Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022

ilustraciones, fotografías a color

Autores:: Montenegro Moreno, Giselle Alejandra

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
dc.title.translated.eng.fl_str_mv	Volumetric brachytherapy treatments implementation for cervical cancer in a public hospital in southwestern Colombia, 2022
title	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
spellingShingle	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022 530 - Física::535 - Luz y radiación relacionada Tratamiento Cuello del útero Radioterapia Treatment Cervix Uteri Radiotherapy Braquiterapia intracavitaria Aplicador Fletcher Control de calidad Análisis dosimétrico Intracavitary brachytherapy Fletcher applicator Quality control Dosimetric analysis
title_short	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
title_full	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
title_fullStr	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
title_full_unstemmed	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
title_sort	Implementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022
dc.creator.fl_str_mv	Montenegro Moreno, Giselle Alejandra
dc.contributor.advisor.none.fl_str_mv	Orejuela Mosquera, Diego Mauricio
dc.contributor.author.none.fl_str_mv	Montenegro Moreno, Giselle Alejandra
dc.contributor.referee.none.fl_str_mv	Salcedo Suarez, Diana Carolina Pinilla Beltrán, Edna Carolina
dc.contributor.supervisor.none.fl_str_mv	Plazas, María Cristina
dc.contributor.orcid.spa.fl_str_mv	Montenegro Moreno, Giselle [0000-0003-4932-9096]
dc.contributor.cvlac.spa.fl_str_mv	Montenegro Moreno, Giselle
dc.subject.ddc.spa.fl_str_mv	530 - Física::535 - Luz y radiación relacionada
topic	530 - Física::535 - Luz y radiación relacionada Tratamiento Cuello del útero Radioterapia Treatment Cervix Uteri Radiotherapy Braquiterapia intracavitaria Aplicador Fletcher Control de calidad Análisis dosimétrico Intracavitary brachytherapy Fletcher applicator Quality control Dosimetric analysis
dc.subject.decs.spa.fl_str_mv	Tratamiento Cuello del útero Radioterapia
dc.subject.decs.eng.fl_str_mv	Treatment Cervix Uteri Radiotherapy
dc.subject.proposal.spa.fl_str_mv	Braquiterapia intracavitaria Aplicador Fletcher Control de calidad Análisis dosimétrico
dc.subject.proposal.eng.fl_str_mv	Intracavitary brachytherapy Fletcher applicator Quality control Dosimetric analysis
description	ilustraciones, fotografías a color
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-12-19
dc.date.accessioned.none.fl_str_mv	2023-04-19T16:08:31Z
dc.date.available.none.fl_str_mv	2023-04-19T16:08:31Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83736
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83736 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	[1] H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray, “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA: A Cancer Journal for Clinicians, vol. 71, pp. 209–249, May 2021 [2] L. Bruni, G. Albero, B. Serrano, M. Mena, J. Collado, D. Gómez, J. Muñoz, F. Bosch, and S. de San José, “Human Papillomavirus and Related Diseases in Colombia,” ICO IARC Information Centre on HPV and Cancer (HPV Information Centre, vol. Summary Report 22 October 2021, 2021. [3] K. Han, M. Milosevic, A. Fyles, M. Pintilie, and A. N. Viswanathan, “Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States”, International Journal of Radiation Oncology Biology Physics, vol. 87, pp. 111–119, Sept. 2013 [4] P. Georg, S. Lang, J. C. Dimopoulos, W. D¨orr, A. E. Sturdza, D. Berger, D. Georg, C. Kirisits, and R. P¨otter, “Dose–Volume Histogram Parameters and Late Side Effects in Magnetic Resonance Image–Guided Adaptive Cervical Cancer Brachytherapy,” International Journal of Radiation OncologyBiologyPhysics, vol. 79, pp. 356–362, Feb. 2011 [5] R. Pötter, P. Georg, J. C. Dimopoulos, M. Grimm, D. Berger, N. Nesvacil, D. Georg, M. P. Schmid, A. Reinthaller, A. Sturdza, and C. Kirisits, “Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer,” Radiotherapy and Oncology, vol. 100, pp. 116–123, July 2011 [6] M. C. Tod and W. J. Meredith, “A Dosage System for Use in the Treatment of Cancer of the Uterine Cervix,” The British Journal of Radiology, vol. 11, pp. 809–824, Dec.1938 [7] A. N. Viswanathan and B. Thomadsen, “American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: General principles,” Brachytherapy, vol. 11, pp. 33–46, Jan. 2012 [8] C. Haie-Meder, R. Pötter, E. Van Limbergen, E. Briot, M. De Brabandere, J. Dimopoulos, I. Dumas, T. P. Hellebust, C. Kirisits, S. Lang, S. Muschitz, J. Nevinson, A. Nulens, P. Petrow, and N. Wachter-Gerstner, “Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV,” Radiotherapy and Oncology, vol. 74, pp. 235–245, Mar. 2005 [9] R. Pötter, C. Haie-Meder, E. V. Limbergen, I. Barillot, M. D. Brabandere, J. Dimopoulos, I. Dumas, B. Erickson, S. Lang, A. Nulens, P. Petrow, J. Rownd, and C. Kirisits, “Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy—3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology,” Radiotherapy and Oncology, vol. 78, pp. 67–77, Jan. 2006 [10] M. J. Rivard, B. M. Coursey, L. A. DeWerd, W. F. Hanson, M. Saiful Huq, G. S. Ibbott, M. G. Mitch, R. Nath, and J. F. Williamson, “Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations,” Medical Physics, vol. 31, pp. 633–674, Feb. 2004 [11] ICRU, Dose and volume specification for reporting intracavitary therapy in gynecology. No. 38 in ICRU report, Bethesda, Md., U.S.A: International Commission on Radiological Units and Measurements, 1985 [12] M. Holmgren, “Brachytherapy for cancer of the cervix. 3D Dose distributions for new ring applicator using BrachyVision, for clinical useBrachytherapy for cancer of the cervix. 3D Dose distributions for new ring applicator using BrachyVision, for clinical use,” 2005 [13] A. Camacho, C. Beltran, A. Ramon, and A. Luis, “Criterios de Evaluación en Planes de Tratamiento de Braquiterapia Intracavitaria Tridimensional HDR,” Asociación Colombiana de Radioterapia Oncológica, vol. 10, 2013 [14] A. Brosed, Fundamentos de fisica médica. Madrid: Aula Documental de Investigación, 2011. OCLC: 908606357 [15] B.-A. Jönsson, “Henri Becquerel’s discovery of radioactivity – 125 years later,” Physica Medica, vol. 87, pp. 144–146, July 2021 [16] G. Kemikler, “History of Brachytherapy,” Turkish Journal of Oncology, 2019 [17] R. N. , et al. “Dosimetry of interstitial brachytherapy sources: Recommendations of the aapm radiation therapy committee task group no. 43,” Med. Phys, vol. 22, pp. 209–34, 1995 [18] R. N. , et al. “Code of practice for brachytherapy physics: Report of the aapm radiation therapy committee task group no. 56,” Med. Phys, vol. 24, pp. 1557–98, 1997 [19] H. K. , et al. “High dose-rate brachytherapy treatment delivery: Report of the aapm radiation therapy committee task group no. 59,” Med. Phys, vol. 25, pp. 375–403, 1998(a) [20] “Calibration of brachytherapy sources.guidelines to secondary standard dosimetry laboratories (ssdls) and medical physicists on standardized methods for calibration of brachytherapy sources.,” [21] International Atomic Energy Agency, Lessons learned from accidental exposures in radiotherapy. 2000 [22] “Calibración, matrices de dosis y control de calidad en braquiterapia: informe del grupo de trabajo de braquiterapia de la sefm,” [23] IAEA, “Aspectos físicos de la garantía de calidad en radioterapia: Protocolo de control de calidad IAEA-TECDOC-1151,” International Atomic Energy Agency, 2020 [24] IAEA, “Calibración de fuentes de fotones y rayos beta usadas en braquiterapia: IAEA TECDOC- 1274/S,” International Atomic Energy Agency, 2004 [25] U. Mahantshetty, S. Gudi, R. Singh, A. Sasidharan, S. C. Sastri, L. Gurram, D. Sharma, S. Ganeshrajah, J. Mg, D. Badakh, A. Basu, F. James, J. Swamidas, T. Kuppuswamy, and R. Bhalavat, “Indian Brachytherapy Society Guidelines for radiotherapeutic management of cervical cancer with special emphasis on high-dose-rate brachytherapy,” Journal of Contemporary Brachytherapy, vol. 11, no. 4, pp. 293–306, 2019 [26] U. Mahantshetty, R. Poetter, S. Beriwal, S. Grover, G. Lavanya, B. Rai, P. Petric, K. Tanderup, H. Carvalho, N. Hegazy, S. Mohamed, T. Ohno, and N. Amornwichet, “IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer,” Radiotherapy and Oncology, vol. 160, pp. 273–284, July 2021 [27] NCI, “NCI Dictionaries, National Cancer Institute,” Feb. 2011. Archive Location: nciglobal, ncienterprise [28] T. Winslow, “Terese Winslow LLC, Medical and Scientific Illustration.” [29] N. Bhatla, D. Aoki, D. N. Sharma, and R. Sankaranarayanan, “Cancer of the cervix uteri,” International Journal of Gynecology & Obstetrics, vol. 143, pp. 22–36, Oct. 2018 [30] N. Bhatla, D. Aoki, D. N. Sharma, and R. Sankaranarayanan, “Cancer of the cervix uteri: 2021 update,” International Journal of Gynecology & Obstetrics, vol. 155, pp. 28– 44, Oct. 2021 [31] OPS, “Clasificación estadística internacional de enfermedades y problemas relacionados con la salud,” Organización Panamericana de la Salud, vol. 1, 2008 [32] IAEA, Implementation of high dose rate brachytherapy in limited resource settings. International Atomic Energy Agency, 2015. OCLC: 913058359 [33] M. Straughn and C. M. Yashar, “Management of locally advanced cervical cancer,” 2017 [34] Varian, “A brave new world in brachytherapy: Applicators & Accessories,” Varian Medical Systems, 2020 [35] Varian, “Instrucciones de uso de BRAVOS™,” Varian Medical Systems, 2020 [36] N. R. Datta, A. Srivastava, K. J. Maria Das, A. Gupta, and N. Rastogi, “Comparative assessment of doses to tumor, rectum, and bladder as evaluated by orthogonal radiographs vs. computer enhanced computed tomography-based intracavitary brachytherapy in cervical cancer,” Brachytherapy, vol. 5, pp. 223–229, Oct. 2006 [37] S. L. Schoeppel, M. L. Lavigne, M. K. Martel, D. L. McShan, B. A. Fraass, and J. A. Roberts, “Three-dimensional treatment planning of intracavitary gynecologic implants: Analysis of ten cases and implications for dose specification,” International Journal of Radiation OncologyBiologyPhysics, vol. 28, pp. 277–283, Jan. 1994 [38] P. Georg, S. Lang, J. C. Dimopoulos, W. D¨orr, A. E. Sturdza, D. Berger, D. Georg, C. Kirisits, and R. P¨otter, “Dose–Volume Histogram Parameters and Late Side Effects in Magnetic Resonance Image–Guided Adaptive Cervical Cancer Brachytherapy,” International Journal of Radiation OncologyBiologyPhysics, vol. 79, pp. 356–362, Feb. 2011 [39] R. N. Eskander, D. Scanderbeg, C. C. Saenz, M. Brown, and C. Yashar, “Comparison of Computed Tomography and Magnetic Resonance Imaging in Cervical Cancer Brachytherapy Target and Normal Tissue Contouring”, International Journal of Gynecological Cancer, vol. 20, pp. 47–53, Jan. 2010 [40] J. L. Forrest, I. Ackerman, L. Barbera, E. A. Barnes, M. Davidson, A. Kiss, and G. Thomas, “Patient Outcome Study of Concurrent Chemoradiation, External Beam Radiotherapy, and High-Dose Rate Brachytherapy in Locally Advanced Carcinoma of the Cervix,” International Journal of Gynecologic Cancer, vol. 20, pp. 1074–1078, July 2010 [41] J. C. Dimopoulos, R. Pötter, S. Lang, E. Fidarova, P. Georg, W. Dörr, and C. Kirisits, “Dose–effect relationship for local control of cervical cancer by magnetic resonance image-guided brachytherapy,” Radiotherapy and Oncology, vol. 93, pp. 311–315, Nov. 2009 [42] F. D. Patel, P. Kumar, G. Karunanidhi, S. C. Sharma, and R. Kapoor, “Optimization of high–dose-rate intracavitary brachytherapy schedule in the treatment of carcinoma of the cervix,” Brachytherapy, vol. 10, pp. 147–153, Mar. 2011 [43] E. Podgorsak, “Radiation oncology physics: A handbook for teachers and students,” International Atomic Energy Agency, 2005 [44] G. J. Kutcher, L. Coia, M. Gillin, W. F. Hanson, S. Leibel, R. J. Morton, J. R. Palta, J. A. Purdy, L. E. Reinstein, G. K. Svensson, M. Weller, and L. Wingfield, “Comprehensive QA for radiation oncology: Report of AAPM Radiation Therapy Committee Task Group 40,” Medical Physics, vol. 21, pp. 581–618, Apr. 1994 [45] HUV, “Reseña histórica huv,” Hospital Universitario del Valle, 2022 [46] I. T. Castro, “Plan operativo anual institucional- vigencia 2022,” Hospital Universitario del Valle, 2022 [47] MinMinas, “Decreto Ley 4131 DEL 3 de Noviembre de 2011,” Ministerio de Minas y Energía, 2011 [48] SGC, “Decreto 2703 DE 2013,” Consejo Directivo del Servicio Geológico Colombiano (SGC), 2013 [49] MinMinas, “Resolución 90698 DE 2014,” Ministerio de Minas y Energía, 2014 [50] MinMinas, “Resolución 40569 DE 2019,” Ministerio de Minas y Energía, 2019 [51] MinMinas, “Resolución 41226 DE 2016,” Ministerio de Minas y Energía, 2016 [52] MinMinas, “Resolución DAN-1213 DEL 6 de mayo de 2022,” Ministerio de Minas y Energía, 2022 [53] MinMinas, “Resolución 181682 DE 2005,” Ministerio de Minas y Energía, 2005 [54] MinMinas, “Resolución 180005 DE 2010,” Ministerio de Minas y Energía, 2010 [55] MinMinas, “Resolución 181434 DE 2002,” Ministerio de Minas y Energía, 2002 [56] MinSalud, “Decreto Número 4725 DE 2005,” Ministerio de la Protección Social, 2005 [57] MinSalud, “Resolución Número 1328 DE 2021,” Ministerio de Salud y Protección Social, 2021 [58] P. Andreo, D. T. Burns, A. E. Nahum, J. Seuntjens, and F. H. Attix, Fundamentals of ionizing radiation dosimetry. Textbook / Pedro Andreo, David T. Burns, Alan E. Nahum, Jan Seuntjens, and Frank H. Attix. Weinheim: Wiley-VCH, 2017 [59] D. Baltas, N. Zamboglou, and L. Sakelliou, The physics of modern brachytherapy for oncology. Series in medical physics and biomedical engineering, Boca Raton: Taylor & Francis, 2007. OCLC: ocm64335913 [60] MinSalud, “Resolución Número 8430 DE 1993,” Ministerio de Salud y Protección Social, 1993 [61] Determinacion de la dosis absorbida en radioterapia con haces externos: un codigo de Practical Internacional para la dosimetria basada en patrones de dosis absorbida en agua. Vienna: International Atomic Energy Agency, 2005. OCLC: 1085579646 [62] SGSSS, Situación del cáncer en la población adulta atendida en el SGSSS de Colombia. Bogotá D.C.: Fondo Colombiano de Enfermedades de Alto Costo, Cuenta de Alto Costo (CAC), 2021 [63] S. C. Chacón-Anaya, M. Durán-Cruz, A. Reding-Bernal, and J. A. Barragán-Pérez, “Dosimetric analysis between Mánchester points,” Gaceta Mexicana de Oncología, vol. 20, p. 5366, June 2021 [64] K. Derks, J. L. Steenhuijsen, H. A. v. d. Berg, S. Houterman, J. Cnossen, P. v. Haaren, and K. D. Jaeger, “Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer,” Journal of Contemporary Brachytherapy, vol. 10, no. 1, pp. 17–25, 2018
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dc.coverage.temporal.spa.fl_str_mv	2022
dc.coverage.country.none.fl_str_mv	Colombia
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia Hospital Universitario del Valle
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Orejuela Mosquera, Diego Mauricio462cc118796bca35c23991ea09b2f204Montenegro Moreno, Giselle Alejandra19e88687cd56506cbed3f1d51f681cb2Salcedo Suarez, Diana CarolinaPinilla Beltrán, Edna CarolinaPlazas, María CristinaMontenegro Moreno, Giselle [0000-0003-4932-9096]Montenegro Moreno, Giselle2022Colombia2023-04-19T16:08:31Z2023-04-19T16:08:31Z2022-12-19https://repositorio.unal.edu.co/handle/unal/83736Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías a colorEn el presente trabajo se presenta la implementación de tratamiento de braquiterapia ginecológica intracavitaria de alta tasa de dosis (HDR) con aplicador Fletcher. El documento se estructura en dos ejes de gran impacto como son: 1) El control de calidad del equipo de braquiterapia y 2) el análisis dosimétrico entre dos tipos de planeaciones: una técnica de prescripción a puntos A y otra con prescripción al volumen clínico objetivo CTV contorneado por el médico radioncólogo. Se llevaron a cabo pruebas al equipo de carga diferida remota BRAVOS con el fin de dar cumplimiento al sistema de seguridad del HDR antes de iniciar un tratamiento, las pruebas del conjunto dosimétrico y la tasa de referencia de Kerma en aire para cada cambio de fuente. Con el fin de realizar el análisis dosimétrico, se hizo una comparación entre los parámetros de la planeación coon prescripción a puntos A con los parámetros de la planeación volumétrica y adicionalmente, se realizó una comparación cruzada, es decir, se evaluaron los parámetros de la planeación volumétrica en la planeación de puntos A para analizar las diferencias de dosis. Los resultados de este trabajo indican el cumplimiento del control de calidad del equipo BRAVOS y adicionalmente, muestra las diferencias dosimétricas entre los dos tipos de planeación. (Texto completo)This paper presents the implementation of high dose rate (HDR) intracavitary gynecological brachytherapy treatment with a Fletcher applicator. The document has two sections that leave an impact on the study: 1) Quality control of the brachytherapy equipment and 2) Dosimetric analysis between two types of planning: a prescription technique to points A and another with a prescription to the target clinical volume. CTV is contoured by the radiation oncologist's doctor. Using remote afterloading equipment BRAVOS, different tests were carried out to comply with the HDR security system before starting treatment, the tests of the dosimetric set, and for each source change, the reference rate of Kerma in the air. In order to carry out the dosimetric analysis, a comparison was made between the planning parameters with prescription at points A with the volumetric planning parameters and additionally, a cross-comparison was made, which means that the volumetric planning parameters were evaluated in the planning of points A to analyze the differences in dose. The results showed compliance with the quality control of the BRAVOS team and also shows the dosimetric differences between the two types of planning.MaestríaMagíster en Física MédicaRadioterapiaviii, 71 páginasapplication/pdfspaUniversidad Nacional de ColombiaHospital Universitario del ValleBogotá - Ciencias - Maestría en Física MédicaFacultad de CienciasBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá530 - Física::535 - Luz y radiación relacionadaTratamientoCuello del úteroRadioterapiaTreatmentCervix UteriRadiotherapyBraquiterapia intracavitariaAplicador FletcherControl de calidadAnálisis dosimétricoIntracavitary brachytherapyFletcher applicatorQuality controlDosimetric analysisImplementación de tratamientos de Braquiterapia volumétrica para cáncer de cuello uterino en un hospital público de mediana y alta complejidad del suroccidente colombiano, 2022Volumetric brachytherapy treatments implementation for cervical cancer in a public hospital in southwestern Colombia, 2022Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TM[1] H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray, “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA: A Cancer Journal for Clinicians, vol. 71, pp. 209–249, May 2021[2] L. Bruni, G. Albero, B. Serrano, M. Mena, J. Collado, D. Gómez, J. Muñoz, F. Bosch, and S. de San José, “Human Papillomavirus and Related Diseases in Colombia,” ICO IARC Information Centre on HPV and Cancer (HPV Information Centre, vol. Summary Report 22 October 2021, 2021.[3] K. Han, M. Milosevic, A. Fyles, M. Pintilie, and A. N. Viswanathan, “Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States”, International Journal of Radiation Oncology Biology Physics, vol. 87, pp. 111–119, Sept. 2013[4] P. Georg, S. Lang, J. C. Dimopoulos, W. D¨orr, A. E. Sturdza, D. Berger, D. Georg, C. Kirisits, and R. 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Jaeger, “Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer,” Journal of Contemporary Brachytherapy, vol. 10, no. 1, pp. 17–25, 2018Público generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83736/5/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD55ORIGINAL1053863172.2022.pdf1053863172.2022.pdfTesis de Maestría en Braquiterapia Ginecológicaapplication/pdf8266064https://repositorio.unal.edu.co/bitstream/unal/83736/4/1053863172.2022.pdfa6c5b7500d07a4b2bb3534267d534fe4MD54THUMBNAIL1053863172.2022.pdf.jpg1053863172.2022.pdf.jpgGenerated Thumbnailimage/jpeg4573https://repositorio.unal.edu.co/bitstream/unal/83736/6/1053863172.2022.pdf.jpg0753ff5ddf912258b4a0a39857337712MD56unal/83736oai:repositorio.unal.edu.co:unal/837362024-08-03 23:10:22.103Repositorio Institucional Universidad Nacional de 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