Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022

ilustraciones a blanco y negro, fotografías

Autores:
Gómez Medina, Andrés Felipe
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/85688
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/85688
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
Hematopoietic stem cell transplantation
Magnetic resonance imaging
Postoperative care - Adverse effects
Trasplante de células madre hematopoyéticas
Imagen por resonancia magnética
Cuidados posoperatorios - Efectos adversos
Trasplante de células madre hematopoyéticas
Pediatría
Resonancia magnética
Mapa ADC
Complicaciones neurológicas post-trasplante
Trasplante de progenitores hematopoyéticos
DWI
Diffusion weighted imaging DWI
Pediatrics
Post-transplant neurological complications
Magnetic resonance imaging
ADC map
Radiología pediátrica
Pediatric radiology specialty
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_31245ccf2761a20fd3202ed5a7300549
oai_identifier_str oai:repositorio.unal.edu.co:unal/85688
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
dc.title.translated.eng.fl_str_mv Central nervous system manifestations in diagnostic images of pediatric patients after hematopoietic stem cell transplant with neurological complications at: Fundación Hospital de la Misericordia from 2016-2022
title Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
spellingShingle Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
Hematopoietic stem cell transplantation
Magnetic resonance imaging
Postoperative care - Adverse effects
Trasplante de células madre hematopoyéticas
Imagen por resonancia magnética
Cuidados posoperatorios - Efectos adversos
Trasplante de células madre hematopoyéticas
Pediatría
Resonancia magnética
Mapa ADC
Complicaciones neurológicas post-trasplante
Trasplante de progenitores hematopoyéticos
DWI
Diffusion weighted imaging DWI
Pediatrics
Post-transplant neurological complications
Magnetic resonance imaging
ADC map
Radiología pediátrica
Pediatric radiology specialty
title_short Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
title_full Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
title_fullStr Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
title_full_unstemmed Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
title_sort Manifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022
dc.creator.fl_str_mv Gómez Medina, Andrés Felipe
dc.contributor.advisor.spa.fl_str_mv Moreno Gómez, Luz Ángela
dc.contributor.author.spa.fl_str_mv Gómez Medina, Andrés Felipe
dc.contributor.cvlac.spa.fl_str_mv Gómez Medina, Andrés Felipe [0001863965]
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
topic 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
610 - Medicina y salud::616 - Enfermedades
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
Hematopoietic stem cell transplantation
Magnetic resonance imaging
Postoperative care - Adverse effects
Trasplante de células madre hematopoyéticas
Imagen por resonancia magnética
Cuidados posoperatorios - Efectos adversos
Trasplante de células madre hematopoyéticas
Pediatría
Resonancia magnética
Mapa ADC
Complicaciones neurológicas post-trasplante
Trasplante de progenitores hematopoyéticos
DWI
Diffusion weighted imaging DWI
Pediatrics
Post-transplant neurological complications
Magnetic resonance imaging
ADC map
Radiología pediátrica
Pediatric radiology specialty
dc.subject.decs.eng.fl_str_mv Hematopoietic stem cell transplantation
Magnetic resonance imaging
Postoperative care - Adverse effects
dc.subject.decs.spa.fl_str_mv Trasplante de células madre hematopoyéticas
Imagen por resonancia magnética
Cuidados posoperatorios - Efectos adversos
dc.subject.proposal.spa.fl_str_mv Trasplante de células madre hematopoyéticas
Pediatría
Resonancia magnética
Mapa ADC
Complicaciones neurológicas post-trasplante
Trasplante de progenitores hematopoyéticos
dc.subject.proposal.eng.fl_str_mv DWI
Diffusion weighted imaging DWI
Pediatrics
Post-transplant neurological complications
Magnetic resonance imaging
ADC map
dc.subject.umls.spa.fl_str_mv Radiología pediátrica
dc.subject.umls.eng.fl_str_mv Pediatric radiology specialty
description ilustraciones a blanco y negro, fotografías
publishDate 2023
dc.date.issued.none.fl_str_mv 2023-12
dc.date.accessioned.none.fl_str_mv 2024-02-12T21:10:32Z
dc.date.available.none.fl_str_mv 2024-02-12T21:10:32Z
dc.type.spa.fl_str_mv Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/85688
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.repo.none.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/85688
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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Antinori, S., et al., Aspergillus meningitis: a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases. J Infect, 2013. 66(3): p. 218-38.
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Boutboul, F., et al., Invasive aspergillosis in allogeneic stem cell transplant recipients: increasing antigenemia is associated with progressive disease. Clin Infect Dis, 2002. 34(7): p. 939-43.
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Pustavoitau, A., A. Bhardwaj, and R. Stevens, Neurological complications of transplantation. J Intensive Care Med, 2011. 26(4): p. 209-22.
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Yoshikawa, T., Human herpesvirus-6 and -7 infections in transplantation. Pediatr Transplant, 2003. 7(1): p. 11-7.
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Ogata, M., et al., Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study. Clin Infect Dis, 2013. 57(5): p. 671-81.
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Iguchi, A., et al., Neurological complications after stem cell transplantation in childhood. Bone Marrow Transplant, 1999. 24(6): p. 647-52.
Rodriguez, T.E., Neurologic complications of bone marrow transplantation. Handb Clin Neurol, 2014. 121: p. 1295-304.
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dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv xiii, 70 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.coverage.temporal.spa.fl_str_mv 2016-2022
dc.coverage.city.spa.fl_str_mv Bogotá, Colombia
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Medicina - Especialidad en Radiología e Imágenes Diagnósticas
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/85688/1/license.txt
https://repositorio.unal.edu.co/bitstream/unal/85688/2/1016033965.2023.pdf
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Moreno Gómez, Luz Ángelad80106f385b1f67170dfc36a43b379aa600Gómez Medina, Andrés Feliped8f07cdc2adedd62725d64dc84f856d5Gómez Medina, Andrés Felipe [0001863965]2016-2022Bogotá, Colombia2024-02-12T21:10:32Z2024-02-12T21:10:32Z2023-12https://repositorio.unal.edu.co/handle/unal/85688Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones a blanco y negro, fotografíasEl trasplante de células madre hematopoyéticas es parte de las líneas de tratamiento de múltiples condiciones neoplásicas, desórdenes genéticos, errores innatos del metabolismo, entre otras. Algunas de estas condiciones con mayor incidencia en la población pediátrica como las enfermedades linfoproliferativas y aplasias medulares. En estos pacientes, existe un porcentaje significativo de complicaciones neurológicas asociadas tanto al estado inmunológico como al tratamiento. Estas complicaciones contribuyen de manera significativa a la morbimortalidad y poseen un espectro amplio de desenlaces. En este estudio se obtuvieron 31 pacientes que presentaron alguna sintomatología neurológica y fueron llevados a realización de resonancia magnética cerebral (RM). Con estas imágenes y los datos clínicos se establecen asociaciones de posibles factores de riesgo, concordancia entre los hallazgos imagenológicos y el diagnóstico clínico de la complicación neurológica, categorizada principalmente en causas infecciosas, cerebrovasculares, asociadas al tratamiento, metabólicas, y carcinogénesis post- trasplante. Se incluyo en la valoración de las imágenes la propuesta de una medida objetiva de valores de intensidad de señal del mapa de ADC (Coeficiente de difusión aparente) de las lesiones en resonancia magnética, estudiando su asociación con pronóstico neurológico, siendo los principales desenlaces objetivo: Recuperación completa, secuelas neurológicas o muerte. (Texto tomado de la fuente)Hematopoietic stem cell transplantation is part of the treatment strategies for multiple neoplastic conditions, genetic disorders, inborn errors of metabolism, among others. Some of these conditions with a higher incidence in the pediatric population include lymphoproliferative diseases and bone marrow aplasia. In these patients, there is a significant percentage of neurological complications associated with both the immune status and the treatment. These complications contribute significantly to morbidity and mortality and have a broad spectrum of outcomes. In this study, 31 patients who presented neurological symptoms and underwent brain magnetic resonance imaging (MRI) were included. Associations of possible risk factors, concordance between imaging findings and the clinical diagnosis of neurological complications were established based on these images and clinical data, categorized primarily into infectious, cerebrovascular, treatment-related, metabolic, and post-transplant carcinogenesis causes. The assessment of the images included the proposal of an objective measure of apparent diffusion coefficient (ADC map) signal intensity values of lesions in magnetic resonance imaging, studying its association with neurological prognosis, with the main objective outcomes being complete recovery, neurological sequelae, or death.Especialidades MédicasEspecialista en Radiología e Imágenes DiagnósticasDe acuerdo con el objetivo, se realizó un estudio observacional de corte transversal con componente analítico. Pacientes menores de 18 años que hayan sido sometidos a trasplante de células madre hematopoyéticas y hayan presentado alguna complicación neurológica posterior a la realización del procedimiento en la Fundación Hospital de la Misericordia - HOMI. Selección de pacientes por conveniencia - no probabilístico, se tomarán todos los pacientes que cumplan los criterios de inclusión entre los años 2016 y 2022, de manera sistemática. Se realiza el estudio con el servicio de servicio de trasplante de progenitores hematopoyéticos y radiología pediátrica de la Fundación Hospital de la Misericordia (HOMI), durante el periodo comprendido entre enero de 2016 a diciembre de 2022. Se revisó la base de datos de pacientes sometidos a TCMH menores de 18 años. Por tratarse de un estudio retrospectivo, se utilizaron las imágenes disponibles en la base de datos DICOM® (Digital Imaging and Communication on Medicine) del aplicativo PACS IndiGO® vigente en HOMI y de los aplicativos de historias clínicas HIS-ISIS® e Indira®. Posteriormente, se seleccionaron los pacientes que contaban con imágenes disponibles de resonancia magnética cerebral. De estos pacientes se realizó la revisión de historias clínicas. En la revisión de las imágenes se contaba con secuencias de resonancia magnética en protocolo de rutina para cerebro, simple o contrastado en un equipo Philips de de 1.5 T. Se obtuvieron secuencias espin-eco T1 sagital volumétrica, axial T2 y FLAIR, coronal T2 y volumétrica T1 posterior a la administración de gadolinio. Secuencia eco-gradiente axial T2, imágenes axiales de difusión con valores b0 y b1000; y el mapa de coeficiente de difusión aparente (ADC). Las variables radiológicas se definieron basadas en la interpretación y los reportes oficiales de las imágenes. Para la obtención de los valores de ADC se descargaron las imágenes en formato DICOM® y se evaluaron en el software visor RadiAnt®, se obtuvo un promedio de tres ROIs con valores de intensidad de señal de la región mayormente afectada basado en una inspección visual. Esto se correlaciono con tres áreas contralaterales o equivalentes no afectadas de parénquima normal obteniendo un resultado de la razón entre estos dos valores. Se introdujeron los datos en un instrumento de recolección en Excel y posteriormente se realizó analisis de datos en el software de estadística R®.Neurorradiología pediátricaxiii, 70 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Radiología e Imágenes DiagnósticasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría610 - Medicina y salud::616 - Enfermedades610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiologíaHematopoietic stem cell transplantationMagnetic resonance imagingPostoperative care - Adverse effectsTrasplante de células madre hematopoyéticasImagen por resonancia magnéticaCuidados posoperatorios - Efectos adversosTrasplante de células madre hematopoyéticasPediatríaResonancia magnéticaMapa ADCComplicaciones neurológicas post-trasplanteTrasplante de progenitores hematopoyéticosDWIDiffusion weighted imaging DWIPediatricsPost-transplant neurological complicationsMagnetic resonance imagingADC mapRadiología pediátricaPediatric radiology specialtyManifestaciones en sistema nervioso central en imágenes diagnósticas de pacientes pediátricos post-trasplante de células madre hematopoyéticas con complicaciones neurológicas en la Fundación Hospital de la Misericordia en 2016-2022Central nervous system manifestations in diagnostic images of pediatric patients after hematopoietic stem cell transplant with neurological complications at: Fundación Hospital de la Misericordia from 2016-2022Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMShin, H., et al., Hematopoietic Stem Cell Transplantation-Associated Neurological Complications and Their Brain MR Imaging Findings in a Pediatric Population. 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Sci Rep, 2015. 5: p. 12242.EstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85688/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1016033965.2023.pdf1016033965.2023.pdfTesis de Especialidad en Radiología e Imágenes Diagnósticasapplication/pdf2822433https://repositorio.unal.edu.co/bitstream/unal/85688/2/1016033965.2023.pdf82cee87db2c52f0240d01759a5604006MD52THUMBNAIL1016033965.2023.pdf.jpg1016033965.2023.pdf.jpgGenerated Thumbnailimage/jpeg4957https://repositorio.unal.edu.co/bitstream/unal/85688/3/1016033965.2023.pdf.jpg8506c4a926cdf130db3e4939c39b6110MD53unal/85688oai:repositorio.unal.edu.co:unal/856882024-02-12 23:03:44.189Repositorio Institucional Universidad Nacional de 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