Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea
Este estudio exploró el diseño, fabricación y evaluación de scaffolds que incorporan propiedades esenciales para la regeneración ósea, incluyendo biocompatibilidad, geometría macroporosa, resistencia mecánica y capacidad de respuesta magnética. Mediante el uso de la geometría de superficies mínimas...
- Autores:
-
Orozco Osorio, Yeison Alejandro
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86844
- Palabra clave:
- 620 - Ingeniería y operaciones afines::621 - Física aplicada
Regeneración Ósea
Materiales Biocompatibles
Biomateriales
Tejido Óseo
Scaffolds
Material Synthesis
Magnetic properties
Additive manufacturing
Bone regeneration
Síntesis de Materiales
Propiedades Magnéticas
Manufactura aditiva
Regeneración Osea
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| dc.title.translated.none.fl_str_mv |
Obtaining Polymer-Ceramic Composite Scaffolds by Masked Stereolithography (MSLA) with Magnetic Properties and Potential Application in Bone Regeneration |
| title |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| spellingShingle |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea 620 - Ingeniería y operaciones afines::621 - Física aplicada Regeneración Ósea Materiales Biocompatibles Biomateriales Tejido Óseo Scaffolds Material Synthesis Magnetic properties Additive manufacturing Bone regeneration Síntesis de Materiales Propiedades Magnéticas Manufactura aditiva Regeneración Osea |
| title_short |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| title_full |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| title_fullStr |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| title_full_unstemmed |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| title_sort |
Obtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración Ósea |
| dc.creator.fl_str_mv |
Orozco Osorio, Yeison Alejandro |
| dc.contributor.advisor.none.fl_str_mv |
García García, Claudia Patricia |
| dc.contributor.author.none.fl_str_mv |
Orozco Osorio, Yeison Alejandro |
| dc.contributor.researchgroup.spa.fl_str_mv |
Materiales Cerámicos y Vítreos |
| dc.contributor.orcid.spa.fl_str_mv |
Orozco Osorio, Yeison Alejandro [0000-0002-6317-6172] |
| dc.subject.ddc.spa.fl_str_mv |
620 - Ingeniería y operaciones afines::621 - Física aplicada |
| topic |
620 - Ingeniería y operaciones afines::621 - Física aplicada Regeneración Ósea Materiales Biocompatibles Biomateriales Tejido Óseo Scaffolds Material Synthesis Magnetic properties Additive manufacturing Bone regeneration Síntesis de Materiales Propiedades Magnéticas Manufactura aditiva Regeneración Osea |
| dc.subject.decs.none.fl_str_mv |
Regeneración Ósea Materiales Biocompatibles Biomateriales Tejido Óseo |
| dc.subject.proposal.eng.fl_str_mv |
Scaffolds Material Synthesis Magnetic properties Additive manufacturing Bone regeneration |
| dc.subject.proposal.spa.fl_str_mv |
Síntesis de Materiales Propiedades Magnéticas Manufactura aditiva Regeneración Osea |
| description |
Este estudio exploró el diseño, fabricación y evaluación de scaffolds que incorporan propiedades esenciales para la regeneración ósea, incluyendo biocompatibilidad, geometría macroporosa, resistencia mecánica y capacidad de respuesta magnética. Mediante el uso de la geometría de superficies mínimas triplemente periódicas (TPMS), resinas fotopolimerizables acrílicas, óxidos de hierro sintetizados y la impresión por máscara de estereolitografía (MSLA), se diseñaron scaffolds con características geométricas precisas. Las propiedades mecánicas se mejoraron mediante el curado de resina, mientras que las partículas de magnetita, obtenidas de nanopartículas sintetizadas, se integraron para conferir propiedades magnéticas. Estos scaffolds exhibieron un equilibrio óptimo entre rigidez, porosidad y capacidad de respuesta magnética. Se obtuvieron scaffolds de resina con óxidos de hierro sintetizados con una resistencia máxima a la compresión entre 4.8 MPa y 9.2 MPa, módulo de Young entre 58 MPa y 174 MPa. Se midieron propiedades magnéticas para los scaffolds sintéticos, como coercitividad magnética de 293 Oe, remanencia magnética entre 11.3 emu/g y 12.3 emu/g, y saturación magnética entre 29.4 emu/g y 37.1 emu/g. Se midió la viscosidad de las mezclas utilizadas para imprimir los scaffolds entre 350 mPa-s y 380 mPa-s, valores adecuados para una impresión 3D correcta, y se obtuvieron medidas del ángulo de contacto entre 90° y 110°. Las mejores propiedades entre los scaffolds fabricados fueron exhibidas por aquellos con un porcentaje en peso del 1%. La evaluación de la biocompatibilidad de los scaffolds sugirió su potencial para futuros ensayos clínicos, respaldado por su capacidad para mantener la viabilidad celular. (Tomado de la fuente) |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-09-18T21:40:19Z |
| dc.date.available.none.fl_str_mv |
2024-09-18T21:40:19Z |
| dc.date.issued.none.fl_str_mv |
2024 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86844 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/86844 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.indexed.spa.fl_str_mv |
LaReferencia |
| dc.relation.references.spa.fl_str_mv |
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Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2García García, Claudia Patricia6448197d2cc32832cb2f81989b4a9a99Orozco Osorio, Yeison Alejandrob71073b6b396b892969b08985a5e89dbMateriales Cerámicos y VítreosOrozco Osorio, Yeison Alejandro [0000-0002-6317-6172]2024-09-18T21:40:19Z2024-09-18T21:40:19Z2024https://repositorio.unal.edu.co/handle/unal/86844Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Este estudio exploró el diseño, fabricación y evaluación de scaffolds que incorporan propiedades esenciales para la regeneración ósea, incluyendo biocompatibilidad, geometría macroporosa, resistencia mecánica y capacidad de respuesta magnética. Mediante el uso de la geometría de superficies mínimas triplemente periódicas (TPMS), resinas fotopolimerizables acrílicas, óxidos de hierro sintetizados y la impresión por máscara de estereolitografía (MSLA), se diseñaron scaffolds con características geométricas precisas. Las propiedades mecánicas se mejoraron mediante el curado de resina, mientras que las partículas de magnetita, obtenidas de nanopartículas sintetizadas, se integraron para conferir propiedades magnéticas. Estos scaffolds exhibieron un equilibrio óptimo entre rigidez, porosidad y capacidad de respuesta magnética. Se obtuvieron scaffolds de resina con óxidos de hierro sintetizados con una resistencia máxima a la compresión entre 4.8 MPa y 9.2 MPa, módulo de Young entre 58 MPa y 174 MPa. Se midieron propiedades magnéticas para los scaffolds sintéticos, como coercitividad magnética de 293 Oe, remanencia magnética entre 11.3 emu/g y 12.3 emu/g, y saturación magnética entre 29.4 emu/g y 37.1 emu/g. Se midió la viscosidad de las mezclas utilizadas para imprimir los scaffolds entre 350 mPa-s y 380 mPa-s, valores adecuados para una impresión 3D correcta, y se obtuvieron medidas del ángulo de contacto entre 90° y 110°. Las mejores propiedades entre los scaffolds fabricados fueron exhibidas por aquellos con un porcentaje en peso del 1%. La evaluación de la biocompatibilidad de los scaffolds sugirió su potencial para futuros ensayos clínicos, respaldado por su capacidad para mantener la viabilidad celular. (Tomado de la fuente)This study explored the design, fabrication, and evaluation of scaffolds that incorporate essential properties for bone regeneration, including biocompatibility, macroporous geometry, mechanical strength, and magnetic responsiveness. Using triply periodic minimal surfaces (TPMS) geometry, acrylic photopolymerizable resins, synthesized iron oxides, and masked stereolithography (MSLA) printing, scaffolds with precise geometric characteristics were designed. Mechanical properties were enhanced through resin curing, while magnetite particles obtained from synthesized nanoparticles were integrated to confer magnetic properties. These scaffolds exhibited an optimal balance between stiffness, porosity, and magnetic responsiveness. Resin scaffolds with synthesized iron oxides achieved maximum compressive strength between 4.8 MPa and 9.2 MPa, Young’s modulus between 58 MPa and 174 MPa. Magnetic properties were measured for the synthetic scaffolds, including magnetic coercivity of 293 Oe, magnetic remanence between 11.3 emu/g and 12.3 emu/g, and magnetic saturation between 29.4 emu/g and 37.1 emu/g. The viscosity of the mixtures used for printing the scaffolds was measured between 350 mPa-s and 380 mPa-s, values suitable for proper 3D printing, and contact angle measurements were obtained between 90° and 110°. The best properties among the manufactured scaffolds were exhibited by those with a 1% weight percentage. The biocompatibility evaluation of the scaffolds suggested their potential for future clinical trials, supported by their ability to maintain cell viability.Agradezco principalmente al proyecto que hizo posible la realización de este trabajo, proyecto titulado “Desarrollo y evaluación in vitro de un prototipo de scaffold de matriz polimérica con adición de partículas magnéticas, funcionalizado con proteínas morfogenéticas BMP-2 producido por manufactura aditiva para regeneración ósea.” Código Hermes 53992. SEGUNDA CONVOCATORIA CONJUNTA DE PROYECTOS DE I+D+i EN EL MARCO DE LA AGENDA REGIONAL DE I+D -> IMaestríaMagíster en Ingeniería FísicaDiseño de experimentos y caracterización de materiales principalmente.Diseño de biomaterialesFísica.Sede Medellín142 páginasapplication/pdfspaUniversidad Nacional de ColombiaMedellín - Ciencias - Maestría en Ingeniería FísicaFacultad de CienciasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín620 - Ingeniería y operaciones afines::621 - Física aplicadaRegeneración ÓseaMateriales BiocompatiblesBiomaterialesTejido ÓseoScaffoldsMaterial SynthesisMagnetic propertiesAdditive manufacturingBone regenerationSíntesis de MaterialesPropiedades MagnéticasManufactura aditivaRegeneración OseaObtención de Scaffolds Compuestos Polímero-Cerámico por Estereolitografía de Mascara (MSLA) con Propiedades Magnéticas y Potencial Aplicación en Regeneración ÓseaObtaining Polymer-Ceramic Composite Scaffolds by Masked Stereolithography (MSLA) with Magnetic Properties and Potential Application in Bone RegenerationTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMLaReferenciaTim D. 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SEGUNDA CONVOCATORIA CONJUNTA DE PROYECTOS DE I+D+i EN EL MARCO DE LA AGENDA REGIONAL DE I+D -> IEstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86844/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1026159675.2024.pdf1026159675.2024.pdfTesis de Maestría en Ingeniería Físicaapplication/pdf3778037https://repositorio.unal.edu.co/bitstream/unal/86844/2/1026159675.2024.pdf734037b78f9ce67937b597aa4aa2cb85MD52THUMBNAIL1026159675.2024.pdf.jpg1026159675.2024.pdf.jpgGenerated Thumbnailimage/jpeg5682https://repositorio.unal.edu.co/bitstream/unal/86844/3/1026159675.2024.pdf.jpg6d87a69434cbcd7a85a2c9fff319bde4MD53unal/86844oai:repositorio.unal.edu.co:unal/868442024-09-18 23:50:00.035Repositorio Institucional Universidad Nacional de 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