torrado-Fonseca M. El método Delphi. REIRE Rev d’Innovación i Recer en Educ [Internet]. 2016 [cited 2020 Oct 19];9(9 (1)):87–102. Available from: https://revistes.ub.edu/index.php/REIRE/article/view/reire2016.9.1916Sánchez R, Echeverry J. Validación de escalas de medición en salud. Rev Salud Pública [Internet]. 2004 [cited 2020 Oct 7];6:302–18. Available from: https://scielosp.org/article/rsap/2004.v6n3/302-318/Parra ABS. La estadística en la validación de escalas, una visión práctica para su construcción o su adaptación. I3+ [Internet]. 2015 Aug 31 [cited 2020 Oct 7];2(2):46–61. Available from: http://revistasdigitales.uniboyaca.edu.co/index.php/reiv3/article/view/111Ventura-León J. Escalas, inventarios y cuestionarios: ¿son lo mismo? Educ Médica [Internet]. 2020 May;21(3):218–20. Available from: https://linkinghub.elsevier.com/retrieve/pii/S157518131930097XRomera C, Casado A. Validación de escalas de medición en salud [Internet]. Dynamic; 2015 [cited 2020 Oct 7]. Available from: https://www.dynasolutions.com/publicaciones/pdf/30.pdfLagunes-Córdoba R. Recomendaciones sobre los procedimientos de construcción y validación de instrumentos y escalas de medición en la psicología de la salud. Psicol y Salud. 2017;27:5.Choudhury N. World Wide Web and Its Journey from Web 1 .0 to Web 4.0. Int J Comput Sci Inf Technol [Internet]. 2014;5(6):8096–100. Available from: https://ijcsit.com/docs/Volume 5/vol5issue06/ijcsit20140506265.pdfSolanki MR, Dongaonkar A. A Journey of Human Comfort: Web 1.0 to Web 4.0. Int J Res Sci Innov [Internet]. 2016;III(Ix):75–8. Available from: https://www.rsisinternational.org/IJRSI/Issue31/75-78.pdfParvathi M, Mariselvi R. A Bird’s Eye on the Evolution – Web 1.0 to Web 5.0. Int J Adv Res Trends Eng Technol [Internet]. 2017;4(4):167–76. Available from: https://bit.ly/2HQTVDLKendall K. The Rise of the No-Code Movement [Internet]. Sitepoint. 2020 [cited 2020 Nov 15]. p. 1. Available from: https://www.sitepoint.com/the-rise-of-the-no-code-movement/Lossada F. El color y sus armonías. Colección. Mérida: Universidad De Los Andes; 2012. 1–70 p.Villagrán Arroyal I. Gestión Del Color. In: Retoque digital de imágenes [Internet]. Primera. Málaga: IC Editorial; 2014. p. 1–60. Available from: http://reader.digitalbooks.pro/book/preview/38703/c1.html?1611870730150#sigil_toc_id_1National Council of Educational Research and Training. COLOUR. In: Towards a New Age Graphic Design Textbook in Graphic Design for Class XII [Internet]. Primera. Delhi; 2011. p. 44–59. Available from: https://ncert.nic.in/textbook/pdf/legd104.pdfGoogle. Selector de color [Internet]. Buscar con Google. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://www.google.com/search?q=selector+de+color&rlz=1C1ALOY_esCO951CO951&oq=selector+de+color&aqs=chrome..69i57j0i512l9.544j0j7&sourceid=chrome&ie=UTF-8Yu L, Zhang L, van de Weijer J, Khan FS, Cheng Y, Parraga CA. Beyond Eleven Color Names for Image Understanding. Mach Vis Appl [Internet]. 2018 Feb 26;29(2):361–73. Available from: http://link.springer.com/10.1007/s00138-017-0902-yW3C. CSS Color Module Level 3 [Internet]. Color Units. 2021 [cited 2022 Jan 26]. p. 1. Available from: https://www.w3.org/TR/css-color-3/#profilesInstituto Nacional de Vigilancia de Medicamentos y Alimentos. Consulta y aprovecha los datos abiertos de Invima [Internet]. Preventino Recomienda a Consumidores. 2021 [cited 2021 Oct 22]. Available from: https://www.invima.gov.co/en/consulta-y-aprovecha-los-datos-abiertos-de-invimaMinisterio de Tecnologías de la Información y Comunicaciones. El Invima demuestra cómo sacarle provecho a los Datos Abiertos [Internet]. Sala de prensa. 2020 [cited 2021 Oct 22]. Available from: https://mintic.gov.co/portal/inicio/Sala-de-prensa/Noticias/135738:El-Invima-demuestra-como-sacarle-provecho-a-los-Datos-AbiertosMinisterio de Tecnologías de la Información y Comunicaciones. Datos Abiertos [Internet]. Buscar. 2021 [cited 2021 Oct 22]. Available from: https://www.datos.gov.co/browse?Información-de-la-Entidad_Nombre-de-la-Entidad=Instituto+Nacional+de+Vigilancia+de+Medicamentos+y+Alimentos&limitTo=datasets&provenance=official&sortBy=newestConverting Colors. Source Values (one color value per line) [Internet]. Mass Conversion. 2021 [cited 2021 Feb 8]. p. 1. Available from: https://convertingcolors.com/mass-conversion.htmlStackoom. How to highlight a cell using the hex color value within the cell? [Internet]. Question. 2015 [cited 2021 Feb 8]. p. 1. Available from: https://stackoom.com/en/question/hruwDe las Salas R. Criterios para la deprescripción de medicamentos en pacientes adultos mayores con diabetes mellitus tipo 2 [Internet]. Universidad Nacional De Colombia; 2020. Available from: https://repositorio.unal.edu.co/handle/unal/79184?show=fullEscobar-Pérez J, Cuervo-Martínez Á. Validez De Contenido Y Juicio De Expertos: Una Aproximación a Su Utilización. Av en Medición. 2008;6(September):27–36.Gobierno y Gestión de Servicios de TI Unal. Guía de condiciones del servicio de correo electrónico [Internet]. Bogota; 2020. p. 1–7. Available from: https://dntic.unal.edu.co/images/documentos/COND_USO_CORREO_ELECTRONICO.pdfStarUML. Download [Internet]. StarUML. 2022 [cited 2022 Jan 19]. p. 1. Available from: https://staruml.io/Talarian. Form Publisher [Internet]. Google WorkSpace Marketplace. 2022 [cited 2022 Apr 14]. p. 1. Available from: https://workspace.google.com/marketplace/app/form_publisher/827172627657Form Publisher. Getting Started [Internet]. Documentation - Form Publisher Support. 2022 [cited 2022 Apr 14]. p. 1. Available from: https://support.form-publisher.com/hc/en-us/categories/201581669-Getting-StartedBoateng GO, Neilands TB, Frongillo EA, Melgar-Quiñonez HR, Young SL. Best Practices for Developing and Validating Scales for Health, Social, and Behavioral Research: A Primer. Front Public Heal. 2018;6(June):1–18.Galicia Alarcón LA, Balderrama Trápaga JA, Edel Navarro R. Content validity by experts judgment: Proposal for a virtual tool. Apertura. 2017;9(2):42–53.Peralta-Linares YA, González-Consuegra R V. Validity and reliability of the Spanish version of the Arrhythmia-specific questionnaire in tachycardia and arrhythmia (ASTA). Rev Colomb Cardiol [Internet]. 2018 Sep;25(5):305–13. Available from: https://rccardiologia.com/previos/RCC 2018 Vol. 25/RCC_2018_25_5_SEP-OCT/RCC_2018_25_5_305-313.pdfSoriano Rodríguez AM. Diseño y validación de instrumentos de medición. Diá-logos. 2015;(14):19–40.Galeano S. Validez y confiabilidad el instrumento Jefferson scale of attitudes toward physician-nurse collaboration en el contexto Colombiano [Internet]. 2018. Available from: http://bdigital.unal.edu.co/64703/1/1529930438619_validez y confiabilidad del JSNPCS. Sandra Juliana Galeano.pdfMagdalena L, Sierra P, Enselmina M, Vargas M. Área de investigación: Administración de la tecnología. XX Congr Int Contaduría, Adm e Informática [Internet]. 2015; Available from: http://congreso.investiga.fca.unam.mx/docs/xx/docs/2.02.pdfManterola C, Otzen T. Assessment of summaries presented in congresses. Study of validation. Rev Chil Cir [Internet]. 2016;68(4):302–9. Available from: http://dx.doi.org/10.1016/j.rchic.2015.11.002Andújar C. Introducción a la teoría y construcción de instrumentos de medición. 2001. 101 p.Mayhua LG. Propiedades psicométricas de los instrumentos de medición en las tesis de la facultad de enfermería de la universidad nacional del altiplano, puno - 2016 [Internet]. Universidad Nacional del Altiplano; 2017. Available from: http://repositorio.unap.edu.pe/handle/UNAP/3636García de Yébenes Prous MJ, Rodríguez Salvanés F, Carmona Ortells L. Validation of questionnaires. Vol. 5, Reumatologia Clinica. 2009. p. 171–7.Abad F, Garrido J, Olea J, Ponsoda V. Introducción a la Psicometría: Teoría Clásica de los Tests y Teoría de la Respuesta al Ítem [Internet]. 1st ed. Madrid: Universidad Autónoma de Madrid; 2006. 1–101 p. Available from: https://www.papelesdelpsicologo.es/pdf/1796.pdfLuján-Tangarife JA, Cardona-Arias JA. Construcción y validación de escalas de medición en salud: Revisión de propiedades psicométricas. Arch Med. 2015;11(3):1–10.Streiner D, Norman G, Cairney J. Health Measurement Scales: A Practical Guide to Their Development and Use. Oxford: Oxford University Press; 2015. 1–415 p.Supo J. Cómo validar un instrumento: Aprende a crear y validar instrumentos como un experto [Internet]. Copyright. 2016. 53 p. Available from: http://www.cua.uam.mx/pdfs/coplavi/s_p/doc_ng/validacion-de-instrumentos-de-medicion.pdfMonkeyLearn. WordCloud Generator [Internet]. Source text. 2022 [cited 2022 Jul 16]. p. 1. Available from: https://monkeylearn.com/word-cloudTristán-López a. Modificación al modelo de Lawshe para el dictamen cuantitativo de la validez de contenido de un instrumento objetivo. Av en medición. 2008;6:37–48.Bernal-García MI, Salamanca Jiménez DR, Perez Gutiérrez N, Quemba Mesa MP. Validez de contenido por juicio de expertos de un instrumento para medir percepciones físico-emocionales en la práctica de disección anatómica. Educ Médica [Internet]. 2020 Nov;21(6):349–56. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1575181318302584Montoya A, Ortiz J, Paul E, Galindo J, Ochoa D. Segmentación A una Base de Datos [Internet]. RPubs by RStudio. 2018 [cited 2022 Jul 16]. p. 1. Available from: https://rpubs.com/andrestoya/391125Rods A. Método Elbow, para elegir el número ideal de clusters [Internet]. Curso de Introducción al Álgebra Lineal: Vectores. 2021 [cited 2022 Jul 16]. p. 1. Available from: https://platzi.com/tutoriales/2127-intro-algebra/11447-metodo-elbow-para-elegir-el-numero-ideal-de-clusters/#:~:text=El método Elbow o **,elemento con su centroide correspondiente.Ortega M. El coeficiente de correlacion de los rangos de spearman caracterización. Rev Habanera Ciencias Médicas [Internet]. 2009;8(2):20. Available from: https://www.redalyc.org/pdf/1804/180414044017.pdfKhamis H. Measures of association: How to choose? Vol. 24, Journal of Diagnostic Medical Sonography. 2008. p. 155–62.Balsamiq®️. Balsamiq Cloud: Fast, Approachable, Collaborative Wireframing [Internet]. Log In to Balsamiq Cloud. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://balsamiq.cloud/#loginGoogle. Sitios web recientes [Internet]. Sites. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://sites.google.com/?hl=esGoogle. Google Drive: acceso sencillo y seguro a todo tu contenido [Internet]. Google WorkSpace. 2022 [cited 2022 Jan 15]. p. 1. Available from: https://www.google.com/intl/es_es/drive/Pixabay. Increíbles Imágenes Gratis Para Descargar [Internet]. Pixabay. 2022 [cited 2022 Jan 18]. p. 1. Available from: https://pixabay.com/es/Sabah A, Ahmed I, Arsalan A, Arif A, Tanwir S, Abbas A. Features , Functions and Selection of Pharmaceutical Packaging materials. Indian J Pharm Sci Res [Internet]. 2014;1(1):1–12. Available from: https://www.researchgate.net/publication/261143936_Features_Functions_and_selection_of_Pharmaceutical_Packing_MaterialsAkers MJ. Sterile Drug Products - Formulation, Packaging, Manufacturing, and Quality [Internet]. 1st ed. Swarbrick J, editor. CRC Press; 2010. 1–516 p. Available from: https://www.routledge.com/Sterile-Drug-Products-Formulation-Packaging-Manufacturing-and-Quality/Akers/p/book/9780849339936#Sierra Martínez N. Envases de vidrio de uso farmacéutico : guía para el control de calidad [Internet]. Baquero C, editor. Bogotá: Universidad Nacional de Colombia; 2012. 1–73 p. Available from: https://repositorio.unal.edu.co/handle/unal/79933Pareek V, Khunteta A. Pharmaceutical packaging: Current trends and future. Int J Pharm Pharm Sci. 2014;6(6):480–5.Borja Orantes J. Recopilación Bibliografica de Materiales de Envase Primario, Secundario y Terciario, para las Formas Farmacéuticas Liquidas, sólidas y semisólidas. Univ El Salvador Fac Química y Frmacia [Internet]. 2016;3(2):331. Available from: http://ri.ues.edu.sv/4988/1/16100316.pdfSchaut RA, Weeks WP. Historical review of glasses used for parenteral packaging. PDA J Pharm Sci Technol. 2017;71(4):279–96.Sacha GA, Saffell-Clemmer W, Abram K, Akers MJ. Practical fundamentals of glass, rubber, and plastic sterile packaging systems. Pharm Dev Technol. 2010;15(1):6–34.Beltrán Rico M, Marcilla Gomis A. TEMA 2. TIPOS DE PLASTICOS, ADITIVACIÓN Y MEZCLADO. In: Tecnología de Polímeros - Procesado y propiedades [Internet]. 1st ed. Alicante: Publicaciones de la Universidad de Alicante; 2012. p. 252– 285. Available from: https://publicaciones.ua.es/es/catalogo/tecnologia-de-polimeros/978-84-9717-232-5Kremer Pigmente. Pigmentos [Internet]. Shop. 2021 [cited 2021 Dec 30]. Available from: https://www.kremer-pigmente.com/es/shop/pigmentos/Calderón Martínez AC. Procedimiento para el manejo adecuado de los desechos de vidrio provenientes de ampollas, generados en el Área de Producción de Líquidos Estériles Inyectables de un Laboratorio Farmacéutico de Guatemala [Internet]. Universidad De San Carlos De Guatemala; 2016. Available from: https://biblioteca-farmacia.usac.edu.gt/Tesis/MAIES201.pdfGad SC. Pharmaceutical Manufacturing Handbook: Production and Processes. Pharmaceutical Manufacturing Handbook: Production and Processes. 2007. 1–1370 p.Schott AG. Viales [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 4]. p. 1. Available from: https://www.schott.com/es-es/products/vialsSchott AG. Jeringas [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.schott.com/es-es/products/syringesStevanato Group. Cartuchos de vidrio de gran Volumen [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/cartuchos/cartuchos-de-vidrio-de-gran-volumen/Fresenius Kabi. The art of innovation freeflex. Technical Manual [Internet]. Vol. 1. Bad Homburg: Fresenius Kabi Deutschland GmbH Technical; 2016. p. 1–20. Available from: https://gruposdetrabajo.sefh.es/gps/images/stories/MANUAL_TECNICO_Freeflex_Fresenius_Kabi.pdfGrifols. Fleboflex® Luer [Internet]. Fleboflex®. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.fleboflex.com/es/fleboflex-luerSchott AG. Ampoule [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.schott.com/es-es/products/ampoulesGerresheimer. Ampoules made of glass [Internet]. Pharmaceutical Primary Packaging. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.gerresheimer.com/catalogue/products/pharmaceutical-primary-packaging/ampoules-made-of-glass.html?limit=allAdelphi Healthcare Packaging. VialVet PET Crimp Neck Vials [Internet]. Plastic Bottles. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/pet-crimp-neck-vialsSGD Pharma. INFUSION BOTTLES [Internet]. Products & Innovation. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.sgd-pharma.com/infusion-bottlesStevanato Group. SG Nexa® 3X EZ-fill® [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/cartuchos/Medi Pharma Plan. Multi Chamber Bag Product [Internet]. Non PVC IV Solution. 2021. p. 1. Available from: http://www.medipharmaplan.com/new/eng/product/non_3.html#Schott AG. Ampollas [Internet]. Mainz; 2021. p. 1–12. Available from: https://www.catalogodelempaque.com/documenta/contenido/120314/Brochure_Ampoules_Spanish_ROW.pdfColeman WP, Flynn TC, Delanzac K, Coleman WP, Coleman KM. Inaccurate labeling of intravenous fluid bags: Implications for anesthesiologists [2]. J Clin Anesth. 2003;15(3):242–3.Hernández F, Navascués I. Notas galénicas: ampollas. Panacea [Internet]. 2000;1(1):11–2. Available from: https://www.tremedica.org/wp-content/uploads/n1_NotasGalenicas.pdfSchott Kaisha. SCHOTT KAISHA Ampoules [Internet]. Products. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.schott-kaisha.com/ampoules.htmlCarraretto AR, Freitas Curi E, de Almeida CED, Monteiro Abatti RE. Ampollas de Vidrio: Riesgos y Beneficios. Rev Bras Anestesiol. 2011;61(4):280–4.Stevanato Group. Ampoules [Internet]. Drug Containment Solution. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/ampoules/Making.com. Types of ampoules: shapes that fit the standards [Internet]. Let’s make ampoules. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://making.com/ampoules/Suzuki S, Gilbar P, Yu B, Matsuyama C, Yamaguchi M. Current status of drug vial optimization use to prevent waste associated with injectable anticancer agents. J Oncol Pharm Pract. 2019;25(1):244–6.West Pharmaceutical Services. Daikyo® Crystal Zenith® Vials [Internet]. Vials. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.westpharma.com/products/vial-containment-solutions/vials/daikyo-crystal-zenith-vialsAdelphi Healthcare Packaging. FluroTec® Stoppers [Internet]. Rubber Stoppers. 2021 [cited 2021 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/flurotec-stoppersAdelphi Healthcare Packaging. Crimp Seals with Plastic Discs [Internet]. Aluminium Crimp Seals. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://adelphi-hp.com/product-range/crimp-seals-with-plastic-discsStevanato Group. Viales SG EZ-fill®: Excelencia operacional en sus procesos de llenado [Internet]. Empaque Primario De Vidrio. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://www.stevanatogroup.com/es/oferta/empaque-primario-de-vidrio/vialesSoto C, Stiner J, Noji DO, Rusheen JM, Huang YM. Creating a Simulated Pharmacy. Simul Healthc. 2016;11(3):218–22.Stevanato Group. EZLINKTM - Vial Adapter [Internet]. Drug Containment Solution. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/vial-systems/ezlink/Becton Dickinson. SmartSiteTM vented vial access device [Internet]. Needle Free Systems And Connectors. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.bd.com/en-uk/products/infusion/iv-therapy/needle-free-systems-and-connectors/smartsite-vented-vial-access-deviceSchott Kaisha. Specialty Products [Internet]. Specialty Products. 2021 [cited 2022 Jan 5]. p. 1. Available from: https://schott-kaisha.com/specialty-products.htmlFACET Pharm/Med Manufacturing. Complex Container/Closure [Internet]. Tube Filling. 2021 [cited 2021 Jan 5]. p. 1. Available from: https://www.facetllc.com/tube-filling/Stoelzle Pharma. Injection vials & infusion bottles [Internet]. Products. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.stoelzle.com/pharma/products/injection-vial/Fresenius Kabi. Bottles, plastic (50 - 1000 ml) [Internet]. Sterile Pharmaceuticals. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://cmo.fresenius-kabi.com/bottles-plasticBBraun. ECOFLAC® PLUS [Internet]. Infusion Therapy. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.bbraun.co.uk/en/products-and-therapies/infusion-therapy/ecoflac--plus.htmlEester C van. Webinar Parenteral Packaging for Cartridges in Drug Delivery Devices [Internet]. Looking to the Future of Parenteral Packaging. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://datwyler.com/media/news/parenteral-packaging-for-cartridges-in-drug-delivery-devices#webinar-1-videoSchott AG. Cartuchos [Internet]. Productos & Experiencia. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.schott.com/es-es/products/cartridgesLangley C, Robert W, Adams L. Cartucho de medicamento que tiene medios de identificación [Internet]. Reino Unido; ES2429901T3, 2008. p. 1. Available from: http://www.oepm.es/pdf/ES/0000/000/02/42/99/ES-2429901_T3.pdfICU Medical. EVA Infusion Bags [Internet]. Compounding Accesories. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.icumed.com/products/specialty/compounding-accessories/eva-infusion-bagsTechno Flex. Dual-Mix® [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/dual-mix/ICU Medical. 2-Chamber Bags [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/2-chamber-bags/ICU Medical. Bolsas de 3 cámaras [Internet]. Multi chamber bags. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.technoflex.net/en/products/3-chamber-bags/American Society for Parenteral and Enteral Nutrition. Part III: Preparing,Labeling, and Dispensing [Internet]. Multi-Chamber Bag Parenteral Nutrition (MCB-PN) Video Series. 2018 [cited 2022 Jan 9]. p. 1. Available from: https://www.nutritioncare.org/MCBPN/BBraun. Cephalosporins in the DUPLEX® Container [Internet]. Ready to Use Drug Delivery System. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/cephalosporins-intheduplexcontainer.htmlBBraun. Carbapenems in the DUPLEX® Container [Internet]. Ready to Use Drug Delivery System. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/carbapenems-in-theduplexcontainer.htmlFresenius Kabi. Multi-chamber bags [Internet]. Sterile Pharmaceuticals. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://cmo.fresenius-kabi.com/multi-chamber-bagsColomb V, Marlowe ML, Bonnot D, Rigo J. Practical use of a new three-chamber bag for parenteral nutrition in pediatric patients. ESPEN J [Internet]. 2012;7(2):e93–9. Available from: http://dx.doi.org/10.1016/j.clnme.2012.01.002BBraun. Bolsas Tricompartimendas [Internet]. Nutrición Parenteral. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraun.es/es/productos-y-terapias/catalogo-de-productos/nutricion-clinica/nutricion-parenteral/bolsas-tricompartimentadas.htmlFresenius Kabi. Locking Protective Cap [Internet]. Accessories. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://freeflexivbags.com/ffx-accessories/Samson Medical Technologies. SmartPak Products [Internet]. SmartPak Products. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://samsonmt.com/smartpak-products/BBraun. Lidocaine Hydrochloride and 5% Dextrose Injection USP [Internet]. Premixed Drugs. 2021 [cited 2022 Jan 9]. p. 1. Available from: https://www.bbraunusa.com/en/products/b/lidocaine-hydrochlorideand5dextroseinjectionusp.htmlFresenius Kabi. Premix Products [Internet]. Freeflex® bags. 2021 [cited 2021 Jan 9]. p. 1. Available from: https://freeflexivbags.com/premix-products/Doyle GR, McCutcheon JA. Clinical Procedures for Safer Patient Care [Internet]. British Columbia Institute of Technology. 2015. 479–487 p. Available from: https://opentextbc.ca/clinicalskills/Becton Dickinson. BD plunger stoppers [Internet]. Add ons and components. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/plunger-stoppersBecton Dickinson. BD plunger rods [Internet]. Add ons and components. 2021 [cited 2021 Jan 6]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/plunger-rodsSong M. An Introduction To Prefilled Syringe Selection — Needle-Free And Dual-Chamber Devices [Internet]. Pharmaceutical Online. 2019 [cited 2022 Jan 6]. p. 1. Available from: https://www.pharmaceuticalonline.com/doc/an-introduction-to-prefilled-syringe-selection-needle-free-and-dual-chamber-devices-0001Jadhav SP, Shaikshanik S, Patil C, Sonawane DD, Jadhav KR, Salunkhe KS. Review on Prefilled Syringe as A Modern Technique for Packaging and Delivery of Parenteral. Int J Recent Sci Res [Internet]. 2020;11(04):38301–6. Available from: http://recentscientific.com/review-prefilled-syringe-modern-technique-packaging-and-delivery-parenteralFisterra. Administración parenteral de medicamentos: conceptos generales [Internet]. Técnicas Atención Primaria. 2011 [cited 2022 Jan 5]. p. 1. Available from: https://www.fisterra.com/ayuda-en-consulta/tecnicas-atencion-primaria/administracion-parenteral-medicamentos-conceptos-generales/Soikes R. Moving from Vial to Prefilled Syringe [Internet]. Pharmaceutical Technology. 2009 [cited 2021 Jan 6]. p. 1. Available from: https://www.pharmtech.com/view/moving-vial-prefilled-syringeGonzales M. Migrating a Drug Product Presentation from Vial to Prefilled Syringe [Internet]. ONdrugDelivery Online. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.ondrugdelivery.com/migrating-a-drug-product-presentation-from-vial-to-prefilled-syringe/Basu B, Dharamsi A, Makwana S, Makasana Y. Prefilled syringes: An innovation in parenteral packaging. Int J Pharm Investig. 2011;1(4):200.Song M. An Introduction To Prefilled Syringe Selection — Prefilled Syringes With Staked-In Needles [Internet]. Pharmaceutical Online. 2019 [cited 2022 Jan 6]. p. 1. Available from: https://www.pharmaceuticalonline.com/doc/an-introduction-to-prefilled-syringe-selection-prefilled-syringes-with-staked-in-needles-0001Credence Medsystems. The Companion Dual Chamber Reconstitution Syringe [Internet]. Safety Syringe System. 2021 [cited 2022 Jan 6]. p. 1. Available from: https://www.credencemed.com/dual-chamber/Becton Dickinson. BD backstops [Internet]. Add ons and components. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/prefillable-syringe-systems/add-ons-and-components/backstopsBecton Dickinson. BD EclipseTM needle [Internet]. Safety needles. 2021 [cited 2021 Jan 10]. p. 1. Available from: https://www.bd.com/en-us/offerings/capabilities/syringes-and-needles/safety-syringes-and-needles/safety-needles/bd-eclipse-needleBecton Dickinson. BD UltraSafe PassiveTM needle guard [Internet]. Safety and shielding systems. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/safety-and-shielding-systems/ultrasafe-passive-needle-guardBecton Dickinson. BD PreventisTM needle shielding system [Internet]. Safety and shielding systems. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://drugdeliverysystems.bd.com/products/safety-and-shielding-systems/preventis-needle-shielding-systemCredence Medsystems. The Companion Staked Needle Syringe [Internet]. Safety Syringe System. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://www.credencemed.com/staked/Owen Mumford. UniSafe® 1mL [Internet]. Prefilled Syringes. 2021 [cited 2022 Jan 10]. p. 1. Available from: https://www.owenmumford.com/en/drug-delivery/prefilled-syringes/unisafer-1mlStevanato Group. SG ISS - Integrated Safety System [Internet]. Syringe Systems. 2021 [cited 2021 Jan 10]. p. 1. Available from: https://www.stevanatogroup.com/en/offering/drug-containment-solutions/syringe-systems/sg-iss/Instituto Nacional de Vigilancia de Medicamentos y Alimentos. Guía etiquetas medicamentos [Internet]. Bogotá; 2017. p. 24. Available from: https://www.invima.gov.co/documents/20143/367911/Guía+de+etiquetas+de+medicamentos.pdf/abec2216-9182-a440-66f0-4fb17242cebc?t=1565042313222&download=trueWorld Health Organization. Parenteral preparations [Internet]. The International Pharmacopoeia - Tenth Edition. 2020 [cited 2022 Jan 10]. p. 1. Available from: https://digicollections.net/phint/2020/index.html#d/b.6.2.1.5Health Canada. Guidance Document: Labelling of Pharmaceutical Drugs for Human Use [Internet]. 2015. p. 90. Available from: https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/dhp-mps/alt_formats/pdf/prodpharma/applic-demande/guide-ld/label_guide_ld-eng.pdfNew Zealand Medicines And Medical Devices Safety Autorithy. Guideline on the Regulation of Therapeutics Products in New Zeland - Part 5: Labelling of medicines and related products [Internet]. New Zealand; 2018. p. 1–18. Available from: https://www.medsafe.govt.nz/regulatory/Guideline/GRTPNZ/Part5.pdfNational Patient Safety Agency. Design for patient safety: A guide to labelling and packaging of injectable medicines [Internet]. 1st ed. United Kingdom; 2008. p. 96. Available from: https://www.rca.ac.uk/research-innovation/research-centres/helen-hamlyn-centre/research-projects/2007-projects/safer-design/Estock JL, Murray AW, Mizah MT, Mangione MP, Goode JS, Eibling DE. Label Design Affects Medication Safety in an Operating Room Crisis. J Patient Saf [Internet]. 2018;14(2):101–6. Available from: http://insights.ovid.com/crossref?an=01209203-201806000-00006International Medication Safety Network. Position Statement: Making Medicines Naming, Labeling and Packaging Safer [Internet]. 2013. p. 11. Available from: http://www.ismp-espana.org/ficheros/IMSN. Making Medicines Naming%2C Labeling and Packaging Safer.pdfPHARMAC. Labelling preferences for prescription pharmaceuticals [Internet]. New Zeland; 2016. p. 1–8. Available from: https://pharmac.govt.nz/medicine-funding-and-supply/medicine-supply-management/pharmac-labelling-preferences-for-prescription-pharmaceuticals/Therapeutic Goods Administration. Medicine labels: Guidance on TGO 91 and TGO 92 [Internet]. 2021. p. 1–79. Available from: https://www.tga.gov.au/sites/default/files/medicine-labels-guidance-tgo-91-and-tgo-92_0.pdfMedicines and Healthcare products Regulatory Agency. Best practice guidance on labelling and packaging of medicines [Internet]. 2014. p. 1–16. Available from: https://www.gov.uk/government/publications/best-practice-in-the-labelling-and-packaging-of-medicines#full-publication-update-historyEuropean Commission. Guideline on the readability of the labelling and package leaflet of medicinal products for human use [Internet]. Bruselas; 2009. p. 1–27. Available from: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-2/c/2009_01_12_readability_guideline_final_en.pdfEuropean Commission. Guideline on the Packaging Information Packaging Information of Medicinal Products for Human Use Authorised by the Union [Internet]. Bruselas; 2016. p. 1–44. Available from: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-2/2016_12_packaging_guidelines_revision_14_4.pdfHealth Products Regulatory Authority. Guide to labels and leaflets for human medicines [Internet]. Irlanda; 2021. p. 30. Available from: https://www.hpra.ie/docs/default-source/publications-forms/guidance-documents/aut-g0034-guide-to-labels-and-leaflets-of-human-medicines-v21.pdf?sfvrsn=60Australian Commission on Safety and Quality in Health Care. Report on the National Round Table on Safer Naming, Labelling and Packaging of Medicines [Internet]. Sidney; 2011. p. 1–51. Available from: https://www.safetyandquality.gov.au/sites/default/files/migrated/National-Round-Table-on-Safer-Naming-Labelling-and-Packaging-Report.pdfGovernment of Canada. Packaging and labelling guide for cannabis products: Requirements under the Cannabis Act and the Cannabis Regulations [Internet]. 2019. 1–40 p. Available from: https://www.canada.ca/content/dam/hc-sc/documents/services/cannabis-regulations-licensed-producers/packaging-labelling-guide-cannabis-products/Packaging_and_labelling_guide_for_cannabis_products_rev.pdfUS Department of Health and Human Services, Center for Drug Evaluation and Research, Food And Drug Administration. Safety Considerations for Container Labels and Carton Labeling Design to Minimize Medication Errors [Internet]. 2013. p. 1–26. Available from: https://www.regulations.gov/docket/FDA-2013-D-0401/documentFood And Drug Administration C for DE and R. Safety Considerations for Product Design to Minimize Medication Errors [Internet]. Guidance for Industry. 2016. p. 480. Available from: https://www.fda.gov/files/drugs/published/Safety-Considerations-for-Product-Design-to-Minimize-Medication-Errors-Guidance-for-Industry.pdfMeeting IA. 17th ISoP Annual Meeting “Pharmacovigilance in the 21st Century” Liverpool, UK 15–18 October, 2017. Drug Saf. 2017;40(10):937–1045.da Silva Pons E, Moraes CG, Falavigna M, Sirtori LR, da Cruz F, Webster G, et al. Users’ preferences and perceptions of the comprehensibility and readability of medication labels. PLoS One. 2019;14(2):1–15.United States Pharmacopeial. Labeling <7> [Internet]. 2019. p. 1–9. Available from: https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/gc-7-labeling-rb-notice-20190830.pdfPatient Dafety Advisory. Drug Labeling and Packaging — Looking Beyond What Meets the Eye. Pennsylvania Patient Saf Report Syst. 2007;4(3):1–6.Institute for Safe Medication Practices. Improving Medication Safety in Community Pharmacy : Assessing Risk and Opportunities For Change [Internet]. 1st ed. 2009. 1–123 p. Available from: https://www.ismp.org/sites/default/files/attachments/2018-02/ISMP_AROC_whole_document.pdfInstitute for Safe Medication Practices Canada. Labelling and Packaging: An Aggregate Analysis of Medication Incident Reports [Internet]. Toronto; 2013. p. 1–22. Available from: www.ismp-canada.orgMomtahan K, Burns CM, Jeon J, Hyland S, Gabriele S. Using human factors methods to evaluate the labelling of injectable drugs. Healthc Q. 2008;11(3 Spec No.):122–8.Mackay E, Jennings J, Webber S. Medicines safety in anaesthetic practice. BJA Educ [Internet]. 2019;19(5):151–7. Available from: https://doi.org/10.1016/j.bjae.2019.01.001Simas da Rocha B, Garcia Moraes C, Miyake Okumura L, da Cruz F, Sirtori L, da Silva Pons E. Interventions to Reduce Problems Related to the Readability and Comprehensibility of Drug Packages and Labels: A Systematic Review. J Patient Saf. 2021;17(8):e1494–506.Norwegian Medicines Agency. Norwegian guideline for packaging of human and veterinary medicinal products with marketing authorisation / registration [Internet]. 2020. p. 1–23. Available from: https://legemiddelverket.no/Documents/English/Regulatory affairs/Guideline_final_pub_coll_19.2.20.pdfGoogle. Google Drive Direct Link Generator [Internet]. How to Get Your Sharing URL. 2021 [cited 2021 Dec 21]. p. 1. Available from: https://sites.google.com/site/gdocs2direct/Instituto Nacional de Vigilancia de Medicamentos y Alimentos. CONSULTA DATOS DE PRODUCTOS [Internet]. Consulta Registro Sanitario. 2022 [cited 2022 Jan 5]. p. 1. Available from: https://consultaregistro.invima.gov.co/Consultas/consultas/consreg_encabcum.jspGarcía ME, Lena F. Aplicación del metodo delphi en el diseño de una investigación cuantitativa sobre el fenómeno FABLAB. Empiria Rev Metodol Ciencias Soc [Internet]. 2018;(40):129–66. Available from: https://doi.org/10.5944/empiria.40.2018.22014Google. Dibujos de Google [Internet]. Chrome web store. 2015 [cited 2022 Jan 18]. p. 1. Available from: https://chrome.google.com/webstore/detail/google-drawings/mkaakpdehdafacodkgkpghoibnmamcme?hl=esCreately. La Guía Fácil de los Diagramas de Clases UML | Tutorial de Diagramas de Clases [Internet]. Diagramas. 2021 [cited 2022 Jan 19]. p. 1. Available from: https://creately.com/blog/es/diagramas/tutorial-de-diagrama-de-clases/Van Wetter C, Boulfalfal H, Anckaert F, Tassin O. PS-045 Look-alike injectable drugs: Detection and first assessment: Abstract PS-045 Table 1. Eur J Hosp Pharm. 2016;23(Suppl 1):A233.2-A233.Montero Delgado JA, Plata Paniagua S, Arenas Villafranca JJ. The problem of different brands of the same drug in Spain: It is time to act. J Healthc Qual Res. 2020;35(2):126–8.Irizarry R. Agrupación. In: Introducción a la ciencia de datos [Internet]. 1st ed. Bookdown; 2021. p. 60. Available from: https://rafalab.github.io/dslibro/clustering.htmlAmat R. Clustering y heatmaps: aprendizaje no supervisado [Internet]. Ciencia De Datos. 2017 [cited 2022 Jul 16]. p. 1. Available from: https://www.cienciadedatos.net/documentos/37_clustering_y_heatmaps#HeatmapsTwitter. What would you like to embed? [Internet]. Twitter Publish. 2022 [cited 2022 May 2]. p. 1. Available from: https://publish.twitter.com/?hideConversation=on&query=https%3A%2F%2Ftwitter.com%2FMartaMullera%2Fstatus%2F1501623547759898629&theme=dark&widget=TweetCreative Commons. Atribución 4.0 Internacional (CC BY 4.0) [Internet]. Licenses. 2022 [cited 2022 Apr 24]. p. 1. Available from: https://creativecommons.org/licenses/by/4.0/deed.esCanva. ¿Qué vas a diseñar? [Internet]. Inicio. 2022 [cited 2022 Apr 24]. p. 1. Available from: https://www.canva.com/Google. Google Maps [Internet]. Google Maps. 2022 [cited 2022 Apr 3]. p. 1. Available from: https://www.google.com/maps/Google. Google My Maps [Internet]. Google Maps. 2022 [cited 2022 Apr 20]. p. 1. Available from: https://mymaps.google.com/International Medication Safety Network. Reporting Form [Internet]. Reporting Portal. 2022. p. 1. Available from: https://www.intmedsafe.net/the-international-medication-error-reporting-portal/report-form/Delegación Española del Institute for Safe Medication Practices. PROGRAMA DE NOTIFICACIÓN DE ERRORES DE MEDICACIÓN [Internet]. Salamanca; 2022. p. 1. Available from: http://www.ismp-espana.org/ficheros/formulario.pdfInstitute for Safe Medication Practices. Healthcare Practitioner’s Medication Error Reporting Form [Internet]. Error Reporting. 2022 [cited 2022 May 2]. p. 1. Available from: https://www.ismp.org/form/merp-formAgencia Española de Medicamentos y Productos Sanitarios. Comunicación de aspectos del etiquetado susceptibles de provocar errores de medicación [Internet]. Ficha técnica, prospecto y etiquetado. 2021 [cited 2022 May 2]. p. 1. Available from: https://www.aemps.gob.es/industria-farmaceutica/etiquetado-y-prospectos/comunicacion-de-aspectos-del-etiquetado-susceptibles-de-provocar-errores-de-medicacion/Vargas-neri JL, Pérez-vázquez P, Em DDL. Panorama de los errores de medicación en Latinoamérica: oportunidades para la ergonomía. 2021;3(2):94–109.Ministerio de Salud de Colombia. Por la cual se define el estándar de datos de medicamentos de uso humano en Colombia y se dictan otras disposiciones [Internet]. Resolución 3311 Colombia; 2018 p. 1–28. Available from: https://www.minsalud.gov.co/Normatividad_Nuevo/3311 Define Estandar de datos de medicamentos de uso Humano en Colombia.pdfAgencia Española de Medicamentos y Productos Sanitarios. Centro de Información de Medicamentos - CIMA [Internet]. Rituximab. 2017 [cited 2022 Feb 28]. p. 1. Available from: https://cima.aemps.es/cima/publico/lista.htmlRaza Owaisi H. 3D covid-19 vaccine vails model [Internet]. TurboSquid. 2019 [cited 2022 Feb 28]. p. 1. Available from: https://www.turbosquid.com/3d-models/3d-vaccine-covid-vails-model-1706186Kovacs V. Online 3D Viewer [Internet]. Online 3D Viewer. 2021 [cited 2022 Feb 28]. p. 1. Available from: https://3dviewer.net/International Medication Safety Network. Targeting International best practice for safe labelling and packaging of prescription medicines [Internet]. The IMSN continues its work on labelling and packaging safety and deepens its relationship with pharmacovigilance. 2018 [cited 2022 Mar 14]. p. 1. Available from: https://www.intmedsafe.net/the-imsn-continues-its-work-on-labelling-and-packaging-safety-and-deepens-its-relationship-with-pharmacovigilance/Varela-Ruiz M, Díaz-Bravo L, García-Durán R. Descripción y usos del método Delphi en investigación del área de la salud. Investig en Eduación Médica [Internet]. 2012;1(2):90–5. Available from: http://riem.facmed.unam.mx/sites/all/archivos/V1Num02/07_MI_DESCRIPCION_Y_USOS.PDFLópez-Gómez E. El método delphi en la investigación actual en educación: Una revisión teórica y metodológica. Educ XX1. 2018;21(1):17–40.Hellier E, Edworthy J, Derbyshire N, Costello A. Considering the impact of medicine label design characteristics on patient safety. Ergonomics. 2006;49(5–6):617–30.Garnica S, Aristizabal A. Making safer medicines: Improving labeling and packaging to prevent medication errors. Drug Saf [Internet]. 2017;40(10):1018. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L618778421%0Ahttp://dx.doi.org/10.1007/s40264-017-0580-8Ostini R, Roughead EE, Kirkpatrick CMJ, Monteith GR, Tett SE. Quality Use of Medicines - Medication safety issues in naming; Look-alike, sound-alike medicine names. Int J Pharm Pract. 2012;20(6):349–57.Machado-Duque ME, Machado-Alba JE, Gaviria-Mendoza A, Valladales-Restrepo LF, Parrado-Fajardo IY, Ospina-Castellanos M, et al. Identificación de errores de medicación mediante un programa de seguimiento y minimización en pacientes ambulatorios de Colombia, 2018-2019. Biomedica. 2020;41(1):1–22.Rando K, Rey G. Errores de medicamentos LASA en anestesiología en Uruguay. Rev Médica del Uruguay. 2017;33(2):53–103.Patel S, Robertson B, McConachie I. Catastrophic drug errors involving tranexamic acid administered during spinal anaesthesia. Anaesthesia. 2019;74(7):904–14.Hellebek A, Schytte-Hansen S, Fischer H, Clemmensen MH, Kart T. Patient safety in drug label design: Analysis of reported adverse events before and after introducing a new label design. Eur J Hosp Pharm. 2013;20(4):212–7.Valverde MP, Martín R. Prevención de errores de medicación. Farm Hosp. 2002;25(6):376–9.International Pharmaceutical Federation. Patient Safety: Pharmacists’ Role in “Medication without harm.” International Pharmaceutical Federation. 2020. p. 105.Bryan R, Aronson JK, Williams A, Jordan S. The problem of look-alike, sound-alike name errors: Drivers and solutions. Br J Clin Pharmacol. 2021;87(2):386–94.Instituto para el Uso Seguro de de los Medicamentos. Boletín de Recomendaciones para la Prevención de Errores de Medicación Los 10 errores de medicación de mayor riesgo. Gob España Minist Sanid [Internet]. 2022;06(51):1–5. Available from: http://www.ismp-espana.org/ficheros/Boletin 50 %28Febrero 2021%29.pdfPérez Ingidua carla, rivas paterna AB, Portolés Pérez antonio, laredo velasco leonor, Vargas Castrillón emilio. La isoapariencia farmacéutica un factor de riesgo de errores de medicación. Metas de Enfermería. 2020;23(7):7–15.Palacio J, Astier P, Hernández MÁ. Drugs: When appearances mislead. Aten Primaria. 2017;49(7):375–7.Nocode.Tech. ¿No sabe codificar? No hay problema. [Internet]. 2022 [cited 2022 Jun 24]. p. 1. Available from: https://es.nocode.tech/Gonzalo F. ¿Qué es Nocode? Desarrollar webs y apps sin código [Internet]. Blog. 2021 [cited 2022 Jun 24]. p. 1. Available from: https://www.nocoders.academy/blog/que-es-nocodeNocodeHackers. Construye tus proyectos sin saber programar [Internet]. 2022 [cited 2022 Jun 24]. p. 1. Available from: https://www.nocodehackers.es/National Patient Safety Agency. Design patient safety: A guide to the graphic design of medication packaging [Internet]. 2nd ed. United Kingdom; 2007. 80 p. Available from: https://webarchive.nationalarchives.gov.uk/ukgwa/20080727044055mp_/http://www.npsa.nhs.uk/EasySiteWeb/GatewayLink.aspx?alId=5599Institute for Safe Medication Practices Canada. Good Label and Package Practices Guide for Prescription Drugs [Internet]. 1st ed. 2019. 1–79 p. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/reports-publications/medeffect-canada/good-label-package-practices-guide-prescription-drugs-profile/guidance-document.htmlInternational Medication Safety Network. Position Statement: Safer design of vaccines packaging and labelling [Internet]. 2015. p. 5. Available from: http://www.ismp-espana.org/ficheros/IMSN-Position-Statement-Vaccines-packaginglabelling-201512.pdfLarmené-Beld KHM, Alting EK, Taxis K. A systematic literature review on strategies to avoid look-alike errors of labels. Eur J Clin Pharmacol. 2018;74(8):985–93.Grifols. Fleboflex®- Nuestro envase por excelencia [Internet]. Fleboflex®. 2021 [cited 2021 Jan 18]. p. 1. Available from: https://www.fleboflex.com/documents/438093/438234/HGFTP11170002%282%29-Fleboflex-F-Luer.pdf/22975b0e-a33e-7c36-023a-663a3a57bc31?t=1572421243000Losada H. Clasificación De Las Tipografías [Internet]. Blog con H de diseño. 2020 [cited 2022 Jan 18]. p. 1. Available from: https://helenalosada.es/clasificacion-de-las-tipografias/Trudeau M, Green E, Cosby R, Charbonneau F, Easty T, Ko Y, et al. Key components of intravenous chemotherapy labeling: A systematic review and practice guideline. J Oncol Pharm Pract. 2011;17(4):409–24.Otero López MJ, Martín Muñoz R, Sánchez Barba M, Abad Sazatornil R, Andreu Crespo A, Arteta Jiménez M, et al. Elaboración de una relación de nombres de medicamentos similares en los que se recomienda utilizar letras mayúsculas resaltadas. Farm Hosp. 2011;35(5):225–35.Health Quality & Safety Commission New Zealand. Tall Man Lettering List: Report December 2013 [Internet]. New Zealand; 2013. 1–40 p. Available from: https://www.hqsc.govt.nz/assets/Medication-Safety/Tall-Man-lettering/Tall-Man-report-Dec-2013.PDFWorld Health Organization. ATC/DDD Index 2022 [Internet]. WHO Collaborating Centre for Drug Statistics Methodology. 2022 [cited 2022 Jan 10]. p. 1. Available from: https://www.whocc.no/atc_ddd_index/Borradale H, Andersen P, Wallis M, Oprescu F. Misreading Injectable Medications—Causes and Solutions: An Integrative Literature Review. Jt Comm J Qual Patient Saf [Internet]. 2020;46(5):291–8. Available from: https://doi.org/10.1016/j.jcjq.2020.01.007Gabriele S. The role of typography in differentiating look-alike/sound-alike drug names. Healthc Q. 2006;9 Spec No:88–95.Rachel M Kruer, Andrew S Jarrell AL. Reducing medication errors in critical care : A multimodal approach. Clin Pharmacol Adv Appl [Internet]. 2014;(6):117–26. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155993/Food And Drug Administration. Strength Conversion in Drug Listing [Internet]. Electronic Drug Registration and Listing System (eDRLS). 2021 [cited 2022 Jan 18]. p. 1. Available from: https://www.fda.gov/drugs/electronic-drug-registration-and-listing-system-edrls/strength-conversion-drug-listingGarnerin P, Perneger T, Chopard P, Arès M, Baalbaki R, Bonnabry P, et al. Drug selection errors in relation to medication labels: A simulation study. Anaesthesia. 2007;62(11):1090–4.Prakash S, Mullick P, Kumar A, Pawar M. Safe Labeling Practices to Minimize Medication Errors in Anesthesia: 5 Case Reports and Review of the Literature. A&A Pract. 2018;10(10):261–4.Berger F. La apariencia distintiva (trade dress): un signo marcario en expansión [Internet]. Universidad De Plermo; 2008. Available from: https://dspace.palermo.edu/dspace/bitstream/handle/10226/855/BERGER TESIS.pdf?sequence=1&isAllowed=yMinisterio de Salud de Colombia. Lista de vías de administración definidas por el Ministerio de Salud en el marco del estándar de datos de medicamentos [Internet]. Bogotá; 2018. p. 1–3. Available from: http://www.medicamentosaunclic.gov.co/contenidos/tabla.pdfMinisterio de Salud de Colombia. Definiciones establecidas por el Ministerio de Salud para las formas farmacéuticas en sus diferentes tipos [Internet]. Bogotá; 2018. p. 4–13. Available from: http://www.medicamentosaunclic.gov.co/contenidos/tabla.pdfLeón L, Orlando Y, Pravia P, Caridad M, Delgado M. Procedimiento para la selección de la Comunidad de Expertos con técnicas multicriterio. Ciencias Holguín. 2016;22(1):34–49.Hurtado S. CRITERIO DE EXPERTOS. SU PROCESAMIENTO A TRAVÉS DEL MÉTODO DELPHY [Internet]. METODOLOGÍA Y EPISTEMOLOGÍA. 2012 [cited 2022 Feb 2]. p. 1. Available from: http://www.ub.edu/histodidactica/index.php?option=com_content&view=article&id=21:criterio-de-expertos-su-procesamiento-a-traves-del-metodo-delphy&catid=11:metodologia-y-epistemologia&Itemid=103Randolph J. Online Kappa Calculator [Internet]. Information. 2016 [cited 2022 May 5]. p. 1. Available from: http://justusrandolph.net/kappa/Adelphi Healthcare Packaging. Ampoules [Internet]. Product range. 2021 [cited 2022 Jan 3]. p. 1. Available from: https://adelphi-hp.com/product-range/ampoulesAPG Pharma Packing. Infusion vial [Internet]. Vials. 2021 [cited 2022 Jan 8]. p. 1. Available from: https://www.apg-pharma.com/vials/infusion-vialMFS. Make Fortnite Skins [Internet]. Make Fortnite Skins. 2020 [cited 2022 Mar 23]. p. 1. Available from: https://make-fortnite-skins.com/Maestrías CundinamarcaFundación CEIBAAdministradoresEstudiantesInvestigadoresMaestrosPúblico generalResponsables políticosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/82966/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1019102077.2022.pdf1019102077.2022.pdfTesis de Maestría en Ciencias - Farmacologíaapplication/pdf8072180https://repositorio.unal.edu.co/bitstream/unal/82966/2/1019102077.2022.pdf24e9c0be3ab3b1a39c552636bd01332bMD52unal/82966oai:repositorio.unal.edu.co:unal/829662023-01-16 21:05:02.461Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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 |