Drug treatment for obesity
Obesity is one of the most critical diseases of the 21st century, which is associated with other health problems such as type 2 diabetes, cardiovascular disease and reduced life expectancy, and a strong effect on the economy. Over time, have developed anti-obesity drugs which work in different ways:...
- Autores:
-
Londoño-Lemos, Milton Enrique
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2012
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/49315
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/49315
http://bdigital.unal.edu.co/42772/
http://bdigital.unal.edu.co/42772/2/
- Palabra clave:
- obesidad
intestino-cerebro
farmacoterapia
mecanismos de acción. Pharmacotherapy for obesity
Obesity
gut-brain
pharmacotherapy
mechanisms of action
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
id |
UNACIONAL2_30aadd6204c1f179b6cba7df6221a569 |
---|---|
oai_identifier_str |
oai:repositorio.unal.edu.co:unal/49315 |
network_acronym_str |
UNACIONAL2 |
network_name_str |
Universidad Nacional de Colombia |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Drug treatment for obesity |
title |
Drug treatment for obesity |
spellingShingle |
Drug treatment for obesity obesidad intestino-cerebro farmacoterapia mecanismos de acción. Pharmacotherapy for obesity Obesity gut-brain pharmacotherapy mechanisms of action |
title_short |
Drug treatment for obesity |
title_full |
Drug treatment for obesity |
title_fullStr |
Drug treatment for obesity |
title_full_unstemmed |
Drug treatment for obesity |
title_sort |
Drug treatment for obesity |
dc.creator.fl_str_mv |
Londoño-Lemos, Milton Enrique |
dc.contributor.author.spa.fl_str_mv |
Londoño-Lemos, Milton Enrique |
dc.subject.proposal.spa.fl_str_mv |
obesidad intestino-cerebro farmacoterapia mecanismos de acción. Pharmacotherapy for obesity Obesity gut-brain pharmacotherapy mechanisms of action |
topic |
obesidad intestino-cerebro farmacoterapia mecanismos de acción. Pharmacotherapy for obesity Obesity gut-brain pharmacotherapy mechanisms of action |
description |
Obesity is one of the most critical diseases of the 21st century, which is associated with other health problems such as type 2 diabetes, cardiovascular disease and reduced life expectancy, and a strong effect on the economy. Over time, have developed anti-obesity drugs which work in different ways: by suppressing appetite, altering metabolism or inhibiting absorption heat. However, these drugs have had serious concerns about the safety of commonly prescribed use derivative side effects, leading the recent withdrawal of sibutramine and rimonabant. As a result of these setbacks, there are few anti-obesity drugs accepted. Knowledge about the gut-brain axis help you understand how the gastro-entero pancreatic, related to a series of peptides and hormones involved in food regulation and the brain, specifically the hypothalamus as a central regulator of the states of hunger and anorexia or appetite and body weight thereby. These lead us to study those drugs that are under research and development as monotherapies and combinations to conclude that there are three drugs already approved by the Food and Drug Administration or by its acronym U.S. FDA (two of them recently approved in 2012) and others which will become accepted for therapeutic use. |
publishDate |
2012 |
dc.date.issued.spa.fl_str_mv |
2012 |
dc.date.accessioned.spa.fl_str_mv |
2019-06-29T08:34:59Z |
dc.date.available.spa.fl_str_mv |
2019-06-29T08:34:59Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/49315 |
dc.identifier.eprints.spa.fl_str_mv |
http://bdigital.unal.edu.co/42772/ http://bdigital.unal.edu.co/42772/2/ |
url |
https://repositorio.unal.edu.co/handle/unal/49315 http://bdigital.unal.edu.co/42772/ http://bdigital.unal.edu.co/42772/2/ |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.spa.fl_str_mv |
http://revistas.unal.edu.co/index.php/rccquifa/article/view/45098 |
dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
dc.relation.ispartofseries.none.fl_str_mv |
Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 217-261 0034-7418 1909-6356 |
dc.relation.references.spa.fl_str_mv |
Londoño-Lemos, Milton Enrique (2012) Drug treatment for obesity. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 217-261 0034-7418 1909-6356 . |
dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
dc.rights.uri.spa.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Revista Colombiana de Ciencias Químico Farmacéuticas |
institution |
Universidad Nacional de Colombia |
bitstream.url.fl_str_mv |
https://repositorio.unal.edu.co/bitstream/unal/49315/1/45098-216217-1-SM.pdf https://repositorio.unal.edu.co/bitstream/unal/49315/2/45098-216217-1-SM.pdf.jpg |
bitstream.checksum.fl_str_mv |
561bd738eaab7700f2c974a271e0e5a2 af08e6c1bf41fba528cbef6d4fa5e6cd |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
repository.mail.fl_str_mv |
repositorio_nal@unal.edu.co |
_version_ |
1814089376233160704 |
spelling |
Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Londoño-Lemos, Milton Enriqued15103fc-674c-4097-a9ec-a858f8afbd153002019-06-29T08:34:59Z2019-06-29T08:34:59Z2012https://repositorio.unal.edu.co/handle/unal/49315http://bdigital.unal.edu.co/42772/http://bdigital.unal.edu.co/42772/2/Obesity is one of the most critical diseases of the 21st century, which is associated with other health problems such as type 2 diabetes, cardiovascular disease and reduced life expectancy, and a strong effect on the economy. Over time, have developed anti-obesity drugs which work in different ways: by suppressing appetite, altering metabolism or inhibiting absorption heat. However, these drugs have had serious concerns about the safety of commonly prescribed use derivative side effects, leading the recent withdrawal of sibutramine and rimonabant. As a result of these setbacks, there are few anti-obesity drugs accepted. Knowledge about the gut-brain axis help you understand how the gastro-entero pancreatic, related to a series of peptides and hormones involved in food regulation and the brain, specifically the hypothalamus as a central regulator of the states of hunger and anorexia or appetite and body weight thereby. These lead us to study those drugs that are under research and development as monotherapies and combinations to conclude that there are three drugs already approved by the Food and Drug Administration or by its acronym U.S. FDA (two of them recently approved in 2012) and others which will become accepted for therapeutic use.La obesidad, una de las enfermedades más críticas del siglo XXI, se halla asociada con otros problemas de salud como la diabetes tipo 2, las enfermedades cardiovasculares y una expectativa de vida reducida, y ejerce un efecto importante sobre la economía. Pese a que se han desarrollado fármacos antiobesidad que actúan de diferentes maneras (disminuyendo el apetito, alterando el metabolismo o inhibiendo la absorción calórica), dichos fármacos han representado serias preocupaciones en cuanto a la seguridad en su uso, a tal punto que, debido a sus efectos secundarios, Se retiraron del mercado la sibutramina y el rimonabant; a consecuencia de estos reveses existen pocos medicamentos antiobesidad aceptados. Por otra parte, el conocimiento acerca del eje intestino-cerebro ayuda a entender cómo funciona el sistema gastroenteropancreático, con relación a una serie de péptidos y hormonas que participan en la regulación alimentaria y el cerebro, específicamente el hipotálamo como centro homeostático de los estados de hambre y anorexia, o del apetito, y por ende, del peso corporal. Esto nos lleva a estudiar aquellos fármacos que se encuentran en fase de investigación y desarrollo como las monoterapias y las combinaciones, para concluir que existen tres fármacos aprobados por la Agencia de Alimentos y Medicamentos (FDA, por sus siglas en inglés), dos de ellos recientemente (en el 2012), y otros que podrían llegar a ser aceptados para su uso terapéutico.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/45098Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 217-261 0034-7418 1909-6356Londoño-Lemos, Milton Enrique (2012) Drug treatment for obesity. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 217-261 0034-7418 1909-6356 .Drug treatment for obesityArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTobesidadintestino-cerebrofarmacoterapiamecanismos de acción. Pharmacotherapy for obesityObesitygut-brainpharmacotherapymechanisms of actionORIGINAL45098-216217-1-SM.pdfapplication/pdf1070407https://repositorio.unal.edu.co/bitstream/unal/49315/1/45098-216217-1-SM.pdf561bd738eaab7700f2c974a271e0e5a2MD51THUMBNAIL45098-216217-1-SM.pdf.jpg45098-216217-1-SM.pdf.jpgGenerated Thumbnailimage/jpeg5953https://repositorio.unal.edu.co/bitstream/unal/49315/2/45098-216217-1-SM.pdf.jpgaf08e6c1bf41fba528cbef6d4fa5e6cdMD52unal/49315oai:repositorio.unal.edu.co:unal/493152023-12-09 23:05:55.598Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |